DK1828381T3 - Templatedirigeret split-and-mix-syntese af småmolekylebiblioteker - Google Patents

Templatedirigeret split-and-mix-syntese af småmolekylebiblioteker

Info

Publication number
DK1828381T3
DK1828381T3 DK05806601T DK05806601T DK1828381T3 DK 1828381 T3 DK1828381 T3 DK 1828381T3 DK 05806601 T DK05806601 T DK 05806601T DK 05806601 T DK05806601 T DK 05806601T DK 1828381 T3 DK1828381 T3 DK 1828381T3
Authority
DK
Denmark
Prior art keywords
molecule
oligonucleotide
template
small molecule
reaction wells
Prior art date
Application number
DK05806601T
Other languages
Danish (da)
English (en)
Inventor
Peter Birk Rasmussen
Original Assignee
Peter Birk Rasmussen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36407493&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1828381(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Peter Birk Rasmussen filed Critical Peter Birk Rasmussen
Application granted granted Critical
Publication of DK1828381T3 publication Critical patent/DK1828381T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK05806601T 2004-11-22 2005-11-22 Templatedirigeret split-and-mix-syntese af småmolekylebiblioteker DK1828381T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200401809 2004-11-22
PCT/DK2005/000747 WO2006053571A2 (en) 2004-11-22 2005-11-22 Template directed split and mix systhesis of small molecule libraries

Publications (1)

Publication Number Publication Date
DK1828381T3 true DK1828381T3 (da) 2009-02-23

Family

ID=36407493

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05806601T DK1828381T3 (da) 2004-11-22 2005-11-22 Templatedirigeret split-and-mix-syntese af småmolekylebiblioteker

Country Status (6)

Country Link
US (8) US8168381B2 (de)
EP (1) EP1828381B1 (de)
AT (1) ATE420170T1 (de)
DE (1) DE602005012319D1 (de)
DK (1) DK1828381T3 (de)
WO (1) WO2006053571A2 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
CN101006177B (zh) 2002-03-15 2011-10-12 纽韦卢森公司 改善的用于合成模制分子的方法
US10730906B2 (en) 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
ES2640279T3 (es) 2002-10-30 2017-11-02 Nuevolution A/S Procedimiento para la síntesis de un complejo bifuncional
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
DK2236606T3 (da) 2003-03-20 2014-02-10 Nuevolution As Kodning af små molekyler ved ligering
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
MXPA06006863A (es) 2003-12-17 2006-09-04 Praecis Pharm Inc Metodo para la sintesis de bibliotecas codificadas.
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
DK1730277T3 (da) 2004-03-22 2010-03-01 Nuevolution As Kodning ved ligering under anvendelse af byggebloksoligonukleotider
DE602005012319D1 (de) * 2004-11-22 2009-02-26 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle
ES2365534T3 (es) * 2005-06-09 2011-10-06 Praecis Pharmaceuticals Inc. Procedimientos para la síntesis de bibliotecas codificadas.
WO2007053358A2 (en) 2005-10-28 2007-05-10 Praecis Pharmaceuticals, Inc. Methods for identifying compounds of interest using encoded libraries
SI2341140T1 (sl) 2005-12-01 2017-12-29 Nuevolution A/S Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic
GB0712245D0 (en) * 2007-06-25 2007-08-01 Cythera Technologies Ltd Combinatorial libraries and related methods
KR20170119729A (ko) 2009-02-13 2017-10-27 엑스-켐, 인크. Ｄｎａ―코딩된 라이브러리의 생성 및 스크리닝 방법
EP2446033B1 (de) * 2009-06-22 2013-10-23 Université de Strasbourg Methode zur herstellung eines adduktes
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
LT2558577T (lt) * 2010-04-16 2019-03-12 Nuevolution A/S Bifunkciniai kompleksai ir tokių kompleksų gamybos ir naudojimo būdai
DK2622073T5 (en) 2010-09-27 2019-02-25 Vipergen Method of Preparing an Enriched Library
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US9695530B2 (en) * 2011-08-11 2017-07-04 Deborah Jean Hall Apparatus to facilitate the commencement and execution of off-loom bead weaving stitches and method(s) of using same
LT2944693T (lt) * 2011-08-26 2019-08-26 Gen9, Inc. Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai
US10865409B2 (en) 2011-09-07 2020-12-15 X-Chem, Inc. Methods for tagging DNA-encoded libraries
AU2013289993B2 (en) 2012-07-13 2018-05-10 X-Chem, Inc. DNA-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
US10603385B2 (en) 2013-06-04 2020-03-31 Tribiotica Llc Methods and compositions for templated assembly of nucleic acid specific heterocompounds
CN118240918A (zh) 2013-06-25 2024-06-25 普罗格诺西斯生物科学公司 采用微流控装置的空间编码生物分析
US9765375B2 (en) 2013-06-28 2017-09-19 General Electric Company Methods for developing binding-elements and uses thereof
EP3146094B1 (de) 2014-05-23 2019-08-28 Centrillion Technology Holdings Corporation Oligonukleotidsondeninversionsverfahren für in-situ-synthetisierte sondenarrays
EP3218479A1 (de) 2014-11-11 2017-09-20 Nanocore ApS Verfahren zur identifizierung von molekülen mit gewünschten eigenschaften
NL2013857B1 (en) * 2014-11-21 2016-10-11 Piculet Biosciences Tech B V Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries.
WO2016089958A1 (en) 2014-12-02 2016-06-09 Tribiotica Llc Methods and kits for theranostic applications
EP4119677B1 (de) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
US10695735B2 (en) 2015-08-18 2020-06-30 Centrillion Technology Holdings Corporation Probe inversion process for in situ synthesized probe arrays
WO2017048709A1 (en) * 2015-09-14 2017-03-23 Arizona Board Of Regents On Behalf Of Arizona State University Generating recominant affinity reagents with arrayed targets
CN115820806A (zh) 2016-06-16 2023-03-21 哈斯达克科学公司 寡核苷酸指导和记录的编码探针分子的组合合成
EP3541415A4 (de) * 2016-11-21 2020-10-14 Tribiotica Llc Verfahren für spaltprotein-template-assemblierung durch proximitätsverstärkte reaktivität
CN110121559A (zh) * 2016-11-21 2019-08-13 特里比奥迪卡有限责任公司 通过模板化组装反应进行蛋白质的定向折叠组装或二聚化的方法
WO2018094070A1 (en) 2016-11-21 2018-05-24 Tribiotica Llc Methods for preventing titration of bimolecular templated assembly reactions by structurally-determined differential hybridizations
WO2018166532A1 (en) 2017-03-17 2018-09-20 Hitgen Ltd. Methods and compositions for synthesis of encoded libraries
EP3619340A4 (de) 2017-05-02 2021-01-20 Haystack Sciences Corporation Moleküle zur verifizierung von oligonukleotidgerichteter kombinatorischer synthese und verfahren zur herstellung und verwendung davon
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US20220064630A1 (en) 2018-12-10 2022-03-03 10X Genomics, Inc. Resolving spatial arrays using deconvolution
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
AU2020211270A1 (en) 2019-01-22 2021-07-15 Vipergen Aps A method for screening of an in vitro display library within a cell
AU2020224663B2 (en) * 2019-02-21 2022-12-08 F. Hoffmann-La Roche Ag Methods, compositions, and devices for solid-state synthesis of expandable polymers for use in single molecule sequencing
EP3976820A1 (de) 2019-05-30 2022-04-06 10X Genomics, Inc. Verfahren zum nachweis der räumlichen heterogenität einer biologischen probe
EP4025711A2 (de) 2019-11-08 2022-07-13 10X Genomics, Inc. Erhöhung der spezifität einer analytbindung
CN112794874A (zh) * 2019-11-13 2021-05-14 成都先导药物开发股份有限公司 一种On-DNA Petasis反应的合成方法
ES2946357T3 (es) 2019-12-23 2023-07-17 10X Genomics Inc Métodos para el análisis espacial usando ligación con molde de ARN
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775A1 (de) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
WO2021263111A1 (en) 2020-06-25 2021-12-30 10X Genomics, Inc. Spatial analysis of dna methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
KR20240056484A (ko) * 2021-06-17 2024-04-30 인시트로, 인코포레이티드 2가 분자 제조 방법
EP4196605A1 (de) 2021-09-01 2023-06-21 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur blockierung einer erfassungssonde auf einer räumlichen anordnung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU669489B2 (en) * 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ATE335754T1 (de) 2001-03-19 2006-09-15 Harvard College Entwicklung neuer molekularer funktionen
WO2002103008A2 (en) * 2001-06-20 2002-12-27 Nuevolution A/S Templated molecules and methods for using such molecules
CN101006177B (zh) 2002-03-15 2011-10-12 纽韦卢森公司 改善的用于合成模制分子的方法
JP4657919B2 (ja) 2002-08-19 2011-03-23 プレジデント アンド フェローズ オブ ハーバード カレッジ 進化する新しい分子機能
ES2640279T3 (es) 2002-10-30 2017-11-02 Nuevolution A/S Procedimiento para la síntesis de un complejo bifuncional
DK2236606T3 (da) 2003-03-20 2014-02-10 Nuevolution As Kodning af små molekyler ved ligering
MXPA06006863A (es) * 2003-12-17 2006-09-04 Praecis Pharm Inc Metodo para la sintesis de bibliotecas codificadas.
DE602005012319D1 (de) * 2004-11-22 2009-02-26 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle

Also Published As

Publication number Publication date
US20180251756A1 (en) 2018-09-06
US8168381B2 (en) 2012-05-01
US8951728B2 (en) 2015-02-10
EP1828381A2 (de) 2007-09-05
EP1828381B1 (de) 2009-01-07
WO2006053571A2 (en) 2006-05-26
US20130237459A1 (en) 2013-09-12
US20150203841A1 (en) 2015-07-23
US20090209430A1 (en) 2009-08-20
US20180163199A1 (en) 2018-06-14
DE602005012319D1 (de) 2009-02-26
WO2006053571A3 (en) 2006-08-17
US20140235509A1 (en) 2014-08-21
ATE420170T1 (de) 2009-01-15
US20140066336A1 (en) 2014-03-06
US20150126381A1 (en) 2015-05-07

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