AU703344B2 - Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface - Google Patents

Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface Download PDF

Info

Publication number
AU703344B2
AU703344B2 AU34103/95A AU3410395A AU703344B2 AU 703344 B2 AU703344 B2 AU 703344B2 AU 34103/95 A AU34103/95 A AU 34103/95A AU 3410395 A AU3410395 A AU 3410395A AU 703344 B2 AU703344 B2 AU 703344B2
Authority
AU
Australia
Prior art keywords
dna
nucleic acid
biosensor
film
electrode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU34103/95A
Other languages
English (en)
Other versions
AU3410395A (en
Inventor
Allen J Bard
Xiao-Hong Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IGEN International Inc
Original Assignee
IGEN International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IGEN International Inc filed Critical IGEN International Inc
Publication of AU3410395A publication Critical patent/AU3410395A/en
Assigned to IGEN INTERNATIONAL, INC. reassignment IGEN INTERNATIONAL, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: IGEN, INC.
Application granted granted Critical
Publication of AU703344B2 publication Critical patent/AU703344B2/en
Priority to AU36767/99A priority Critical patent/AU3676799A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/005Enzyme electrodes involving specific analytes or enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
AU34103/95A 1994-08-26 1995-08-25 Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface Ceased AU703344B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU36767/99A AU3676799A (en) 1994-08-26 1999-06-25 Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to solid surface

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29663094A 1994-08-26 1994-08-26
US08/296630 1994-08-26
PCT/US1995/010630 WO1996006946A1 (fr) 1994-08-26 1995-08-25 Biocapteur et procede destines a la detection par luminescence electrophotochimique d'acides nucleiques adsorbes sur une surface solide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU36767/99A Division AU3676799A (en) 1994-08-26 1999-06-25 Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to solid surface

Publications (2)

Publication Number Publication Date
AU3410395A AU3410395A (en) 1996-03-22
AU703344B2 true AU703344B2 (en) 1999-03-25

Family

ID=23142843

Family Applications (1)

Application Number Title Priority Date Filing Date
AU34103/95A Ceased AU703344B2 (en) 1994-08-26 1995-08-25 Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface

Country Status (5)

Country Link
EP (1) EP0777741A4 (fr)
JP (1) JPH10509025A (fr)
AU (1) AU703344B2 (fr)
CA (1) CA2198489A1 (fr)
WO (1) WO1996006946A1 (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786141A (en) * 1994-08-26 1998-07-28 Bard; Allen J. Electrogenerated chemiluminescence labels for analysis and/or referencing
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
CN1192097C (zh) * 1995-03-10 2005-03-09 梅索磅秤技术有限公司 多阵列、多特异性的电化学发光检验
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
FR2762013B1 (fr) * 1997-04-09 1999-06-04 Cis Bio Int Systemes de detection d'hybridation d'acides nucleiques, leur procede de preparation et leurs utilisations
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7935481B1 (en) 1999-07-26 2011-05-03 Osmetech Technology Inc. Sequence determination of nucleic acids using electronic detection
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
AU2907201A (en) * 1999-12-09 2001-06-18 Motorola, Inc. Methods and compositions relating to electrical detection of nucleic acid reactions
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US6706479B2 (en) * 2000-10-05 2004-03-16 Virginia Tech Intellectual Properties, Inc. Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips
WO2005016115A2 (fr) 2003-01-23 2005-02-24 Montana State University Biocapteurs faisant intervenir des ligands immobilises sur des dendrimeres et utilisation de ceux-ci
WO2005005952A2 (fr) 2003-05-13 2005-01-20 The Trustees Of Boston College Detection electrocatalytique de l'hybridation d'acides nucleiques
US7741033B2 (en) * 2003-05-13 2010-06-22 Trustees Of Boston College Electrocatalytic nucleic acid hybridization detection
WO2006075497A1 (fr) * 2004-12-21 2006-07-20 Kyoto University Sonde, dispositif d'identification de region nucleotidique et procede d'identification de region nucleotidique
CN102216762B (zh) 2008-09-02 2016-02-10 多伦多大学董事局 纳米结构的微电极以及集成所述微电极的生物传感器件
EP2663857B1 (fr) 2011-01-11 2018-12-12 The Governing Council Of The University Of Toronto Procédé de détection de protéines
WO2012122564A2 (fr) 2011-03-10 2012-09-13 Xagenic, Inc. Dispositifs et méthodes de diagnostic et de préparation d'échantillons
BR112018001956A2 (pt) 2015-08-20 2018-09-11 Hoffmann La Roche ?método de medição de analitos e kit?
EP3427057A1 (fr) 2016-03-07 2019-01-16 H. Hoffnabb-La Roche Ag Détection d'anticorps anti-p53
JP7068323B2 (ja) 2017-02-02 2022-05-16 エフ.ホフマン-ラ ロシュ アーゲー 少なくとも2種のペグ化された分析物特異的結合剤を使用する免疫アッセイ
CN111936522A (zh) 2018-04-18 2020-11-13 豪夫迈·罗氏有限公司 新型抗胸苷激酶抗体
EP3844503A1 (fr) 2018-08-31 2021-07-07 F. Hoffmann-La Roche AG Thymidine kinase (tk-1) dans la détermination d'indices de pronostic pour le dlbcl
CN114144674A (zh) 2019-07-22 2022-03-04 豪夫迈·罗氏有限公司 P物质作为用于子宫内膜异位症的非侵入性诊断的血液生物标志物
WO2021013784A1 (fr) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a8 utilisée en tant que biomarqueur sanguin pour le diagnostic non invasif de l'endométriose
CN114144675A (zh) 2019-07-22 2022-03-04 豪夫迈·罗氏有限公司 S100a9作为血液生物标志物用于子宫内膜异位症的非侵入性诊断
EP4004555A1 (fr) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a6 en tant que biomarqueur du sang pour le diagnostic non invasif de l'endométriose
BR112022001140A2 (pt) 2019-07-22 2022-03-15 Hoffmann La Roche Métodos para avaliar se um paciente tem endometriose ou está em risco de desenvolver endometriose, selecionar um paciente para terapia e monitorar um paciente que sofre de endometriose ou que está sendo tratado para endometriose
WO2021094409A1 (fr) 2019-11-15 2021-05-20 F. Hoffmann-La Roche Ag Dérivation d'antibiotiques de bêta-lactame pour des mesures par spectrométrie de masse dans des échantillons de patients
CN111272742B (zh) * 2020-03-06 2022-11-08 安徽大学 基于金属有机凝胶复合材料和金属有机框架的电致化学发光传感器及其制备和检测方法
US20230406909A1 (en) 2020-11-02 2023-12-21 Roche Diagnostics Operations, Inc. Sars-cov-2 nucleocapsid antibodies
WO2022207628A1 (fr) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf comme biomarqueur sanguin pour le diagnostic non invasif de l'endométriose
WO2022207685A1 (fr) 2021-04-01 2022-10-06 F. Hoffmann-La Roche Ag Psp94 utilisée en tant que biomarqueur sanguin pour le diagnostic non invasif de l'endométriose
CN117337394A (zh) 2021-05-17 2024-01-02 豪夫迈·罗氏有限公司 sFRP4作为血液生物标志物用于子宫腺肌病的非侵入性诊断
WO2023072904A1 (fr) 2021-10-26 2023-05-04 F. Hoffmann-La Roche Ag Anticorps monoclonaux spécifiques du rbd du sars-cov-2
WO2023131594A1 (fr) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Dérivatisation de composés dans des échantillons de patients pour la pharmacovigilance thérapeutique (tdm)
WO2023247752A1 (fr) 2022-06-23 2023-12-28 F. Hoffmann-La Roche Ag Procédé de diagnostic de l'endométriose et de classification du stade de l'endométriose
WO2024017985A1 (fr) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Protéine 1 de liaison au facteur de croissance des fibroblastes (fgfbp1) utilisée en tant que biomarqueur (sanguin) pour le diagnostic du syndrome des ovaires polykystiques
WO2024017982A1 (fr) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Leukotriène a4 hydrolase (lta4h) en tant que biomarqueur (sang) pour le diagnostic du syndrome des ovaires polykystiques
WO2024017983A1 (fr) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Protéine de type météorine (metrnl) utilisée en tant que biomarqueur (sang) pour le diagnostic du syndrome des ovaires polykystiques
CN115414930B (zh) * 2022-08-26 2023-10-31 重庆医科大学 Ru(bpy)32+阳极或阴极共反应物及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1258580A (fr) * 1967-12-28 1971-12-30
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5124022A (en) * 1989-08-23 1992-06-23 Aluminum Company Of America Electrolytic capacitor and method of making same
US5019343A (en) * 1989-12-15 1991-05-28 W. R. Grace & Co.-Conn. Control of corrosion in aqueous systems using certain phosphonomethyl amines
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANAL. CHEM, 66(6) PP.769-777(1994) *

Also Published As

Publication number Publication date
CA2198489A1 (fr) 1996-03-07
AU3410395A (en) 1996-03-22
EP0777741A1 (fr) 1997-06-11
JPH10509025A (ja) 1998-09-08
EP0777741A4 (fr) 1999-01-13
WO1996006946A1 (fr) 1996-03-07

Similar Documents

Publication Publication Date Title
AU703344B2 (en) Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface
Xu et al. Immobilization and hybridization of DNA on an aluminum (III) alkanebisphosphonate thin film with electrogenerated chemiluminescent detection
US6127127A (en) Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6096500A (en) Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US7160678B1 (en) Compositions for the electronic detection of analytes utilizing monolayers
US7829275B2 (en) Light addressable electrochemical detection of duplex structures
US20090036315A1 (en) Device and methods for detecting and quantifying one or more target agents
US6387625B1 (en) Monolayer and electrode for detecting a label-bearing target and method of use thereof
AU6337696A (en) Electrochemical detection of nucleic acid hybridization
WO2007092552A2 (fr) Dispositif et procédés de détection et de quantification d'un ou plusieurs agents cibles
KR100459394B1 (ko) 인터컬레이터를 이용한 핵산의 전기화학발광 검출방법
US20100279278A1 (en) Methods of detecting one or more bioterrorism target agents
AU3676799A (en) Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to solid surface
JP4706074B2 (ja) 生体分子固定化用の三脚型機能性界面分子とこれを用いた遺伝子検出デバイス
WO2005042783A1 (fr) Detection electrochimique de l'hybridation de l'acide nucleique amelioree par une saute de temperature
Palchetti et al. Electrochemical adsorption technique for immobilization of single-stranded oligonucleotides onto carbon screen-printed electrodes
WONG Recent trends in DNA biosensing technologies
CA2471339A1 (fr) Methode et dispositif pour la detection electrique quantitative d'analytes
CN116376552A (zh) 单原子电化学发光探针及其制备方法和应用
US20070077593A1 (en) Substrate as a ligate carrier
Zarei Development of Light-Addressable Electrode Arrays Towards the Application of DNA Hybridization Biosensor
JP4037766B2 (ja) 標的核酸の検出方法および伸長方法、並びにアッセイキット
KR19990028484A (ko) 핵산 하이브리드의 전기화학적 검출방법
CN1375696A (zh) 纳米微球放大技术压电dna生物传感器检测超痕量dna的方法
JP2007187491A (ja) 電気化学検出用電極およびその製造方法