ZA786303B - Improved triester process for the synthesis of oligonucleotides - Google Patents

Improved triester process for the synthesis of oligonucleotides

Info

Publication number: ZA786303B
Authority: ZA; South Africa
Prior art keywords: oligonucleotides; synthesis; improved; triester process; triester
Prior art date: 1977-11-08

Application number

ZA00786303A

Other languages

English (en)

Inventor

K Itakura

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-11-08

Filing date

1978-11-08

Publication date

1979-10-31

1978-11-08 Application filed by Genentech Inc filed Critical Genentech Inc

1979-10-31 Publication of ZA786303B publication Critical patent/ZA786303B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

ZA00786303A 1977-11-08 1978-11-08 Improved triester process for the synthesis of oligonucleotides ZA786303B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US84960877A	1977-11-08	1977-11-08

Publications (1)

Publication Number	Publication Date
ZA786303B true ZA786303B (en)	1979-10-31

Family

ID=25306107

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA00786303A ZA786303B (en)	1977-11-08	1978-11-08	Improved triester process for the synthesis of oligonucleotides

Country Status (22)

Country	Link
EP (1)	EP0002322A3 (xx)
JP (1)	JPS5473787A (xx)
AU (1)	AU4136078A (xx)
BE (1)	BE871781A (xx)
BR (1)	BR7807288A (xx)
DD (1)	DD141836A5 (xx)
DE (1)	DE2848054A1 (xx)
DK (1)	DK493678A (xx)
ES (1)	ES474850A1 (xx)
FI (1)	FI783364A (xx)
FR (1)	FR2407939A1 (xx)
GB (1)	GB2007670A (xx)
IL (1)	IL55893A0 (xx)
LU (1)	LU80483A1 (xx)
NL (1)	NL7811043A (xx)
NO (1)	NO783721L (xx)
OA (1)	OA06003A (xx)
PL (1)	PL210786A1 (xx)
PT (1)	PT68754A (xx)
SE (1)	SE7811459L (xx)
ZA (1)	ZA786303B (xx)
ZM (1)	ZM9478A1 (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2422717B1 (fr) *	1977-11-08	1985-12-06	Genentech Inc	Procede permettant l'expression microbienne de polypeptides et moyens appropries
US4342832A (en) *	1979-07-05	1982-08-03	Genentech, Inc.	Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4474947A (en) *	1982-04-08	1984-10-02	Biosearch	Benzazolides and their employment in phosphate ester oligonucleotide synthesis processes
JPS61152695A (ja) *	1984-12-26	1986-07-11	Nippon Shinyaku Co Ltd	長鎖ｄｎａの合成法
ES2616051T3 (es)	2008-12-02	2017-06-09	Wave Life Sciences Japan, Inc.	Método para la síntesis de ácidos nucleicos modificados en el átomo de fósforo
JP5998326B2 (ja)	2009-07-06	2016-09-28	ウェイブライフサイエンスリミテッドＷａｖｅＬｉｆｅＳｃｉｅｎｃｅｓＬｔｄ．	新規核酸プロドラッグおよびその使用方法
US10428019B2 (en)	2010-09-24	2019-10-01	Wave Life Sciences Ltd.	Chiral auxiliaries
EP3248982A1 (en)	2011-07-19	2017-11-29	Wave Life Sciences Ltd.	Thiosulfonate reagents for the synthesis of functionalized nucleic acids
KR101835401B1 (ko)	2012-07-13	2018-03-08	신 니뽄 바이오메디칼 라보라토리즈, 엘티디.	키랄 핵산 어쥬번트
PL2872147T3 (pl)	2012-07-13	2023-09-25	Wave Life Sciences Ltd.	Sposób wytwarzania chiralnych oligonukleotydów
SG11201500239VA (en)	2012-07-13	2015-03-30	Wave Life Sciences Japan	Asymmetric auxiliary group
US10322173B2 (en)	2014-01-15	2019-06-18	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
JPWO2015108047A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
WO2015108048A1 (ja)	2014-01-15	2015-07-23	株式会社新日本科学	抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
SG10201912897UA (en)	2014-01-16	2020-02-27	Wave Life Sciences Ltd	Chiral design

1978
- 1978-09-06 BR BR7807288A patent/BR7807288A/pt unknown
- 1978-11-06 DE DE19782848054 patent/DE2848054A1/de not_active Withdrawn
- 1978-11-06 FI FI783364A patent/FI783364A/fi unknown
- 1978-11-06 EP EP78300595A patent/EP0002322A3/en not_active Withdrawn
- 1978-11-06 ES ES474850A patent/ES474850A1/es not_active Expired
- 1978-11-06 AU AU41360/78A patent/AU4136078A/en active Pending
- 1978-11-06 NL NL7811043A patent/NL7811043A/xx not_active Application Discontinuation
- 1978-11-06 DK DK493678A patent/DK493678A/da unknown
- 1978-11-06 GB GB7843445A patent/GB2007670A/en not_active Withdrawn
- 1978-11-06 BE BE1009120A patent/BE871781A/xx unknown
- 1978-11-06 FR FR7831349A patent/FR2407939A1/fr not_active Withdrawn
- 1978-11-06 IL IL55893A patent/IL55893A0/xx unknown
- 1978-11-06 NO NO783721A patent/NO783721L/no unknown
- 1978-11-06 SE SE7811459A patent/SE7811459L/xx unknown
- 1978-11-06 JP JP13721478A patent/JPS5473787A/ja active Pending
- 1978-11-07 DD DD78208919A patent/DD141836A5/de unknown
- 1978-11-07 PT PT68754A patent/PT68754A/pt unknown
- 1978-11-08 LU LU80483A patent/LU80483A1/xx unknown
- 1978-11-08 OA OA56653A patent/OA06003A/xx unknown
- 1978-11-08 ZM ZM94/78A patent/ZM9478A1/xx unknown
- 1978-11-08 PL PL21078678A patent/PL210786A1/xx unknown
- 1978-11-08 ZA ZA00786303A patent/ZA786303B/xx unknown

Also Published As

Publication number	Publication date
DE2848054A1 (de)	1979-05-10
GB2007670A (en)	1979-05-23
FR2407939A1 (fr)	1979-06-01
SE7811459L (sv)	1979-05-09
PL210786A1 (pl)	1979-07-16
ES474850A1 (es)	1979-12-01
EP0002322A2 (en)	1979-06-13
EP0002322A3 (en)	1979-06-27
JPS5473787A (en)	1979-06-13
AU4136078A (en)	1979-05-17
IL55893A0 (en)	1979-01-31
BE871781A (fr)	1979-05-07
NL7811043A (nl)	1979-05-10
OA06003A (fr)	1981-06-30
FI783364A (fi)	1979-05-09
PT68754A (en)	1978-12-01
ZM9478A1 (en)	1980-03-21
NO783721L (no)	1979-05-09
DD141836A5 (de)	1980-05-21
BR7807288A (pt)	1979-06-12
LU80483A1 (fr)	1979-03-22
DK493678A (da)	1979-07-12

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