BE871781A - Procede ameliore de synthese d'oligonucleotides par la voie "triester" - Google Patents
Procede ameliore de synthese d'oligonucleotides par la voie "triester"Info
- Publication number
- BE871781A BE871781A BE1009120A BE1009120A BE871781A BE 871781 A BE871781 A BE 871781A BE 1009120 A BE1009120 A BE 1009120A BE 1009120 A BE1009120 A BE 1009120A BE 871781 A BE871781 A BE 871781A
- Authority
- BE
- Belgium
- Prior art keywords
- triester
- oligonucleotides
- route
- synthesis
- improved process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84960877A | 1977-11-08 | 1977-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE871781A true BE871781A (fr) | 1979-05-07 |
Family
ID=25306107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE1009120A BE871781A (fr) | 1977-11-08 | 1978-11-06 | Procede ameliore de synthese d'oligonucleotides par la voie "triester" |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0002322A3 (de) |
| JP (1) | JPS5473787A (de) |
| AU (1) | AU4136078A (de) |
| BE (1) | BE871781A (de) |
| BR (1) | BR7807288A (de) |
| DD (1) | DD141836A5 (de) |
| DE (1) | DE2848054A1 (de) |
| DK (1) | DK493678A (de) |
| ES (1) | ES474850A1 (de) |
| FI (1) | FI783364A (de) |
| FR (1) | FR2407939A1 (de) |
| GB (1) | GB2007670A (de) |
| IL (1) | IL55893A0 (de) |
| LU (1) | LU80483A1 (de) |
| NL (1) | NL7811043A (de) |
| NO (1) | NO783721L (de) |
| OA (1) | OA06003A (de) |
| PL (1) | PL210786A1 (de) |
| PT (1) | PT68754A (de) |
| SE (1) | SE7811459L (de) |
| ZA (1) | ZA786303B (de) |
| ZM (1) | ZM9478A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2422717B1 (fr) * | 1977-11-08 | 1985-12-06 | Genentech Inc | Procede permettant l'expression microbienne de polypeptides et moyens appropries |
| US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
| US4474947A (en) * | 1982-04-08 | 1984-10-02 | Biosearch | Benzazolides and their employment in phosphate ester oligonucleotide synthesis processes |
| JPS61152695A (ja) * | 1984-12-26 | 1986-07-11 | Nippon Shinyaku Co Ltd | 長鎖ｄｎａの合成法 |
| ES2616051T3 (es) | 2008-12-02 | 2017-06-09 | Wave Life Sciences Japan, Inc. | Método para la síntesis de ácidos nucleicos modificados en el átomo de fósforo |
| JP5998326B2 (ja) | 2009-07-06 | 2016-09-28 | ウェイブ ライフ サイエンス リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | 新規核酸プロドラッグおよびその使用方法 |
| US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
| EP3248982A1 (de) | 2011-07-19 | 2017-11-29 | Wave Life Sciences Ltd. | Thiosulfonate reagente zur synthese von funktionalisierten nukleinsäuren |
| KR101835401B1 (ko) | 2012-07-13 | 2018-03-08 | 신 니뽄 바이오메디칼 라보라토리즈, 엘티디. | 키랄 핵산 어쥬번트 |
| PL2872147T3 (pl) | 2012-07-13 | 2023-09-25 | Wave Life Sciences Ltd. | Sposób wytwarzania chiralnych oligonukleotydów |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| SG10201912897UA (en) | 2014-01-16 | 2020-02-27 | Wave Life Sciences Ltd | Chiral design |
-
1978
- 1978-09-06 BR BR7807288A patent/BR7807288A/pt unknown
- 1978-11-06 DE DE19782848054 patent/DE2848054A1/de not_active Withdrawn
- 1978-11-06 FI FI783364A patent/FI783364A/fi unknown
- 1978-11-06 EP EP78300595A patent/EP0002322A3/de not_active Withdrawn
- 1978-11-06 ES ES474850A patent/ES474850A1/es not_active Expired
- 1978-11-06 AU AU41360/78A patent/AU4136078A/en active Pending
- 1978-11-06 NL NL7811043A patent/NL7811043A/xx not_active Application Discontinuation
- 1978-11-06 DK DK493678A patent/DK493678A/da unknown
- 1978-11-06 GB GB7843445A patent/GB2007670A/en not_active Withdrawn
- 1978-11-06 BE BE1009120A patent/BE871781A/xx unknown
- 1978-11-06 FR FR7831349A patent/FR2407939A1/fr not_active Withdrawn
- 1978-11-06 IL IL55893A patent/IL55893A0/xx unknown
- 1978-11-06 NO NO783721A patent/NO783721L/no unknown
- 1978-11-06 SE SE7811459A patent/SE7811459L/xx unknown
- 1978-11-06 JP JP13721478A patent/JPS5473787A/ja active Pending
- 1978-11-07 DD DD78208919A patent/DD141836A5/de unknown
- 1978-11-07 PT PT68754A patent/PT68754A/pt unknown
- 1978-11-08 LU LU80483A patent/LU80483A1/xx unknown
- 1978-11-08 OA OA56653A patent/OA06003A/xx unknown
- 1978-11-08 ZM ZM94/78A patent/ZM9478A1/xx unknown
- 1978-11-08 PL PL21078678A patent/PL210786A1/xx unknown
- 1978-11-08 ZA ZA00786303A patent/ZA786303B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2848054A1 (de) | 1979-05-10 |
| GB2007670A (en) | 1979-05-23 |
| FR2407939A1 (fr) | 1979-06-01 |
| SE7811459L (sv) | 1979-05-09 |
| PL210786A1 (pl) | 1979-07-16 |
| ZA786303B (en) | 1979-10-31 |
| ES474850A1 (es) | 1979-12-01 |
| EP0002322A2 (de) | 1979-06-13 |
| EP0002322A3 (de) | 1979-06-27 |
| JPS5473787A (en) | 1979-06-13 |
| AU4136078A (en) | 1979-05-17 |
| IL55893A0 (en) | 1979-01-31 |
| NL7811043A (nl) | 1979-05-10 |
| OA06003A (fr) | 1981-06-30 |
| FI783364A (fi) | 1979-05-09 |
| PT68754A (en) | 1978-12-01 |
| ZM9478A1 (en) | 1980-03-21 |
| NO783721L (no) | 1979-05-09 |
| DD141836A5 (de) | 1980-05-21 |
| BR7807288A (pt) | 1979-06-12 |
| LU80483A1 (fr) | 1979-03-22 |
| DK493678A (da) | 1979-07-12 |
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