ATE547411T1 - 3-pyrrolo-cyclohexylen-2-dihydroindolinonderiva e und anwendungen davon - Google Patents
3-pyrrolo-cyclohexylen-2-dihydroindolinonderiva e und anwendungen davonInfo
- Publication number
- ATE547411T1 ATE547411T1 AT07817351T AT07817351T ATE547411T1 AT E547411 T1 ATE547411 T1 AT E547411T1 AT 07817351 T AT07817351 T AT 07817351T AT 07817351 T AT07817351 T AT 07817351T AT E547411 T1 ATE547411 T1 AT E547411T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclohexylene
- pyrrolo
- activity
- formula
- pharmaceutically acceptable
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200610098202XA CN101195601A (zh) | 2006-12-04 | 2006-12-04 | 2-二氢吲哚酮衍生物及其制备方法和用途 |
| CNA2006101612208A CN101200446A (zh) | 2006-12-15 | 2006-12-15 | 3-吡咯并环己亚基-2-二氢吲哚酮衍生物及其用途 |
| PCT/CN2007/071161 WO2008067756A1 (fr) | 2006-12-04 | 2007-12-03 | Dérivés de 3-pyrrolo-cyclohexylène-2-dihydro-indolinone et utilisations de ceux-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE547411T1 true ATE547411T1 (de) | 2012-03-15 |
Family
ID=39491676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07817351T ATE547411T1 (de) | 2006-12-04 | 2007-12-03 | 3-pyrrolo-cyclohexylen-2-dihydroindolinonderiva e und anwendungen davon |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8084621B2 (de) |
| EP (1) | EP2123649B1 (de) |
| JP (1) | JP5542445B2 (de) |
| AT (1) | ATE547411T1 (de) |
| ES (1) | ES2383084T3 (de) |
| WO (1) | WO2008067756A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2635568B1 (de) | 2010-11-01 | 2017-08-16 | Scinopharm (Kunshan) Biochemical Technology Co., Ltd. | Verfahren zur herstellung von 3- (pyrrol-2-yl) methylen) -2-pyrrolones mit 2-silyloxy-pyrrolen |
| BR112013018515B1 (pt) | 2011-01-26 | 2021-06-29 | Nerviano Medical Sciences S.R.I | Derivados de pirrol tricíclico, processo para sua preparação e seu uso como inibidores da quinase |
| CN102675184A (zh) * | 2011-03-15 | 2012-09-19 | 江苏先声药物研究有限公司 | 一种酪氨酸激酶抑制剂的盐形式 |
| US20150087687A1 (en) | 2012-03-23 | 2015-03-26 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
| CN103664738B (zh) * | 2012-09-12 | 2016-07-13 | 南京优科生物医药研究有限公司 | 一种羧酰胺化合物l-苹果酸盐的结晶多晶型物 |
| JP6678455B2 (ja) | 2012-12-21 | 2020-04-08 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| WO2014100716A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| JP2016505000A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| US9221794B2 (en) | 2012-12-21 | 2015-12-29 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| WO2014100730A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| CA2953572A1 (en) | 2014-08-04 | 2016-02-11 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2023186137A1 (zh) * | 2022-04-01 | 2023-10-05 | 成都百裕制药股份有限公司 | 吲哚酮衍生物及其在医药上的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316429B1 (en) * | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
| US6525072B1 (en) * | 1998-08-31 | 2003-02-25 | Sugen, Inc. | Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity |
| FR2801216A1 (fr) | 1999-11-23 | 2001-05-25 | Centre Nat Rech Scient | Utilisation de derives d'indirubine pour la fabrication de medicaments |
| ME00415B (me) | 2000-02-15 | 2011-10-10 | Pharmacia & Upjohn Co Llc | Pirol supstituisani 2-indol protein kinazni inhibitori |
| DE10125763A1 (de) | 2001-05-17 | 2002-11-28 | Schering Ag | Verwendung selektiver Indirubinderivate als VEGF-R Inhibitoren |
| TWI259081B (en) | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| BRPI0413281A (pt) * | 2003-08-06 | 2006-10-10 | Sugen Inc | 3-ciclopentilideno-1,3,dihidroindol-2-onas geometricamente restringidas como potentes inibidores de proteìna cinase |
| EP1686987A4 (de) | 2003-11-26 | 2009-02-25 | Scripps Research Inst | Fortschrittliche proteinkinase-hemmer auf indolinonbasis |
| US8207180B2 (en) * | 2006-11-28 | 2012-06-26 | Nerviano Medical Sciences S.R.L. | Tricyclic indoles and (4,5-dihydro) indoles |
-
2007
- 2007-12-03 WO PCT/CN2007/071161 patent/WO2008067756A1/zh active Application Filing
- 2007-12-03 US US12/517,351 patent/US8084621B2/en active Active
- 2007-12-03 AT AT07817351T patent/ATE547411T1/de active
- 2007-12-03 JP JP2009539592A patent/JP5542445B2/ja active Active
- 2007-12-03 EP EP07817351A patent/EP2123649B1/de active Active
- 2007-12-03 ES ES07817351T patent/ES2383084T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2383084T3 (es) | 2012-06-18 |
| EP2123649B1 (de) | 2012-02-29 |
| US20100160318A1 (en) | 2010-06-24 |
| US8084621B2 (en) | 2011-12-27 |
| EP2123649A1 (de) | 2009-11-25 |
| JP2010511638A (ja) | 2010-04-15 |
| JP5542445B2 (ja) | 2014-07-09 |
| EP2123649A4 (de) | 2010-10-13 |
| WO2008067756A1 (fr) | 2008-06-12 |
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