ATE474931T1 - Epitop-synchronisierung in antigen präsentierenden zellen - Google Patents
Epitop-synchronisierung in antigen präsentierenden zellenInfo
- Publication number
- ATE474931T1 ATE474931T1 AT01930922T AT01930922T ATE474931T1 AT E474931 T1 ATE474931 T1 AT E474931T1 AT 01930922 T AT01930922 T AT 01930922T AT 01930922 T AT01930922 T AT 01930922T AT E474931 T1 ATE474931 T1 AT E474931T1
- Authority
- AT
- Austria
- Prior art keywords
- housekeeping
- disclosed
- antigen
- cells
- presenting cells
- Prior art date
Links
- 210000000612 antigen-presenting cell Anatomy 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 5
- 229960005486 vaccine Drugs 0.000 abstract 4
- 230000028993 immune response Effects 0.000 abstract 2
- 230000002093 peripheral effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 244000000056 intracellular parasite Species 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56157200A | 2000-04-28 | 2000-04-28 | |
US56046500A | 2000-04-28 | 2000-04-28 | |
US56157100A | 2000-04-28 | 2000-04-28 | |
US09/561,074 US6861234B1 (en) | 2000-04-28 | 2000-04-28 | Method of epitope discovery |
PCT/US2001/013806 WO2001082963A2 (en) | 2000-04-28 | 2001-04-27 | Method of identifying and producing antigen peptides and use thereof as vaccines |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE474931T1 true ATE474931T1 (de) | 2010-08-15 |
Family
ID=27504814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01930922T ATE474931T1 (de) | 2000-04-28 | 2001-04-27 | Epitop-synchronisierung in antigen präsentierenden zellen |
Country Status (13)
Country | Link |
---|---|
US (1) | US20070269464A1 (de) |
EP (4) | EP1276896B1 (de) |
JP (1) | JP2003535824A (de) |
CN (1) | CN1440462A (de) |
AT (1) | ATE474931T1 (de) |
AU (3) | AU5741001A (de) |
CA (1) | CA2405363A1 (de) |
DE (1) | DE60142615D1 (de) |
DK (1) | DK1276896T3 (de) |
ES (1) | ES2347762T3 (de) |
HK (1) | HK1053333A1 (de) |
NZ (1) | NZ521715A (de) |
WO (1) | WO2001082963A2 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
US20030138808A1 (en) * | 1998-02-19 | 2003-07-24 | Simard John J.L. | Expression vectors encoding epitopes of target-associated antigens |
US20030215425A1 (en) * | 2001-12-07 | 2003-11-20 | Simard John J. L. | Epitope synchronization in antigen presenting cells |
US6773695B2 (en) | 2000-10-05 | 2004-08-10 | Mannkind Corporation | Modulation of allergic response |
EP1595548A3 (de) * | 2001-03-07 | 2006-02-22 | Mannkind Corporation | Anti-Neovaskulatur Präparationen zur Krebsbehandlung |
EP1372736A4 (de) | 2001-03-07 | 2004-11-17 | Mannkind Corp | Präparate gegen gefässneubildung bei krebs |
EP1752160A3 (de) | 2001-04-06 | 2007-05-30 | Mannkind Corporation | Epitop-Sequenzen |
WO2003008537A2 (en) | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Epitope sequences |
AU2008229888B2 (en) * | 2001-11-07 | 2012-07-05 | Mannkind Corporation | Expression vectors encoding epitopes of target-associated antigens and methods for their design |
EP2314712B1 (de) | 2001-11-07 | 2014-01-08 | Mannkind Corporation | Für Epitope von Antigenen kodierende Expressionsvektoren sowie Verfahren zu deren Konzeption |
CN1691964A (zh) * | 2002-09-06 | 2005-11-02 | 曼康公司 | 表位序列 |
US8343502B2 (en) | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
KR20140067141A (ko) | 2002-12-16 | 2014-06-03 | 글로브이뮨 | 면역 요법으로서의 효모계 백신 |
WO2005010190A1 (en) * | 2003-07-22 | 2005-02-03 | Ludwig Institute For Cancer Research | Ssx-2 peptides presented by hla class ii molucules |
MX2007008010A (es) * | 2004-12-29 | 2007-09-07 | Mannkind Corp | Metodos para desviar celulas cd4+ en la induccion de una inmuno respuesta. |
AU2005321898B2 (en) * | 2004-12-29 | 2012-07-19 | Mannkind Corporation | Use of compositions comprising various tumor-associated antigens as anti-cancer vaccines |
SG162817A1 (en) * | 2005-06-17 | 2010-07-29 | Mannkind Corp | Methods and compositions.to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma |
WO2006138568A2 (en) * | 2005-06-17 | 2006-12-28 | Mannkind Corporation | Multivalent entrain-and-amplify immunotherapeutics for carcinoma |
ES2579762T3 (es) | 2006-03-01 | 2016-08-16 | Janssen Pharmaceutica N.V. | Tratamiento del cáncer combinando agente linfo - reductor con CLTs y citoquinas |
EP1996716B1 (de) | 2006-03-20 | 2011-05-11 | The Regents of the University of California | Manipulierte anti-prostatastammzellenantigen (psca)-antikörper für krebs-targeting |
WO2008008541A2 (en) * | 2006-07-14 | 2008-01-17 | Mannkind Corporation | Methods to elicit, enhance and sustain immune responses against mhc class-i restricted epitopes, for prophylactic or therapeutic purposes |
AU2007298494B2 (en) | 2006-09-21 | 2013-09-26 | Vaxil Biotherapeutics Ltd. | Antigen specific multi epitope vaccines |
CN101246176B (zh) * | 2007-02-13 | 2013-06-05 | 许洋 | 鳞状细胞癌抗原阴性***血清蛋白质检测的质谱试剂及其制备方法 |
JP6126773B2 (ja) | 2007-09-04 | 2017-05-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 癌のターゲッティングおよび検出のための高親和性抗前立腺幹細胞抗原(psca)抗体 |
WO2010096486A1 (en) | 2009-02-17 | 2010-08-26 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
CA2782333C (en) | 2009-12-02 | 2019-06-04 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
US20130224249A1 (en) * | 2010-09-03 | 2013-08-29 | Ludwig Institute For Cancer Research Ltd. | Recombinant trypanosoma cruzi cells useful as anti-cancer immune agents |
JP2014516538A (ja) * | 2011-05-26 | 2014-07-17 | ジーニウス バイオテクノロジー インベストメンツ リミテッド ライアビリティ カンパニー | 調節された免疫優勢療法 |
CN107817348A (zh) * | 2012-09-05 | 2018-03-20 | 亚利桑那州评议委员会,亚利桑那州法人团体,代理和代表亚利桑那州立大学 | 发现治疗靶标的方法 |
KR20150130284A (ko) * | 2013-03-15 | 2015-11-23 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암 백신 및 이를 이용한 치료 방법 |
BR112016008806A2 (pt) | 2013-11-01 | 2017-10-03 | Pfizer | Vetores para expressão de antígenos associados à próstata |
CN104761644A (zh) * | 2014-01-03 | 2015-07-08 | 百奇生物科技(苏州)有限公司 | 大肠杆菌表达的融合蛋白mbp-mart-1及其制备和应用 |
CN103837688A (zh) * | 2014-03-27 | 2014-06-04 | 吉林农业大学 | 一种检测犬猫弓形虫抗体的间接elisa试剂盒 |
ES2868305T3 (es) | 2014-03-28 | 2021-10-21 | Univ Washington Through Its Center For Commercialization | Vacunas contra el cáncer de mama y de ovario |
WO2015149010A1 (en) * | 2014-03-28 | 2015-10-01 | University Of Washington Through Its Center For Commercialization | Methods of identifying antigens for vaccines |
US9549914B2 (en) | 2014-04-03 | 2017-01-24 | The Johns Hopkins University | Treatment of human cytomegalovirus by modulating Wnt |
CN113549153A (zh) * | 2014-05-29 | 2021-10-26 | 宏观基因有限公司 | 三特异性结合分子和其使用方法 |
CN104142401B (zh) * | 2014-07-25 | 2016-04-20 | 北京普恩光德生物科技开发有限公司 | ***相关抗原检测试剂盒 |
WO2016128060A1 (en) * | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
CN105067731B (zh) * | 2015-06-05 | 2017-06-16 | 中国农业科学院兰州兽医研究所 | 一种弓形虫感染后血清中生物标记物的筛选方法及筛选出的生物标记物的应用 |
