CA2199002C - Micropores sur la peau humaine pour l'administration de medicaments et suivi medical - Google Patents
Micropores sur la peau humaine pour l'administration de medicaments et suivi medicalInfo
- Publication number
- CA2199002C CA2199002C CA002199002A CA2199002A CA2199002C CA 2199002 C CA2199002 C CA 2199002C CA 002199002 A CA002199002 A CA 002199002A CA 2199002 A CA2199002 A CA 2199002A CA 2199002 C CA2199002 C CA 2199002C
- Authority
- CA
- Canada
- Prior art keywords
- tlle
- selected area
- stratum corneum
- skin
- light source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3203—Fluid jet cutting instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00137—Details of operation mode
- A61B2017/00154—Details of operation mode pulsed
- A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Surgical Instruments (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Laser Surgery Devices (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Méthode pour rendre la peau plus perméable à un analyte aux fins du diagnostic ou à un médicament à des fins thérapeutiques, qui fait appel à une technique de perçage d'un micropore et, facultativement, à l'énergie sonique et à un activateur chimique. Si l'on a recours à l'énergie sonique, celle-ci peut être modulée de différentes façons : modulation de fréquence, modulation d'amplitude, modulation de phase ou combinaisons de types de modulation. Pour percer un micropore, a) on enlève la couche cornée en chauffant rapidement en un point l'eau de façon à vaporiser l'eau et à éroder ainsi les cellules; b) on perfore la couche cornée avec une micro-lancette calibrée de façon à pratiquer un micropore pouvant atteindre environ 1 000 m de diamètre; c) on enlève la couche cornée en concentrant un faisceau bien focalisé d'énergie sonique sur la couche cornée; d) on perfore hydrauliquement la couche cornée avec un jet ou un liquide à haute pression pour former un micropore pouvant atteindre environ 1 000 m de diamètre, ou e) on perfore la couche cornée avec de brèves impulsions d'énergie électrique pour former un micropore pouvant atteindre environ 1 000 m de diamètre. Un colorant avec un maximum d'absorption correspondant à la longueur d'onde d'une source de lumière pulsée peut être absorbée dans la couche cornée pour concentrer l'énergie de la source de lumière pulsée et faciliter l'ablation de la couche cornée. Ou encore on peut mettre la couche cornée en contact avec un fil sous tension.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52054795A | 1995-08-29 | 1995-08-29 | |
US08/520,547 | 1995-08-29 | ||
US804395P | 1995-10-30 | 1995-10-30 | |
US60/008,043 | 1995-10-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2199002A1 CA2199002A1 (fr) | 1997-03-01 |
CA2199002C true CA2199002C (fr) | 1999-02-23 |
Family
ID=26677684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002199002A Expired - Lifetime CA2199002C (fr) | 1995-08-29 | 1996-08-29 | Micropores sur la peau humaine pour l'administration de medicaments et suivi medical |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0858285A4 (fr) |
JP (2) | JP3899427B2 (fr) |
CN (1) | CN1174713C (fr) |
AU (1) | AU707065B2 (fr) |
BR (1) | BR9610012A (fr) |
CA (1) | CA2199002C (fr) |
ES (1) | ES2536459T3 (fr) |
GB (1) | GB2307414B (fr) |
HK (1) | HK1009321A1 (fr) |
IL (1) | IL123379A (fr) |
NO (1) | NO334437B1 (fr) |
PT (1) | PT1563788E (fr) |
TR (1) | TR199800347T1 (fr) |
WO (1) | WO1997007734A1 (fr) |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6315772B1 (en) | 1993-09-24 | 2001-11-13 | Transmedica International, Inc. | Laser assisted pharmaceutical delivery and fluid removal |
AR008242A1 (es) | 1996-06-18 | 1999-12-29 | Alza Corp | Dispositivo para atravesar el estrato corneo de una superficie corporal |
US6183434B1 (en) * | 1996-07-03 | 2001-02-06 | Spectrx, Inc. | Multiple mechanical microporation of skin or mucosa |
DE69718495T2 (de) * | 1996-09-17 | 2003-11-20 | Deka Products Lp | System zur medikamentenabgabe durch transport |
US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
US6527716B1 (en) | 1997-12-30 | 2003-03-04 | Altea Technologies, Inc. | Microporation of tissue for delivery of bioactive agents |
WO1998029134A2 (fr) * | 1996-12-31 | 1998-07-09 | Altea Technologies, Inc. | Formation de micropores sur un tissu pour l'administration d'agents bioactifs |
US6027496A (en) | 1997-03-25 | 2000-02-22 | Abbott Laboratories | Removal of stratum corneum by means of light |
JP4338307B2 (ja) | 1997-10-21 | 2009-10-07 | アボット・ラボラトリーズ | 間質液を収集する装置および方法 |
US6155992A (en) * | 1997-12-02 | 2000-12-05 | Abbott Laboratories | Method and apparatus for obtaining interstitial fluid for diagnostic tests |
US6918901B1 (en) | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
CN1206004C (zh) | 1997-12-11 | 2005-06-15 | 阿尔扎有限公司 | 增强透皮物剂流量的装置 |
CN1170603C (zh) * | 1997-12-11 | 2004-10-13 | 阿尔扎有限公司 | 增强透皮物剂流量的装置 |
KR100572539B1 (ko) * | 1997-12-11 | 2006-04-24 | 알자 코포레이션 | 경피성 작용제 유동률을 증진시키기 위한 장치 |
ATE375752T1 (de) * | 1998-03-06 | 2007-11-15 | Spectrx Inc | Integrierte gewebeporations-, flüssigkeitsammel- und analysevorrichtung |
US6530915B1 (en) | 1998-03-06 | 2003-03-11 | Spectrx, Inc. | Photothermal structure for biomedical applications, and method therefor |
US6173202B1 (en) * | 1998-03-06 | 2001-01-09 | Spectrx, Inc. | Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue |
US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US6569157B1 (en) * | 1998-05-18 | 2003-05-27 | Abbott Laboratories | Removal of stratum corneum by means of light |
US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US7344499B1 (en) | 1998-06-10 | 2008-03-18 | Georgia Tech Research Corporation | Microneedle device for extraction and sensing of bodily fluids |
US6077660A (en) * | 1998-06-10 | 2000-06-20 | Abbott Laboratories | Diagnostic assay requiring a small sample of biological fluid |
AU759738B2 (en) | 1998-07-14 | 2003-04-17 | Nitto Denko Corporation | Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport |
US7384396B2 (en) | 1998-07-21 | 2008-06-10 | Spectrx Inc. | System and method for continuous analyte monitoring |
BR9912333A (pt) * | 1998-07-21 | 2001-04-17 | Spectrx Inc | Sistema para monitorar continuamente uma caracterìstica de um fluido biológico extraìdo de um organismo e processo para extrair um fluido biológico de uma membrana biológica de um organismo e monitorar continuamente uma caracterìstica do mesmo. |
NZ510923A (en) * | 1998-09-04 | 2003-09-26 | Powderject Res Ltd | Monitoring methods using particle delivery methods |
US6468229B1 (en) | 1998-10-20 | 2002-10-22 | Abbott Laboratories | Apparatus and method for the collection of interstitial fluids |
US6611706B2 (en) | 1998-11-09 | 2003-08-26 | Transpharma Ltd. | Monopolar and bipolar current application for transdermal drug delivery and analyte extraction |
US6148232A (en) | 1998-11-09 | 2000-11-14 | Elecsys Ltd. | Transdermal drug delivery and analyte extraction |
US6597946B2 (en) | 1998-11-09 | 2003-07-22 | Transpharma Ltd. | Electronic card for transdermal drug delivery and analyte extraction |
