ATE337324T1 - Neue phosphor enthaltende medikamentenvorläuferverbindungen - Google Patents
Neue phosphor enthaltende medikamentenvorläuferverbindungenInfo
- Publication number
- ATE337324T1 ATE337324T1 AT00917729T AT00917729T ATE337324T1 AT E337324 T1 ATE337324 T1 AT E337324T1 AT 00917729 T AT00917729 T AT 00917729T AT 00917729 T AT00917729 T AT 00917729T AT E337324 T1 ATE337324 T1 AT E337324T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphorus containing
- drug compounds
- containing pre
- new phosphorus
- drugs
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 229910052698 phosphorus Inorganic materials 0.000 title 1
- 239000011574 phosphorus Substances 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12301399P | 1999-03-05 | 1999-03-05 | |
| US15312799P | 1999-09-08 | 1999-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE337324T1 true ATE337324T1 (de) | 2006-09-15 |
Family
ID=26821130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00917729T ATE337324T1 (de) | 1999-03-05 | 2000-03-03 | Neue phosphor enthaltende medikamentenvorläuferverbindungen |
Country Status (19)
| Country | Link |
|---|---|
| EP (2) | EP1165570B9 (de) |
| JP (1) | JP5063837B2 (de) |
| CN (1) | CN1321999C (de) |
| AT (1) | ATE337324T1 (de) |
| AU (1) | AU775332B2 (de) |
| CA (1) | CA2362805A1 (de) |
| CY (1) | CY1105799T1 (de) |
| CZ (1) | CZ20013180A3 (de) |
| DE (1) | DE60030263T2 (de) |
| DK (1) | DK1165570T3 (de) |
| ES (1) | ES2272268T3 (de) |
| HK (1) | HK1043796B (de) |
| HU (1) | HUP0200260A3 (de) |
| IL (2) | IL145052A0 (de) |
| MX (1) | MXPA01008937A (de) |
| NZ (1) | NZ513728A (de) |
| PT (1) | PT1165570E (de) |
| SK (1) | SK12442001A3 (de) |
| WO (1) | WO2000052015A2 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
| US6752981B1 (en) | 1999-09-08 | 2004-06-22 | Metabasis Therapeutics, Inc. | Prodrugs for liver specific drug delivery |
| IL151248A0 (en) * | 2000-03-08 | 2003-04-10 | Metabasis Therapeutics Inc | Novel aryl fructose-1,6-bisphosphatase inhibitors |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| NZ547204A (en) | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
| AU2003205544A1 (en) | 2002-01-18 | 2003-07-30 | Leo Pharma A/S | Mmp inhibitors |
| NZ536327A (en) | 2002-05-13 | 2007-08-31 | Metabasis Therapeutics Inc | PMEA and PMPA cyclic producing synthesis |
| WO2004037161A2 (en) | 2002-05-13 | 2004-05-06 | Metabasis Therapeutics, Inc. | Cyclic prodrugs of pmea one of its analogues |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| JP2005533824A (ja) | 2002-06-28 | 2005-11-10 | イデニクス（ケイマン）リミテツド | フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン |
| MXPA04012709A (es) | 2002-06-28 | 2005-09-30 | Idenix Cayman Ltd | Profarmacos modificados de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae. |
| KR101026294B1 (ko) | 2002-10-31 | 2011-03-31 | 메타베이시스 테라퓨틱스, 인크. | 1,3-프로판-1-아릴 디올의 신규 시클릭 포스페이트디에스테르 및 프로드럭 제조에서의 이들의 용도 |
| WO2004046331A2 (en) | 2002-11-15 | 2004-06-03 | Idenix (Cayman) Limited | 2’-branched nucleosides and flaviviridae mutation |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| EA014685B1 (ru) | 2003-04-25 | 2010-12-30 | Джилид Сайэнс, Инк. | Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе |
| WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
| US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| AU2004233897A1 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| US7432273B2 (en) | 2003-10-24 | 2008-10-07 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| WO2005044279A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Purine nucleoside phosphonate conjugates |
| US7273715B2 (en) | 2003-10-24 | 2007-09-25 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds with GS-9005 ester hydrolase A |
| BRPI0417988A (pt) | 2003-12-22 | 2007-04-27 | Gilead Sciences Inc | análogos de fosfonato antivirais |
| MXPA06014013A (es) | 2004-06-08 | 2007-03-15 | Metabasis Therapeutics Inc | Sintesis mediada por acidos de lewis de esteres ciclicos. |
| ATE505196T1 (de) | 2004-07-27 | 2011-04-15 | Gilead Sciences Inc | Nukleosid phosphonat konjugate als anti hiv mittel |
| US7524831B2 (en) | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
| US20090232879A1 (en) | 2005-05-26 | 2009-09-17 | Metabasis Therapeutics, Inc. | Thyromimetics for the Treatment of Fatty Liver Diseases |
| US20090060866A1 (en) * | 2007-08-31 | 2009-03-05 | Idenix Pharmaceuticals, Inc. | Phosphadiazine hcv polymerase inhibitors i and ii |
| WO2009129120A2 (en) | 2008-04-15 | 2009-10-22 | Rfs Pharma, Llc | Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections |
| US20100093667A1 (en) | 2008-07-08 | 2010-04-15 | Gilead Sciences, Inc. | Salts of hiv inhibitor compounds |
| MX2011003239A (es) | 2008-09-26 | 2011-04-28 | Merck Sharp & Dohme | Nuevos derivados de bencimidazol ciclicos utiles como agentes anti-diabeticos. |
| AU2009307884B2 (en) | 2008-10-22 | 2014-07-31 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| MX2011004505A (es) | 2008-10-29 | 2011-05-31 | Merck Sharp & Dohme | Derivados novedosos de bencimidazol ciclico, utiles como agentes antidiabeticos. |
| US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| WO2015123352A1 (en) | 2014-02-13 | 2015-08-20 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
| CA2997762A1 (en) | 2015-09-10 | 2017-03-16 | Becton, Dickinson And Company | Cyclophosphamide analogs for use as immunogens and assay conjugates for an immunoassay of cyclophosphamide and ifosfamide |
| CN106565626B (zh) * | 2016-10-10 | 2022-06-10 | 淮海工学院 | 2-氨基-4-芳基-5-甲硫基噻唑类化合物的合成方法 |
| WO2018094265A2 (en) | 2016-11-21 | 2018-05-24 | Viking Therapeutics, Inc. | Method of treating glycogen storage disease |
| BR112019025659A2 (pt) | 2017-06-05 | 2020-08-25 | Viking Therapeutics, Inc. | composições para o tratamento de fibrose |
| SI3661937T1 (sl) | 2017-08-01 | 2021-11-30 | Gilead Sciences, Inc. | Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb |
| CN111108214B (zh) | 2017-09-21 | 2023-10-13 | 贝克顿·迪金森公司 | 危险污染物收集试剂盒和快速测试 |
| CN111788196A (zh) | 2018-01-09 | 2020-10-16 | 配体药物公司 | 缩醛化合物及其治疗用途 |
| CA3094167A1 (en) | 2018-03-22 | 2019-09-26 | Viking Therapeutics, Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
| CN112469411B (zh) * | 2018-04-30 | 2023-10-13 | 联合生物科技公司 | 供在由衰老细胞引起或介导的状况的临床管理中使用和用于治疗癌症的作为Bcl家族拮抗剂的氨基膦酸酯 |
| WO2019213526A1 (en) * | 2018-05-04 | 2019-11-07 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| CN111434671B (zh) * | 2019-01-11 | 2023-07-11 | 凯思凯迪（上海）医药科技有限公司 | 肝脏特异性ampk激动剂及其制法和应用 |
| CN113383222A (zh) | 2019-01-28 | 2021-09-10 | 贝克顿·迪金森公司 | 具有集成的拭子和测试装置的有害污染物收集装置 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE554888A (de) * | 1956-12-20 | |||
| CH492738A (de) * | 1967-09-13 | 1970-06-30 | Sandoz Ag | Verfahren zur Herstellung von 2-(Bis-(2-chloräthyl)aminophenyl-4- -amino)-2H-1,3,2-oxazaphosphorin-tetrahydro-2-oxid |
| DE2752125A1 (de) * | 1977-11-22 | 1979-05-23 | Max Planck Gesellschaft | Neue phosphororganische ringverbindungen, ihre herstellung und verwendung |
| DE3132221A1 (de) * | 1981-08-14 | 1983-05-19 | Behringwerke Ag, 3550 Marburg | Neue cyclophosphamid-derivate, verfahren zu ihrer herstellung und ihre verwendung |
| DE3133077A1 (de) * | 1981-08-21 | 1983-03-10 | Henkel KGaA, 4000 Düsseldorf | Neue cytostatisch wirksame epoxidgruppen tragende 1,3,2-oxazaphosphorin-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung in pharmazeutischen zubereitungen |
| DE3569737D1 (en) * | 1984-03-01 | 1989-06-01 | Asta Pharma Ag | Salts of oxazaphosphorine derivatives |
| FR2562543B1 (fr) | 1984-04-10 | 1987-09-25 | Elf Aquitaine | Nouveaux phosphonites cycliques, leur preparation et applications |
| NL8403224A (nl) | 1984-10-24 | 1986-05-16 | Oce Andeno Bv | Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen. |
| US4757141A (en) * | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
| DE3600289A1 (de) * | 1986-01-08 | 1987-07-09 | Bayer Ag | Cyclische malonylphosphonsaeurediamide, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel |
| CA1334752C (en) * | 1988-08-02 | 1995-03-14 | Ryozo Sakoda | Drug effect-enhancing agent for antitumor drug |
| US5658889A (en) | 1989-01-24 | 1997-08-19 | Gensia Pharmaceuticals, Inc. | Method and compounds for aica riboside delivery and for lowering blood glucose |
| DK0481214T3 (da) * | 1990-09-14 | 1999-02-22 | Acad Of Science Czech Republic | Prolægemidler af phosphonater |
| US5157027A (en) | 1991-05-13 | 1992-10-20 | E. R. Squibb & Sons, Inc. | Bisphosphonate squalene synthetase inhibitors and method |
| WO1997022614A1 (en) * | 1995-12-19 | 1997-06-26 | Darwin Discovery Limited | Ifosfamide, analogues thereof and their preparation |
| JPH09241284A (ja) * | 1996-03-08 | 1997-09-16 | Koji Yamashita | 新規なオキシアザホスホリン誘導体 |
| GB9618634D0 (en) * | 1996-09-06 | 1996-10-16 | Univ Southampton | Anti cancer drugs |
| WO1998039342A1 (en) | 1997-03-07 | 1998-09-11 | Metabasis Therapeutics, Inc. | Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase |
| AU6452098A (en) | 1997-03-07 | 1998-09-22 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
| JP2001515482A (ja) | 1997-03-07 | 2001-09-18 | メタバシス・セラピューティクス・インコーポレイテッド | フルクトース−１，６−ビスホスファターゼの新規なベンズイミダゾールインヒビター |
| WO2000014095A1 (en) * | 1998-09-09 | 2000-03-16 | Metabasis Therapeutics, Inc. | Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase |
-
2000
- 2000-03-03 EP EP00917729A patent/EP1165570B9/de not_active Expired - Lifetime
- 2000-03-03 DE DE60030263T patent/DE60030263T2/de not_active Expired - Lifetime
- 2000-03-03 SK SK1244-2001A patent/SK12442001A3/sk unknown
- 2000-03-03 CA CA002362805A patent/CA2362805A1/en not_active Abandoned
- 2000-03-03 EP EP06119343A patent/EP1724276A1/de not_active Withdrawn
- 2000-03-03 NZ NZ513728A patent/NZ513728A/en not_active IP Right Cessation
- 2000-03-03 AU AU38658/00A patent/AU775332B2/en not_active Expired
- 2000-03-03 AT AT00917729T patent/ATE337324T1/de not_active IP Right Cessation
- 2000-03-03 WO PCT/US2000/005672 patent/WO2000052015A2/en active IP Right Grant
- 2000-03-03 JP JP2000602240A patent/JP5063837B2/ja not_active Expired - Lifetime
- 2000-03-03 CN CNB00807173XA patent/CN1321999C/zh not_active Expired - Lifetime
- 2000-03-03 CZ CZ20013180A patent/CZ20013180A3/cs unknown
- 2000-03-03 DK DK00917729T patent/DK1165570T3/da active
- 2000-03-03 HU HU0200260A patent/HUP0200260A3/hu unknown
- 2000-03-03 MX MXPA01008937A patent/MXPA01008937A/es active IP Right Grant
- 2000-03-03 IL IL14505200A patent/IL145052A0/xx active IP Right Grant
- 2000-03-03 PT PT00917729T patent/PT1165570E/pt unknown
- 2000-03-03 ES ES00917729T patent/ES2272268T3/es not_active Expired - Lifetime
-
2001
- 2001-08-22 IL IL145052A patent/IL145052A/en not_active IP Right Cessation
-
2002
- 2002-07-02 HK HK02104972.2A patent/HK1043796B/zh not_active IP Right Cessation
-
2006
- 2006-11-20 CY CY20061101686T patent/CY1105799T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20013180A3 (cs) | 2002-02-13 |
| CN1321999C (zh) | 2007-06-20 |
| MXPA01008937A (es) | 2004-04-05 |
| HK1043796A1 (en) | 2002-09-27 |
| EP1165570B1 (de) | 2006-08-23 |
| DE60030263T2 (de) | 2007-08-30 |
| HUP0200260A3 (en) | 2002-11-28 |
| CA2362805A1 (en) | 2000-09-08 |
| AU775332B2 (en) | 2004-07-29 |
| DK1165570T3 (da) | 2006-12-18 |
| HK1043796B (zh) | 2007-02-23 |
| WO2000052015A2 (en) | 2000-09-08 |
| EP1165570A2 (de) | 2002-01-02 |
| PT1165570E (pt) | 2007-01-31 |
| IL145052A (en) | 2007-07-24 |
| HUP0200260A2 (en) | 2002-06-29 |
| NZ513728A (en) | 2001-09-28 |
| CY1105799T1 (el) | 2011-02-02 |
| JP2002538161A (ja) | 2002-11-12 |
| IL145052A0 (en) | 2002-06-30 |
| AU3865800A (en) | 2000-09-21 |
| EP1724276A1 (de) | 2006-11-22 |
| WO2000052015A3 (en) | 2001-02-15 |
| CN1353719A (zh) | 2002-06-12 |
| JP5063837B2 (ja) | 2012-10-31 |
| ES2272268T3 (es) | 2007-05-01 |
| EP1165570B9 (de) | 2007-02-21 |
| DE60030263D1 (de) | 2006-10-05 |
| SK12442001A3 (sk) | 2002-06-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE337324T1 (de) | Neue phosphor enthaltende medikamentenvorläuferverbindungen | |
| ATE303149T1 (de) | Orale pharmazeutische zusammensetzung aus cefpodoxim-proxetil | |
| ATE303131T1 (de) | Zusammensetzungen zur nasalen verabreichung | |
| SE0102439D0 (sv) | New compounds | |
| DE60334773D1 (de) | Formulierungen zur oralen verabreichung von wirkstoffen | |
| FR2772763B1 (fr) | Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant | |
| CY1105387T1 (el) | Υποκατεστημενα παραγωγα 2-διαλκυλαμινοαλκυλοδιφαινθλιου | |
| SE9901875D0 (sv) | Novel compounds | |
| ATE389401T1 (de) | Verfahren zur herstellung von pharmazeutischen zusammensetzungen enthaltend epothilon-analoga zur krebsbehandlung | |
| PT1322160E (pt) | Combinacoes de substancias activas com propriedades insecticidas e acaricidas | |
| BR0114252A (pt) | Derivados de nitrosodifenilamina | |
| DK2308496T3 (da) | Formulering indeholdende fosfatderivater af elektrontransfermidler | |
| ATE276744T1 (de) | Neutrale-kationische lipide zur verabreichung von nukleinesäuren und arzneimitteln | |
| EA200000431A2 (ru) | Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их | |
| CY1106376T1 (el) | Δικυκλικα παραγωγα των αμινο-πυραζινονων, μεθοδος παρασκευης τους και οι φαρμακευτικες συνθεσεις που τα πepιεχουν | |
| ATE240299T1 (de) | Diester prodrugs von decahydroischinoline-3- carbonsäure | |
| DE50108172D1 (de) | Verfahren zur herstellung von spirocyclischen tetronsäurederivaten | |
| AR029468A1 (es) | Derivados de aminoacidos n-mercaptoacilados, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| DK0972521T3 (da) | Farmaceutisk præparat, der indeholder interferon-gamma-stimulatorer | |
| YU81502A (sh) | Ciklopostini, postupak za njihovu proizvodnju i njihova primena | |
| EA200000261A3 (ru) | Новые замещенные димерные соединения, способ их получения и содержащияся их фармацевтическая композиция | |
| DE50107493D1 (de) | Perlpolymerisate enthaltend halogenfreie phosphorverbindungen | |
| EP1634886A3 (de) | Neue Phosphor enthaltende Medikamentenvorläuferverbindungen | |
| MXPA04001856A (es) | Indan-1-oles c2-sustituidos y sus derivados, metodo para su produccion y su uso como medicamentos. | |
| IT1302289B1 (it) | Composizioni farmaceutiche ad attivita' antineoplastica |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1165570 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |