ATE453657T1 - Verfahren zur herstellung von 3alpha(beta)- - Google Patents
Verfahren zur herstellung von 3alpha(beta)-Info
- Publication number
- ATE453657T1 ATE453657T1 AT06763188T AT06763188T ATE453657T1 AT E453657 T1 ATE453657 T1 AT E453657T1 AT 06763188 T AT06763188 T AT 06763188T AT 06763188 T AT06763188 T AT 06763188T AT E453657 T1 ATE453657 T1 AT E453657T1
- Authority
- AT
- Austria
- Prior art keywords
- 3alpha
- beta
- producing
- alkyl
- cholanic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Seasonings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000912A ITMI20050912A1 (it) | 2005-05-19 | 2005-05-19 | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| PCT/EP2006/062446 WO2006122977A2 (en) | 2005-05-19 | 2006-05-19 | PROCESS FOR PREPARING 3α(β)-7α(β)-DIHYDROXY-6α(β)-ALKYL-5β-CHOLANIC ACID |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453657T1 true ATE453657T1 (de) | 2010-01-15 |
Family
ID=35841713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06763188T ATE453657T1 (de) | 2005-05-19 | 2006-05-19 | Verfahren zur herstellung von 3alpha(beta)- |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7994352B2 (de) |
| EP (1) | EP1888614B1 (de) |
| JP (1) | JP5127700B2 (de) |
| CN (1) | CN101203526B (de) |
| AT (1) | ATE453657T1 (de) |
| AU (1) | AU2006248906B2 (de) |
| CA (1) | CA2608539C (de) |
| DE (1) | DE602006011457D1 (de) |
| DK (1) | DK1888614T3 (de) |
| ES (1) | ES2338698T3 (de) |
| IT (1) | ITMI20050912A1 (de) |
| WO (1) | WO2006122977A2 (de) |
Families Citing this family (98)
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| ATE303399T1 (de) | 2001-03-12 | 2005-09-15 | Intercept Pharmaceuticals Inc | Steroide als agonisten für fxr |
| US10987362B2 (en) | 2004-03-12 | 2021-04-27 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using FXR ligands |
| PL1734970T3 (pl) | 2004-03-12 | 2015-05-29 | Intercept Pharmaceuticals Inc | Leczenie zwłóknienia z zastosowaniem ligandów FXR |
| ITMI20050912A1 (it) | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| ES2438271T3 (es) | 2007-01-19 | 2014-01-16 | Intercept Pharmaceuticals, Inc. | Ácidos biliares 23-sustituidos como moduladores de TGR5 y métodos de uso de los mismos |
| CN105037476B (zh) | 2008-07-30 | 2018-06-12 | 英特塞普特医药品公司 | Tgr5调节剂及其使用方法 |
| DK2698375T3 (en) | 2008-11-19 | 2018-05-28 | Intercept Pharmaceuticals Inc | TGR5 modulators and methods for using them |
| MX2011006422A (es) | 2008-12-19 | 2011-09-15 | Panima Pharmaceuticals Ag | Autoanticuerpos humanos anti-alfa-sinucleina. |
| EA030777B9 (ru) | 2011-06-23 | 2019-02-28 | Байоджен Интернэшнл Нейросайенз Гмбх | Анти-альфа-синуклеинсвязывающие молекулы |
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| CN111944006B (zh) * | 2014-11-17 | 2021-12-17 | 正大天晴药业集团股份有限公司 | 新的7-酮-6β-烷基胆烷酸衍生物在制备奥贝胆酸以及其在医药领域的用途 |
| TWI688571B (zh) * | 2014-11-19 | 2020-03-21 | 英商Ｎｚｐ英國有限公司 | 化合物（四） |
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| CA2968305A1 (en) * | 2014-11-19 | 2016-05-26 | NZP UK Limited | 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators |
| DK3221331T3 (da) * | 2014-11-19 | 2019-12-02 | Nzp Uk Ltd | 6-alkyl-7-hydroxy-4-en-3-on-steroider som mellemprodukter til fremstilling af steroide fxr-modulatorer |
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| EA036404B1 (ru) | 2015-02-06 | 2020-11-06 | Интерсепт Фармасьютикалз, Инк. | Фармацевтические композиции для комбинированной терапии |
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| CN106632564B (zh) * | 2015-10-30 | 2021-04-13 | 苏州泽璟生物制药股份有限公司 | 奥贝胆酸盐及其无定形物和药物组合物 |
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| CN106046094A (zh) * | 2016-05-30 | 2016-10-26 | 福建广生堂药业股份有限公司 | 一种奥贝胆酸二聚体杂质及其制备方法 |
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-
2005
- 2005-05-19 IT IT000912A patent/ITMI20050912A1/it unknown
-
2006
- 2006-05-19 WO PCT/EP2006/062446 patent/WO2006122977A2/en not_active Application Discontinuation
- 2006-05-19 CN CN2006800170256A patent/CN101203526B/zh not_active Expired - Fee Related
- 2006-05-19 JP JP2008511719A patent/JP5127700B2/ja not_active Expired - Fee Related
- 2006-05-19 DE DE602006011457T patent/DE602006011457D1/de active Active
- 2006-05-19 US US11/914,559 patent/US7994352B2/en active Active
- 2006-05-19 ES ES06763188T patent/ES2338698T3/es active Active
- 2006-05-19 AT AT06763188T patent/ATE453657T1/de active
- 2006-05-19 AU AU2006248906A patent/AU2006248906B2/en not_active Ceased
- 2006-05-19 CA CA2608539A patent/CA2608539C/en active Active
- 2006-05-19 DK DK06763188.7T patent/DK1888614T3/da active
- 2006-05-19 EP EP06763188A patent/EP1888614B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008540612A (ja) | 2008-11-20 |
| ES2338698T3 (es) | 2010-05-11 |
| WO2006122977A2 (en) | 2006-11-23 |
| CA2608539C (en) | 2013-02-26 |
| AU2006248906A1 (en) | 2006-11-23 |
| CN101203526A (zh) | 2008-06-18 |
| CA2608539A1 (en) | 2006-11-23 |
| ITMI20050912A1 (it) | 2006-11-20 |
| DE602006011457D1 (de) | 2010-02-11 |
| US7994352B2 (en) | 2011-08-09 |
| CN101203526B (zh) | 2012-09-05 |
| AU2006248906B2 (en) | 2012-04-12 |
| WO2006122977A3 (en) | 2007-01-18 |
| JP5127700B2 (ja) | 2013-01-23 |
| EP1888614A2 (de) | 2008-02-20 |
| DK1888614T3 (da) | 2010-05-10 |
| EP1888614B1 (de) | 2009-12-30 |
| US20080214515A1 (en) | 2008-09-04 |
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