US6708060B1 (en) | 1998-11-09 | 2004-03-16 | Transpharma Ltd. | Handheld apparatus and method for transdermal drug delivery and analyte extraction |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
EP2168497A3 (fr) * | 1999-06-08 | 2010-12-01 | Altea Therapeutics Corporation | Appareil de micropores de membranes biologiques utilisant des dispositifs d'interface tissulaire à couche mince |
US20030078499A1 (en) | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
US6355054B1 (en) * | 1999-11-05 | 2002-03-12 | Ceramoptec Industries, Inc. | Laser system for improved transbarrier therapeutic radiation delivery |
DE19963034A1 (de) | 1999-12-24 | 2001-06-28 | Roche Diagnostics Gmbh | System zur verbesserten Bestimmung des Glukosespiegels anhand von Messungen in interstitieller Flüssigkeit |
IL136008A0 (en) | 2000-05-07 | 2001-05-20 | Elecsys Ltd | Electrically-mediated transdermal drug injection |
US6706032B2 (en) | 2000-06-08 | 2004-03-16 | Massachusetts Institute Of Technology | Localized molecular and ionic transport to and from tissues |
US7597692B2 (en) | 2000-06-08 | 2009-10-06 | Massachusetts Institute Of Technology | Microscission processes and procedures |
AUPR044000A0 (en) * | 2000-09-28 | 2000-10-26 | Norwood Abbey Ltd | Diagnostic device |
US6537243B1 (en) | 2000-10-12 | 2003-03-25 | Abbott Laboratories | Device and method for obtaining interstitial fluid from a patient for diagnostic tests |
US6882884B1 (en) | 2000-10-13 | 2005-04-19 | Soundskin, L.L.C. | Process for the stimulation of production of extracellular dermal proteins in human tissue |
US6733493B2 (en) * | 2000-11-16 | 2004-05-11 | Innotech Usa, Inc. | Laser skin perforator |
WO2002064193A2 (fr) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Appareils a microaiguilles et fabrication |
AU2002231207A1 (en) | 2000-12-21 | 2002-07-01 | Biovalve Technologies, Inc. | Microneedle array systems |
JP4704583B2 (ja) * | 2001-02-28 | 2011-06-15 | 有限会社開発顧問室 | パッチテスト用シート |
US6855117B2 (en) | 2001-08-01 | 2005-02-15 | Johnson & Johnson Consumer Companies, Inc. | Method of treating the skin of a subject |
US6790179B2 (en) | 2001-08-01 | 2004-09-14 | Johnson & Johnson Consumer Companies, Inc. | Method of examining and diagnosing skin health |
US6840910B2 (en) | 2001-08-01 | 2005-01-11 | Johnson & Johnson Consumer Companies, Inc. | Method of distributing skin care products |
AU2002327675A1 (en) | 2001-09-19 | 2003-04-01 | Biovalve Technologies, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
CA2499838C (fr) | 2001-09-21 | 2012-12-18 | Biovalve Technologies, Inc. | Amenagements de micro-aiguilles activees par pression de gaz, systemes et procedes correspondants |
EP1450876B1 (fr) | 2001-11-07 | 2016-08-17 | Syneron Medical Ltd. | Systeme integre d'administration transdermique de medicament |
US9918665B2 (en) | 2002-03-11 | 2018-03-20 | Nitto Denko Corporation | Transdermal porator and patch system and method for using same |
US7392080B2 (en) | 2002-03-11 | 2008-06-24 | Altea Therapeutics Corporation | Transdermal drug delivery patch system, method of making same and method of using same |
WO2003089043A2 (fr) | 2002-04-19 | 2003-10-30 | Transpharma Medical Ltd. | Administration de medicaments et extraction d'analyte par voie transdermique a l'aide d'un appareil tenu a la main |
US8133505B2 (en) | 2002-10-31 | 2012-03-13 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized medications |
IL152574A (en) | 2002-10-31 | 2009-09-22 | Transpharma Medical Ltd | A system for passing through the skin of dry items or dried medicines |
IL152575A (en) | 2002-10-31 | 2008-12-29 | Transpharma Medical Ltd | A skin-to-skin transmission system of water-insoluble drugs |
US7662404B2 (en) | 2002-10-31 | 2010-02-16 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides |
IL152573A (en) | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | A system for the transmission through the skin of a medical preparation against vomiting and nausea |
US7383084B2 (en) | 2002-10-31 | 2008-06-03 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized medications |
US7258673B2 (en) | 2003-06-06 | 2007-08-21 | Lifescan, Inc | Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein |
KR20060108682A (ko) * | 2003-10-24 | 2006-10-18 | 알자 코포레이션 | 경피 약물 전달을 증대시키기 위한 전처리 방법 및 장치 |
WO2005041871A2 (fr) * | 2003-10-24 | 2005-05-12 | Alza Corporation | Dispositif et procede d'amelioration de l'administration transdermique de medicament |
US8016811B2 (en) | 2003-10-24 | 2011-09-13 | Altea Therapeutics Corporation | Method for transdermal delivery of permeant substances |
RU2007118684A (ru) | 2004-10-21 | 2008-11-27 | БАЙЕР ХЕЛТКЭА ЭлЭлСи (US) | Способ и система для определения концентрации анализируемого вещества в жидкости организма |
JP2006326147A (ja) * | 2005-05-30 | 2006-12-07 | Shingo Wakamatsu | レーザー治療装置 |
TWI419717B (zh) * | 2005-06-17 | 2013-12-21 | Altea Therapeutics Corp | 滲透傳送系統及其使用方法 |
JP5011935B2 (ja) * | 2006-10-11 | 2012-08-29 | パナソニック株式会社 | 血液検査装置 |
JP5011936B2 (ja) * | 2006-10-11 | 2012-08-29 | パナソニック株式会社 | 血液検査装置 |
US8010188B2 (en) | 2006-11-14 | 2011-08-30 | Kagoshima University | Drug injecting device |
EP2152358B1 (fr) | 2007-04-27 | 2011-03-02 | Echo Therapeutics, Inc. | Dispositif permettant d'améliorer la perméabilité de la peau pour la détection de substances à analyser ou l'administration transdermique de médicaments |
JP5466161B2 (ja) | 2007-10-09 | 2014-04-09 | トランスファーマ メディカル リミテッド | 磁気的なパッチ連結物 |
CA2696227A1 (fr) | 2007-10-17 | 2009-04-23 | Transpharma Medical Ltd. | Verification de la vitesse de dissolution |
JP5407868B2 (ja) * | 2007-11-06 | 2014-02-05 | コニカミノルタ株式会社 | 微小開口形成装置およびそれを用いる体液収集システム |
WO2009072108A2 (fr) | 2007-12-05 | 2009-06-11 | Syneron Medical Ltd. | Applicateur d'énergie électromagnétique jetable et son procédé d'utilisation |
GB0811856D0 (en) | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
US8606366B2 (en) | 2009-02-18 | 2013-12-10 | Syneron Medical Ltd. | Skin treatment apparatus for personal use and method for using same |
US20100256466A1 (en) * | 2009-04-02 | 2010-10-07 | Avraham Shekalim | Metabolite Management System |
EP2459092B1 (fr) | 2009-07-27 | 2019-09-18 | Novoxel Ltd. | Dispositif d'ablation de tissu |
PT105635B (pt) * | 2011-04-19 | 2014-04-11 | Univ De Coimbra | Dispositivo para a administração eficiente de compostos na pele ou barreiras biológicas, ou através dessas, usando filmes finos absorventes de luz |
EP3957262A1 (fr) | 2013-12-18 | 2022-02-23 | Novoxel Ltd. | Dispositifs de vaporisation tissulaire |
US11083515B2 (en) | 2013-12-18 | 2021-08-10 | Novoxel Ltd. | Methods and devices for thermal tissue vaporization and compression |
JP2017536142A (ja) * | 2014-09-15 | 2017-12-07 | ノヴォクセル リミテッド | 組織の熱外科的蒸散および切開のための方法および装置 |
WO2016141144A1 (fr) * | 2015-03-03 | 2016-09-09 | Guided Therapy Systems, Llc | Procédés et systèmes de transport de matériaux à travers une membrane imperméable ou semi-perméable par l'intermédiaire de microcanaux créés artificiellement |
WO2017102867A1 (fr) * | 2015-12-15 | 2017-06-22 | Koninklijke Philips N.V. | Dispositif et procédé de traitement de surface |
CN108780085A (zh) * | 2016-01-15 | 2018-11-09 | 辛辛那提大学 | 先进的电穿孔装置和用于获得生物流体中的分析物的方法 |
AU2017280014B2 (en) * | 2016-06-20 | 2022-05-26 | University Of North Texas | Laser-assisted machining (LAM) of non-monolithic composite bone material |
FI127811B (en) * | 2016-11-21 | 2019-03-15 | Helsingin Yliopisto | APPARATUS FOR SAMPLING ONE OR MORE ANALYTICAL SAMPLES |
EP3361402A1 (fr) * | 2017-02-14 | 2018-08-15 | Roche Diabetes Care GmbH | Méthode, produit de programme informatique et dispositif portable pour l'analyse des niveaux de glucose dans un liquide de corps au moyen de données de surveillance de glucose |
US11441994B2 (en) * | 2017-07-27 | 2022-09-13 | Tata Consultancy Services Limited | Method and system for in-silico design of skin electroporation |
WO2019025610A1 (fr) * | 2017-08-03 | 2019-02-07 | Fibrotx Oü | Dosage d'écoulement latéral et dispositif pour application de soins de la peau |
CN109157280A (zh) * | 2018-08-10 | 2019-01-08 | 重庆大学 | 不可逆电穿孔组织消融效果动态实时评估设备 |
US20220257303A1 (en) * | 2019-06-28 | 2022-08-18 | Passport Technologies, Inc. | Methods and systems for controlling energy delivery to filament devices |
TWI735137B (zh) * | 2019-08-02 | 2021-08-01 | 華廣生技股份有限公司 | 生理訊號傳感裝置 |
CN110613893A (zh) * | 2019-10-31 | 2019-12-27 | 南京工业职业技术学院 | 一种新型励磁线圈 |
CN111693434B (zh) * | 2020-06-19 | 2024-01-19 | 中建路桥集团有限公司 | 一种测试混凝土抗渗性能的实验装置 |
CN114504373A (zh) * | 2020-11-16 | 2022-05-17 | 澳美力科技(成都)有限公司 | 一种新型射频变频美容仪 |
CN112957124B (zh) * | 2021-01-30 | 2023-08-22 | 南京理工大学 | 一种能量靶向调控的离体激光生物组织焊接缝合方法 |
CN113397698B (zh) * | 2021-05-20 | 2023-04-18 | 东莞市飞越激光设备有限公司 | 一种保证高精度和高速度的激光切线装置 |
CN114343839A (zh) * | 2021-12-30 | 2022-04-15 | 德州环球之光医疗科技有限公司 | 一种基于可调的螺旋线型激光光斑的治疗图形转换方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775361A (en) * | 1986-04-10 | 1988-10-04 | The General Hospital Corporation | Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport |
US4863970A (en) * | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
ATE131081T1 (de) * | 1988-01-21 | 1995-12-15 | Massachusetts Inst Technology | Molekültransport durch gewebe mit der verwendung von elektroporation. |
US5139023A (en) | 1989-06-02 | 1992-08-18 | Theratech Inc. | Apparatus and method for noninvasive blood glucose monitoring |
US5016615A (en) * | 1990-02-20 | 1991-05-21 | Riverside Research Institute | Local application of medication with ultrasound |
US5115805A (en) * | 1990-02-23 | 1992-05-26 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
GB9014307D0 (en) | 1990-06-27 | 1990-08-15 | Scient Generics Ltd | Method of treatment and compositions therefor |
JP3189337B2 (ja) * | 1991-11-08 | 2001-07-16 | 日本電気株式会社 | 皮膚角層の除去器具および除去方法 |
US5344418A (en) * | 1991-12-12 | 1994-09-06 | Shahriar Ghaffari | Optical system for treatment of vascular lesions |
US5165418B1 (en) | 1992-03-02 | 1999-12-14 | Nikola I Tankovich | Blood sampling device and method using a laser |
US5246437A (en) * | 1992-04-10 | 1993-09-21 | Abela George S | Cell treatment apparatus and method |
US5643252A (en) * | 1992-10-28 | 1997-07-01 | Venisect, Inc. | Laser perforator |
US5279552A (en) * | 1993-01-11 | 1994-01-18 | Anton Magnet | Intradermal injection device |
US5267985A (en) * | 1993-02-11 | 1993-12-07 | Trancell, Inc. | Drug delivery by multiple frequency phonophoresis |
US5582184A (en) * | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
US5458140A (en) | 1993-11-15 | 1995-10-17 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers |
US5445611A (en) * | 1993-12-08 | 1995-08-29 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal delivery with ultrasound and chemical enhancers |