NZ739721A (en) | 2015-08-07 | 2019-09-27 | Imaginab Inc | Antigen binding constructs to target molecules |
CN105175498A (zh) * | 2015-10-09 | 2015-12-23 | 深圳市康尔诺生物技术有限公司 | 一种***相关的热休克蛋白复合物及其应用 |
US11464839B2 (en) | 2015-12-04 | 2022-10-11 | Mayo Foundation For Medical Education And Research | Methods and vaccines for inducing immune responses to multiple different MHC molecules |
CA3009542C (en) * | 2015-12-23 | 2023-08-29 | Medigene Immunotherapies Gmbh | Novel generation of antigen-specific tcrs |
CA3028002A1 (en) * | 2016-06-27 | 2018-01-04 | Juno Therapeutics, Inc. | Method of identifying peptide epitopes, molecules that bind such epitopes and related uses |
CN110809580A (zh) * | 2017-01-24 | 2020-02-18 | 安贝科思生物制剂公司 | 用于靶向癌症中包含非典型hla-i和新抗原的复合体的方法和组合物 |
WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
WO2018217852A1 (en) * | 2017-05-23 | 2018-11-29 | Gettysburg College | Crispr based tool for characterizing bacterial serovar diversity |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4439199A (en) * | 1980-02-19 | 1984-03-27 | Alza Corporation | Method for administering immunopotentiator |
US4683199A (en) * | 1983-01-31 | 1987-07-28 | Sloan-Kettering Institute For Cancer Research | Interleukin-2 dependent cytotoxic T-cell clones |
US5168062A (en) * | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
US5196321A (en) * | 1986-10-02 | 1993-03-23 | Massachusetts Institute Of Technology | Methods for in vitro cleavage of ubiquitin fusion proteins |
US5132213A (en) * | 1986-10-02 | 1992-07-21 | Massachusetts Institute Of Technology | Method for producing proteins and polypeptides using ubiquitin fusions |
US5093242A (en) * | 1986-10-02 | 1992-03-03 | Massachusetts Institute Of Technology | Methods of generating desired amino-terminal residues in proteins |
US4937190A (en) * | 1987-10-15 | 1990-06-26 | Wisconsin Alumni Research Foundation | Translation enhancer |
JPH03503482A (ja) * | 1988-02-12 | 1991-08-08 | コモンウェルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガナイゼーション | ポックスウイルスベクター |
US6723832B1 (en) * | 1996-10-03 | 2004-04-20 | Ludwig Institute For Cancer Research | Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof |
US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
DE69033295T2 (de) | 1989-11-03 | 2000-05-25 | Donald L Morton | Nachweismethode für Harnkarzinom-assoziierte Antigene |
DE4143467C2 (de) * | 1991-05-17 | 1995-02-09 | Max Planck Gesellschaft | Peptidmotiv und dessen Verwendung |
US6037135A (en) * | 1992-08-07 | 2000-03-14 | Epimmune Inc. | Methods for making HLA binding peptides and their uses |
DE4228458A1 (de) * | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronische Expressionseinheiten und deren Verwendung |
US5744316A (en) * | 1992-12-22 | 1998-04-28 | Ludwig Institute For Cancer Research | Isolated, tyrosinase derived peptides and uses thereof |
US5989565A (en) | 1993-01-29 | 1999-11-23 | University Of Pittsburgh | Elution and identification of T cell epitopes from viable cells |
EP0689551B1 (de) * | 1993-03-17 | 2008-02-20 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Immunogene chimäre umfassend nucleinsäuresequenzen, die signalsequenzpeptide des endoplasmatischen reticulums und mindestens ein anderes peptid codieren, deren verwendung in impfstoffen und zur behandlung von krankheiten |
US5679647A (en) * | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
US5478556A (en) * | 1994-02-28 | 1995-12-26 | Elliott; Robert L. | Vaccination of cancer patients using tumor-associated antigens mixed with interleukin-2 and granulocyte-macrophage colony stimulating factor |
US5874560A (en) * | 1994-04-22 | 1999-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Melanoma antigens and their use in diagnostic and therapeutic methods |
DE4423392A1 (de) * | 1994-07-04 | 1996-01-11 | Birsner & Grob Biotech Gmbh | Verfahren zur Identifizierung antigener Peptide |
FR2722208B1 (fr) * | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
US5962428A (en) * | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
US5698396A (en) * | 1995-06-07 | 1997-12-16 | Ludwig Institute For Cancer Research | Method for identifying auto-immunoreactive substances from a subject |
AU738649B2 (en) * | 1996-04-26 | 2001-09-20 | Rijksuniversiteit Te Leiden | Methods for selecting and producing T cell peptide epitopes and vaccines incorporating said selected epitopes |
US6287756B1 (en) * | 1997-05-05 | 2001-09-11 | Ludwig Institute For Cancer Research | Methods for determining presence of cancer in a sample by determining expression of an SSX gene |
EP0928688A4 (de) | 1997-07-03 | 2000-10-18 | Matsushita Electric Ind Co Ltd | Tintenstrahlaufzeichnungskopf und verfahren zur herstellung |
FR2794370B1 (fr) * | 1999-06-03 | 2003-10-17 | Biovector Therapeutics | Fragments proteiques polyepitopiques, leur obtention et leurs utilisations notamment en vaccination |
EP1118860A1 (de) * | 2000-01-21 | 2001-07-25 | Rijksuniversiteit te Leiden | Verfahren zur Auswahl und zur Herstellung von T-Zellen-Peptidepitopen sowie darauf basierten Impfstoffen |
US6861234B1 (en) * | 2000-04-28 | 2005-03-01 | Mannkind Corporation | Method of epitope discovery |
US20030215425A1 (en) * | 2001-12-07 | 2003-11-20 | Simard John J. L. | Epitope synchronization in antigen presenting cells |
US20040236514A1 (en) * | 2001-12-13 | 2004-11-25 | Lee Stephen C. | Controlling distribution of epitopes in polypeptide sequences |
-
2001
- 2001-04-27 AT AT01930922T patent/ATE474931T1/de not_active IP Right Cessation
- 2001-04-27 EP EP01930922A patent/EP1276896B1/de not_active Expired - Lifetime
- 2001-04-27 DK DK01930922.8T patent/DK1276896T3/da active
- 2001-04-27 CN CN01812119A patent/CN1440462A/zh active Pending
- 2001-04-27 ES ES01930922T patent/ES2347762T3/es not_active Expired - Lifetime
- 2001-04-27 JP JP2001579836A patent/JP2003535824A/ja active Pending
- 2001-04-27 DE DE60142615T patent/DE60142615D1/de not_active Expired - Lifetime
- 2001-04-27 EP EP10170170A patent/EP2248910A1/de not_active Withdrawn
- 2001-04-27 EP EP10178756A patent/EP2278023A1/de not_active Withdrawn
- 2001-04-27 NZ NZ521715A patent/NZ521715A/en not_active IP Right Cessation
- 2001-04-27 CA CA002405363A patent/CA2405363A1/en not_active Abandoned
- 2001-04-27 AU AU5741001A patent/AU5741001A/xx active Pending
- 2001-04-27 WO PCT/US2001/013806 patent/WO2001082963A2/en active Application Filing
- 2001-04-27 AU AU2001257410A patent/AU2001257410B8/en not_active Ceased
- 2001-04-27 EP EP10178766A patent/EP2278024A1/de not_active Withdrawn
-
2003
- 2003-06-09 HK HK03104029.4A patent/HK1053333A1/xx not_active IP Right Cessation
-
2007
- 2007-03-07 US US11/683,397 patent/US20070269464A1/en not_active Abandoned
-
2010
- 2010-12-14 AU AU2010251790A patent/AU2010251790B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
US20070269464A1 (en) | 2007-11-22 |
AU2010251790A1 (en) | 2011-01-06 |
JP2003535824A (ja) | 2003-12-02 |
AU2001257410B9 (en) | 2006-10-05 |
DE60142615D1 (de) | 2010-09-02 |
WO2001082963A3 (en) | 2002-04-11 |
AU2001257410B8 (en) | 2006-12-21 |
NZ521715A (en) | 2008-01-31 |
AU2010251790B2 (en) | 2013-02-07 |
CA2405363A1 (en) | 2001-11-08 |
EP2278023A1 (de) | 2011-01-26 |
AU5741001A (en) | 2001-11-12 |
EP2248910A1 (de) | 2010-11-10 |
CN1440462A (zh) | 2003-09-03 |
AU2001257410B2 (en) | 2006-08-24 |
EP1276896A2 (de) | 2003-01-22 |
EP1276896B1 (de) | 2010-07-21 |
HK1053333A1 (en) | 2003-10-17 |
EP2278024A1 (de) | 2011-01-26 |
ES2347762T3 (es) | 2010-11-04 |
DK1276896T3 (da) | 2010-10-18 |
WO2001082963A2 (en) | 2001-11-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE474931T1 (de) | Epitop-synchronisierung in antigen präsentierenden zellen | |
CY1118629T1 (el) | Εμβολιο ιου ερπητα ζωστηρα | |
NO20015073L (no) | Vaksiner | |
CY1113044T1 (el) | Παραλλαγματα αντιγονου αρχεγονων κυτταρων προστατη (psca) και υποαλληλουχιες εξ αυτων | |
GB2434367A (en) | Improved vaccines | |
EA200702633A1 (ru) | Вакцина против малярии | |
IL164812A0 (en) | Packaged virus-like particles for use as adjuvants: method of preparation and use | |
DE60012042D1 (de) | Entepneumovirus und entsprechendes impfstoff | |
WO2005105139A3 (en) | Mage-3 and ny-eso-1 based polyvalent vaccine for cancer immunotherapy | |
WO2008000261A3 (en) | Expanding the t cell repertoire to include subdominant epitopes by vaccination with antigens delivered as protein fragments or peptide cocktails | |
ATE494907T1 (de) | Pharmazeutische zusammensetzungen, die immunologisch aktive herpes simplex virus proteinfragmente enthalten | |
WO2006113622A3 (en) | Direct vaccination of the bone marrow | |
EA200900738A1 (ru) | Слитые белки, содержащие антигены отторжения опухоли ny-eso-1 и lage-1 | |
BRPI0606165A2 (pt) | método de indução de uma resposta imunológica de célula t de memória contra pelo menos um antìgeno em um paciente humano, uso de uma composição imunogênica que compreende um vetor de vìrus de infecção virulenta não-replicante ou emparelhado de replicação que expressa o produto de tradução de um gene de ag85a micobacterial, uso de um antìgeno na manufatura de um medicamento para o tratamento de uma doença em um paciente mediante a indução de uma resposta imunológica de célula t de memória central e vacina vetorada | |
WO2003078640A3 (en) | Recombinant drug-sensitive vaccinia virus as smallpox vaccine | |
AU2003288510A1 (en) | Immunizing fish against viral infection | |
JP2014516538A5 (de) | ||
WO2003057823A3 (en) | Epitope synchronization in antigen presenting cells | |
WO2002009752A3 (en) | Immunological adjuvant compounds | |
WO2003083083A3 (en) | Methods of using flt3-ligand in immunization protocols | |
DE69720065D1 (de) | Therapeutische anwendungen von antigenen oder epitopen assoziert mit unvollständiger zellulärer peptidprozesierung , z.b.: exprimiert in rma-s zellen transfiziert mit b7-1 gen | |
ZA200706389B (en) | Compositions for immunizing against mycobacterium | |
DK56389D0 (da) | Forhindring og behandling af retroviralt frembragte sygdomme | |
FR2796282B1 (fr) | Vaccin inactive contre la calicivirose feline | |
ATE526035T1 (de) | Tollwut-impfstoff |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |