CN1195276A - 用于输药及检测的人体皮肤微穿孔方法 - Google Patents
用于输药及检测的人体皮肤微穿孔方法 Download PDFInfo
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- CN1195276A CN1195276A CN96196671A CN96196671A CN1195276A CN 1195276 A CN1195276 A CN 1195276A CN 96196671 A CN96196671 A CN 96196671A CN 96196671 A CN96196671 A CN 96196671A CN 1195276 A CN1195276 A CN 1195276A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3203—Fluid jet cutting instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00137—Details of operation mode
- A61B2017/00154—Details of operation mode pulsed
- A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Optics & Photonics (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Surgical Instruments (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Laser Surgery Devices (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
差分热模型的初始条件 | |
周围空气温度 | Ta=20℃ |
皮肤表面温度 | Ts=30℃ |
真皮温度 | Td=37℃ |
染料汽化温度 | Tvap=550℃ |
角质层汽化温度 | Tc1=123℃ |
组织损伤温度 | Tc2=70℃ |
“疼痛”温度 | Tc3=45℃ |
照射区域的半径 | Rhot=30微米 |
施用的能量密度 | FLUX=400J/cm2 |
参量 | 染料 | 角质层 | 表 皮 | 真皮 |
导热率 | 0.00046 | 0.00123 | 0.00421 | 0.00421 |
密度 | 0.67 | 1.28 | 1.09 | 1.09 |
比热 | 0.8 | 1.88 | 3.35 | 3.35 |
Claims (61)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52054795A | 1995-08-29 | 1995-08-29 | |
US08/520,547 | 1995-08-29 | ||
US804395P | 1995-10-30 | 1995-10-30 | |
US60/008,043 | 1995-10-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1195276A true CN1195276A (zh) | 1998-10-07 |
CN1174713C CN1174713C (zh) | 2004-11-10 |
Family
ID=26677684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB961966718A Expired - Lifetime CN1174713C (zh) | 1995-08-29 | 1996-08-29 | 用于输药及检测的人体皮肤微穿孔设备 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0858285A4 (zh) |
JP (2) | JP3899427B2 (zh) |
CN (1) | CN1174713C (zh) |
AU (1) | AU707065B2 (zh) |
BR (1) | BR9610012A (zh) |
CA (1) | CA2199002C (zh) |
ES (1) | ES2536459T3 (zh) |
GB (1) | GB2307414B (zh) |
HK (1) | HK1009321A1 (zh) |
IL (1) | IL123379A (zh) |
NO (1) | NO334437B1 (zh) |
PT (1) | PT1563788E (zh) |
TR (1) | TR199800347T1 (zh) |
WO (1) | WO1997007734A1 (zh) |
Cited By (15)
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CN102307607A (zh) * | 2009-04-02 | 2012-01-04 | G-感觉有限公司 | 代谢物管理*** |
CN103492020A (zh) * | 2011-04-19 | 2014-01-01 | 科英布拉大学 | 用于利用吸光薄膜将化合物高效输送至或透过皮肤或生物屏障的器件 |
CN107205771A (zh) * | 2014-09-15 | 2017-09-26 | 诺服塞尔有限公司 | 用于热外科汽化及切割组织的方法和装置 |
CN108780085A (zh) * | 2016-01-15 | 2018-11-09 | 辛辛那提大学 | 先进的电穿孔装置和用于获得生物流体中的分析物的方法 |
CN109414230A (zh) * | 2016-11-21 | 2019-03-01 | 格鲁科莫迪肯公司 | 用于取样一种或多种分析物的装置 |
CN109875678A (zh) * | 2018-08-10 | 2019-06-14 | 重庆大学 | 不可逆电穿孔组织消融效果动态实时评估设备及评估方法 |
CN110249390A (zh) * | 2017-02-14 | 2019-09-17 | 豪夫迈·罗氏有限公司 | 用于分析指示体液中的葡萄糖水平的葡萄糖监测数据的计算机实现的方法和便携式设备,以及计算机程序产品 |
CN110613893A (zh) * | 2019-10-31 | 2019-12-27 | 南京工业职业技术学院 | 一种新型励磁线圈 |
CN111107935A (zh) * | 2017-08-03 | 2020-05-05 | 菲帛罗缇埃克斯有限公司 | 用于皮肤护理应用的侧流测定装置 |
CN111693434A (zh) * | 2020-06-19 | 2020-09-22 | 中建路桥集团有限公司 | 一种测试混凝土抗渗性能的实验装置 |
CN112957124A (zh) * | 2021-01-30 | 2021-06-15 | 南京理工大学 | 一种能量靶向调控的激光生物组织焊接缝合方法 |
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CN114343839A (zh) * | 2021-12-30 | 2022-04-15 | 德州环球之光医疗科技有限公司 | 一种基于可调的螺旋线型激光光斑的治疗图形转换方法 |
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WO1998000193A1 (en) * | 1996-07-03 | 1998-01-08 | Altea Technologies, Inc. | Multiple mechanical microporation of skin or mucosa |
US5983136A (en) * | 1996-09-17 | 1999-11-09 | Deka Products Limited Partnership | System for delivery of drugs by transport |
US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
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Also Published As
Publication number | Publication date |
---|---|
GB2307414B (en) | 1998-03-11 |
BR9610012A (pt) | 1999-12-21 |
PT1563788E (pt) | 2015-06-02 |
IL123379A (en) | 2002-04-21 |
JP3899427B2 (ja) | 2007-03-28 |
NO980878L (no) | 1998-04-27 |
AU707065B2 (en) | 1999-07-01 |
HK1009321A1 (en) | 1999-05-28 |
CN1174713C (zh) | 2004-11-10 |
CA2199002C (en) | 1999-02-23 |
WO1997007734A1 (en) | 1997-03-06 |
CA2199002A1 (en) | 1997-03-01 |
IL123379A0 (en) | 1998-09-24 |
ES2536459T3 (es) | 2015-05-25 |
NO334437B1 (no) | 2014-03-03 |
TR199800347T1 (xx) | 1998-05-21 |
JP2006192285A (ja) | 2006-07-27 |
EP0858285A4 (en) | 2000-05-17 |
GB9702766D0 (en) | 1997-04-02 |
EP0858285A1 (en) | 1998-08-19 |
JPH11511360A (ja) | 1999-10-05 |
GB2307414A (en) | 1997-05-28 |
NO980878D0 (no) | 1998-02-27 |
AU6863196A (en) | 1997-03-19 |
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