DK147304C - Analogifremgangsmaade til fremstilling af (-) daunosaminyl-4-demethoxydaunomycinon som en blanding af (7s : 9r) og (7r : 9r) alfa-anomere - Google Patents

Analogifremgangsmaade til fremstilling af (-) daunosaminyl-4-demethoxydaunomycinon som en blanding af (7s : 9r) og (7r : 9r) alfa-anomere

Info

Publication number
DK147304C
DK147304C DK256875A DK256875A DK147304C DK 147304 C DK147304 C DK 147304C DK 256875 A DK256875 A DK 256875A DK 256875 A DK256875 A DK 256875A DK 147304 C DK147304 C DK 147304C
Authority
DK
Denmark
Prior art keywords
demethoxydaunomycinon
daunosaminyl
anomers
alfa
analogue
Prior art date
Application number
DK256875A
Other languages
English (en)
Other versions
DK256875A (da
DK147304B (da
Inventor
Bianca Patelli
Luigi Bernardi
Federico Arcamone
Aurelio Di Marco
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of DK256875A publication Critical patent/DK256875A/da
Publication of DK147304B publication Critical patent/DK147304B/da
Application granted granted Critical
Publication of DK147304C publication Critical patent/DK147304C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK256875A 1974-06-12 1975-06-09 Analogifremgangsmaade til fremstilling af (-) daunosaminyl-4-demethoxydaunomycinon som en blanding af (7s : 9r) og (7r : 9r) alfa-anomere DK147304C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2608374A GB1467383A (en) 1974-06-12 1974-06-12 Daunomycin analogues
GB2608374 1974-06-12

Publications (3)

Publication Number Publication Date
DK256875A DK256875A (da) 1975-12-13
DK147304B DK147304B (da) 1984-06-12
DK147304C true DK147304C (da) 1984-12-17

Family

ID=10238087

Family Applications (1)

Application Number Title Priority Date Filing Date
DK256875A DK147304C (da) 1974-06-12 1975-06-09 Analogifremgangsmaade til fremstilling af (-) daunosaminyl-4-demethoxydaunomycinon som en blanding af (7s : 9r) og (7r : 9r) alfa-anomere

Country Status (17)

Country Link
US (1) US4046878A (da)
JP (1) JPS5840557B2 (da)
AT (1) AT337363B (da)
BE (1) BE830090A (da)
BG (1) BG61059B2 (da)
CH (1) CH611317A5 (da)
DE (2) DE19375027I2 (da)
DK (1) DK147304C (da)
ES (1) ES438431A1 (da)
FR (1) FR2274629A1 (da)
GB (1) GB1467383A (da)
HK (1) HK982A (da)
MY (1) MY103666A (da)
NL (1) NL173272C (da)
SE (1) SE423633B (da)
SU (1) SU645588A3 (da)
ZA (1) ZA753722B (da)

Families Citing this family (44)

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GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
US4161480A (en) * 1978-06-05 1979-07-17 G. D. Searle & Co. Intermediates for the synthesis of 4-demethoxydaunorubicin
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
IL55431A (en) * 1978-08-24 1982-07-30 Yeda Res & Dev Anthracycline type antibiotics,their preparation and pharmaceutical compositions comprising them
NL8001417A (nl) * 1979-03-17 1980-09-19 Erba Farmitalia Antitumorglycosiden.
JPS5673039A (en) * 1979-08-20 1981-06-17 Hoffmann La Roche Naphthacene derivative
DE3060472D1 (en) * 1979-09-01 1982-07-15 Erba Farmitalia Anthracycline glycosides, processes for their preparation and pharmaceutical composition containing them
DE3100968A1 (de) * 1980-01-16 1982-01-14 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4348388A (en) * 1980-04-02 1982-09-07 G.D. Searle & Co. 11-Amino-11-deoxydaunorubicin and analogs
ZA814722B (en) * 1980-07-18 1982-07-28 Hoffmann La Roche Novel anthracycline glycosides
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
US5138042A (en) * 1981-05-28 1992-08-11 Farmitalia Carlo Erba S.P.A. 6-deoxyanthracyclines
US4563444A (en) * 1982-05-26 1986-01-07 Farmitalia Carlo Erba S.P.A. Anthracycline glycosides, use and compositions containing same
US4604381A (en) * 1982-07-16 1986-08-05 Farmitalia Carlo Erba S.P.A. 4-demethoxy-13-dihydrodaunorubicin and use thereof
US4562177A (en) * 1982-08-17 1985-12-31 The Ohio State University Research Foundation 3'-Amino-2' halo-anthracycline antibiotics
US4564674A (en) * 1983-10-31 1986-01-14 Sagami Chemical Research Center Process for an anthracycline derivative, and an anthracyclinone derivative useful for the process
US4496485A (en) * 1983-11-25 1985-01-29 G. D. Searle & Co. Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same
US4697005A (en) * 1985-03-20 1987-09-29 Ohio State University Research Foundation 1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
NZ224252A (en) * 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
JPS63191263U (da) * 1987-05-29 1988-12-09
GB2212154B (en) * 1987-11-10 1991-03-27 Erba Carlo Spa New 4-demethoxy anthracycline derivatives
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
GB8818167D0 (en) * 1988-07-29 1988-09-01 Erba Carlo Spa Novel 4-substituted anthracyclinones & process for their preparation
ATE153027T1 (de) * 1992-03-02 1997-05-15 Pfizer Zuckerderivate von makroliden
AU2003299378A1 (en) * 2002-10-11 2004-05-04 Board Of Regents, The University Of Texas System Method and compounds for inhibiting hec1 activity for the treatment of proliferative diseases
AU2006207321B2 (en) 2005-01-21 2012-09-06 Astex Therapeutics Limited Pharmaceutical compounds
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8551973B2 (en) * 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
EA019295B1 (ru) * 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Соединения пуриновых нуклеозидов и способ их получения
EP2376088B1 (en) 2008-12-23 2017-02-22 Gilead Pharmasset LLC 6-O-Substituted-2-amino-purine nucleoside phosphoramidates
CN102812045B (zh) 2009-11-13 2018-04-13 第一三共欧洲有限公司 用于治疗或预防人表皮生长因子受体‑3(her‑3)相关疾病的材料和方法
JP2013527145A (ja) 2010-03-31 2013-06-27 ギリード・ファーマセット・エルエルシー リン含有活性化剤の立体選択的合成
CA2815154A1 (en) 2010-08-06 2012-02-09 U3 Pharma Gmbh Use of her3 binding agents in prostate treatment
DE102011113652A1 (de) 2011-09-19 2013-03-21 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Idarubicinhydrochlorid
RS57350B1 (sr) 2011-10-03 2018-08-31 Mx Adjuvac Ab Nanočestice, postupak dobijanja i njihova primena kao nosača amfipatičnih ili hidrofobnih molekula u medicini, uključujući i terapiju kancera, kao i prehrambenih jedinjenja
AR095962A1 (es) 2013-04-01 2015-11-25 Moreinx Ab Nanopartículas, compuestas de esterol y saponina de quillaja saponaria molina, proceso para preparación y uso de las mismas como portadores para moléculas anfipáticas o hidrófobas en el campo de la medicina incluyendo tratamiento de cáncer y compuestos relacionados con alimentos
EP3669890A1 (en) 2018-12-18 2020-06-24 Croda International PLC Filamentous nanoparticles having vaccine adjuvant effect

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Publication number Priority date Publication date Assignee Title
US3427300A (en) * 1965-11-12 1969-02-11 Merck & Co Inc Anti-inflammatory steroid 2'-acetamido-2'-deoxy-glucoside compounds
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
US3686163A (en) * 1968-05-14 1972-08-22 Farmaceutici Italia Dihydrodaunomycin antibiotic and derivatives thereof

Also Published As

Publication number Publication date
ATA437375A (de) 1976-10-15
DE2525633B2 (da) 1979-03-01
JPS518260A (da) 1976-01-23
DE19375027I2 (de) 2002-06-13
FR2274629B1 (da) 1980-01-11
US4046878A (en) 1977-09-06
BE830090A (fr) 1975-12-11
SE7506589L (sv) 1975-12-15
DK256875A (da) 1975-12-13
JPS5840557B2 (ja) 1983-09-06
NL173272C (nl) 1984-01-02
SU645588A3 (ru) 1979-01-30
MY103666A (en) 1993-08-28
GB1467383A (en) 1977-03-16
DE2525633C3 (da) 1979-10-18
FR2274629A1 (fr) 1976-01-09
DK147304B (da) 1984-06-12
NL7506745A (nl) 1975-12-16
ES438431A1 (es) 1977-02-01
CH611317A5 (da) 1979-05-31
DE2525633A1 (de) 1976-01-02
ZA753722B (en) 1976-09-29
BG61059B2 (bg) 1996-09-30
HK982A (en) 1982-01-22
AU8197975A (en) 1976-12-16
AT337363B (de) 1977-06-27
NL173272B (nl) 1983-08-01
SE423633B (sv) 1982-05-17

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