DE69624668T2 (de) * | 1995-07-25 | 2003-08-28 | Massachusetts Inst Technology | Verbesserter transdermaler transport unter verwendung von ultraschall |
-
1996
- 1996-08-29 CA CA002199002A patent/CA2199002C/fr not_active Expired - Lifetime
- 1996-08-29 JP JP51055297A patent/JP3899427B2/ja not_active Expired - Lifetime
- 1996-08-29 PT PT50110022T patent/PT1563788E/pt unknown
- 1996-08-29 WO PCT/US1996/013865 patent/WO1997007734A1/fr not_active Application Discontinuation
- 1996-08-29 GB GB9702766A patent/GB2307414B/en not_active Expired - Lifetime
- 1996-08-29 BR BR9610012-5A patent/BR9610012A/pt not_active Application Discontinuation
- 1996-08-29 ES ES05011002.2T patent/ES2536459T3/es not_active Expired - Lifetime
- 1996-08-29 AU AU68631/96A patent/AU707065B2/en not_active Expired
- 1996-08-29 EP EP96929098A patent/EP0858285A4/fr not_active Withdrawn
- 1996-08-29 CN CNB961966718A patent/CN1174713C/zh not_active Expired - Lifetime
- 1996-08-29 TR TR1998/00347T patent/TR199800347T1/xx unknown
- 1996-08-29 IL IL12337996A patent/IL123379A/en not_active IP Right Cessation
-
1998
- 1998-02-27 NO NO19980878A patent/NO334437B1/no not_active IP Right Cessation
- 1998-08-24 HK HK98110113A patent/HK1009321A1/xx not_active IP Right Cessation
-
2006
- 2006-02-15 JP JP2006038655A patent/JP2006192285A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
PT1563788E (pt) | 2015-06-02 |
BR9610012A (pt) | 1999-12-21 |
EP0858285A4 (fr) | 2000-05-17 |
HK1009321A1 (en) | 1999-05-28 |
IL123379A0 (en) | 1998-09-24 |
JPH11511360A (ja) | 1999-10-05 |
JP3899427B2 (ja) | 2007-03-28 |
EP0858285A1 (fr) | 1998-08-19 |
AU6863196A (en) | 1997-03-19 |
GB2307414A (en) | 1997-05-28 |
GB2307414B (en) | 1998-03-11 |
CA2199002A1 (fr) | 1997-03-01 |
ES2536459T3 (es) | 2015-05-25 |
TR199800347T1 (xx) | 1998-05-21 |
CN1195276A (zh) | 1998-10-07 |
AU707065B2 (en) | 1999-07-01 |
NO980878L (no) | 1998-04-27 |
CN1174713C (zh) | 2004-11-10 |
GB9702766D0 (en) | 1997-04-02 |
WO1997007734A1 (fr) | 1997-03-06 |
NO980878D0 (no) | 1998-02-27 |
JP2006192285A (ja) | 2006-07-27 |
NO334437B1 (no) | 2014-03-03 |
IL123379A (en) | 2002-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2199002C (fr) | Micropores sur la peau humaine pour l'administration de medicaments et suivi medical | |
US5885211A (en) | Microporation of human skin for monitoring the concentration of an analyte | |
CA2789115C (fr) | Formation de micropores sur un tissu pour l'administration d'agents bioactifs | |
US9579380B2 (en) | Microporation of tissue for delivery of bioactive agents | |
US6527716B1 (en) | Microporation of tissue for delivery of bioactive agents | |
US20020169394A1 (en) | Integrated tissue poration, fluid harvesting and analysis device, and method therefor | |
US5458140A (en) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers | |
EP1059939B1 (fr) | Appareil permettant d'accroitre les debits d'un fluide dans un tissu biologique rendu microporeux | |
AU738597B2 (en) | Laser assisted topical anesthetic permeation | |
US5445611A (en) | Enhancement of transdermal delivery with ultrasound and chemical enhancers | |
Lee et al. | Permeabilization and recovery of the stratum corneum in vivo: the synergy of photomechanical waves and sodium lauryl sulfate | |
EP1563788B1 (fr) | Microporation de la peau humaine pour l'administration des médicaments et applications de surveillance | |
RU2209031C2 (ru) | Формирование микропор в коже человека для доставки лекарственных препаратов и мониторинга | |
WO2002026148A1 (fr) | Permeation et prelevement ameliores par irradiation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20160829 |