ATE445704T1 - Expressionsvektor für tierische zellen - Google Patents
Expressionsvektor für tierische zellenInfo
- Publication number
- ATE445704T1 ATE445704T1 AT01957013T AT01957013T ATE445704T1 AT E445704 T1 ATE445704 T1 AT E445704T1 AT 01957013 T AT01957013 T AT 01957013T AT 01957013 T AT01957013 T AT 01957013T AT E445704 T1 ATE445704 T1 AT E445704T1
- Authority
- AT
- Austria
- Prior art keywords
- vector
- expression vector
- present
- animal cells
- expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4717—Plasma globulins, lactoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2000-0043996A KR100408844B1 (ko) | 2000-07-29 | 2000-07-29 | 동물세포 발현벡터 |
PCT/KR2001/001285 WO2002014525A2 (en) | 2000-07-29 | 2001-07-27 | Expression vector using for animal cell |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE445704T1 true ATE445704T1 (de) | 2009-10-15 |
Family
ID=19680759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01957013T ATE445704T1 (de) | 2000-07-29 | 2001-07-27 | Expressionsvektor für tierische zellen |
Country Status (10)
Country | Link |
---|---|
US (1) | US7422874B2 (de) |
EP (1) | EP1392835B1 (de) |
JP (1) | JP4138479B2 (de) |
KR (1) | KR100408844B1 (de) |
CN (1) | CN1262663C (de) |
AT (1) | ATE445704T1 (de) |
AU (1) | AU2001278797A1 (de) |
DE (1) | DE60140218D1 (de) |
ES (1) | ES2333774T3 (de) |
WO (1) | WO2002014525A2 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2435972C (en) * | 2001-01-26 | 2011-09-13 | University Of Lausanne | Matrix attachment regions and methods for use thereof |
KR101086533B1 (ko) * | 2002-05-24 | 2011-11-23 | 쉐링 코포레이션 | 중화 사람 항-igfr 항체, 이를 제조하는 방법 및 이를 포함하는 조성물 |
AU2003263161A1 (en) * | 2002-09-20 | 2004-04-08 | Novo Nordisk A/S | Method for making recombinant proteins |
US6933136B2 (en) | 2002-09-20 | 2005-08-23 | Novo Nordisk A/S | Method for making recombinant proteins |
KR100755931B1 (ko) * | 2003-06-11 | 2007-09-06 | (주)두비엘 | 고분자형 만노스 결합형 렉틴의 대량 생산방법 및 상기방법으로 제조된 만노스 결합형 렉틴 재조합 단백질의제제화 |
US7135338B2 (en) * | 2003-06-11 | 2006-11-14 | Dobeel Corporation | Methods for overexpression of high molecular weight form of mannose binding lectin (MBL) and a specific formulation for active treatment for systemic infection with microorganism |
KR101229989B1 (ko) | 2003-10-24 | 2013-02-06 | 셀렉시스 에스. 에이. | Mar 서열의 복합 트랜스펙션 방법에 의한 포유동물 세포에서의 고효율 유전자 전달 및 발현 |
ATE514783T1 (de) | 2003-11-12 | 2011-07-15 | Schering Corp | Plasmidsystem zur expression mehrerer gene |
TW200526684A (en) | 2003-11-21 | 2005-08-16 | Schering Corp | Anti-IGFR1 antibody therapeutic combinations |
DK1812459T3 (da) * | 2004-10-28 | 2011-05-23 | Dobeel Co Ltd | Fremgangsmåde til masseproduktion af multimer mannosebindende lectin |
US8772021B2 (en) | 2005-03-04 | 2014-07-08 | Celltrion, Inc. | Expression vector for animal cell comprising at least one copy of MAR DNA sequences at the 3′ terminal of transcription termination region of a gene and method for the expression of foreign gene using the vector |
KR100779761B1 (ko) * | 2005-10-28 | 2007-11-30 | 대한민국 | 인슐린 억제 및 사람 ide 유전자로 형질전환된 동물 및그 제조방법 |
KR100836745B1 (ko) * | 2007-01-31 | 2008-06-10 | (주)두비엘 | Hbv 백신 및 그의 제조 방법 |
KR101229418B1 (ko) | 2007-06-15 | 2013-02-05 | 재단법인 목암생명공학연구소 | 활성형 재조합 혈액응고 9인자의 대량생산 방법 |
CN101348786B (zh) * | 2007-07-20 | 2011-05-11 | 谭孟群 | 一种人β珠蛋白基因及其重组腺相关病毒载体 |
US20110195451A1 (en) * | 2008-06-10 | 2011-08-11 | Isis Innovation Limited | Protein Expression |
KR101054362B1 (ko) | 2008-07-03 | 2011-08-05 | 재단법인 목암생명공학연구소 | 재조합 단백질의 푸코스 함량을 감소시키는 방법 |
US8137933B2 (en) | 2008-11-12 | 2012-03-20 | Schering Corporation | Mammalian expression vector pUHAB |
WO2010110340A1 (ja) * | 2009-03-27 | 2010-09-30 | 国立大学法人広島大学 | 哺乳動物細胞内で目的遺伝子を増幅し高発現させる方法、および当該方法を実施するために用いられるキット |
SG178940A1 (en) * | 2009-09-18 | 2012-04-27 | Selexis Sa | Products and methods for enhanced transgene expression and processing |
MX2012003816A (es) * | 2009-10-01 | 2012-07-04 | Toto Ltd | Construccion de adn y procedimiento para la generacion de celulas cho recombinantes usando la misma. |
US20130034875A1 (en) * | 2009-10-01 | 2013-02-07 | Toto Ltd. | Dna construct, and process for production of recombinant cho cell using same |
EP2625277B1 (de) | 2010-10-08 | 2017-09-06 | Cadila Healthcare Limited | Expressionsvektor für hohe expression rekombinanter proteine |
JP5931174B2 (ja) * | 2011-03-30 | 2016-06-08 | パンジェン バイオテク インコーポレイテッド | 動物細胞発現ベクター |
EP2692911B1 (de) | 2011-03-31 | 2017-02-22 | Kunimine Industries Co., Ltd. | Gebrauch eines mittels zum suchen nach proteinkristallisationsbedingungen und verfahren zum suchen nach proteinkristallisationsbedingungen |
KR101420274B1 (ko) * | 2011-06-13 | 2014-07-21 | 주식회사 종근당 | Csp-b 5'sar 인자를 포함하는 동물세포 발현 벡터 및 이를 이용한 재조합 단백질의 제조방법 |
UA118332C2 (uk) | 2011-09-22 | 2019-01-10 | Емджен Інк. | Білок, що зв'язує антиген cd27l |
EP2794878B1 (de) | 2011-12-22 | 2020-03-18 | F.Hoffmann-La Roche Ag | Expressionsvektororganisation, neuartige produktionszellenerzeugungsverfahren und ihre verwendung für die rekombinante erzeugung von polypeptiden |
CN113881702A (zh) * | 2011-12-22 | 2022-01-04 | 弗·哈夫曼-拉罗切有限公司 | 表达载体元件组合、新的生产用细胞产生方法及其在重组产生多肽中的用途 |
JO3623B1 (ar) | 2012-05-18 | 2020-08-27 | Amgen Inc | البروتينات المرتبطة بمولد المستضاد st2 |
UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
US9546203B2 (en) | 2013-03-14 | 2017-01-17 | Amgen Inc. | Aglycosylated Fc-containing polypeptides with cysteine substitutions |
WO2014144817A2 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Inhibitory polypeptides specific to wnt inhibitors |
CN103194455B (zh) * | 2013-04-08 | 2014-10-15 | 山东省农业科学院畜牧兽医研究所 | 高效表达的猪粒细胞巨噬细胞集落刺激因子基因及其表达蛋白的用途 |
NZ713636A (en) | 2013-05-30 | 2022-07-01 | Kiniksa Pharmaceuticals Ltd | Oncostatin m receptor antigen binding proteins |
EP3712166A1 (de) | 2013-09-05 | 2020-09-23 | Amgen Inc. | Fc-haltige moleküle mit vorhersagbaren, konsistenten und reproduzierbaren glycoformprofilen |
TWI736514B (zh) | 2013-09-05 | 2021-08-21 | 美商薩羅塔治療公司 | 酸性α葡萄糖苷酶之反義股誘導之外顯子2包含 |
KR101591823B1 (ko) | 2013-12-27 | 2016-02-04 | 재단법인 목암생명공학연구소 | 증가된 유전자 발현능을 갖는 발현벡터 |
US10851144B2 (en) | 2015-04-10 | 2020-12-01 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
CN107787332B (zh) | 2015-04-24 | 2022-09-09 | 豪夫迈·罗氏有限公司 | 多特异性抗原结合蛋白 |
JP7010812B2 (ja) | 2015-09-22 | 2022-02-10 | ジェネンテック, インコーポレイテッド | Fc含有タンパク質の発現 |
KR20180069839A (ko) | 2015-10-08 | 2018-06-25 | 자임워크스 인코포레이티드 | 카파 및 람다 경사슬을 포함하는 항원-결합 폴리펩티드 구조체 및 이의 용도 |
JP6983772B2 (ja) | 2015-11-02 | 2021-12-17 | ジェネンテック, インコーポレイテッド | タンパク質のフコシル化及び脱フコシル化形態の作製方法 |
US11060089B2 (en) | 2016-04-18 | 2021-07-13 | Sarepta Therapeutics, Inc. | Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene |
EP3808764A1 (de) | 2016-05-04 | 2021-04-21 | Amgen Inc. | Interleukin-2-muteine zur expansion von t-regulatorischen zellen |
WO2018150345A1 (en) * | 2017-02-16 | 2018-08-23 | De Vita Bio Life Sciences | An expression vector |
CN110831978A (zh) | 2017-06-30 | 2020-02-21 | 酵活有限公司 | 稳定的嵌合fab |
CN110343718A (zh) * | 2018-04-03 | 2019-10-18 | 新乡医学院 | 一种高效稳定的细胞表达载体、表达***及其制备方法、应用 |
EP4385573A2 (de) | 2019-08-13 | 2024-06-19 | Amgen Inc. | Interleukin-2-muteine zur expansion von t-regulatorischen zellen |
CA3162705A1 (en) | 2019-12-17 | 2021-06-24 | Amgen Inc. | Dual interleukin-2 /tnf receptor agonist for use in therapy |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4956288A (en) * | 1988-04-22 | 1990-09-11 | Biogen, Inc. | Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA |
US5108901A (en) * | 1988-09-02 | 1992-04-28 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
ATE217319T1 (de) | 1992-10-05 | 2002-05-15 | Univ North Carolina State | Verfahren zur erhöhung der expression und zur verminderung der expressionsvariabilität von fremdgenen in pflanzenzellen |
EP0693126B9 (de) * | 1993-04-02 | 2007-09-12 | Rigel Pharmaceuticals, Inc. | Methode zur selektiven inaktivierung der viralen replication |
US5773695A (en) | 1996-01-26 | 1998-06-30 | North Carolina State University | Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells |
AU718551B2 (en) | 1996-06-06 | 2000-04-13 | Novartis Ag | Vectors comprising SAR elements |
AU729929B2 (en) | 1996-06-11 | 2001-02-15 | Pioneer Hi-Bred International, Inc. | A synthetic plant core promoter and upstream regulatory element |
US6245974B1 (en) | 1997-08-06 | 2001-06-12 | North Carolina State University | Matrix attachment regions |
KR100313559B1 (ko) | 1998-07-22 | 2002-03-08 | 허영섭 | 수용성 TGFβ 수용체를 발현하는 재조합 세포주 및 전기세포주를 이용한 암치료 방법 |
AU762382B2 (en) * | 1998-09-29 | 2003-06-26 | Pioneer Hi-Bred International, Inc. | MAR/SAR elements flanking RSYN7-driven construct |
CA2435972C (en) * | 2001-01-26 | 2011-09-13 | University Of Lausanne | Matrix attachment regions and methods for use thereof |
-
2000
- 2000-07-29 KR KR10-2000-0043996A patent/KR100408844B1/ko active IP Right Review Request
-
2001
- 2001-07-27 JP JP2002519651A patent/JP4138479B2/ja not_active Expired - Lifetime
- 2001-07-27 EP EP01957013A patent/EP1392835B1/de not_active Expired - Lifetime
- 2001-07-27 ES ES01957013T patent/ES2333774T3/es not_active Expired - Lifetime
- 2001-07-27 AT AT01957013T patent/ATE445704T1/de not_active IP Right Cessation
- 2001-07-27 WO PCT/KR2001/001285 patent/WO2002014525A2/en active Application Filing
- 2001-07-27 DE DE60140218T patent/DE60140218D1/de not_active Expired - Lifetime
- 2001-07-27 AU AU2001278797A patent/AU2001278797A1/en not_active Abandoned
- 2001-07-27 CN CNB018135579A patent/CN1262663C/zh not_active Expired - Lifetime
- 2001-07-27 US US10/343,303 patent/US7422874B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2002014525A2 (en) | 2002-02-21 |
WO2002014525A3 (en) | 2003-11-20 |
US7422874B2 (en) | 2008-09-09 |
EP1392835B1 (de) | 2009-10-14 |
US20040038394A1 (en) | 2004-02-26 |
CN1444657A (zh) | 2003-09-24 |
CN1262663C (zh) | 2006-07-05 |
KR100408844B1 (ko) | 2003-12-06 |
AU2001278797A1 (en) | 2002-02-25 |
KR20020010327A (ko) | 2002-02-04 |
JP2004506428A (ja) | 2004-03-04 |
DE60140218D1 (de) | 2009-11-26 |
ES2333774T3 (es) | 2010-03-01 |
EP1392835A4 (de) | 2006-04-19 |
JP4138479B2 (ja) | 2008-08-27 |
EP1392835A2 (de) | 2004-03-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |