WO2007046867A3 - Piperidine derivatives and their uses as therapeutic agents - Google Patents

Piperidine derivatives and their uses as therapeutic agents Download PDF

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Publication number
WO2007046867A3
WO2007046867A3 PCT/US2006/019354 US2006019354W WO2007046867A3 WO 2007046867 A3 WO2007046867 A3 WO 2007046867A3 US 2006019354 W US2006019354 W US 2006019354W WO 2007046867 A3 WO2007046867 A3 WO 2007046867A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agents
piperidine derivatives
mammal
formula
disclosed
Prior art date
Application number
PCT/US2006/019354
Other languages
French (fr)
Other versions
WO2007046867A2 (en
Inventor
Vishnumurthy Kodumuru
Original Assignee
Xenon Pharmaceuticals Inc
Roth Carol J
Vishnumurthy Kodumuru
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc, Roth Carol J, Vishnumurthy Kodumuru filed Critical Xenon Pharmaceuticals Inc
Publication of WO2007046867A2 publication Critical patent/WO2007046867A2/en
Publication of WO2007046867A3 publication Critical patent/WO2007046867A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where K, K, L, M, W, V, R2, R3 and R5 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
PCT/US2006/019354 2005-05-19 2006-05-19 Piperidine derivatives and their uses as therapeutic agents WO2007046867A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68295205P 2005-05-19 2005-05-19
US60/682,952 2005-05-19

Publications (2)

Publication Number Publication Date
WO2007046867A2 WO2007046867A2 (en) 2007-04-26
WO2007046867A3 true WO2007046867A3 (en) 2007-07-05

Family

ID=37885399

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/019354 WO2007046867A2 (en) 2005-05-19 2006-05-19 Piperidine derivatives and their uses as therapeutic agents

Country Status (1)

Country Link
WO (1) WO2007046867A2 (en)

Families Citing this family (18)

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Publication number Priority date Publication date Assignee Title
RU2009108280A (en) 2006-08-08 2010-09-20 Санофи-Авентис (Fr) Arylamino-arylalkyl-substituted imidazolidine-2,4-dione, methods for their preparation containing these compounds and their use
AU2007288245A1 (en) 2006-08-24 2008-02-28 Novartis Ag 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyrazol-3-yl) -thiazole derivatives as well as related compounds as stearoyl-CoA desaturase (SCD) inhibitors for the treatment of metabolic, cardiovascular and other disorders
GB0722077D0 (en) 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
JP5597210B2 (en) 2009-02-17 2014-10-01 メルク カナダ インコーポレイテッド Novel spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
EP2459568A4 (en) 2009-07-28 2013-02-27 Merck Frosst Canada Ltd Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase
WO2011023754A1 (en) 2009-08-26 2011-03-03 Sanofi-Aventis Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
AU2010302577A1 (en) * 2009-10-01 2012-03-15 Novartis Ag Pyrazole derivatives which modulate stearoyl-CoA desaturase
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683704B1 (en) 2011-03-08 2014-12-17 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120054A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
KR20140084164A (en) 2011-10-15 2014-07-04 제넨테크, 인크. Scd1 antagonists for treating cancer
JP6293127B2 (en) 2012-05-22 2018-03-14 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド Selective inhibitor of undifferentiated cells
SG10202110874TA (en) 2016-06-07 2021-11-29 Jacobio Pharmaceuticals Co Ltd Novel heterocyclic derivatives useful as shp2 inhibitors
EA201992253A1 (en) 2017-03-23 2020-03-31 Джакобио Фармасьютикалс Ко., Лтд. NEW HETEROCYCLIC DERIVATIVES APPLICABLE AS SHP2 INHIBITORS

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0398427A1 (en) * 1989-05-15 1990-11-22 Janssen Pharmaceutica N.V. Antirhinoviral pyridazinamines
EP0435381A1 (en) * 1989-12-26 1991-07-03 Janssen Pharmaceutica N.V. Antipicornaviral pyridazinamines
EP0537696A1 (en) * 1991-10-18 1993-04-21 Dr. Karl Thomae GmbH Heterobiaryl derivatives, medicines containing those compounds and process for their preparation
WO1997026258A1 (en) * 1996-01-15 1997-07-24 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
WO2002000661A1 (en) * 2000-06-26 2002-01-03 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS
WO2003022809A2 (en) * 2001-09-13 2003-03-20 Smithkline Beecham P.L.C. Urea-compounds active as vanilloid receptor antagonists for the treatment of pain
WO2005011657A2 (en) * 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Piperazine derivatives and their use as therapeutic agents
WO2006012226A2 (en) * 2004-06-24 2006-02-02 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
WO2006020598A2 (en) * 2004-08-10 2006-02-23 Incyte Corporation Amido compounds and their use as pharmaceuticals
WO2006034338A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
EP1647553A1 (en) * 2003-07-17 2006-04-19 Astellas Pharma Inc. 2-acylaminothiazole derivative or salt thereof
WO2006052913A1 (en) * 2004-11-04 2006-05-18 Vertex Pharmaceuticals Incorporated PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0398427A1 (en) * 1989-05-15 1990-11-22 Janssen Pharmaceutica N.V. Antirhinoviral pyridazinamines
EP0435381A1 (en) * 1989-12-26 1991-07-03 Janssen Pharmaceutica N.V. Antipicornaviral pyridazinamines
EP0537696A1 (en) * 1991-10-18 1993-04-21 Dr. Karl Thomae GmbH Heterobiaryl derivatives, medicines containing those compounds and process for their preparation
WO1997026258A1 (en) * 1996-01-15 1997-07-24 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
WO2002000661A1 (en) * 2000-06-26 2002-01-03 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS
WO2003022809A2 (en) * 2001-09-13 2003-03-20 Smithkline Beecham P.L.C. Urea-compounds active as vanilloid receptor antagonists for the treatment of pain
EP1647553A1 (en) * 2003-07-17 2006-04-19 Astellas Pharma Inc. 2-acylaminothiazole derivative or salt thereof
WO2005011657A2 (en) * 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Piperazine derivatives and their use as therapeutic agents
WO2006012226A2 (en) * 2004-06-24 2006-02-02 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
WO2006020598A2 (en) * 2004-08-10 2006-02-23 Incyte Corporation Amido compounds and their use as pharmaceuticals
WO2006034338A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
WO2006052913A1 (en) * 2004-11-04 2006-05-18 Vertex Pharmaceuticals Incorporated PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES

Also Published As

Publication number Publication date
WO2007046867A2 (en) 2007-04-26

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