ATE445704T1 - Expressionsvektor für tierische zellen - Google Patents

Expressionsvektor für tierische zellen

Info

Publication number
ATE445704T1
ATE445704T1 AT01957013T AT01957013T ATE445704T1 AT E445704 T1 ATE445704 T1 AT E445704T1 AT 01957013 T AT01957013 T AT 01957013T AT 01957013 T AT01957013 T AT 01957013T AT E445704 T1 ATE445704 T1 AT E445704T1
Authority
AT
Austria
Prior art keywords
vector
expression vector
present
animal cells
expression
Prior art date
Application number
AT01957013T
Other languages
English (en)
Inventor
Jong-Mook Kim
Jung-Seob Kim
Sun-Mo Oh
Jae-Seung Yoon
Kwang-Hee Baek
Soo-Il Chung
Doo-Hong Park
Yeup Yoon
Original Assignee
Mogam Biotech Res Inst
Neurotech Pharmaceuticals Co L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mogam Biotech Res Inst, Neurotech Pharmaceuticals Co L filed Critical Mogam Biotech Res Inst
Application granted granted Critical
Publication of ATE445704T1 publication Critical patent/ATE445704T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4717—Plasma globulins, lactoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT01957013T 2000-07-29 2001-07-27 Expressionsvektor für tierische zellen ATE445704T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2000-0043996A KR100408844B1 (ko) 2000-07-29 2000-07-29 동물세포 발현벡터
PCT/KR2001/001285 WO2002014525A2 (en) 2000-07-29 2001-07-27 Expression vector using for animal cell

Publications (1)

Publication Number Publication Date
ATE445704T1 true ATE445704T1 (de) 2009-10-15

Family

ID=19680759

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01957013T ATE445704T1 (de) 2000-07-29 2001-07-27 Expressionsvektor für tierische zellen

Country Status (10)

Country Link
US (1) US7422874B2 (de)
EP (1) EP1392835B1 (de)
JP (1) JP4138479B2 (de)
KR (1) KR100408844B1 (de)
CN (1) CN1262663C (de)
AT (1) ATE445704T1 (de)
AU (1) AU2001278797A1 (de)
DE (1) DE60140218D1 (de)
ES (1) ES2333774T3 (de)
WO (1) WO2002014525A2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2435972C (en) * 2001-01-26 2011-09-13 University Of Lausanne Matrix attachment regions and methods for use thereof
KR101086533B1 (ko) * 2002-05-24 2011-11-23 쉐링 코포레이션 중화 사람 항-ｉｇｆｒ 항체, 이를 제조하는 방법 및 이를 포함하는 조성물
AU2003263161A1 (en) * 2002-09-20 2004-04-08 Novo Nordisk A/S Method for making recombinant proteins
US6933136B2 (en) 2002-09-20 2005-08-23 Novo Nordisk A/S Method for making recombinant proteins
KR100755931B1 (ko) * 2003-06-11 2007-09-06 (주)두비엘 고분자형 만노스 결합형 렉틴의 대량 생산방법 및 상기방법으로 제조된 만노스 결합형 렉틴 재조합 단백질의제제화
US7135338B2 (en) * 2003-06-11 2006-11-14 Dobeel Corporation Methods for overexpression of high molecular weight form of mannose binding lectin (MBL) and a specific formulation for active treatment for systemic infection with microorganism
KR101229989B1 (ko) 2003-10-24 2013-02-06 셀렉시스 에스. 에이. Ｍａｒ 서열의 복합 트랜스펙션 방법에 의한 포유동물 세포에서의 고효율 유전자 전달 및 발현
ATE514783T1 (de) 2003-11-12 2011-07-15 Schering Corp Plasmidsystem zur expression mehrerer gene
TW200526684A (en) 2003-11-21 2005-08-16 Schering Corp Anti-IGFR1 antibody therapeutic combinations
DK1812459T3 (da) * 2004-10-28 2011-05-23 Dobeel Co Ltd Fremgangsmåde til masseproduktion af multimer mannosebindende lectin
US8772021B2 (en) 2005-03-04 2014-07-08 Celltrion, Inc. Expression vector for animal cell comprising at least one copy of MAR DNA sequences at the 3′ terminal of transcription termination region of a gene and method for the expression of foreign gene using the vector
KR100779761B1 (ko) * 2005-10-28 2007-11-30 대한민국 인슐린 억제 및 사람 ｉｄｅ 유전자로 형질전환된 동물 및그 제조방법
KR100836745B1 (ko) * 2007-01-31 2008-06-10 (주)두비엘 Ｈｂｖ 백신 및 그의 제조 방법
KR101229418B1 (ko) 2007-06-15 2013-02-05 재단법인 목암생명공학연구소 활성형 재조합 혈액응고 9인자의 대량생산 방법
CN101348786B (zh) * 2007-07-20 2011-05-11 谭孟群 一种人β珠蛋白基因及其重组腺相关病毒载体
US20110195451A1 (en) * 2008-06-10 2011-08-11 Isis Innovation Limited Protein Expression
KR101054362B1 (ko) 2008-07-03 2011-08-05 재단법인 목암생명공학연구소 재조합 단백질의 푸코스 함량을 감소시키는 방법
US8137933B2 (en) 2008-11-12 2012-03-20 Schering Corporation Mammalian expression vector pUHAB
WO2010110340A1 (ja) * 2009-03-27 2010-09-30 国立大学法人広島大学 哺乳動物細胞内で目的遺伝子を増幅し高発現させる方法、および当該方法を実施するために用いられるキット
SG178940A1 (en) * 2009-09-18 2012-04-27 Selexis Sa Products and methods for enhanced transgene expression and processing
MX2012003816A (es) * 2009-10-01 2012-07-04 Toto Ltd Construccion de adn y procedimiento para la generacion de celulas cho recombinantes usando la misma.
US20130034875A1 (en) * 2009-10-01 2013-02-07 Toto Ltd. Dna construct, and process for production of recombinant cho cell using same
EP2625277B1 (de) 2010-10-08 2017-09-06 Cadila Healthcare Limited Expressionsvektor für hohe expression rekombinanter proteine
JP5931174B2 (ja) * 2011-03-30 2016-06-08 パンジェン バイオテク インコーポレイテッド 動物細胞発現ベクター
EP2692911B1 (de) 2011-03-31 2017-02-22 Kunimine Industries Co., Ltd. Gebrauch eines mittels zum suchen nach proteinkristallisationsbedingungen und verfahren zum suchen nach proteinkristallisationsbedingungen
KR101420274B1 (ko) * 2011-06-13 2014-07-21 주식회사 종근당 Ｃｓｐ－ｂ ５＇ｓａｒ 인자를 포함하는 동물세포 발현 벡터 및 이를 이용한 재조합 단백질의 제조방법
UA118332C2 (uk) 2011-09-22 2019-01-10 Емджен Інк. Білок, що зв'язує антиген cd27l
EP2794878B1 (de) 2011-12-22 2020-03-18 F.Hoffmann-La Roche Ag Expressionsvektororganisation, neuartige produktionszellenerzeugungsverfahren und ihre verwendung für die rekombinante erzeugung von polypeptiden
CN113881702A (zh) * 2011-12-22 2022-01-04 弗·哈夫曼-拉罗切有限公司 表达载体元件组合、新的生产用细胞产生方法及其在重组产生多肽中的用途
JO3623B1 (ar) 2012-05-18 2020-08-27 Amgen Inc البروتينات المرتبطة بمولد المستضاد st2
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
US9546203B2 (en) 2013-03-14 2017-01-17 Amgen Inc. Aglycosylated Fc-containing polypeptides with cysteine substitutions
WO2014144817A2 (en) 2013-03-15 2014-09-18 Amgen Inc. Inhibitory polypeptides specific to wnt inhibitors
CN103194455B (zh) * 2013-04-08 2014-10-15 山东省农业科学院畜牧兽医研究所 高效表达的猪粒细胞巨噬细胞集落刺激因子基因及其表达蛋白的用途
NZ713636A (en) 2013-05-30 2022-07-01 Kiniksa Pharmaceuticals Ltd Oncostatin m receptor antigen binding proteins
EP3712166A1 (de) 2013-09-05 2020-09-23 Amgen Inc. Fc-haltige moleküle mit vorhersagbaren, konsistenten und reproduzierbaren glycoformprofilen
TWI736514B (zh) 2013-09-05 2021-08-21 美商薩羅塔治療公司 酸性α葡萄糖苷酶之反義股誘導之外顯子２包含
KR101591823B1 (ko) 2013-12-27 2016-02-04 재단법인 목암생명공학연구소 증가된 유전자 발현능을 갖는 발현벡터
US10851144B2 (en) 2015-04-10 2020-12-01 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
CN107787332B (zh) 2015-04-24 2022-09-09 豪夫迈·罗氏有限公司 多特异性抗原结合蛋白
JP7010812B2 (ja) 2015-09-22 2022-02-10 ジェネンテック， インコーポレイテッド Ｆｃ含有タンパク質の発現
KR20180069839A (ko) 2015-10-08 2018-06-25 자임워크스 인코포레이티드 카파 및 람다 경사슬을 포함하는 항원-결합 폴리펩티드 구조체 및 이의 용도
JP6983772B2 (ja) 2015-11-02 2021-12-17 ジェネンテック， インコーポレイテッド タンパク質のフコシル化及び脱フコシル化形態の作製方法
US11060089B2 (en) 2016-04-18 2021-07-13 Sarepta Therapeutics, Inc. Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene
EP3808764A1 (de) 2016-05-04 2021-04-21 Amgen Inc. Interleukin-2-muteine zur expansion von t-regulatorischen zellen
WO2018150345A1 (en) * 2017-02-16 2018-08-23 De Vita Bio Life Sciences An expression vector
CN110831978A (zh) 2017-06-30 2020-02-21 酵活有限公司 稳定的嵌合fab
CN110343718A (zh) * 2018-04-03 2019-10-18 新乡医学院 一种高效稳定的细胞表达载体、表达***及其制备方法、应用
EP4385573A2 (de) 2019-08-13 2024-06-19 Amgen Inc. Interleukin-2-muteine zur expansion von t-regulatorischen zellen
CA3162705A1 (en) 2019-12-17 2021-06-24 Amgen Inc. Dual interleukin-2 /tnf receptor agonist for use in therapy

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956288A (en) * 1988-04-22 1990-09-11 Biogen, Inc. Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
ATE217319T1 (de) 1992-10-05 2002-05-15 Univ North Carolina State Verfahren zur erhöhung der expression und zur verminderung der expressionsvariabilität von fremdgenen in pflanzenzellen
EP0693126B9 (de) * 1993-04-02 2007-09-12 Rigel Pharmaceuticals, Inc. Methode zur selektiven inaktivierung der viralen replication
US5773695A (en) 1996-01-26 1998-06-30 North Carolina State University Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells
AU718551B2 (en) 1996-06-06 2000-04-13 Novartis Ag Vectors comprising SAR elements
AU729929B2 (en) 1996-06-11 2001-02-15 Pioneer Hi-Bred International, Inc. A synthetic plant core promoter and upstream regulatory element
US6245974B1 (en) 1997-08-06 2001-06-12 North Carolina State University Matrix attachment regions
KR100313559B1 (ko) 1998-07-22 2002-03-08 허영섭 수용성 TGFβ 수용체를 발현하는 재조합 세포주 및 전기세포주를 이용한 암치료 방법
AU762382B2 (en) * 1998-09-29 2003-06-26 Pioneer Hi-Bred International, Inc. MAR/SAR elements flanking RSYN7-driven construct
CA2435972C (en) * 2001-01-26 2011-09-13 University Of Lausanne Matrix attachment regions and methods for use thereof

Also Published As

Publication number Publication date
WO2002014525A2 (en) 2002-02-21
WO2002014525A3 (en) 2003-11-20
US7422874B2 (en) 2008-09-09
EP1392835B1 (de) 2009-10-14
US20040038394A1 (en) 2004-02-26
CN1444657A (zh) 2003-09-24
CN1262663C (zh) 2006-07-05
KR100408844B1 (ko) 2003-12-06
AU2001278797A1 (en) 2002-02-25
KR20020010327A (ko) 2002-02-04
JP2004506428A (ja) 2004-03-04
DE60140218D1 (de) 2009-11-26
ES2333774T3 (es) 2010-03-01
EP1392835A4 (de) 2006-04-19
JP4138479B2 (ja) 2008-08-27
EP1392835A2 (de) 2004-03-03

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