ATE420170T1 - Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle - Google Patents

Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle

Info

Publication number
ATE420170T1
ATE420170T1 AT05806601T AT05806601T ATE420170T1 AT E420170 T1 ATE420170 T1 AT E420170T1 AT 05806601 T AT05806601 T AT 05806601T AT 05806601 T AT05806601 T AT 05806601T AT E420170 T1 ATE420170 T1 AT E420170T1
Authority
AT
Austria
Prior art keywords
molecule
oligonucleotide
mattrice
small molecule
reaction wells
Prior art date
Application number
AT05806601T
Other languages
English (en)
Inventor
Peter Birk Rasmussen
Original Assignee
Peter Birk Rasmussen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36407493&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE420170(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Peter Birk Rasmussen filed Critical Peter Birk Rasmussen
Application granted granted Critical
Publication of ATE420170T1 publication Critical patent/ATE420170T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1065Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1068Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05806601T 2004-11-22 2005-11-22 Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle ATE420170T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200401809 2004-11-22

Publications (1)

Publication Number Publication Date
ATE420170T1 true ATE420170T1 (de) 2009-01-15

Family

ID=36407493

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05806601T ATE420170T1 (de) 2004-11-22 2005-11-22 Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle

Country Status (6)

Country Link
US (8) US8168381B2 (de)
EP (1) EP1828381B1 (de)
AT (1) ATE420170T1 (de)
DE (1) DE602005012319D1 (de)
DK (1) DK1828381T3 (de)
WO (1) WO2006053571A2 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
DK1487978T3 (da) 2002-03-15 2009-03-23 Nuevolution As Forbedret fremgangsmåde til syntese af templatemolekyler
EP1539980B1 (de) 2002-08-01 2016-02-17 Nuevolution A/S MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN
EP1558744B1 (de) 2002-10-30 2011-06-15 Nuevolution A/S Enzymatisches codieren
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
WO2004083427A2 (en) 2003-03-20 2004-09-30 Nuevolution A/S Ligational encoding of small molecules
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
EP2366705A1 (de) 2003-12-17 2011-09-21 Praecis Pharmaceuticals Incorporated Verfahren zur Synthese von codierten Bibliotheken
EP1730277B1 (de) 2004-03-22 2009-10-28 Nuevolution A/S Ligationscodierung unter verwendung von oligonukleotidbausteinen
ATE420170T1 (de) * 2004-11-22 2009-01-15 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle
PT1910538E (pt) * 2005-06-09 2011-07-28 Praecis Pharm Inc Métodos para a síntese de bibliotecas codificadas
EP2368868A1 (de) 2005-10-28 2011-09-28 Praecis Pharmaceuticals Inc. Verfahren zur Identifikation von Verbindungen von Interesse mithilfe kodierter Bibliotheken
LT3018206T (lt) 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
GB0712245D0 (en) * 2007-06-25 2007-08-01 Cythera Technologies Ltd Combinatorial libraries and related methods
EP3653763A1 (de) 2009-02-13 2020-05-20 X-Chem, Inc. Verfahren zur erstellung und durchsuchung von dna-codierten bibliotheken
US8716191B2 (en) 2009-06-22 2014-05-06 Universite De Strasbourg Method of preparing an adduct
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
CN103119165B (zh) 2010-09-27 2017-04-12 威泊根私人有限公司 制备富集文库的方法
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US9695530B2 (en) * 2011-08-11 2017-07-04 Deborah Jean Hall Apparatus to facilitate the commencement and execution of off-loom bead weaving stitches and method(s) of using same
LT3594340T (lt) * 2011-08-26 2021-10-25 Gen9, Inc. Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai
KR102124613B1 (ko) 2011-09-07 2020-06-19 엑스-켐, 인크. Dna-코딩된 라이브러리에 태그부착하는 방법
DK2872680T3 (en) 2012-07-13 2018-07-09 X Chem Inc DNA-encoded libraries with coding oligonucleotide compounds that cannot be read with polymerases
US10603385B2 (en) 2013-06-04 2020-03-31 Tribiotica Llc Methods and compositions for templated assembly of nucleic acid specific heterocompounds
US9879313B2 (en) 2013-06-25 2018-01-30 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
US9765375B2 (en) 2013-06-28 2017-09-19 General Electric Company Methods for developing binding-elements and uses thereof
EP3146094B1 (de) * 2014-05-23 2019-08-28 Centrillion Technology Holdings Corporation Oligonukleotidsondeninversionsverfahren für in-situ-synthetisierte sondenarrays
EP3218479A1 (de) 2014-11-11 2017-09-20 Nanocore ApS Verfahren zur identifizierung von molekülen mit gewünschten eigenschaften
NL2013857B1 (en) * 2014-11-21 2016-10-11 Piculet Biosciences Tech B V Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries.
CA2968552A1 (en) 2014-12-02 2016-06-09 Tribiotica Llc Methods and kits for theranostic applications
EP4119677B1 (de) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
US10695735B2 (en) 2015-08-18 2020-06-30 Centrillion Technology Holdings Corporation Probe inversion process for in situ synthesized probe arrays
US11124791B2 (en) 2015-09-14 2021-09-21 Arizona Board Of Regents On Behalf Of Arizona State University Generating recombinant affinity reagents with arrayed targets
CN115820806A (zh) 2016-06-16 2023-03-21 哈斯达克科学公司 寡核苷酸指导和记录的编码探针分子的组合合成
EP3541940A4 (de) * 2016-11-21 2020-10-14 Tribiotica Llc Verfahren für gerichtete faltassemblierung oder dimerisierung von proteinen durch template-reaktionen
US11186839B2 (en) 2016-11-21 2021-11-30 Tribiotica Llc Methods for preventing titration of bimolecular templated assembly reactions by structurally-determined differential hybridizations
CN110191953A (zh) * 2016-11-21 2019-08-30 特里比奥迪卡有限责任公司 通过接近增强的反应性实现***蛋白模板组装的方法
WO2018166532A1 (en) 2017-03-17 2018-09-20 Hitgen Ltd. Methods and compositions for synthesis of encoded libraries
EP3619340A4 (de) 2017-05-02 2021-01-20 Haystack Sciences Corporation Moleküle zur verifizierung von oligonukleotidgerichteter kombinatorischer synthese und verfahren zur herstellung und verwendung davon
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US20220025447A1 (en) 2018-12-10 2022-01-27 10X Genomics, Inc. Generating spatial arrays with gradients
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
SG11202107913VA (en) 2019-01-22 2021-08-30 Vipergen Aps A method for screening of an in vitro display library within a cell
JP2022523362A (ja) * 2019-02-21 2022-04-22 ストラトス ゲノミクス インコーポレイテッド 単一分子配列決定における使用のための拡張可能ポリマーの固体合成のための方法、組成物、およびデバイス
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
CN112794874A (zh) * 2019-11-13 2021-05-14 成都先导药物开发股份有限公司 一种On-DNA Petasis反应的合成方法
EP3891300B1 (de) 2019-12-23 2023-03-29 10X Genomics, Inc. Verfahren zur räumlichen analyse mittels rna-template-ligation
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775A1 (de) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
EP4162074B1 (de) 2020-06-08 2024-04-24 10X Genomics, Inc. Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon
EP4165207A1 (de) 2020-06-10 2023-04-19 10X Genomics, Inc. Verfahren zur bestimmung einer position eines analyten in einer biologischen probe
AU2021294334A1 (en) 2020-06-25 2023-02-02 10X Genomics, Inc. Spatial analysis of DNA methylation
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
EP4121555A1 (de) 2020-12-21 2023-01-25 10X Genomics, Inc. Verfahren, zusammensetzungen und systeme zur erfassung von sonden und/oder barcodes
IL309435A (en) * 2021-06-17 2024-02-01 Insitro Inc Methods of preparing bivalent molecules
EP4196605A1 (de) 2021-09-01 2023-06-21 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur blockierung einer erfassungssonde auf einer räumlichen anordnung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006121A1 (en) * 1991-09-18 1993-04-01 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ES2271306T5 (es) 2001-03-19 2013-10-16 President And Fellows Of Harvard College Evolución de una nueva función molecular
NZ530098A (en) * 2001-06-20 2006-02-24 Nuevolution As Templated molecules and methods for using such molecules
DK1487978T3 (da) 2002-03-15 2009-03-23 Nuevolution As Forbedret fremgangsmåde til syntese af templatemolekyler
JP4657919B2 (ja) * 2002-08-19 2011-03-23 プレジデント アンド フェローズ オブ ハーバード カレッジ 進化する新しい分子機能
EP1558744B1 (de) * 2002-10-30 2011-06-15 Nuevolution A/S Enzymatisches codieren
WO2004083427A2 (en) * 2003-03-20 2004-09-30 Nuevolution A/S Ligational encoding of small molecules
EP2366705A1 (de) 2003-12-17 2011-09-21 Praecis Pharmaceuticals Incorporated Verfahren zur Synthese von codierten Bibliotheken
ATE420170T1 (de) * 2004-11-22 2009-01-15 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle

Also Published As

Publication number Publication date
US20150126381A1 (en) 2015-05-07
US20140066336A1 (en) 2014-03-06
US20090209430A1 (en) 2009-08-20
US20180251756A1 (en) 2018-09-06
US20150203841A1 (en) 2015-07-23
US20180163199A1 (en) 2018-06-14
DK1828381T3 (da) 2009-02-23
US8951728B2 (en) 2015-02-10
US20140235509A1 (en) 2014-08-21
US8168381B2 (en) 2012-05-01
EP1828381B1 (de) 2009-01-07
DE602005012319D1 (de) 2009-02-26
WO2006053571A3 (en) 2006-08-17
EP1828381A2 (de) 2007-09-05
US20130237459A1 (en) 2013-09-12
WO2006053571A2 (en) 2006-05-26

Similar Documents

Publication Publication Date Title
ATE420170T1 (de) Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle
DE602005017370D1 (de) Ligationscodierung unter verwendung von oligonukleotidbausteinen
WO2004016767A3 (en) Evolving new molecular function
ATE424455T1 (de) Ligationsvermittelnde codierung von kleinen molekülen
ATE490318T1 (de) Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken
CY1118646T1 (el) Μεθοδος βιομηχανικης κατασκευης εμβολιων
TW200602387A (en) A polymer and a process for producing the same
ATE462005T1 (de) Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie
DK3085783T3 (da) Bispecifikt antistof som substitution for funktionelle proteiner
DK2385141T3 (da) Flerkomponentnukleinsyreenzymer og fremgangsmåder til anvendelse heraf
ATE441711T1 (de) Peptide fähig die dimerisierung von c-jun zu inhibieren
WO2007117346A3 (en) Programming microfluidic devices with molecular information
DE60139331D1 (de) Verfahren zur polynukleotidsynthese
NO20060775L (no) Muskarine acetylkolinreseptorantagonister
ATE445010T1 (de) Stellenspezifisches system zur erstellung vielfältiger proteinsequenzen
ATE423845T1 (de) Methoden zur klonierung und herstelung von kettenfragmenten mit lesbarem inhalt an information
DE60324779D1 (de) Antikörperbibliotheken
ATE530590T1 (de) Verfahren zur herstellung von polyesterolen
WO2002086155A3 (en) Method for the preferential nucleic acid amplification of selected nucleic acid regions
DK1711531T3 (da) Neutraliserende anti-TLR4/-MD-2-antistoffer og fremgangsmåder til anvendelse deraf
WO2005064018A3 (en) Microwave mediated synthesis of nucleic acid probes
WO2007028126A3 (en) Methods and systems for identifying insulin mimetics
WO2005007882A3 (de) Probenzubereitungseinheit
BR0305430A (pt) Dormente de dois ou mais blocos e processo para sua fabricação
DE602005021875D1 (de) Nachweisverfahren für einen liganden der selektiv eine funktionelle kaskade modulieren kann und ein target impliziert sowie dessen verwendung für hochdurchsatz-screening von molekülen die von interesse sind

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties