FR2274629A1 - Analogues de la daunomycine - Google Patents

Analogues de la daunomycine

Info

Publication number
FR2274629A1
FR2274629A1 FR7517881A FR7517881A FR2274629A1 FR 2274629 A1 FR2274629 A1 FR 2274629A1 FR 7517881 A FR7517881 A FR 7517881A FR 7517881 A FR7517881 A FR 7517881A FR 2274629 A1 FR2274629 A1 FR 2274629A1
Authority
FR
France
Prior art keywords
daunomycin
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7517881A
Other languages
English (en)
Other versions
FR2274629B1 (fr
Inventor
Bianca Patelli
Luigi Bernardi
Federico Arcamone
Aurelio Di Marco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of FR2274629A1 publication Critical patent/FR2274629A1/fr
Application granted granted Critical
Publication of FR2274629B1 publication Critical patent/FR2274629B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FR7517881A 1974-06-12 1975-06-09 Analogues de la daunomycine Granted FR2274629A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2608374A GB1467383A (en) 1974-06-12 1974-06-12 Daunomycin analogues

Publications (2)

Publication Number Publication Date
FR2274629A1 true FR2274629A1 (fr) 1976-01-09
FR2274629B1 FR2274629B1 (fr) 1980-01-11

Family

ID=10238087

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7517881A Granted FR2274629A1 (fr) 1974-06-12 1975-06-09 Analogues de la daunomycine

Country Status (17)

Country Link
US (1) US4046878A (fr)
JP (1) JPS5840557B2 (fr)
AT (1) AT337363B (fr)
BE (1) BE830090A (fr)
BG (1) BG61059B2 (fr)
CH (1) CH611317A5 (fr)
DE (2) DE2525633A1 (fr)
DK (1) DK147304C (fr)
ES (1) ES438431A1 (fr)
FR (1) FR2274629A1 (fr)
GB (1) GB1467383A (fr)
HK (1) HK982A (fr)
MY (1) MY103666A (fr)
NL (1) NL173272C (fr)
SE (1) SE423633B (fr)
SU (1) SU645588A3 (fr)
ZA (1) ZA753722B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0288268A2 (fr) * 1987-04-21 1988-10-26 FARMITALIA CARLO ERBA S.r.l. 4-Déméthoxy-4-aminoanthracyclines
EP0354995A1 (fr) * 1988-07-29 1990-02-21 FARMITALIA CARLO ERBA S.r.L. Anthracyclinones 4-substituées et anthracyclinone glycosides et leur préparation
EP0337665A3 (en) * 1988-04-11 1990-04-11 Farmitalia Carlo Erba S.R.L. Process for preparing 4-demethoxydaunomycinone

