EA200900738A1 - Слитые белки, содержащие антигены отторжения опухоли ny-eso-1 и lage-1 - Google Patents
Слитые белки, содержащие антигены отторжения опухоли ny-eso-1 и lage-1Info
- Publication number
- EA200900738A1 EA200900738A1 EA200900738A EA200900738A EA200900738A1 EA 200900738 A1 EA200900738 A1 EA 200900738A1 EA 200900738 A EA200900738 A EA 200900738A EA 200900738 A EA200900738 A EA 200900738A EA 200900738 A1 EA200900738 A1 EA 200900738A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- lage
- eso
- tensions
- tumor
- slip
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 4
- 102000036639 antigens Human genes 0.000 title abstract 4
- 108091007433 antigens Proteins 0.000 title abstract 4
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 title abstract 2
- 102100039510 Cancer/testis antigen 2 Human genes 0.000 title abstract 2
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 title abstract 2
- 101000889345 Homo sapiens Cancer/testis antigen 2 Proteins 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001188—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Предложены слитые белки, содержащие антиген, имеющий происхождение из NY-ESO-1, связанный с антигеном, имеющим происхождение из LAGE-1, которые могут дополнительно содержать носители, партнеры по слиянию или тому подобное. Также предложены способы получения таких слитых белков, изготовления их в виде препарата и их применения. Такие белки полезны в качестве компонентов вакцин для индукции иммунного ответа против ряда клеток, несущих раковые антигены,
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0700759A GB0700759D0 (en) | 2007-01-15 | 2007-01-15 | Novel fusion protein |
US91484807P | 2007-04-30 | 2007-04-30 | |
US91492507P | 2007-04-30 | 2007-04-30 | |
GB0709707A GB0709707D0 (en) | 2007-05-21 | 2007-05-21 | Novel fusion protein |
PCT/US2008/050879 WO2008089074A2 (en) | 2007-01-15 | 2008-01-11 | Fusion proteins comprising the tumor rejection antigens ny-eso-1 and lage-1 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200900738A1 true EA200900738A1 (ru) | 2010-02-26 |
EA016818B1 EA016818B1 (ru) | 2012-07-30 |
Family
ID=41111108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200900738A EA016818B1 (ru) | 2007-01-15 | 2008-01-11 | Слитые белки, содержащие антигены отторжения опухоли ny-eso-1 и lage-1 |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP2118128B1 (ru) |
JP (1) | JP2010532656A (ru) |
KR (1) | KR20090122426A (ru) |
BR (1) | BRPI0806501A2 (ru) |
CA (1) | CA2674458A1 (ru) |
DK (1) | DK2118128T3 (ru) |
EA (1) | EA016818B1 (ru) |
ES (1) | ES2398492T3 (ru) |
HR (1) | HRP20130022T1 (ru) |
MX (1) | MX2009007572A (ru) |
PE (1) | PE20081687A1 (ru) |
PL (1) | PL2118128T3 (ru) |
SI (1) | SI2118128T1 (ru) |
TW (1) | TW200902049A (ru) |
WO (1) | WO2008089074A2 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008308474A (ja) * | 2007-06-18 | 2008-12-25 | Nitto Denko Corp | 抗原ペプチド製剤の調製方法 |
EP2408933A2 (en) | 2009-03-17 | 2012-01-25 | MDxHealth SA | Improved detection of gene expression |
GB0910046D0 (en) | 2009-06-10 | 2009-07-22 | Glaxosmithkline Biolog Sa | Novel compositions |
US20140322344A1 (en) * | 2011-08-31 | 2014-10-30 | National University Corporation Tokyo Medical And Dental University | Vaccine preparation for cancer treatment |
GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
