ATE463562T1 - Lp-pla2-aktivitätstest mit hohem durchsatz - Google Patents

Lp-pla2-aktivitätstest mit hohem durchsatz

Info

Publication number
ATE463562T1
ATE463562T1 AT04753533T AT04753533T ATE463562T1 AT E463562 T1 ATE463562 T1 AT E463562T1 AT 04753533 T AT04753533 T AT 04753533T AT 04753533 T AT04753533 T AT 04753533T AT E463562 T1 ATE463562 T1 AT E463562T1
Authority
AT
Austria
Prior art keywords
throughput
activity assessment
pla2 activity
pla2
assessment
Prior art date
Application number
AT04753533T
Other languages
English (en)
Inventor
Yun-Fu Hu
George Walker
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE463562T1 publication Critical patent/ATE463562T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18Carboxylic ester hydrolases (3.1.1)
    • C12N9/20Triglyceride splitting, e.g. by means of lipase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/916Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918Carboxylic ester hydrolases (3.1.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Color Electrophotography (AREA)
AT04753533T 2003-05-28 2004-05-27 Lp-pla2-aktivitätstest mit hohem durchsatz ATE463562T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47377703P 2003-05-28 2003-05-28
PCT/US2004/016716 WO2005001416A2 (en) 2003-05-28 2004-05-27 High throughput assay of lp-pla2 activity

Publications (1)

Publication Number Publication Date
ATE463562T1 true ATE463562T1 (de) 2010-04-15

Family

ID=33551459

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04753533T ATE463562T1 (de) 2003-05-28 2004-05-27 Lp-pla2-aktivitätstest mit hohem durchsatz

Country Status (13)

Country Link
US (1) US7531316B2 (de)
EP (2) EP2253702A1 (de)
JP (2) JP4892350B2 (de)
AT (1) ATE463562T1 (de)
CY (1) CY1110138T1 (de)
DE (1) DE602004026439D1 (de)
DK (1) DK1633864T3 (de)
ES (1) ES2341772T3 (de)
HR (1) HRP20100285T1 (de)
PL (1) PL1633864T3 (de)
PT (1) PT1633864E (de)
SI (1) SI1633864T1 (de)
WO (1) WO2005001416A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1633864T3 (pl) 2003-05-28 2010-09-30 Glaxo Group Ltd Wysokowydajny test aktywności Lp-PLA2
US20070281323A1 (en) 2004-02-03 2007-12-06 Wolfert Robert L Methods Of Detecting Lp-PLA2 Activity
US20150017671A1 (en) 2004-04-16 2015-01-15 Yaping Shou Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity
EP1735457A4 (de) 2004-04-16 2007-08-29 Glaxo Group Ltd VERFAHREN ZUR BESTIMMUNG VON Lp-PLA2-AKTIVITÄT UND HEMMUNG VON Lp-PLA2 AKTIVITÄT
US20140283157A1 (en) 2013-03-15 2014-09-18 Diadexus, Inc. Lipoprotein-associated phospholipase a2 antibody compositions and methods of use
EP3258269B1 (de) * 2015-02-10 2019-06-05 Shenzhen New Industries Biomedical Engineering Co. Ltd. Reagenzienkit für den nachweis von lipoproteinassoziierter phospholipase a2 und herstellungsverfahren sowie anwendung für reagenzienkit
CN104820097A (zh) * 2015-05-22 2015-08-05 北京协和洛克生物技术有限责任公司 一种定量检测样本中脂蛋白磷脂酶a2浓度的液态芯片试剂盒及其制备方法
DE112017003142T8 (de) 2016-06-22 2019-08-08 Asahi Kasei Pharma Corporation Messung der Aktivität der LP-PLA2

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3204681B2 (ja) 1991-05-24 2001-09-04 株式会社シノテスト 新規なエーテル型チオリン脂質化合物およびその製造法
DE69423436T2 (de) * 1993-06-25 2000-09-07 Smithkline Beecham Plc An lipoprotein gebundene phospholipase a2, inhibitoren davon und deren verwendung für diagnose und therapie
JPH0759597A (ja) 1993-08-23 1995-03-07 Shinotesuto:Kk 血小板活性化因子アセチルヒドロラーゼ活性測定方法
DE69427392T2 (de) 1993-10-06 2002-05-23 Icos Corp Acethylhydrolase des plättchen aktivierenden faktors
US6146625A (en) * 1993-10-06 2000-11-14 Icos Corporation Platelet-activating factor acetylhydrolase
JPH1017600A (ja) 1996-06-28 1998-01-20 Suntory Ltd 血小板活性化因子アセチルヒドロラーゼおよびその遺伝子
JP4220603B2 (ja) 1998-12-02 2009-02-04 アルフレッサファーマ株式会社 血小板活性化因子アセチルヒドロラーゼ活性の測定方法
US20020102231A1 (en) * 1999-05-07 2002-08-01 Icos Corporation Therapeutic uses of PAF-AH products in diabetes
FR2815857B1 (fr) 2000-10-30 2003-02-14 Oreal Composition, notamment cosmetique, renfermant un retinoide et une silicone benzotriazole
EP1318154B1 (de) 2001-12-07 2004-06-16 SIRS-Lab GmbH Verbindungen zur Bestimmung der Aktivität von Phospholipase A2
US20030134082A1 (en) * 2001-12-21 2003-07-17 Morin Brian G. Carpet comprising a low-shrink backing of polypropylene tape fibers
US20070077614A1 (en) 2003-04-01 2007-04-05 Wolfert Robert L Uses of lp-pla2 in combination to assess coronary risk
PL1633864T3 (pl) 2003-05-28 2010-09-30 Glaxo Group Ltd Wysokowydajny test aktywności Lp-PLA2
US20070281323A1 (en) 2004-02-03 2007-12-06 Wolfert Robert L Methods Of Detecting Lp-PLA2 Activity
EP1735457A4 (de) 2004-04-16 2007-08-29 Glaxo Group Ltd VERFAHREN ZUR BESTIMMUNG VON Lp-PLA2-AKTIVITÄT UND HEMMUNG VON Lp-PLA2 AKTIVITÄT

Also Published As

Publication number Publication date
US20070065892A1 (en) 2007-03-22
WO2005001416A3 (en) 2005-03-17
EP1633864B1 (de) 2010-04-07
WO2005001416A2 (en) 2005-01-06
PT1633864E (pt) 2010-06-24
JP2012050443A (ja) 2012-03-15
EP1633864A2 (de) 2006-03-15
HRP20100285T1 (hr) 2010-06-30
ES2341772T3 (es) 2010-06-28
DK1633864T3 (da) 2010-07-12
CY1110138T1 (el) 2015-01-14
JP5637959B2 (ja) 2014-12-10
DE602004026439D1 (de) 2010-05-20
EP1633864A4 (de) 2006-06-14
PL1633864T3 (pl) 2010-09-30
SI1633864T1 (sl) 2010-07-30
JP4892350B2 (ja) 2012-03-07
US7531316B2 (en) 2009-05-12
EP2253702A1 (de) 2010-11-24
JP2007502131A (ja) 2007-02-08

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