ATE399784T1 - Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen - Google Patents

Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen

Info

Publication number
ATE399784T1
ATE399784T1 AT02802815T AT02802815T ATE399784T1 AT E399784 T1 ATE399784 T1 AT E399784T1 AT 02802815 T AT02802815 T AT 02802815T AT 02802815 T AT02802815 T AT 02802815T AT E399784 T1 ATE399784 T1 AT E399784T1
Authority
AT
Austria
Prior art keywords
kits
compositions
methods
luminescent compounds
concerning
Prior art date
Application number
AT02802815T
Other languages
English (en)
Inventor
Keith Wood
Erika Hawkins
Mike Scurria
Dieter Klaubert
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promega Corp filed Critical Promega Corp
Application granted granted Critical
Publication of ATE399784T1 publication Critical patent/ATE399784T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Electroluminescent Light Sources (AREA)
  • Decoration By Transfer Pictures (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02802815T 2001-11-02 2002-11-01 Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen ATE399784T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/053,482 US7268229B2 (en) 2001-11-02 2001-11-02 Compounds to co-localize luminophores with luminescent proteins

Publications (1)

Publication Number Publication Date
ATE399784T1 true ATE399784T1 (de) 2008-07-15

Family

ID=21984572

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02802815T ATE399784T1 (de) 2001-11-02 2002-11-01 Zusammensetzungen, verfahren und kits, die lumineszierende verbindungen betreffen

Country Status (10)

Country Link
US (2) US7268229B2 (de)
EP (2) EP1894933B1 (de)
JP (1) JP4958388B2 (de)
CN (2) CN101440089A (de)
AT (1) ATE399784T1 (de)
CA (1) CA2462506C (de)
DE (1) DE60227408D1 (de)
DK (1) DK1451155T3 (de)
ES (1) ES2307829T3 (de)
WO (1) WO2003040100A1 (de)

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EP1588143B1 (de) 2002-12-23 2014-03-05 Promega Corporation Verbesserte assays auf luciferase-basis
WO2006130551A2 (en) 2005-05-31 2006-12-07 Promega Corporation Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
US7709468B2 (en) 2005-09-02 2010-05-04 Abbott Laboratories Imidazo based heterocycles
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JP2007277097A (ja) * 2006-04-03 2007-10-25 Mie Univ 発光化合物、発光方法、及びその製造方法
US7709253B2 (en) * 2006-08-04 2010-05-04 The Board Of Trustees Of The Leland Stanford Junior University Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists
EP2087132B1 (de) * 2006-10-24 2017-01-25 Gene Stream Pty Ltd. Luciferase-signal verstärkende zusammensetzungen
US20090075309A1 (en) * 2007-09-06 2009-03-19 Gambhir Sanjiv S Bisdeoxycoelenterazine derivatives, methods of use, and BRET2 systems
US8183007B2 (en) 2008-07-22 2012-05-22 Promega Corporation ADP detection based methods using adenylate cyclase and bioluminescence
EP2323996B1 (de) 2008-08-18 2014-10-22 Promega Corporation Luminogene verbindungen und verfahren zum nachweis von cytochrom p450-3a-enzymen
US8546568B2 (en) 2009-02-09 2013-10-01 Jnc Corporation Coelenterazine analogs and manufacturing method thereof
DK3181687T3 (en) 2009-05-01 2018-09-10 Promega Corp Synthetic oplophorus luciferases with increased light yield
JP5605727B2 (ja) 2010-04-06 2014-10-15 Ｊｎｃ株式会社 セレンテラジン類縁体及びセレンテラミド類縁体
EP2569425B1 (de) 2010-05-10 2016-07-06 The Regents of The University of California Endoribonukleasezusammensetzungen und verfahren zu ihrer verwendung
WO2012061477A1 (en) * 2010-11-02 2012-05-10 Promega Corporation Coelenterazine derivatives and methods of using same
US8669103B2 (en) 2010-11-02 2014-03-11 Promega Corporation Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use
EP2751089B1 (de) 2011-09-02 2018-11-14 Promega Corporation Verbindungen und verfahren zum testen des redoxzustandes metabolisch aktiver zellen und verfahren zur messung von nad(p)/nad (p)h
JP6511720B2 (ja) 2013-02-28 2019-05-15 Jnc株式会社 コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法
JP6040846B2 (ja) * 2013-04-08 2016-12-07 Jnc株式会社 セレンテラジン類縁体
JP6484987B2 (ja) 2013-10-21 2019-03-20 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
JP6442825B2 (ja) 2013-12-26 2018-12-26 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
US9790537B2 (en) 2014-01-29 2017-10-17 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
JP6588917B2 (ja) 2014-01-29 2019-10-09 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 生細胞への適用のためのプロ基質
JP6265020B2 (ja) 2014-04-16 2018-01-24 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
WO2016040788A1 (en) * 2014-09-11 2016-03-17 Promega Corporation Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
EP4219736A1 (de) 2014-09-12 2023-08-02 Promega Corporation Interne proteinmarker
JP6510041B2 (ja) 2014-10-08 2019-05-08 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 生物発光サクシネート検出アッセイ
EP3313846B1 (de) 2015-06-25 2020-05-06 Promega Corporation Thienopyrroleverbindungen unde deren verwendungen als inhibitoren von oplophorus-luciferasen
US9924073B2 (en) 2016-02-15 2018-03-20 Promega Corporation Substituted imidazo[1,2-a]pyrazines as luciferase substrates and preparation method thereof
US10316070B2 (en) 2016-09-09 2019-06-11 Promega Corporation Dual protected pro-coelenterazine substrates
US10280447B2 (en) 2016-11-01 2019-05-07 Promega Corporation Substituted imidazo[1,2-A]pyrazines tethered to energy acceptors
WO2018102693A1 (en) 2016-12-01 2018-06-07 Promega Corporation Cell impermeable coelenterazine analogues
JP7161475B2 (ja) 2016-12-28 2022-10-26 プロメガ コーポレイション 官能化ｎａｎｏｌｕｃ阻害剤
JP7204728B2 (ja) * 2017-07-06 2023-01-16 プロメガ コーポレイション 血清中で安定なプロセレンテラジン類似体
WO2019213119A1 (en) 2018-05-01 2019-11-07 Promega Corporation Coelenterazine compounds as nanoluc suicide substrates
JP7357009B2 (ja) 2018-06-01 2023-10-05 プロメガ コーポレイション Ｏｐｌｏｐｈｏｒｕｓルシフェラーゼ由来生物発光性複合体の阻害剤
EP3829648A1 (de) 2018-07-27 2021-06-09 Promega Corporation Chinon enthaltende konjugate
AU2019355136A1 (en) 2018-10-03 2021-04-29 Promega Corporation Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof
JP2023503653A (ja) 2019-11-27 2023-01-31 プロメガ コーポレイション 多分子ルシフェラーゼペプチド及びポリペプチド
WO2021119149A1 (en) 2019-12-10 2021-06-17 Promega Corporation Compositions and methods for bioluminescent detection using multifunctional probes
US20210363565A1 (en) 2020-05-22 2021-11-25 Promega Corporation Enhancement of kinase target engagement
CN113683617B (zh) * 2021-07-16 2022-08-30 山东大学 一种基于腔肠素-h的氘代化合物及其制备方法与应用
WO2023215505A1 (en) 2022-05-04 2023-11-09 Promega Corporation Modified dehalogenase with extended surface loop regions
WO2023215514A2 (en) 2022-05-04 2023-11-09 Promega Corporation Bioluminescence-triggered photocatalytic labeling

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Also Published As

Publication number Publication date
EP1451155B1 (de) 2008-07-02
CN101440089A (zh) 2009-05-27
DK1451155T3 (da) 2008-11-10
US20030153090A1 (en) 2003-08-14
EP1894933B1 (de) 2013-07-03
DE60227408D1 (de) 2008-08-14
US7537912B2 (en) 2009-05-26
CA2462506C (en) 2010-04-06
WO2003040100A1 (en) 2003-05-15
EP1894933A2 (de) 2008-03-05
US20080050760A1 (en) 2008-02-28
JP2005515977A (ja) 2005-06-02
EP1451155A4 (de) 2006-03-01
ES2307829T3 (es) 2008-12-01
CA2462506A1 (en) 2003-05-15
EP1451155A1 (de) 2004-09-01
CN1612860A (zh) 2005-05-04
JP4958388B2 (ja) 2012-06-20
CN100439338C (zh) 2008-12-03
EP1894933A3 (de) 2008-03-26
US7268229B2 (en) 2007-09-11

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