CN109893648A (zh) | 2013-06-28 | 2019-06-18 | 奥克兰联合服务有限公司 | 氨基酸缀合物和肽缀合物及缀合方法 |
EP3053592A4 (en) | 2013-10-01 | 2017-09-06 | Mie University | T cell-inducing vaccine containing interepitope sequence promoting antigen presentation |
JP2018505152A (ja) | 2014-12-23 | 2018-02-22 | アン ブリンブル マーガレット | アミノ酸複合体及びペプチド複合体ならびにそれらの使用 |
EP3419962A4 (en) | 2016-02-26 | 2020-03-11 | Auckland Uniservices Limited | AMINO ACID AND PEPTIDE CONJUGATES AND CONJUGATION METHOD |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06205672A (ja) * | 1992-03-19 | 1994-07-26 | Nippon Zeon Co Ltd | 日本脳炎ウイルス及びb型肝炎ウイルスの表面抗原タンパク質の抗原部位を持つキメラタンパク質の製造法、およびそれに用いる組み換えバキュロウイルス |
US6686147B1 (en) * | 1998-07-15 | 2004-02-03 | Ludwig Institute For Cancer Research | Cancer associated antigens and uses therefor |
EP1272633B1 (en) * | 2000-03-30 | 2011-04-27 | Dendreon Corporation | Compositions and methods for dendritic cell-based immunotherapy |
US20030044813A1 (en) * | 2001-03-30 | 2003-03-06 | Old Lloyd J. | Cancer-testis antigens |
AU2004314347B2 (en) * | 2003-12-24 | 2011-05-19 | Aduro Biotech, Inc. | Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof |
GB0409940D0 (en) * | 2004-05-04 | 2004-06-09 | Glaxosmithkline Biolog Sa | Vaccine |
CN101090974B (zh) * | 2004-11-16 | 2011-05-11 | 克鲁塞尔荷兰公司 | 包含重组病毒载体的多价疫苗 |
CA2653402A1 (en) * | 2006-05-26 | 2007-12-06 | Glaxosmithkline Biologicals S.A. | Method |
NZ578285A (en) * | 2007-01-15 | 2011-12-22 | Glaxosmithkline Biolog Sa | Fusion protein comprising a prame linked to a immunological fusion partner protein and additional amino acids at the n terminal end of the fusion partner sequence |
-
2008
- 2008-01-11 ES ES08727588T patent/ES2398492T3/es active Active
- 2008-01-11 KR KR1020097016892A patent/KR20090122426A/ko not_active Application Discontinuation
- 2008-01-11 CA CA002674458A patent/CA2674458A1/en not_active Abandoned
- 2008-01-11 DK DK08727588.9T patent/DK2118128T3/da active
- 2008-01-11 JP JP2009545705A patent/JP2010532656A/ja active Pending
- 2008-01-11 MX MX2009007572A patent/MX2009007572A/es active IP Right Grant
- 2008-01-11 PE PE2008000128A patent/PE20081687A1/es not_active Application Discontinuation
- 2008-01-11 PL PL08727588T patent/PL2118128T3/pl unknown
- 2008-01-11 EA EA200900738A patent/EA016818B1/ru not_active IP Right Cessation
- 2008-01-11 TW TW097101220A patent/TW200902049A/zh unknown
- 2008-01-11 SI SI200830870T patent/SI2118128T1/sl unknown
- 2008-01-11 WO PCT/US2008/050879 patent/WO2008089074A2/en active Application Filing
- 2008-01-11 BR BRPI0806501-2A2A patent/BRPI0806501A2/pt not_active IP Right Cessation
- 2008-01-11 EP EP08727588A patent/EP2118128B1/en not_active Not-in-force
-
2013
- 2013-01-14 HR HRP20130022AT patent/HRP20130022T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
KR20090122426A (ko) | 2009-11-30 |
TW200902049A (en) | 2009-01-16 |
PE20081687A1 (es) | 2008-12-25 |
WO2008089074A9 (en) | 2012-07-12 |
MX2009007572A (es) | 2009-10-13 |
DK2118128T3 (da) | 2013-02-18 |
BRPI0806501A2 (pt) | 2014-04-22 |
JP2010532656A (ja) | 2010-10-14 |
WO2008089074A3 (en) | 2008-12-31 |
PL2118128T3 (pl) | 2013-03-29 |
HRP20130022T1 (hr) | 2013-02-28 |
EA016818B1 (ru) | 2012-07-30 |
EP2118128A2 (en) | 2009-11-18 |
WO2008089074A2 (en) | 2008-07-24 |
ES2398492T3 (es) | 2013-03-19 |
EP2118128B1 (en) | 2012-11-07 |
CA2674458A1 (en) | 2008-07-24 |
SI2118128T1 (sl) | 2013-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |