BE1003093A3 - Procede de preparation d'une composition pharmaceutique sous forme de microparticules. - Google Patents
Procede de preparation d'une composition pharmaceutique sous forme de microparticules. Download PDFInfo
- Publication number
- BE1003093A3 BE1003093A3 BE9000729A BE9000729A BE1003093A3 BE 1003093 A3 BE1003093 A3 BE 1003093A3 BE 9000729 A BE9000729 A BE 9000729A BE 9000729 A BE9000729 A BE 9000729A BE 1003093 A3 BE1003093 A3 BE 1003093A3
- Authority
- BE
- Belgium
- Prior art keywords
- preparation
- microparticles
- pharmaceutical composition
- extrusion
- composition
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000011859 microparticle Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract 2
- 238000001125 extrusion Methods 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 102000055006 Calcitonin Human genes 0.000 abstract 1
- 108060001064 Calcitonin Proteins 0.000 abstract 1
- 101000904177 Clupea pallasii Gonadoliberin-1 Proteins 0.000 abstract 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 abstract 1
- 102000005157 Somatostatin Human genes 0.000 abstract 1
- 108010056088 Somatostatin Proteins 0.000 abstract 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
- 229920002253 Tannate Polymers 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
- 229960004015 calcitonin Drugs 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 238000007580 dry-mixing Methods 0.000 abstract 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 abstract 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229940102213 injectable suspension Drugs 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 abstract 1
- 229960000553 somatostatin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
On prèpare une composition pharmaceutique se présentant sous forme de microparticules d'un copolymère d'acide lactique et glycolique incorporant à titre de substance active un pamoate, tannate, stéarate ou palmitate d'un peptide naturel ou synthétique comprenant de 3 à 45 acides aminés, tel que le LH-RH, la somatostatine, le GR-RH ou la calcitonine ou de l'un de leurs analogues ou homologues synthétiques. La préparation comprend le mélange à sec des ingrédients, sous forme pulvérulente, la précompression et le préchauffage du mélange suivis d'une extrusion du mélange précomprimé et préchauffé. Le produit résultant de l'extrusion est ensuite pulvérisé et finalement tamisé. La composition s'utilise pour la préparation de suspension injectables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2829/89A CH679207A5 (fr) | 1989-07-28 | 1989-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE1003093A3 true BE1003093A3 (fr) | 1991-11-19 |
Family
ID=4242536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE9000729A BE1003093A3 (fr) | 1989-07-28 | 1990-07-18 | Procede de preparation d'une composition pharmaceutique sous forme de microparticules. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5134122A (fr) |
| JP (1) | JPH0662427B2 (fr) |
| AT (1) | AT397197B (fr) |
| AU (1) | AU619996B2 (fr) |
| BE (1) | BE1003093A3 (fr) |
| CA (1) | CA2021767C (fr) |
| CH (1) | CH679207A5 (fr) |
| DE (1) | DE4023134C2 (fr) |
| DK (1) | DK175495B1 (fr) |
| ES (1) | ES2020890A6 (fr) |
| FI (1) | FI97688C (fr) |
| FR (1) | FR2650182B1 (fr) |
| GB (1) | GB2234169B (fr) |
| GR (1) | GR1001215B (fr) |
| IE (1) | IE65397B1 (fr) |
| IL (1) | IL95120A (fr) |
| IT (1) | IT1243357B (fr) |
| LU (1) | LU87772A1 (fr) |
| NL (1) | NL194858C (fr) |
| NO (1) | NO300304B1 (fr) |
| PT (1) | PT94842B (fr) |
| SE (1) | SE504279C2 (fr) |
| ZA (1) | ZA905654B (fr) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH30995A (en) * | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
| US5538739A (en) * | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
| CH681425A5 (fr) * | 1990-11-14 | 1993-03-31 | Debio Rech Pharma Sa | |
| ES2185615T3 (es) * | 1990-05-16 | 2003-05-01 | Southern Res Inst | Uso y liberacion controlada de las microcapsulas para estimular el crecimiento de la fibra nerviosa. |
| US6517859B1 (en) | 1990-05-16 | 2003-02-11 | Southern Research Institute | Microcapsules for administration of neuroactive agents |
| CH683149A5 (fr) * | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
| US5470582A (en) * | 1992-02-07 | 1995-11-28 | Syntex (U.S.A.) Inc. | Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles |
| US5876452A (en) * | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
| US6013853A (en) * | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
| GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| US5456917A (en) * | 1993-04-12 | 1995-10-10 | Cambridge Scientific, Inc. | Method for making a bioerodible material for the sustained release of a medicament and the material made from the method |
| CA2178592C (fr) * | 1993-12-09 | 2009-07-28 | Jurgen Engel | Suspensions pour injection a action prolongee et procede de preparation |
| DE4342092B4 (de) * | 1993-12-09 | 2007-01-11 | Zentaris Gmbh | Langwirkende Injektionssuspension und Verfahren zur Herstellung |
| US5569468A (en) * | 1994-02-17 | 1996-10-29 | Modi; Pankaj | Vaccine delivery system for immunization, using biodegradable polymer microspheres |
| US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| US5430021A (en) * | 1994-03-18 | 1995-07-04 | Pharmavene, Inc. | Hydrophobic drug delivery systems |
| US5595760A (en) * | 1994-09-02 | 1997-01-21 | Delab | Sustained release of peptides from pharmaceutical compositions |
| FR2748205A1 (fr) | 1996-05-06 | 1997-11-07 | Debio Rech Pharma Sa | Compositions pharmaceutiques pour la liberation controlee de principes actifs insolubles |
| US5945128A (en) * | 1996-09-04 | 1999-08-31 | Romano Deghenghi | Process to manufacture implants containing bioactive peptides |
| AU4571097A (en) * | 1996-10-09 | 1998-05-05 | Takeda Chemical Industries Ltd. | A method for producing a microparticle |
| WO1998032423A1 (fr) * | 1997-01-29 | 1998-07-30 | Takeda Chemical Industries, Ltd. | Microspheres a liberation prolongee, leur production et utilisation |
| US6071982A (en) * | 1997-04-18 | 2000-06-06 | Cambridge Scientific, Inc. | Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same |
| AU1384199A (en) | 1997-11-07 | 1999-05-31 | Chiron Corporation | Method for producing igf-1 sustained-release formulations |
| IT1304152B1 (it) * | 1998-12-10 | 2001-03-08 | Mediolanum Farmaceutici Srl | Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato |
| US6455526B1 (en) | 1998-12-16 | 2002-09-24 | Aventis Pharmaceuticals, Inc. | Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same |
| UA73101C2 (en) * | 1998-12-16 | 2005-06-15 | Aventic Pharmaceuticals Inc | Antagonist of serotonin receptor encapsulated by biodegradable polymer and method for its manufacture |
| EP2286792A1 (fr) | 1999-02-26 | 2011-02-23 | Novartis Vaccines and Diagnostics, Inc. | Microemulsions avec une surface adsorbante, comprenant une émulsion de microgouttes |
| US7713739B1 (en) | 2000-11-17 | 2010-05-11 | Novartis Vaccines And Diagnostics, Inc. | Microparticle-based transfection and activation of dendritic cells |
| ES2169980B1 (es) | 1999-12-17 | 2003-11-01 | Lipotec Sa | Microcapsulas para la liberacion prolongada de farmacos. |
| US6362308B1 (en) | 2000-08-10 | 2002-03-26 | Alkermes Controlled Therapeutics Inc. Ii | Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content |
| US20040022853A1 (en) * | 2001-04-26 | 2004-02-05 | Control Delivery Systems, Inc. | Polymer-based, sustained release drug delivery system |
| NZ528994A (en) * | 2001-04-26 | 2006-02-24 | Control Delivery Sys Inc | Sustained release drug delivery system containing codrugs |
| ES2290294T3 (es) * | 2001-05-23 | 2008-02-16 | Hexal Ag | Procedimiento para la fabricacion de implantes por medio de la preparacion libre de disolventes de un producto homogeneizado. |
| CA2451187C (fr) | 2001-06-22 | 2012-08-14 | Southern Biosystems, Inc. | Implants coaxiaux a liberation prolongee d'ordre 0 |
| IN2014DN10834A (fr) * | 2001-09-17 | 2015-09-04 | Psivida Inc | |
| US8088726B2 (en) * | 2002-06-25 | 2012-01-03 | Takeda Pharmaceutical Company Limited | Process for producing sustained-release composition |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| SG168407A1 (en) | 2003-01-28 | 2011-02-28 | Ironwood Pharmaceuticals Inc | Methods and compositions for the treatment of gastrointestinal disorders |
| GB0304726D0 (en) * | 2003-03-01 | 2003-04-02 | Ardana Bioscience Ltd | New Process |
| CA2523830A1 (fr) * | 2003-04-30 | 2004-11-11 | Debiopharm S.A. | Methodes et compositions mettant en oeuvre la gonadoliberine |
| US9149440B2 (en) * | 2003-09-02 | 2015-10-06 | University Of South Florida | Nanoparticles for drug-delivery |
| JP5105578B2 (ja) | 2003-11-05 | 2012-12-26 | サーコード バイオサイエンス インコーポレイテッド | 細胞接着のモジュレーター |
| WO2005063276A1 (fr) * | 2003-12-23 | 2005-07-14 | Debiopharm S.A. | Procedes et compositions faisant appel a la gonadoliberine |
| FR2865938B1 (fr) | 2004-02-05 | 2006-06-02 | Sod Conseils Rech Applic | Formulation retard solide comprenant de l'acetate de triptoreline |
| CA2575988C (fr) | 2004-08-04 | 2014-02-18 | Brookwood Pharmaceuticals, Inc. | Procede de production de systemes d'administration, et systemes d'administration |
| US8398638B2 (en) * | 2004-08-30 | 2013-03-19 | Spineovations, Inc. | Method of treating spinal internal disk derangement |
| EP1674082A1 (fr) * | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Procédé pour la manufacture des suspensions ou lyophilisates steriles des complexes mal-soluble de peptides basic, des formulations pharmaceutiques avec ces complexes et leur utilisation comme medicament |
| CA2960117C (fr) | 2005-05-17 | 2018-01-30 | Sarcode Bioscience Inc. | Antagonistes de lfa-1 destines au traitement de troubles de l'oeil |
| KR100722607B1 (ko) | 2006-05-11 | 2007-05-28 | 주식회사 펩트론 | 분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법 |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| DK2170930T3 (da) | 2007-06-04 | 2012-11-05 | Synergy Pharmaceuticals Inc | Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme |
| UA99830C2 (uk) * | 2007-06-06 | 2012-10-10 | Дебио Ресшерчи Фармасютикю С.А. | Фармацевтична композиція з пролонгованим вивільненням, виготовлена з мікрочастинок |
| WO2009054914A1 (fr) * | 2007-10-19 | 2009-04-30 | Sarcode Corporation | Compositions et procédés pour le traitement de la rétinopathie diabétique |
| EP2222281B1 (fr) | 2007-12-20 | 2018-12-05 | Evonik Corporation | Procédé pour préparer des microparticules ayant un faible volume de solvant résiduel |
| US8469961B2 (en) * | 2008-03-05 | 2013-06-25 | Neville Alleyne | Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints |
| US20100010549A1 (en) * | 2008-03-05 | 2010-01-14 | Neville Alleyne | device and method of minimally invasive extracapsular ligamentous augmentation for canine stifle ligament injuries |
| WO2009139817A2 (fr) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Produit pharmaceutique cristallin et ses procédés de préparation et d'utilisation |
| EP2276508A4 (fr) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | Administration d'antagonistes de lfa-1 au système gastro-intestinal |
| JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| EP2421517A4 (fr) * | 2009-04-23 | 2013-08-07 | Sustained Nano Systems Llc | Dispositif d'administration à libération contrôlée |
| US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| KR101411349B1 (ko) | 2010-12-24 | 2014-06-25 | 주식회사 삼양바이오팜 | 생리활성 펩타이드를 포함하는 마이크로입자 및 그의 제조방법, 및 그를 포함하는 약제학적 조성물 |
| WO2012151343A1 (fr) | 2011-05-04 | 2012-11-08 | Balance Therapeutics, Inc. | Dérivés de pentylènetétrazole |
| EP2630964A1 (fr) * | 2012-02-22 | 2013-08-28 | Immundiagnostik AG | Procédé et médicament pour traiter des patients souffrant de prédiabète et diabètes de type 2 |
| WO2013172468A1 (fr) | 2012-05-14 | 2013-11-21 | 帝人株式会社 | Composition stérilisée |
| CA2879982C (fr) | 2012-07-25 | 2020-09-01 | Sarcode Bioscience Inc. | Inhibiteur de lfa-1 et polymorphe de celui-ci |
| EP2958577A2 (fr) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Agonistes du recepteur de la guanylate cyclase pour l'utilisation dans l'irrigation du colon |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| JP6534994B2 (ja) | 2013-10-08 | 2019-06-26 | フェリング ベスローテン フェンノートシャップ | Ｐｇｓｓにより作製されるｇｎｒｈを含む微粒子 |
| JP6661531B2 (ja) | 2013-10-10 | 2020-03-11 | シナジー ファーマシューティカルズ インコーポレイテッド | オピオイド誘発性機能障害の治療に有用なグアニル酸シクラーゼのアゴニスト |
| ES2693579T3 (es) | 2015-01-16 | 2018-12-12 | Spineovations, Inc. | Método de tratamiento del disco intervertebral |
| EP3402804A1 (fr) | 2016-01-11 | 2018-11-21 | Synergy Pharmaceuticals Inc. | Formulations et méthodes pour traiter la rectocolite hémorragique |
| AU2018300080A1 (en) | 2017-07-11 | 2020-02-13 | Sustained Nano Systems Llc | Hypercompressed pharmaceutical formulations |
| CN111032054A (zh) | 2017-07-11 | 2020-04-17 | 持续纳米***有限责任公司 | 超压缩聚合物剂型的辐射灭菌 |
| CA3077011A1 (fr) | 2017-09-26 | 2019-04-04 | Nanomi B.V. | Procede de preparation de microparticules par une technique de double emulsion |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60181029A (ja) * | 1984-02-29 | 1985-09-14 | Toyo Jozo Co Ltd | 徐放性製剤の製法 |
| FR2620621A1 (fr) * | 1987-09-21 | 1989-03-24 | Bpd Biopharm Dev Ltd | Composition pharmaceutique pour la liberation soutenue et controlee de polypeptides insolubles dans l'eau |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3976071A (en) * | 1974-01-07 | 1976-08-24 | Dynatech Corporation | Methods of improving control of release rates and products useful in same |
| US3978203A (en) * | 1974-07-12 | 1976-08-31 | Dynatech Corporation | Sustained release of pharmaceuticals from polyester matrices |
| US4107288A (en) * | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US4010125A (en) * | 1975-06-12 | 1977-03-01 | Schally Andrew Victor | [D-Trp6 ]-LH-RH and intermediates therefor |
| US4622244A (en) * | 1979-09-04 | 1986-11-11 | The Washington University | Process for preparation of microcapsules |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
| US4349530A (en) * | 1980-12-11 | 1982-09-14 | The Ohio State University | Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal |
| US4483807A (en) * | 1981-01-27 | 1984-11-20 | Japan Atomic Energy Research Institute | Process for producing a slow release composite |
| IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| CH661206A5 (fr) * | 1983-09-23 | 1987-07-15 | Debiopharm Sa | Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes. |
| US4666704A (en) * | 1985-05-24 | 1987-05-19 | International Minerals & Chemical Corp. | Controlled release delivery system for macromolecules |
| IL79134A (en) * | 1985-07-29 | 1991-06-10 | American Cyanamid Co | Continuous release peptide implants for parenteral administration |
| US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
| JPS63218632A (ja) * | 1987-03-06 | 1988-09-12 | Japan Atom Energy Res Inst | ホルモンに徐放性機能を付与した生体分解型コポリ（グルコ−ル酸／ｌ−乳酸）複合体の製造方法 |
| US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| DE3734223A1 (de) * | 1987-10-09 | 1989-04-20 | Boehringer Ingelheim Kg | Implantierbares, biologisch abbaubares wirkstofffreigabesystem |
-
1989
- 1989-07-28 CH CH2829/89A patent/CH679207A5/fr not_active IP Right Cessation
-
1990
- 1990-07-16 IE IE259290A patent/IE65397B1/en not_active IP Right Cessation
- 1990-07-17 GB GB9015722A patent/GB2234169B/en not_active Expired - Lifetime
- 1990-07-18 AU AU59103/90A patent/AU619996B2/en not_active Expired
- 1990-07-18 IL IL9512090A patent/IL95120A/en not_active IP Right Cessation
- 1990-07-18 ZA ZA905654A patent/ZA905654B/xx unknown
- 1990-07-18 BE BE9000729A patent/BE1003093A3/fr not_active IP Right Cessation
- 1990-07-19 FI FI903643A patent/FI97688C/fi active IP Right Grant
- 1990-07-19 NL NL9001646A patent/NL194858C/nl not_active IP Right Cessation
- 1990-07-20 US US07/555,973 patent/US5134122A/en not_active Expired - Lifetime
- 1990-07-20 DE DE4023134A patent/DE4023134C2/de not_active Expired - Lifetime
- 1990-07-20 FR FR909009333A patent/FR2650182B1/fr not_active Expired - Lifetime
- 1990-07-23 IT IT02101990A patent/IT1243357B/it active IP Right Grant
- 1990-07-23 CA CA002021767A patent/CA2021767C/fr not_active Expired - Lifetime
- 1990-07-23 NO NO903264A patent/NO300304B1/no not_active IP Right Cessation
- 1990-07-23 AT AT0154590A patent/AT397197B/de not_active IP Right Cessation
- 1990-07-23 ES ES9001976A patent/ES2020890A6/es not_active Expired - Fee Related
- 1990-07-25 LU LU87772A patent/LU87772A1/fr unknown
- 1990-07-25 GR GR900100568A patent/GR1001215B/el not_active IP Right Cessation
- 1990-07-27 DK DK199001807A patent/DK175495B1/da not_active IP Right Cessation
- 1990-07-27 JP JP2201063A patent/JPH0662427B2/ja not_active Expired - Lifetime
- 1990-07-27 SE SE9002522A patent/SE504279C2/sv not_active IP Right Cessation
- 1990-07-27 PT PT94842A patent/PT94842B/pt not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60181029A (ja) * | 1984-02-29 | 1985-09-14 | Toyo Jozo Co Ltd | 徐放性製剤の製法 |
| FR2620621A1 (fr) * | 1987-09-21 | 1989-03-24 | Bpd Biopharm Dev Ltd | Composition pharmaceutique pour la liberation soutenue et controlee de polypeptides insolubles dans l'eau |
Non-Patent Citations (2)
| Title |
|---|
| PROC. NATL. ACAD. SCI. USA, vol. 85, no. 15, August 1988, pages 5688-5692; M. MASON-GARCIA et al.: "Radioimmunoassay for octapeptide analogs of somatostatin: Measurement of serum levels after administration of long-acting microcapsule formulations" * |
| WPIL FILE SUPPLIER, accession no. 85-267444 [43], Derwent Publications Ltd, London, GB; & JP-A-60 181 029 (TOYO JOZO K.K. et al.) 14-09-1985 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BE1003093A3 (fr) | Procede de preparation d'une composition pharmaceutique sous forme de microparticules. | |
| EP0183527B1 (fr) | Médicament absorbable à base de calcitonine | |
| US5059587A (en) | Physiologically active peptide composition for nasal administration | |
| DE69731957T2 (de) | Orale pharmazeutische produkte mit peptiden | |
| AU623610B2 (en) | A free-flowing granular composition containing ibuprofen and a method for its preparation | |
| EP0661989B1 (fr) | Formulations de proteines a liberation prolongee | |
| US6399103B1 (en) | Method of producing a sustained-release preparation | |
| IE861813L (en) | New Polysaccharide Esters and their Salts | |
| EP0251459A2 (fr) | Composition pharmaceutique à libération contrôlée | |
| DE3345314A1 (de) | Oligomere hydroxycarbonsaeurederivate, deren herstellung und verwendung | |
| KR910007516A (ko) | 서방성 활성 화합물을 함유한 압착물 | |
| YU46701B (sh) | Postupak u za dobijanje osnovnog nosećeg materijala za dozne oblike lekova sa produženim izdvajanjem aktivne supstance | |
| GB2237510B (en) | Small particle drug compositions for nasal administration | |
| CA2009890A1 (fr) | Acide valproique | |
| PT85591A (en) | Process for the preparation of multiple unit dosage pharmaceutical compositions comprising as a pharmaceutilly active compound l-dopa | |
| FR2698788B1 (fr) | Composition pharmaceutique effervescente contenant de l'ibuprofène et son procédé de préparation. | |
| NL8802274A (nl) | Zetpillen. | |
| DE69719083T2 (de) | Neuartige orale Zubereitungen von Calcitonin | |
| EP0402186A3 (fr) | Procédé de fabrication d'un amidon directement compressible en vue de l'utilisation dans la fabrication de comprimés et comprimés obtenus | |
| CA1203480A (fr) | Produits comprimes, avec degagement retarde du pricipe actif | |
| DE3913350A1 (de) | Saeureadditionssalze aus amidiertem taurin oder glycin, deren herstellung und verwendung | |
| GB1458414A (en) | Composition and method of treatin ulcers | |
| US20010002263A1 (en) | Complex of human growth hormone and zinc and use | |
| EP0249811B1 (fr) | Composition pharmaceutique administrable par voie parentérale contenant une calcitonine comme substance active | |
| EP0205865B1 (fr) | Préparations pharmaceutiques à effet antihypertenseur et cardioprotecteur |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE20 | Patent expired |
Owner name: S.A. *DEBIO RECHERCHE PHARMACEUTIQUE Effective date: 20100718 |