BG106102A - Микрогранули, неразтворими в стомашния сок , метод за тяхното получаване и фармацевтични препарати - Google Patents

Микрогранули, неразтворими в стомашния сок , метод за тяхното получаване и фармацевтични препарати

Info

Publication number
BG106102A
BG106102A BG106102A BG10610201A BG106102A BG 106102 A BG106102 A BG 106102A BG 106102 A BG106102 A BG 106102A BG 10610201 A BG10610201 A BG 10610201A BG 106102 A BG106102 A BG 106102A
Authority
BG
Bulgaria
Prior art keywords
gastric fluid
microgranules
pharmaceutical preparations
obtaining same
gastric
Prior art date
Application number
BG106102A
Other languages
English (en)
Other versions
BG65415B1 (bg
Inventor
Bruno Criere
Pascal Suplie
Pascal Oury
Original Assignee
Laboratoires Des Produits Ethiques Ethypharm S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9545866&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG106102(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratoires Des Produits Ethiques Ethypharm S.A. filed Critical Laboratoires Des Produits Ethiques Ethypharm S.A.
Publication of BG106102A publication Critical patent/BG106102A/bg
Publication of BG65415B1 publication Critical patent/BG65415B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Микрогранулите съдържат инхибитор на стомашната протонна помпа, с изключение на омепразол, и включват активен слой, съдържащ активната съставка, и външен слой, осигуряващ неразтворимост в стомашния сок. Активният слой и външният слой съдържат хидрофобна субстанция, която повишава устойчивостта на микрогранулите при съхранение. Микрогранулите не съдържат алкално съединение и йонен сърфактант.
BG106102A 1999-05-21 2001-11-13 Микрогранули, неразтворими в стомашния сок, методза тяхното получаване и фармацевтични препарати BG65415B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9906479A FR2793688B1 (fr) 1999-05-21 1999-05-21 Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques
PCT/FR2000/001367 WO2000071121A1 (fr) 1999-05-21 2000-05-19 Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques

Publications (2)

Publication Number Publication Date
BG106102A true BG106102A (bg) 2002-07-31
BG65415B1 BG65415B1 (bg) 2008-07-31

Family

ID=9545866

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106102A BG65415B1 (bg) 1999-05-21 2001-11-13 Микрогранули, неразтворими в стомашния сок, методза тяхното получаване и фармацевтични препарати

Country Status (35)

Country Link
US (1) US8409612B1 (bg)
EP (1) EP1178799B1 (bg)
JP (2) JP5344781B2 (bg)
KR (1) KR100603915B1 (bg)
CN (1) CN1243546C (bg)
AR (1) AR024036A1 (bg)
AT (1) ATE247960T1 (bg)
AU (1) AU771759B2 (bg)
BG (1) BG65415B1 (bg)
BR (1) BR0010832A (bg)
CA (1) CA2373972C (bg)
CZ (1) CZ302946B6 (bg)
DE (1) DE60004815T2 (bg)
DK (1) DK1178799T3 (bg)
EA (1) EA003943B1 (bg)
EE (1) EE04902B1 (bg)
ES (1) ES2204598T3 (bg)
FR (1) FR2793688B1 (bg)
GE (1) GEP20053580B (bg)
HK (1) HK1042851B (bg)
HR (1) HRP20010940B1 (bg)
HU (1) HU227590B1 (bg)
IL (2) IL146484A0 (bg)
IS (1) IS2160B (bg)
MX (1) MXPA01011973A (bg)
NO (1) NO331643B1 (bg)
PL (1) PL198355B1 (bg)
PT (1) PT1178799E (bg)
RS (1) RS50241B (bg)
SI (1) SI1178799T1 (bg)
SK (1) SK287605B6 (bg)
TR (1) TR200103325T2 (bg)
UA (1) UA72522C2 (bg)
WO (1) WO2000071121A1 (bg)
ZA (1) ZA200109472B (bg)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2821745B1 (fr) * 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques Granules et granules enrobes au gout masque
FR2822704B1 (fr) * 2001-03-29 2005-02-18 Chiesi Sa Sels de cetoacides et d'acides amines gastroresistants et leur utilisation pour la preparation de medicaments
FR2845289B1 (fr) * 2002-10-04 2004-12-03 Ethypharm Sa Spheroides, procede de preparation et compositions pharmaceutiques.
ES2234393B2 (es) * 2003-04-29 2006-09-01 Laboratorios Belmac, S.A. "formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido".
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
EP2825159B1 (en) 2012-03-15 2022-06-22 Boehringer Ingelheim Vetmedica GmbH Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
AU2014292086B2 (en) 2013-07-19 2019-08-08 Boehringer Ingelheim Vetmedica Gmbh Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
EP2925305B1 (en) 2013-12-04 2016-07-27 Boehringer Ingelheim Vetmedica GmbH Improved pharmaceutical compositions of pimobendan
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4153677A (en) * 1978-05-18 1979-05-08 Sterling Drug Inc. Controlled-release composition
DK151608C (da) * 1982-08-13 1988-06-20 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat med kontrolleret afgivelse
GB8809421D0 (en) * 1988-04-21 1988-05-25 Fordonal Sa Antacid compositions with prolonged gastric residence time
JPH0768125B2 (ja) 1988-05-18 1995-07-26 エーザイ株式会社 酸不安定化合物の内服用製剤
US5654009A (en) * 1991-03-25 1997-08-05 Fujisawa Pharmaceutical Co., Ltd. Delayed action preparation
EP0520119A1 (de) * 1991-06-17 1992-12-30 Spirig Ag Pharmazeutische Präparate Neue orale Diclofenaczubereitung
US5681585A (en) * 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
FR2692146B1 (fr) 1992-06-16 1995-06-02 Ethypharm Sa Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention.
CA2185883C (en) * 1994-03-18 2005-08-23 Alfred Schmidt The use of dimeticone as a transport and carrier system and/or drug delivery system
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
GB2290965A (en) 1994-07-11 1996-01-17 Therapicon Srl Multiple layer capsules for drugs
EP0800385B1 (en) * 1994-09-30 2000-12-20 Takeda Chemical Industries, Ltd. Oral sustained-release preparation
ES2094694B1 (es) * 1995-02-01 1997-12-16 Esteve Quimica Sa Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
US5708017A (en) 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
DK1092434T3 (da) 1995-09-21 2004-07-26 Pharma Pass Ii Llc Hidtil ukendt sammensætning indeholdende lansoprazol og fremgangsmåde til fremstilling deraf
JPH1029937A (ja) * 1996-05-15 1998-02-03 Kobayashi Seiyaku Kogyo Kk メフェナム酸水溶液製剤
ZA979937B (en) 1996-11-06 1999-05-18 Sharmatek Inc Delayed delivery system for acid-sensitive drugs
GB9710800D0 (en) * 1997-05-23 1997-07-23 Cipla Limited Pharmaceutical composition and method of preparing it
ES2137862B1 (es) 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
US6013280A (en) * 1997-10-07 2000-01-11 Fuisz Technologies Ltd. Immediate release dosage forms containing microspheres
ATE303809T1 (de) * 1997-12-08 2005-09-15 Altana Pharma Ag Orale verabreichungsform enthaltend einen protonenpumpeninhbitor (z.b. pantoprazole)
SE9704869D0 (sv) 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II
SE9704870D0 (sv) 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
FR2774288B1 (fr) * 1998-01-30 2001-09-07 Ethypharm Sa Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques

Also Published As

Publication number Publication date
CA2373972C (fr) 2011-07-12
WO2000071121A1 (fr) 2000-11-30
CZ302946B6 (cs) 2012-01-25
HU227590B1 (hu) 2011-09-28
CN1243546C (zh) 2006-03-01
EP1178799B1 (fr) 2003-08-27
HUP0201304A3 (en) 2007-11-28
EE200100615A (et) 2003-02-17
EA200101221A1 (ru) 2002-04-25
PT1178799E (pt) 2004-01-30
BR0010832A (pt) 2002-03-05
JP2003500358A (ja) 2003-01-07
DE60004815D1 (de) 2003-10-02
IS6151A (is) 2001-11-08
EA003943B1 (ru) 2003-10-30
NO20015480L (no) 2002-01-10
KR100603915B1 (ko) 2006-07-24
SK16322001A3 (sk) 2002-05-09
HRP20010940A2 (en) 2003-02-28
GEP20053580B (en) 2005-07-25
YU82301A (sh) 2004-07-15
SK287605B6 (sk) 2011-03-04
ATE247960T1 (de) 2003-09-15
EP1178799A1 (fr) 2002-02-13
PL351658A1 (en) 2003-05-19
NO20015480D0 (no) 2001-11-08
ZA200109472B (en) 2002-08-07
IL146484A (en) 2006-04-10
JP5344781B2 (ja) 2013-11-20
US8409612B1 (en) 2013-04-02
IS2160B (is) 2006-11-15
CN1351494A (zh) 2002-05-29
ES2204598T3 (es) 2004-05-01
CZ20014155A3 (cs) 2002-04-17
TR200103325T2 (tr) 2002-05-21
UA72522C2 (en) 2005-03-15
AU771759B2 (en) 2004-04-01
MXPA01011973A (es) 2002-05-06
FR2793688A1 (fr) 2000-11-24
EE04902B1 (et) 2007-10-15
DE60004815T2 (de) 2004-06-17
AR024036A1 (es) 2002-09-04
RS50241B (sr) 2009-07-15
IL146484A0 (en) 2002-07-25
NO331643B1 (no) 2012-02-13
HK1042851B (zh) 2004-01-30
HRP20010940B1 (en) 2004-10-31
DK1178799T3 (da) 2003-12-22
HUP0201304A2 (en) 2002-08-28
FR2793688B1 (fr) 2003-06-13
WO2000071121A9 (fr) 2002-05-23
HK1042851A1 (en) 2002-08-30
AU4765300A (en) 2000-12-12
KR20020011990A (ko) 2002-02-09
BG65415B1 (bg) 2008-07-31
JP2011157390A (ja) 2011-08-18
PL198355B1 (pl) 2008-06-30
CA2373972A1 (fr) 2000-11-30
SI1178799T1 (en) 2003-12-31

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