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
US4161480A (en) * 1978-06-05 1979-07-17 G. D. Searle & Co. Intermediates for the synthesis of 4-demethoxydaunorubicin
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
IL55431A (en) * 1978-08-24 1982-07-30 Yeda Res & Dev Anthracycline type antibiotics,their preparation and pharmaceutical compositions comprising them
NL8001417A (nl) * 1979-03-17 1980-09-19 Erba Farmitalia Antitumorglycosiden.
BE884828A (fr) * 1979-08-20 1981-02-19 Hoffmann La Roche Derives de naphtacene
CA1154013A (fr) * 1979-09-01 1983-09-20 Alberto Bargiotti Glycosides antitumoraux, leur preparation leur utilisation et les compositions les renfermant
DE3100968A1 (de) * 1980-01-16 1982-01-14 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4348388A (en) * 1980-04-02 1982-09-07 G.D. Searle & Co. 11-Amino-11-deoxydaunorubicin and analogs
ZA814722B (en) * 1980-07-18 1982-07-28 Hoffmann La Roche Novel anthracycline glycosides
US5138042A (en) * 1981-05-28 1992-08-11 Farmitalia Carlo Erba S.P.A. 6-deoxyanthracyclines
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4563444A (en) * 1982-05-26 1986-01-07 Farmitalia Carlo Erba S.P.A. Anthracycline glycosides, use and compositions containing same
US4604381A (en) * 1982-07-16 1986-08-05 Farmitalia Carlo Erba S.P.A. 4-demethoxy-13-dihydrodaunorubicin and use thereof
US4562177A (en) * 1982-08-17 1985-12-31 The Ohio State University Research Foundation 3'-Amino-2' halo-anthracycline antibiotics
US4564674A (en) * 1983-10-31 1986-01-14 Sagami Chemical Research Center Process for an anthracycline derivative, and an anthracyclinone derivative useful for the process
US4496485A (en) * 1983-11-25 1985-01-29 G. D. Searle & Co. Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same
US4697005A (en) * 1985-03-20 1987-09-29 Ohio State University Research Foundation 1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
JPS63191263U (fr) * 1987-05-29 1988-12-09
GB2212154B (en) * 1987-11-10 1991-03-27 Erba Carlo Spa New 4-demethoxy anthracycline derivatives
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
JP2563080B2 (ja) * 1992-03-02 1996-12-11 フアイザー・インコーポレイテツド マクロライドの糖誘導体
AU2003299378A1 (en) * 2002-10-11 2004-05-04 Board Of Regents, The University Of Texas System Method and compounds for inhibiting hec1 activity for the treatment of proliferative diseases
BRPI0606480A (pt) 2005-01-21 2008-03-11 Astex Therapeutics Ltd compostos farmacêuticos
WO2008044045A1 (fr) 2006-10-12 2008-04-17 Astex Therapeutics Limited Combinaisons pharmaceutiques
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
WO2010075554A1 (fr) * 2008-12-23 2010-07-01 Pharmasset, Inc. Synthèse de nucléosides de type purine
EA019341B1 (ru) * 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
PA8855701A1 (es) * 2008-12-23 2010-07-27 Análogos de nucleósidos
ES2655737T3 (es) 2009-11-13 2018-02-21 Daiichi Sankyo Europe Gmbh Materiales y métodos para tratar o prevenir las enfermedades asociadas a HER-3
BR112012024884A2 (pt) 2010-03-31 2016-10-18 Gilead Pharmasset Llc síntese estereosseletiva de ativos contendo fósforo
JP2013540694A (ja) 2010-08-06 2013-11-07 ウー３・フアルマ・ゲー・エム・ベー・ハー Ｈｅｒ３結合剤の前立腺治療における使用
DE102011113652A1 (de) 2011-09-19 2013-03-21 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Idarubicinhydrochlorid
PT2750683T (pt) 2011-10-03 2018-06-26 Mx Adjuvac Ab Nanopartículas, processo de preparação e seu uso como transportadores para moléculas hidrofóbicas anfipáticas no domínio da medicina, incluindo tratamento de cancro e compostos relacionados a alimentos
WO2014163558A1 (fr) 2013-04-01 2014-10-09 Moreinx Ab Nanoparticules, constituées de stérol et de saponine de quillaja saponaria molina, leur procédé de préparation et leur utilisation comme support pour des molécules amphipathiques ou hydrophobes dans le domaine médical, notamment pour le traitement du cancer, et composés alimentaires
EP3669890A1 (fr) 2018-12-18 2020-06-24 Croda International PLC Nanoparticules filamenteuses ayant un effet d'adjuvant de vaccin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3427300A (en) * 1965-11-12 1969-02-11 Merck & Co Inc Anti-inflammatory steroid 2'-acetamido-2'-deoxy-glucoside compounds
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
US3686163A (en) * 1968-05-14 1972-08-22 Farmaceutici Italia Dihydrodaunomycin antibiotic and derivatives thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0288268A2 (fr) * 1987-04-21 1988-10-26 FARMITALIA CARLO ERBA S.r.l. 4-Déméthoxy-4-aminoanthracyclines
EP0288268A3 (en) * 1987-04-21 1988-12-14 Farmitalia Carlo Erba S.R.L. 4-demethoxy-4-amino-anthracyclines
US4985548A (en) * 1987-04-21 1991-01-15 Farmitalia Carlo Erba S.R.L. 4-demethoxy-4-amino-anthracyclines
EP0337665A3 (en) * 1988-04-11 1990-04-11 Farmitalia Carlo Erba S.R.L. Process for preparing 4-demethoxydaunomycinone
US5103029A (en) * 1988-04-11 1992-04-07 Farmitalia Carlo Erba S.R.L. Process for preparing 4-demethoxydaunomycinone
EP0354995A1 (fr) * 1988-07-29 1990-02-21 FARMITALIA CARLO ERBA S.r.L. Anthracyclinones 4-substituées et anthracyclinone glycosides et leur préparation
WO1990001490A1 (fr) * 1988-07-29 1990-02-22 Farmitalia Carlo Erba S.R.L. Anthracyclinones a substitution en position 4 et glucosides d'anthracycline et leur preparation

Also Published As

Publication number Publication date
DE2525633C3 (fr) 1979-10-18
SE423633B (sv) 1982-05-17
MY103666A (en) 1993-08-28
FR2274629B1 (fr) 1980-01-11
GB1467383A (en) 1977-03-16
DE2525633A1 (de) 1976-01-02
BG61059B2 (bg) 1996-09-30
US4046878A (en) 1977-09-06
NL7506745A (nl) 1975-12-16
BE830090A (fr) 1975-12-11
ZA753722B (en) 1976-09-29
SE7506589L (sv) 1975-12-15
ATA437375A (de) 1976-10-15
CH611317A5 (fr) 1979-05-31
HK982A (en) 1982-01-22
JPS518260A (fr) 1976-01-23
ES438431A1 (es) 1977-02-01
DE19375027I2 (de) 2002-06-13
DE2525633B2 (fr) 1979-03-01
DK147304B (da) 1984-06-12
AU8197975A (en) 1976-12-16
SU645588A3 (ru) 1979-01-30
AT337363B (de) 1977-06-27
NL173272B (nl) 1983-08-01
NL173272C (nl) 1984-01-02
DK256875A (da) 1975-12-13
DK147304C (da) 1984-12-17
JPS5840557B2 (ja) 1983-09-06

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Legal Events

Date Code Title Description
CD Change of name or company name
TP Transmission of property
TP Transmission of property
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0089, 920424

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0089, 750609

CL Concession to grant licences