AU523496B2 - Aminoalkyl benzene derivatives - Google Patents

Aminoalkyl benzene derivatives

Info

Publication number
AU523496B2
AU523496B2 AU36067/78A AU3606778A AU523496B2 AU 523496 B2 AU523496 B2 AU 523496B2 AU 36067/78 A AU36067/78 A AU 36067/78A AU 3606778 A AU3606778 A AU 3606778A AU 523496 B2 AU523496 B2 AU 523496B2
Authority
AU
Australia
Prior art keywords
benzene derivatives
aminoalkyl benzene
aminoalkyl
derivatives
benzene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU36067/78A
Other languages
English (en)
Other versions
AU3606778A (en
Inventor
Et Al Barry John Price
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB20660/77A external-priority patent/GB1604674A/en
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Publication of AU3606778A publication Critical patent/AU3606778A/en
Application granted granted Critical
Publication of AU523496B2 publication Critical patent/AU523496B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/08—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
AU36067/78A 1977-05-17 1978-05-12 Aminoalkyl benzene derivatives Expired AU523496B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB20660/77A GB1604674A (en) 1977-05-17 1977-05-17 Aminoalkyl-benzene derivatives
GB7720660 1977-05-17
GB4012977 1977-09-27
GB1744478 1978-05-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU84117/82A Division AU541144B2 (en) 1977-05-17 1982-05-25 Aminoalkylbenzene derivatives

Publications (2)

Publication Number Publication Date
AU3606778A AU3606778A (en) 1979-11-15
AU523496B2 true AU523496B2 (en) 1982-07-29

Family

ID=27257503

Family Applications (2)

Application Number Title Priority Date Filing Date
AU36067/78A Expired AU523496B2 (en) 1977-05-17 1978-05-12 Aminoalkyl benzene derivatives
AU84117/82A Expired AU541144B2 (en) 1977-05-17 1982-05-25 Aminoalkylbenzene derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU84117/82A Expired AU541144B2 (en) 1977-05-17 1982-05-25 Aminoalkylbenzene derivatives

Country Status (13)

Country Link
JP (1) JPS53149936A (de)
AU (2) AU523496B2 (de)
CH (2) CH643238A5 (de)
DE (1) DE2821410A1 (de)
DK (1) DK214878A (de)
ES (1) ES469953A1 (de)
FI (1) FI781490A (de)
FR (2) FR2401135A1 (de)
IE (1) IE46886B1 (de)
IT (1) IT1156755B (de)
NL (1) NL7805344A (de)
NZ (1) NZ187235A (de)
SE (1) SE443558B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU611705B2 (en) * 1987-08-03 1991-06-20 Kyorin Pharmaceutical Co. Ltd. Urea derivatives

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233302A (en) * 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
YU56680A (en) * 1979-03-02 1983-04-30 Glaxo Group Ltd Process for obtaining new 1,2,4-triazole derivatives
JPS609750B2 (ja) * 1979-07-03 1985-03-12 帝国臓器製薬株式会社 新規なｎ−置換フエノキシプロピルアミド化合物
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
US4293557A (en) 1979-07-03 1981-10-06 Teikoku Hormone Mfg. Co., Ltd. Antiulcer phenoxypropylamine derivatives
EP0029303B1 (de) * 1979-10-22 1985-01-30 Glaxo Group Limited 1,2,4-Triazol-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
US4238487A (en) * 1979-10-31 1980-12-09 Merck & Co., Inc. Aminoalkyl benzofuran derivatives
FR2477537A1 (fr) * 1980-03-07 1981-09-11 Francaise Sucrerie Nouvelles guanidines acylees, urees et urees substituees, leur procede de fabrication et leur application en tant que medicaments
US4490533A (en) * 1980-12-22 1984-12-25 Merck & Co., Inc. Aminoalkyl pyridine derivatives
EP0057981A3 (de) 1981-02-09 1982-08-25 Beecham Group Plc Aromatische Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung
JPS57165348A (en) * 1981-04-06 1982-10-12 Teikoku Hormone Mfg Co Ltd Novel aminoalkylbenzene derivative
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
US4522943A (en) * 1981-05-18 1985-06-11 Bristol-Myers Company Chemical compounds
IE53068B1 (en) * 1981-06-15 1988-05-25 Merck & Co Inc Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
EP0071434B1 (de) * 1981-07-24 1987-01-28 Glaxo Group Limited Heterocyclische Derivate
US4411899A (en) * 1981-12-21 1983-10-25 Merck & Co., Inc. Substituted derivatives of amino alkane diols as gastric secretion inhibitors
JPS5988458A (ja) * 1982-11-12 1984-05-22 Toyama Chem Co Ltd アミン誘導体およびその塩
JPH01131172A (ja) * 1987-08-28 1989-05-24 Toyama Chem Co Ltd アミン誘導体およびその塩、それらの製造法、並びにそれらを含有する抗潰瘍剤
CA2134229A1 (en) * 1992-05-12 1993-11-13 Osamu Kitagawa Novel quaternary ammonium salts and use thereof as medicine
TWI328009B (en) 2003-05-21 2010-08-01 Glaxo Group Ltd Quinoline derivatives as phosphodiesterase inhibitors
GB2455176A (en) * 2007-11-01 2009-06-03 Acucela Inc Amine derivatives useful for treating ophthalmic diseases and disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE636468A (de) *
US2785201A (en) * 1953-12-24 1957-03-12 Personnes A Responsabilite Lim Compounds of bis quaternary ammonium derivatives of phenylethylamine
US3047628A (en) * 1957-02-19 1962-07-31 Hoffmann La Roche Benzylamine derivatives
GB993581A (en) * 1960-03-03 1965-05-26 Wellcome Found Phenoxyalkylguanidines and their synthesis and pharmaceutical preparations containing them
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
JPS5227757A (en) * 1975-08-26 1977-03-02 Kyowa Hakko Kogyo Co Ltd Preparation of 6-aminomethylnaphthalene derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU611705B2 (en) * 1987-08-03 1991-06-20 Kyorin Pharmaceutical Co. Ltd. Urea derivatives

Also Published As

Publication number Publication date
AU541144B2 (en) 1984-12-20
FR2401135A1 (fr) 1979-03-23
CH643233A5 (en) 1984-05-30
IT7849419A0 (it) 1978-05-17
NZ187235A (en) 1981-10-19
IT1156755B (it) 1987-02-04
FR2398718B1 (de) 1982-10-15
JPS53149936A (en) 1978-12-27
AU8411782A (en) 1982-08-26
JPH0112744B2 (de) 1989-03-02
IE780940L (en) 1978-11-17
FI781490A (fi) 1978-11-18
FR2401135B1 (de) 1983-08-19
ES469953A1 (es) 1979-09-16
FR2398718A1 (fr) 1979-02-23
DE2821410A1 (de) 1978-11-30
CH643238A5 (en) 1984-05-30
SE443558B (sv) 1986-03-03
NL7805344A (nl) 1978-11-21
SE7805591L (sv) 1978-11-18
IE46886B1 (en) 1983-10-19
AU3606778A (en) 1979-11-15
DK214878A (da) 1978-11-18

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