ATE534625T1 - Substituierte n-phenyl-bipyrrolidinharnstoffe und deren therapeutische verwendung - Google Patents
Substituierte n-phenyl-bipyrrolidinharnstoffe und deren therapeutische verwendungInfo
- Publication number
- ATE534625T1 ATE534625T1 AT08838702T AT08838702T ATE534625T1 AT E534625 T1 ATE534625 T1 AT E534625T1 AT 08838702 T AT08838702 T AT 08838702T AT 08838702 T AT08838702 T AT 08838702T AT E534625 T1 ATE534625 T1 AT E534625T1
- Authority
- AT
- Austria
- Prior art keywords
- phenyl
- substituted
- therapeutic use
- bipyrrolidine
- ureas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Toxicology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98060607P | 2007-10-17 | 2007-10-17 | |
PCT/US2008/079763 WO2009052068A1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE534625T1 true ATE534625T1 (de) | 2011-12-15 |
Family
ID=40248052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08838702T ATE534625T1 (de) | 2007-10-17 | 2008-10-14 | Substituierte n-phenyl-bipyrrolidinharnstoffe und deren therapeutische verwendung |
Country Status (25)
Country | Link |
---|---|
US (1) | US8222290B2 (de) |
EP (1) | EP2215058B1 (de) |
JP (1) | JP5380455B2 (de) |
KR (1) | KR20100082349A (de) |
CN (1) | CN101903341B (de) |
AT (1) | ATE534625T1 (de) |
AU (1) | AU2008312641A1 (de) |
CA (1) | CA2702933C (de) |
CY (1) | CY1112391T1 (de) |
DK (1) | DK2215058T3 (de) |
ES (1) | ES2378011T3 (de) |
HK (1) | HK1146056A1 (de) |
HR (1) | HRP20120166T1 (de) |
IL (1) | IL205002A0 (de) |
MA (1) | MA31889B1 (de) |
MX (1) | MX2010003948A (de) |
MY (1) | MY148807A (de) |
NZ (1) | NZ584692A (de) |
PL (1) | PL2215058T3 (de) |
PT (1) | PT2215058E (de) |
RS (1) | RS52221B (de) |
RU (1) | RU2478094C2 (de) |
SI (1) | SI2215058T1 (de) |
WO (1) | WO2009052068A1 (de) |
ZA (1) | ZA201002114B (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101903339B (zh) | 2007-10-17 | 2012-06-27 | 赛诺菲-安万特 | 取代的n-苯基-联吡咯烷羧酰胺及其治疗用途 |
RU2477721C2 (ru) | 2007-10-17 | 2013-03-20 | Санофи-Авентис | Замещенные n-фенилпирролидинилметилпирролидинамиды и их терапевтическое применение в качестве модуляторов рецептора н3 гистамина |
AU2008312635B2 (en) * | 2007-10-17 | 2013-05-16 | Sanofi | Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
KR100940437B1 (ko) | 2008-06-13 | 2010-02-10 | 주식회사 엘지화학 | 발열체 및 이의 제조방법 |
KR20090129927A (ko) | 2008-06-13 | 2009-12-17 | 주식회사 엘지화학 | 발열체 및 이의 제조방법 |
US10412788B2 (en) | 2008-06-13 | 2019-09-10 | Lg Chem, Ltd. | Heating element and manufacturing method thereof |
JP2013526530A (ja) * | 2010-05-11 | 2013-06-24 | サノフイ | 置換されたn−フェニルスピロラクタムビピロリジン、その製造及び治療上の使用 |
TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
AR081908A1 (es) | 2010-05-11 | 2012-10-31 | Sanofi Aventis | N-heteroaril-espirolactama-bipirrolidinas sustituidas, preparacion y usos terapeuticos de las mismas |
WO2011143155A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
EP2569297A1 (de) | 2010-05-11 | 2013-03-20 | Sanofi | Substituierte n-heterocycloalkyl-bipyrrolidinphenylamidderivate, ihre zubereitung und therapeutische verwendung |
AR081383A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
EP2569303A1 (de) | 2010-05-11 | 2013-03-20 | Sanofi | Substituierte n-alkyl- und n-acyl-tetrahydroisochinolinderivate, ihre zubereitung und therapeutische verwendung |
KR20140009251A (ko) * | 2010-11-15 | 2014-01-22 | 애브비 인코포레이티드 | Nampt 및 rock 억제제 |
BR112013021496B1 (pt) * | 2011-02-23 | 2021-10-13 | Suven Life Sciences Limited | Composto, composição farmacêutica, uso da composição farmacêutica, processo para a preparação de um composto e uso do composto |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
EP1556046A1 (de) * | 2002-10-23 | 2005-07-27 | Janssen Pharmaceutica N.V. | Phenylpiperidine und phenylpyrrolidine als histamin-h3-rezeptor-modulatoren |
US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CA2600757C (en) | 2005-03-17 | 2014-02-18 | Eli Lilly And Company | Pyrrolidine derivatives as histamine h3 receptor antagonists |
CN101151244B (zh) * | 2005-04-01 | 2014-09-03 | 伊莱利利公司 | 组胺h3受体活性剂、制备和治疗用途 |
EP1904442B1 (de) * | 2005-07-01 | 2011-09-07 | Eli Lilly And Company | Histamin-h3-rezeptor-mittel, deren herstellung und therapeutische verwendung |
CN101296902A (zh) * | 2005-10-27 | 2008-10-29 | Ucb医药有限公司 | 包含内酰胺或内酰胺衍生部分的化合物、制备它们的方法和它们的用途 |
CN101903339B (zh) | 2007-10-17 | 2012-06-27 | 赛诺菲-安万特 | 取代的n-苯基-联吡咯烷羧酰胺及其治疗用途 |
AU2008312635B2 (en) | 2007-10-17 | 2013-05-16 | Sanofi | Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
RU2477721C2 (ru) | 2007-10-17 | 2013-03-20 | Санофи-Авентис | Замещенные n-фенилпирролидинилметилпирролидинамиды и их терапевтическое применение в качестве модуляторов рецептора н3 гистамина |
-
2008
- 2008-10-14 AU AU2008312641A patent/AU2008312641A1/en not_active Abandoned
- 2008-10-14 PT PT08838702T patent/PT2215058E/pt unknown
- 2008-10-14 SI SI200830552T patent/SI2215058T1/sl unknown
- 2008-10-14 MY MYPI2010001300A patent/MY148807A/en unknown
- 2008-10-14 ES ES08838702T patent/ES2378011T3/es active Active
- 2008-10-14 PL PL08838702T patent/PL2215058T3/pl unknown
- 2008-10-14 NZ NZ584692A patent/NZ584692A/en not_active IP Right Cessation
- 2008-10-14 CN CN2008801212096A patent/CN101903341B/zh not_active Expired - Fee Related
- 2008-10-14 AT AT08838702T patent/ATE534625T1/de active
- 2008-10-14 KR KR1020107010481A patent/KR20100082349A/ko not_active Application Discontinuation
- 2008-10-14 WO PCT/US2008/079763 patent/WO2009052068A1/en active Application Filing
- 2008-10-14 CA CA2702933A patent/CA2702933C/en not_active Expired - Fee Related
- 2008-10-14 DK DK08838702.2T patent/DK2215058T3/da active
- 2008-10-14 RS RS20120067A patent/RS52221B/en unknown
- 2008-10-14 MX MX2010003948A patent/MX2010003948A/es active IP Right Grant
- 2008-10-14 JP JP2010530054A patent/JP5380455B2/ja not_active Expired - Fee Related
- 2008-10-14 EP EP08838702A patent/EP2215058B1/de active Active
- 2008-10-14 RU RU2010119554/04A patent/RU2478094C2/ru not_active IP Right Cessation
-
2010
- 2010-03-15 US US12/724,045 patent/US8222290B2/en active Active
- 2010-03-25 ZA ZA2010/02114A patent/ZA201002114B/en unknown
- 2010-04-11 IL IL205002A patent/IL205002A0/en unknown
- 2010-05-17 MA MA32842A patent/MA31889B1/fr unknown
-
2011
- 2011-01-12 HK HK11100257.5A patent/HK1146056A1/xx not_active IP Right Cessation
-
2012
- 2012-02-20 HR HR20120166T patent/HRP20120166T1/hr unknown
- 2012-02-23 CY CY20121100185T patent/CY1112391T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA201002114B (en) | 2010-12-29 |
AU2008312641A1 (en) | 2009-04-23 |
MA31889B1 (fr) | 2010-12-01 |
US20100173908A1 (en) | 2010-07-08 |
WO2009052068A1 (en) | 2009-04-23 |
EP2215058B1 (de) | 2011-11-23 |
RU2478094C2 (ru) | 2013-03-27 |
PT2215058E (pt) | 2012-03-06 |
EP2215058A1 (de) | 2010-08-11 |
CN101903341B (zh) | 2012-10-03 |
CN101903341A (zh) | 2010-12-01 |
KR20100082349A (ko) | 2010-07-16 |
HK1146056A1 (en) | 2011-05-13 |
MY148807A (en) | 2013-05-31 |
CA2702933C (en) | 2012-12-18 |
ES2378011T3 (es) | 2012-04-04 |
RS52221B (en) | 2012-10-31 |
MX2010003948A (es) | 2010-04-30 |
JP2011500697A (ja) | 2011-01-06 |
RU2010119554A (ru) | 2011-11-27 |
JP5380455B2 (ja) | 2014-01-08 |
SI2215058T1 (sl) | 2012-03-30 |
CY1112391T1 (el) | 2015-12-09 |
US8222290B2 (en) | 2012-07-17 |
PL2215058T3 (pl) | 2012-04-30 |
HRP20120166T1 (hr) | 2012-03-31 |
DK2215058T3 (da) | 2012-03-12 |
NZ584692A (en) | 2011-12-22 |
CA2702933A1 (en) | 2009-04-23 |
IL205002A0 (en) | 2010-11-30 |
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