ATE534293T1 - Diarylaminhaltige verbindungen und zusammensetzungen und deren verwendung als modulatoren von c-kit-rezeptoren - Google Patents
Diarylaminhaltige verbindungen und zusammensetzungen und deren verwendung als modulatoren von c-kit-rezeptorenInfo
- Publication number
- ATE534293T1 ATE534293T1 AT06815653T AT06815653T ATE534293T1 AT E534293 T1 ATE534293 T1 AT E534293T1 AT 06815653 T AT06815653 T AT 06815653T AT 06815653 T AT06815653 T AT 06815653T AT E534293 T1 ATE534293 T1 AT E534293T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- compositions
- modulators
- kit receptors
- containing compounds
- Prior art date
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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Application Number | Priority Date | Filing Date | Title |
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US72101505P | 2005-09-27 | 2005-09-27 | |
PCT/US2006/037820 WO2007038669A2 (en) | 2005-09-27 | 2006-09-26 | Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors |
Publications (1)
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ATE534293T1 true ATE534293T1 (de) | 2011-12-15 |
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AT06815653T ATE534293T1 (de) | 2005-09-27 | 2006-09-26 | Diarylaminhaltige verbindungen und zusammensetzungen und deren verwendung als modulatoren von c-kit-rezeptoren |
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US (6) | US7514447B2 (de) |
EP (1) | EP1928236B1 (de) |
JP (1) | JP5335426B2 (de) |
KR (1) | KR101415426B1 (de) |
CN (1) | CN101272685A (de) |
AT (1) | ATE534293T1 (de) |
AU (1) | AU2006297089B2 (de) |
BR (1) | BRPI0616575A2 (de) |
CA (1) | CA2622494A1 (de) |
EC (1) | ECSP088402A (de) |
ES (1) | ES2378153T3 (de) |
IL (1) | IL189927A0 (de) |
MA (1) | MA29851B1 (de) |
NO (1) | NO20081975L (de) |
NZ (1) | NZ566862A (de) |
RU (1) | RU2436776C2 (de) |
TN (1) | TNSN08140A1 (de) |
WO (1) | WO2007038669A2 (de) |
ZA (1) | ZA200801732B (de) |
Families Citing this family (35)
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US8193206B2 (en) | 2005-06-14 | 2012-06-05 | Taigen Biotechnology Co., Ltd. | Pyrimidine compounds |
JP5118029B2 (ja) * | 2005-06-14 | 2013-01-16 | タイゲン バイオテクノロジー カンパニー,リミテッド | ピリミジン化合物 |
ATE534293T1 (de) * | 2005-09-27 | 2011-12-15 | Irm Llc | Diarylaminhaltige verbindungen und zusammensetzungen und deren verwendung als modulatoren von c-kit-rezeptoren |
MY155275A (en) | 2006-03-31 | 2015-09-30 | Novartis Ag | 4-(4-[6-(trifluoromethyl-pyridin-3-ylamino)-n-containing-heteroaryl]-phenyl)-cyclohexyl)-acetic acid derivatives and pharmaceutical uses thereof |
KR101122481B1 (ko) | 2007-05-04 | 2012-02-29 | 아이알엠 엘엘씨 | C-kit 및 pdgfr 키나제 억제제로서의 피리미딘 유도체 및 조성물 |
JP5603770B2 (ja) | 2007-05-31 | 2014-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr2受容体拮抗薬およびその使用 |
WO2009026204A1 (en) * | 2007-08-22 | 2009-02-26 | Irm Llc | 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors |
KR101218926B1 (ko) * | 2007-08-22 | 2013-01-04 | 아이알엠 엘엘씨 | 키나제 억제제로서의 5-(4-(할로알콕시)페닐)피리미딘-2-아민 화합물 및 조성물 |
US20090170842A1 (en) * | 2007-11-14 | 2009-07-02 | University Of Kansas | Brca1-based breast or ovarian cancer prevention agents and methods of use |
JP5230755B2 (ja) | 2008-02-22 | 2013-07-10 | アイアールエム・リミテッド・ライアビリティ・カンパニー | c−kitおよびPDGFRキナーゼ阻害剤としてのヘテロ環化合物および組成物 |
CA2720229C (en) | 2008-04-21 | 2015-02-17 | Taigen Biotechnology Co., Ltd. | Heterocyclic compounds |
CN102256963B (zh) | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
PT2513093E (pt) | 2009-12-17 | 2014-10-22 | Boehringer Ingelheim Int | Novos antagonistas do receptor ccr2 e suas utilizações |
WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
JP5646736B2 (ja) | 2010-05-12 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用 |
US8841313B2 (en) | 2010-05-17 | 2014-09-23 | Boehringer Ingelheim International Gmbh | CCR2 antagonists and uses thereof |
US9018212B2 (en) | 2010-05-25 | 2015-04-28 | Boehringer Ingelheim International Gmbh | Pyridazine carboxamides as CCR2 receptor antagonists |
US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
GB201009603D0 (en) | 2010-06-08 | 2010-07-21 | Cambridge Entpr Ltd | Anti-inflammatory agent |
RU2436786C1 (ru) * | 2010-07-23 | 2011-12-20 | Александр Васильевич Иващенко | Замещенные индолы, противовирусный активный компонент, способ получения и применения |
EP2718288B1 (de) * | 2011-06-09 | 2015-03-11 | Boehringer Ingelheim International GmbH | Substituierte piperidine als gpr119-modulatoren zur behandlung von stoffwechselerkrankungen |
WO2013010839A1 (en) | 2011-07-15 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Novel and selective ccr2 antagonists |
RU2686323C2 (ru) | 2013-03-13 | 2019-04-25 | Форма Терапьютикс, Инк. | Новые соединения и композиции для ингибирования fasn |
PT3071559T (pt) * | 2013-11-18 | 2018-02-05 | Elanco Tiergesundheit Ag | Novos compostos |
EP3233077A4 (de) | 2014-12-19 | 2018-08-08 | The Broad Institute Inc. | Dopamin-d2-rezeptor-liganden |
EP3233799B1 (de) | 2014-12-19 | 2021-05-19 | The Broad Institute, Inc. | Dopamin-d2-rezeptor-liganden |
AU2016287584B2 (en) | 2015-07-02 | 2020-03-26 | Centrexion Therapeutics Corporation | (4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
CN109328018A (zh) | 2016-12-15 | 2019-02-12 | 雀巢产品技术援助有限公司 | 调节伴侣动物体内的磷或酶的组合物和方法 |
TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
WO2020092395A1 (en) | 2018-10-29 | 2020-05-07 | Forma Therapeutics, Inc. | SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE |
BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CN114763342A (zh) * | 2021-01-09 | 2022-07-19 | 江苏天士力帝益药业有限公司 | 一种高纯度4-甲基哌嗪-1-甲酸酯的合成方法 |
US20230080054A1 (en) * | 2021-01-22 | 2023-03-16 | Ildong Pharmaceutical Co., Ltd. | Inhibitors of anoctamin 6 protein and uses thereof |
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DE1670536B2 (de) * | 1966-11-09 | 1975-05-28 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Neue 2-Anilino-5-acylamino-pyrimidlne |
DE1918073A1 (de) * | 1969-04-09 | 1970-10-15 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer 5-Aryl-1H-1,5-benzodiazepin-2,4-dione |
GB1534593A (en) * | 1976-09-03 | 1978-12-06 | Soc D Etudes Prod Chimique | N-2,6-dichlorophenyl-2-aminopyrimidine and therapeutic compositions containing it |
EP0164204A1 (de) | 1984-05-12 | 1985-12-11 | FISONS plc | Pharmazeutisch nützliche Pyrimidine |
CZ281874B6 (cs) * | 1991-11-25 | 1997-03-12 | Pfizer Inc. | Indolové deriváty, způsob jejich přípravy, meziprodukty tohoto postupu, farmaceutické prostředky obsahující tyto indolové deriváty a použití. |
JP2003523942A (ja) * | 1999-06-30 | 2003-08-12 | メルク エンド カムパニー インコーポレーテッド | Srcキナーゼ阻害剤化合物 |
GB0022438D0 (en) * | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
CA2452390A1 (en) * | 2001-06-29 | 2003-01-09 | Ab Science | Use of tyrosine kinase inhibitors for treating bone loss |
WO2003011837A1 (en) * | 2001-08-01 | 2003-02-13 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
CA2463563A1 (en) | 2001-10-12 | 2003-04-17 | Irm Llc | Kinase inhibitor scaffolds and methods for their preparation |
WO2005113548A1 (en) * | 2004-05-20 | 2005-12-01 | Sugen, Inc. | Thiophene heteroaryl amines |
AU2006227628A1 (en) * | 2005-03-16 | 2006-09-28 | Targegen, Inc. | Pyrimidine compounds and methods of use |
MX2007008848A (es) * | 2005-06-08 | 2008-04-16 | Targegen Inc | Metodos y composiciones para el tratamiento de desordenes oculares. |
ATE534293T1 (de) * | 2005-09-27 | 2011-12-15 | Irm Llc | Diarylaminhaltige verbindungen und zusammensetzungen und deren verwendung als modulatoren von c-kit-rezeptoren |
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2006
- 2006-09-26 AT AT06815653T patent/ATE534293T1/de active
- 2006-09-26 JP JP2008533595A patent/JP5335426B2/ja not_active Expired - Fee Related
- 2006-09-26 US US11/535,455 patent/US7514447B2/en active Active
- 2006-09-26 BR BRPI0616575-3A patent/BRPI0616575A2/pt not_active IP Right Cessation
- 2006-09-26 RU RU2008116313/04A patent/RU2436776C2/ru not_active IP Right Cessation
- 2006-09-26 CN CNA2006800355479A patent/CN101272685A/zh active Pending
- 2006-09-26 AU AU2006297089A patent/AU2006297089B2/en not_active Ceased
- 2006-09-26 WO PCT/US2006/037820 patent/WO2007038669A2/en active Application Filing
- 2006-09-26 CA CA002622494A patent/CA2622494A1/en not_active Abandoned
- 2006-09-26 ES ES06815653T patent/ES2378153T3/es active Active
- 2006-09-26 KR KR1020087007357A patent/KR101415426B1/ko not_active IP Right Cessation
- 2006-09-26 EP EP06815653A patent/EP1928236B1/de not_active Not-in-force
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- 2007-10-31 US US11/932,945 patent/US7563894B2/en active Active
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- 2008-03-26 TN TNP2008000140A patent/TNSN08140A1/fr unknown
- 2008-04-04 MA MA30814A patent/MA29851B1/fr unknown
- 2008-04-24 NO NO20081975A patent/NO20081975L/no not_active Application Discontinuation
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