EA200000431A2 - Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их - Google Patents

Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их

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Publication number
EA200000431A2
EA200000431A2 EA200000431A EA200000431A EA200000431A2 EA 200000431 A2 EA200000431 A2 EA 200000431A2 EA 200000431 A EA200000431 A EA 200000431A EA 200000431 A EA200000431 A EA 200000431A EA 200000431 A2 EA200000431 A2 EA 200000431A2
Authority
EA
Eurasian Patent Office
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
new substituted
dimeric compounds
Prior art date
Application number
EA200000431A
Other languages
English (en)
Other versions
EA003391B1 (ru
EA200000431A3 (ru
Inventor
Патрик Депре
Сэд Йус
Гвенаэль Шев
Жеральд Гийоме
Мари-Клод Вио
Карлос Ларрайа
Каролин Беннежан
Филипп Делагранж
Пьер Ренар
Кароль Декамп-Франсуа
Original Assignee
Адир Э Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Адир Э Компани filed Critical Адир Э Компани
Publication of EA200000431A2 publication Critical patent/EA200000431A2/ru
Publication of EA200000431A3 publication Critical patent/EA200000431A3/ru
Publication of EA003391B1 publication Critical patent/EA003391B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Изобретение относится к соединениям формулы (I)A-G-Cy-G-Cy'-G-B (I)где A представляет группу NRC(Q)R, C(Q)NRRили NRC(Q)NRR;B представляет группу NRC(Q)R, NRC(Q)NRR, C(Q)NRR, C(Q)OR, NRC(Q)ORили NRR;Gи Gпредставляют необязательно замещенную алкиленовую цепь;Cy и Cy', которые являются различными, представляют кольцевую структуруилиGпредставляет цепьЛекарственные препараты.
EA200000431A 1999-05-19 2000-05-18 Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их EA003391B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9906331A FR2793793B1 (fr) 1999-05-19 1999-05-19 Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
EA200000431A2 true EA200000431A2 (ru) 2000-12-25
EA200000431A3 EA200000431A3 (ru) 2001-02-26
EA003391B1 EA003391B1 (ru) 2003-04-24

Family

ID=9545746

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000431A EA003391B1 (ru) 1999-05-19 2000-05-18 Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их

Country Status (21)

Country Link
US (1) US6310074B1 (ru)
EP (1) EP1057826B1 (ru)
JP (1) JP3688552B2 (ru)
KR (1) KR100472520B1 (ru)
CN (1) CN1128142C (ru)
AT (1) ATE237610T1 (ru)
AU (1) AU766322B2 (ru)
BR (1) BR0003313A (ru)
DE (1) DE60002126T2 (ru)
DK (1) DK1057826T3 (ru)
EA (1) EA003391B1 (ru)
ES (1) ES2197062T3 (ru)
FR (1) FR2793793B1 (ru)
HK (1) HK1030937A1 (ru)
HU (1) HUP0001961A3 (ru)
NO (1) NO20002548L (ru)
NZ (1) NZ504613A (ru)
PL (1) PL340165A1 (ru)
PT (1) PT1057826E (ru)
SI (1) SI1057826T1 (ru)
ZA (1) ZA200002490B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI284124B (en) * 2002-12-03 2007-07-21 Hoffmann La Roche Aminoalkoxyindoles
WO2005062795A2 (en) 2003-12-19 2005-07-14 Plexxikon, Inc. Compounds and methods for development of ret modulators
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
AU2006272951A1 (en) * 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
EP1893612B1 (en) * 2005-06-22 2011-08-03 Plexxikon, Inc. Pyrrolo [2, 3-b]pyridine derivatives as protein kinase inhibitors
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
CN101641351A (zh) 2006-12-21 2010-02-03 普莱希科公司 用于激酶调节的化合物和方法及其适应症
WO2009012283A1 (en) 2007-07-17 2009-01-22 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AR075262A1 (es) * 2008-07-30 2011-03-23 Ferrer Int Compuestos de 1,6-dihidro-2h-3-oxa-6-aza-as-indaceno, proceso para prepararlos, composicion farmaceutica que los comprende, sus usos como medicamentos, o en tratamientos o prevenciones de condiciones asociadas con un funcionamiento alterado de los sistemas regulados por la melatonina, sus usos para
SG173178A1 (en) 2009-04-03 2011-09-29 Hoffmann La Roche Propane- i-sulfonic acid {3- [5- (4 -chloro-phenyl) -1h-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
NZ629615A (en) 2009-11-06 2016-01-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
EA028821B9 (ru) 2011-02-07 2018-10-31 Плексксикон, Инк. Соединения и способы для модуляции киназ, а также показания к их применению
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1639427A3 (ru) * 1987-07-03 1991-03-30 Глэксо Груп Лимитед (Фирма) Способ получени производных индола или их фармацевтически приемлемых солей
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE69210959T2 (de) * 1991-11-18 1996-09-26 Lilly Industries Ltd Benzo(b)thiophen-2-carboxamide zur Behandlung von Krankheiten des Zentralnervensystems
FR2689124A1 (fr) * 1992-03-27 1993-10-01 Adir Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2696453B1 (fr) * 1992-10-02 1994-12-23 Adir Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
EP0675109A1 (en) * 1992-12-21 1995-10-04 Taisho Pharmaceutical Co. Ltd N-substituted indole derivative
KR100248643B1 (ko) * 1994-06-29 2000-07-01 디. 제이. 우드 아릴 및 헤테로아릴 알콕시나프탈렌 유도체
FR2731223A1 (fr) * 1995-03-02 1996-09-06 Pf Medicament Nouveaux derives bi-tryptaminiques, leur procede de preparation et leur utilisation a titre de medicaments

Also Published As

Publication number Publication date
DK1057826T3 (da) 2003-07-21
NO20002548L (no) 2000-11-20
FR2793793A1 (fr) 2000-11-24
DE60002126T2 (de) 2004-03-18
NZ504613A (en) 2001-06-29
HU0001961D0 (en) 2000-07-28
FR2793793B1 (fr) 2004-02-27
CN1128142C (zh) 2003-11-19
HUP0001961A2 (hu) 2001-08-28
EA003391B1 (ru) 2003-04-24
SI1057826T1 (en) 2003-08-31
AU766322B2 (en) 2003-10-16
KR100472520B1 (ko) 2005-03-07
HUP0001961A3 (en) 2002-10-28
JP2001011035A (ja) 2001-01-16
KR20010029729A (ko) 2001-04-16
DE60002126D1 (de) 2003-05-22
ATE237610T1 (de) 2003-05-15
CN1277962A (zh) 2000-12-27
EP1057826A1 (fr) 2000-12-06
ZA200002490B (en) 2000-11-20
NO20002548D0 (no) 2000-05-18
ES2197062T3 (es) 2004-01-01
HK1030937A1 (en) 2001-05-25
JP3688552B2 (ja) 2005-08-31
EA200000431A3 (ru) 2001-02-26
BR0003313A (pt) 2001-03-13
AU3542000A (en) 2000-11-23
PT1057826E (pt) 2003-08-29
EP1057826B1 (fr) 2003-04-16
PL340165A1 (en) 2000-11-20
US6310074B1 (en) 2001-10-30

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU