FR2407939A1 - Procede ameliore de synthese d'oligonucleotides par la voe " triester " - Google Patents
Procede ameliore de synthese d'oligonucleotides par la voe " triester "Info
- Publication number
- FR2407939A1 FR2407939A1 FR7831349A FR7831349A FR2407939A1 FR 2407939 A1 FR2407939 A1 FR 2407939A1 FR 7831349 A FR7831349 A FR 7831349A FR 7831349 A FR7831349 A FR 7831349A FR 2407939 A1 FR2407939 A1 FR 2407939A1
- Authority
- FR
- France
- Prior art keywords
- synthesis
- component
- improved process
- voe
- triester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PROCEDE AMELIORE DE SYNTHESE DE POLYNUCLEOTIDES EN COPULANT, COMME PREMIER COMPOSANT, UN NUCLEOTIDE DE FORMULE I OU II, C'EST-A-DIRE UN COMPOSANT AYANT UN GROUPEMENT DIESTER DE 3-PHOSPHATE MASQUE, AVEC, COMME SECOND COMPOSANT, UN NUCLEOSIDE OU NUCLEOTIDE DE FORMULE III OU IV AYANT UN GROUPEMENT 5-HYDROXYLE LIBRE DISPONIBLE, LA COPULATION ETANT EFFECTUEE EN PRESENCE D'UN AGENT DE COPULATION ET EN PRESENCE D'UN EXCES MOLAIRE SUBSTANTIEL DU PREMIER COMPOSANT PAR RAPPORT AU SECOND. APPLICATION A LA PREPARATION D'OLIGODESOXYRIBONUCLEOTIDES QUI PEUVENT ETRE TRANSFORMES EN FRAGMENTS D'ADN QUE L'ON PEUT INSERER DANS L'ADN DE PLASMIDE EN VUE DE SON CODAGE POUR STIMULER, PAR EXEMPLE, LA SYNTHESE D'HORMONES POLYPEPTIDIQUES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84960877A | 1977-11-08 | 1977-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2407939A1 true FR2407939A1 (fr) | 1979-06-01 |
Family
ID=25306107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7831349A Withdrawn FR2407939A1 (fr) | 1977-11-08 | 1978-11-06 | Procede ameliore de synthese d'oligonucleotides par la voe " triester " |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0002322A3 (fr) |
| JP (1) | JPS5473787A (fr) |
| AU (1) | AU4136078A (fr) |
| BE (1) | BE871781A (fr) |
| BR (1) | BR7807288A (fr) |
| DD (1) | DD141836A5 (fr) |
| DE (1) | DE2848054A1 (fr) |
| DK (1) | DK493678A (fr) |
| ES (1) | ES474850A1 (fr) |
| FI (1) | FI783364A (fr) |
| FR (1) | FR2407939A1 (fr) |
| GB (1) | GB2007670A (fr) |
| IL (1) | IL55893A0 (fr) |
| LU (1) | LU80483A1 (fr) |
| NL (1) | NL7811043A (fr) |
| NO (1) | NO783721L (fr) |
| OA (1) | OA06003A (fr) |
| PL (1) | PL210786A1 (fr) |
| PT (1) | PT68754A (fr) |
| SE (1) | SE7811459L (fr) |
| ZA (1) | ZA786303B (fr) |
| ZM (1) | ZM9478A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2422717B1 (fr) * | 1977-11-08 | 1985-12-06 | Genentech Inc | Procede permettant l'expression microbienne de polypeptides et moyens appropries |
| US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
| US4474947A (en) * | 1982-04-08 | 1984-10-02 | Biosearch | Benzazolides and their employment in phosphate ester oligonucleotide synthesis processes |
| JPS61152695A (ja) * | 1984-12-26 | 1986-07-11 | Nippon Shinyaku Co Ltd | 長鎖ｄｎａの合成法 |
| ES2616051T3 (es) | 2008-12-02 | 2017-06-09 | Wave Life Sciences Japan, Inc. | Método para la síntesis de ácidos nucleicos modificados en el átomo de fósforo |
| JP5998326B2 (ja) | 2009-07-06 | 2016-09-28 | ウェイブ ライフ サイエンス リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | 新規核酸プロドラッグおよびその使用方法 |
| US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
| EP3248982A1 (fr) | 2011-07-19 | 2017-11-29 | Wave Life Sciences Ltd. | Reactifs de type thiosulfonate pour la synthèse d'acides nucléiques fonctionnalisés |
| KR101835401B1 (ko) | 2012-07-13 | 2018-03-08 | 신 니뽄 바이오메디칼 라보라토리즈, 엘티디. | 키랄 핵산 어쥬번트 |
| PL2872147T3 (pl) | 2012-07-13 | 2023-09-25 | Wave Life Sciences Ltd. | Sposób wytwarzania chiralnych oligonukleotydów |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| WO2015108048A1 (fr) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | Adjuvant d'acide nucléique chiral ayant un effet antitumoral et agent antitumoral |
| SG10201912897UA (en) | 2014-01-16 | 2020-02-27 | Wave Life Sciences Ltd | Chiral design |
-
1978
- 1978-09-06 BR BR7807288A patent/BR7807288A/pt unknown
- 1978-11-06 DE DE19782848054 patent/DE2848054A1/de not_active Withdrawn
- 1978-11-06 FI FI783364A patent/FI783364A/fi unknown
- 1978-11-06 EP EP78300595A patent/EP0002322A3/fr not_active Withdrawn
- 1978-11-06 ES ES474850A patent/ES474850A1/es not_active Expired
- 1978-11-06 AU AU41360/78A patent/AU4136078A/en active Pending
- 1978-11-06 NL NL7811043A patent/NL7811043A/xx not_active Application Discontinuation
- 1978-11-06 DK DK493678A patent/DK493678A/da unknown
- 1978-11-06 GB GB7843445A patent/GB2007670A/en not_active Withdrawn
- 1978-11-06 BE BE1009120A patent/BE871781A/fr unknown
- 1978-11-06 FR FR7831349A patent/FR2407939A1/fr not_active Withdrawn
- 1978-11-06 IL IL55893A patent/IL55893A0/xx unknown
- 1978-11-06 NO NO783721A patent/NO783721L/no unknown
- 1978-11-06 SE SE7811459A patent/SE7811459L/xx unknown
- 1978-11-06 JP JP13721478A patent/JPS5473787A/ja active Pending
- 1978-11-07 DD DD78208919A patent/DD141836A5/de unknown
- 1978-11-07 PT PT68754A patent/PT68754A/pt unknown
- 1978-11-08 LU LU80483A patent/LU80483A1/fr unknown
- 1978-11-08 OA OA56653A patent/OA06003A/fr unknown
- 1978-11-08 ZM ZM94/78A patent/ZM9478A1/xx unknown
- 1978-11-08 PL PL21078678A patent/PL210786A1/xx unknown
- 1978-11-08 ZA ZA00786303A patent/ZA786303B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2848054A1 (de) | 1979-05-10 |
| GB2007670A (en) | 1979-05-23 |
| SE7811459L (sv) | 1979-05-09 |
| PL210786A1 (pl) | 1979-07-16 |
| ZA786303B (en) | 1979-10-31 |
| ES474850A1 (es) | 1979-12-01 |
| EP0002322A2 (fr) | 1979-06-13 |
| EP0002322A3 (fr) | 1979-06-27 |
| JPS5473787A (en) | 1979-06-13 |
| AU4136078A (en) | 1979-05-17 |
| IL55893A0 (en) | 1979-01-31 |
| BE871781A (fr) | 1979-05-07 |
| NL7811043A (nl) | 1979-05-10 |
| OA06003A (fr) | 1981-06-30 |
| FI783364A (fi) | 1979-05-09 |
| PT68754A (en) | 1978-12-01 |
| ZM9478A1 (en) | 1980-03-21 |
| NO783721L (no) | 1979-05-09 |
| DD141836A5 (de) | 1980-05-21 |
| BR7807288A (pt) | 1979-06-12 |
| LU80483A1 (fr) | 1979-03-22 |
| DK493678A (da) | 1979-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |