AU707065B2 - Microporation of human skin for drug delivery and monitoring applications - Google Patents
Microporation of human skin for drug delivery and monitoring applications Download PDFInfo
- Publication number
- AU707065B2 AU707065B2 AU68631/96A AU6863196A AU707065B2 AU 707065 B2 AU707065 B2 AU 707065B2 AU 68631/96 A AU68631/96 A AU 68631/96A AU 6863196 A AU6863196 A AU 6863196A AU 707065 B2 AU707065 B2 AU 707065B2
- Authority
- AU
- Australia
- Prior art keywords
- selected area
- stratum corneum
- skin
- temperature
- light source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3203—Fluid jet cutting instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00137—Details of operation mode
- A61B2017/00154—Details of operation mode pulsed
- A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Optics & Photonics (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Surgical Instruments (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Laser Surgery Devices (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52054795A | 1995-08-29 | 1995-08-29 | |
US08/520547 | 1995-08-29 | ||
US804395P | 1995-10-30 | 1995-10-30 | |
US60/008043 | 1995-10-30 | ||
PCT/US1996/013865 WO1997007734A1 (fr) | 1995-08-29 | 1996-08-29 | Realisation de micropores sur la peau humaine pour l'administration de medicaments et les applications de monitorage |
Publications (2)
Publication Number | Publication Date |
---|---|
AU6863196A AU6863196A (en) | 1997-03-19 |
AU707065B2 true AU707065B2 (en) | 1999-07-01 |
Family
ID=26677684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU68631/96A Expired AU707065B2 (en) | 1995-08-29 | 1996-08-29 | Microporation of human skin for drug delivery and monitoring applications |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0858285A4 (fr) |
JP (2) | JP3899427B2 (fr) |
CN (1) | CN1174713C (fr) |
AU (1) | AU707065B2 (fr) |
BR (1) | BR9610012A (fr) |
CA (1) | CA2199002C (fr) |
ES (1) | ES2536459T3 (fr) |
GB (1) | GB2307414B (fr) |
HK (1) | HK1009321A1 (fr) |
IL (1) | IL123379A (fr) |
NO (1) | NO334437B1 (fr) |
PT (1) | PT1563788E (fr) |
TR (1) | TR199800347T1 (fr) |
WO (1) | WO1997007734A1 (fr) |
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6056738A (en) * | 1997-01-31 | 2000-05-02 | Transmedica International, Inc. | Interstitial fluid monitoring |
DE69719761T2 (de) | 1996-06-18 | 2003-12-18 | Alza Corp., Palo Alto | Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten |
WO1998000193A1 (fr) * | 1996-07-03 | 1998-01-08 | Altea Technologies, Inc. | Microporation mecanique multiple de la peau ou de la muqueuse |
US5983136A (en) * | 1996-09-17 | 1999-11-09 | Deka Products Limited Partnership | System for delivery of drugs by transport |
US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
US6527716B1 (en) | 1997-12-30 | 2003-03-04 | Altea Technologies, Inc. | Microporation of tissue for delivery of bioactive agents |
WO1998029134A2 (fr) * | 1996-12-31 | 1998-07-09 | Altea Technologies, Inc. | Formation de micropores sur un tissu pour l'administration d'agents bioactifs |
US6027496A (en) * | 1997-03-25 | 2000-02-22 | Abbott Laboratories | Removal of stratum corneum by means of light |
EP1017320A1 (fr) | 1997-10-21 | 2000-07-12 | Townsend Engineering Company | Appareil et procede pour la collecte de fluides interstitiels |
US6155992A (en) * | 1997-12-02 | 2000-12-05 | Abbott Laboratories | Method and apparatus for obtaining interstitial fluid for diagnostic tests |
US6918901B1 (en) | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
CA2313700C (fr) | 1997-12-11 | 2009-11-24 | Alza Corporation | Dispositif renforcant le flux d'agents transdermiques |
EP1035889B1 (fr) * | 1997-12-11 | 2002-07-31 | Alza Corporation | Dispositif renforcant le flux d'agents transdermiques |
PT1037686E (pt) * | 1997-12-11 | 2005-10-31 | Alza Corp | Aparelho para potenciar o fluxo de agente transdermico |
US6173202B1 (en) | 1998-03-06 | 2001-01-09 | Spectrx, Inc. | Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue |
US6530915B1 (en) | 1998-03-06 | 2003-03-11 | Spectrx, Inc. | Photothermal structure for biomedical applications, and method therefor |
ATE385405T1 (de) * | 1998-03-06 | 2008-02-15 | Spectrx Inc | Integrierte porations-, sammel- und analysevorrichtung und verfahren dafür |
US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US6569157B1 (en) * | 1998-05-18 | 2003-05-27 | Abbott Laboratories | Removal of stratum corneum by means of light |
US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6077660A (en) * | 1998-06-10 | 2000-06-20 | Abbott Laboratories | Diagnostic assay requiring a small sample of biological fluid |
US7344499B1 (en) | 1998-06-10 | 2008-03-18 | Georgia Tech Research Corporation | Microneedle device for extraction and sensing of bodily fluids |
WO2000003758A1 (fr) | 1998-07-14 | 2000-01-27 | Spectrx, Inc. | Elimination commandee d'une membrane biologique par une charge pyrotechnique en vue d'un transport transmembranaire |
US7384396B2 (en) | 1998-07-21 | 2008-06-10 | Spectrx Inc. | System and method for continuous analyte monitoring |
AU5004299A (en) * | 1998-07-21 | 2000-02-14 | Altea Technologies, Inc. | System and method for continuous analyte monitoring |
CN1324228A (zh) * | 1998-09-04 | 2001-11-28 | 鲍德杰克特研究有限公司 | 采用颗粒运送的监测方法 |
US6468229B1 (en) | 1998-10-20 | 2002-10-22 | Abbott Laboratories | Apparatus and method for the collection of interstitial fluids |
US6597946B2 (en) | 1998-11-09 | 2003-07-22 | Transpharma Ltd. | Electronic card for transdermal drug delivery and analyte extraction |
US6148232A (en) | 1998-11-09 | 2000-11-14 | Elecsys Ltd. | Transdermal drug delivery and analyte extraction |
US6708060B1 (en) | 1998-11-09 | 2004-03-16 | Transpharma Ltd. | Handheld apparatus and method for transdermal drug delivery and analyte extraction |
US6611706B2 (en) | 1998-11-09 | 2003-08-26 | Transpharma Ltd. | Monopolar and bipolar current application for transdermal drug delivery and analyte extraction |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
ES2260021T3 (es) * | 1999-06-08 | 2006-11-01 | Altea Therapeutics Corporation | Aparatos para la microporacion de membranas biologicas utilizando dispositivos de interfaz de tejido de pelicula delgada, y su metodo. |
US20030078499A1 (en) | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
US6355054B1 (en) * | 1999-11-05 | 2002-03-12 | Ceramoptec Industries, Inc. | Laser system for improved transbarrier therapeutic radiation delivery |
DE19963034A1 (de) | 1999-12-24 | 2001-06-28 | Roche Diagnostics Gmbh | System zur verbesserten Bestimmung des Glukosespiegels anhand von Messungen in interstitieller Flüssigkeit |
IL136008A0 (en) | 2000-05-07 | 2001-05-20 | Elecsys Ltd | Electrically-mediated transdermal drug injection |
US6706032B2 (en) | 2000-06-08 | 2004-03-16 | Massachusetts Institute Of Technology | Localized molecular and ionic transport to and from tissues |
US7597692B2 (en) | 2000-06-08 | 2009-10-06 | Massachusetts Institute Of Technology | Microscission processes and procedures |
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US6537243B1 (en) | 2000-10-12 | 2003-03-25 | Abbott Laboratories | Device and method for obtaining interstitial fluid from a patient for diagnostic tests |
US6882884B1 (en) | 2000-10-13 | 2005-04-19 | Soundskin, L.L.C. | Process for the stimulation of production of extracellular dermal proteins in human tissue |
US6733493B2 (en) * | 2000-11-16 | 2004-05-11 | Innotech Usa, Inc. | Laser skin perforator |
WO2002064193A2 (fr) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Appareils a microaiguilles et fabrication |
WO2002050584A2 (fr) | 2000-12-21 | 2002-06-27 | Biovalve Technologies, Inc. | Systemes de reseaux de micro-aiguilles |
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US6855117B2 (en) | 2001-08-01 | 2005-02-15 | Johnson & Johnson Consumer Companies, Inc. | Method of treating the skin of a subject |
US6790179B2 (en) | 2001-08-01 | 2004-09-14 | Johnson & Johnson Consumer Companies, Inc. | Method of examining and diagnosing skin health |
US6840910B2 (en) | 2001-08-01 | 2005-01-11 | Johnson & Johnson Consumer Companies, Inc. | Method of distributing skin care products |
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US9918665B2 (en) | 2002-03-11 | 2018-03-20 | Nitto Denko Corporation | Transdermal porator and patch system and method for using same |
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JP6876045B2 (ja) * | 2015-12-15 | 2021-05-26 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 表面処理装置及び方法 |
CN108780085A (zh) * | 2016-01-15 | 2018-11-09 | 辛辛那提大学 | 先进的电穿孔装置和用于获得生物流体中的分析物的方法 |
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WO2019025610A1 (fr) * | 2017-08-03 | 2019-02-07 | Fibrotx Oü | Dosage d'écoulement latéral et dispositif pour application de soins de la peau |
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1996
- 1996-08-29 WO PCT/US1996/013865 patent/WO1997007734A1/fr not_active Application Discontinuation
- 1996-08-29 EP EP96929098A patent/EP0858285A4/fr not_active Withdrawn
- 1996-08-29 GB GB9702766A patent/GB2307414B/en not_active Expired - Lifetime
- 1996-08-29 JP JP51055297A patent/JP3899427B2/ja not_active Expired - Lifetime
- 1996-08-29 CN CNB961966718A patent/CN1174713C/zh not_active Expired - Lifetime
- 1996-08-29 BR BR9610012-5A patent/BR9610012A/pt not_active Application Discontinuation
- 1996-08-29 IL IL12337996A patent/IL123379A/en not_active IP Right Cessation
- 1996-08-29 ES ES05011002.2T patent/ES2536459T3/es not_active Expired - Lifetime
- 1996-08-29 TR TR1998/00347T patent/TR199800347T1/xx unknown
- 1996-08-29 AU AU68631/96A patent/AU707065B2/en not_active Expired
- 1996-08-29 CA CA002199002A patent/CA2199002C/fr not_active Expired - Lifetime
- 1996-08-29 PT PT50110022T patent/PT1563788E/pt unknown
-
1998
- 1998-02-27 NO NO19980878A patent/NO334437B1/no not_active IP Right Cessation
- 1998-08-24 HK HK98110113A patent/HK1009321A1/xx not_active IP Right Cessation
-
2006
- 2006-02-15 JP JP2006038655A patent/JP2006192285A/ja not_active Withdrawn
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US5019034A (en) * | 1988-01-21 | 1991-05-28 | Massachusetts Institute Of Technology | Control of transport of molecules across tissue using electroporation |
US5019034B1 (en) * | 1988-01-21 | 1995-08-15 | Massachusetts Inst Technology | Control of transport of molecules across tissue using electroporation |
US5323769A (en) * | 1990-02-23 | 1994-06-28 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
US5267985A (en) * | 1993-02-11 | 1993-12-07 | Trancell, Inc. | Drug delivery by multiple frequency phonophoresis |
Also Published As
Publication number | Publication date |
---|---|
GB2307414B (en) | 1998-03-11 |
BR9610012A (pt) | 1999-12-21 |
PT1563788E (pt) | 2015-06-02 |
IL123379A (en) | 2002-04-21 |
JP3899427B2 (ja) | 2007-03-28 |
NO980878L (no) | 1998-04-27 |
CN1195276A (zh) | 1998-10-07 |
HK1009321A1 (en) | 1999-05-28 |
CN1174713C (zh) | 2004-11-10 |
CA2199002C (fr) | 1999-02-23 |
WO1997007734A1 (fr) | 1997-03-06 |
CA2199002A1 (fr) | 1997-03-01 |
IL123379A0 (en) | 1998-09-24 |
ES2536459T3 (es) | 2015-05-25 |
NO334437B1 (no) | 2014-03-03 |
TR199800347T1 (xx) | 1998-05-21 |
JP2006192285A (ja) | 2006-07-27 |
EP0858285A4 (fr) | 2000-05-17 |
GB9702766D0 (en) | 1997-04-02 |
EP0858285A1 (fr) | 1998-08-19 |
JPH11511360A (ja) | 1999-10-05 |
GB2307414A (en) | 1997-05-28 |
NO980878D0 (no) | 1998-02-27 |
AU6863196A (en) | 1997-03-19 |
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Owner name: SPECTRX, INC. Free format text: FORMER OWNER WAS: SPECTRX, INC., ALTEA TECHNOLOGIES, INC. |
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