DE69604653T2 - Taxol derivate, deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen - Google Patents

Taxol derivate, deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen

Info

Publication number: DE69604653T2
Authority: DE; Germany
Prior art keywords: production; pharmaceutical compositions; compositions containing; taxol derivatives; taxol
Prior art date: 1995-03-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69604653T

Other languages

English (en)

Other versions

DE69604653D1 (de

Inventor

Herve Bouchard

Jean-Dominique Bourzat

Alain Commercon

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharma SA

Original Assignee

Rhone Poulenc Rorer SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-27

Filing date

1996-03-25

Publication date

2000-05-31

1995-03-27 Priority claimed from FR9503545A external-priority patent/FR2732340B1/fr

1995-12-22 Priority claimed from FR9515381A external-priority patent/FR2742754B1/fr

1996-03-25 Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA

1999-11-18 Publication of DE69604653D1 publication Critical patent/DE69604653D1/de

2000-05-31 Application granted granted Critical

2000-05-31 Publication of DE69604653T2 publication Critical patent/DE69604653T2/de

2016-03-26 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DE69604653T 1995-03-27 1996-03-25 Taxol derivate, deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen Expired - Lifetime DE69604653T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9503545A FR2732340B1 (fr)	1995-03-27	1995-03-27	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR9515381A FR2742754B1 (fr)	1995-12-22	1995-12-22	Procede de preparation de taxoides
PCT/FR1996/000441 WO1996030356A1 (fr)	1995-03-27	1996-03-25	Nouveaux taxoïdes, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number	Publication Date
DE69604653D1 DE69604653D1 (de)	1999-11-18
DE69604653T2 true DE69604653T2 (de)	2000-05-31

Family

ID=26231838

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69606028T Expired - Lifetime DE69606028T2 (de)	1995-03-27	1996-03-25	Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzung
DE69604653T Expired - Lifetime DE69604653T2 (de)	1995-03-27	1996-03-25	Taxol derivate, deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69606028T Expired - Lifetime DE69606028T2 (de)	1995-03-27	1996-03-25	Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzung

Country Status (41)

Country	Link
US (3)	US5889043A (de)
EP (2)	EP0817780B1 (de)
JP (2)	JP3790826B2 (de)
KR (2)	KR100485309B1 (de)
CN (2)	CN1213042C (de)
AP (2)	AP785A (de)
AR (1)	AR001440A1 (de)
AT (2)	ATE185562T1 (de)
AU (2)	AU711227B2 (de)
BG (2)	BG63121B1 (de)
BR (2)	BR9607929A (de)
CA (2)	CA2214319C (de)
CO (1)	CO4700576A1 (de)
CZ (2)	CZ287326B6 (de)
DE (2)	DE69606028T2 (de)
DK (2)	DK0817779T3 (de)
DZ (1)	DZ2009A1 (de)
EA (2)	EA000567B1 (de)
EE (2)	EE03609B1 (de)
ES (2)	ES2143187T3 (de)
GE (2)	GEP20002188B (de)
GR (2)	GR3031526T3 (de)
HU (2)	HU223732B1 (de)
IL (1)	IL117636A (de)
IS (2)	IS2058B (de)
MA (1)	MA23823A1 (de)
MY (1)	MY121225A (de)
NO (2)	NO316379B1 (de)
NZ (2)	NZ304900A (de)
OA (2)	OA10513A (de)
PE (1)	PE51097A1 (de)
PL (2)	PL188284B1 (de)
PT (1)	PT817779E (de)
RO (2)	RO115878B1 (de)
SK (2)	SK281927B6 (de)
TN (1)	TNSN96043A1 (de)
TR (2)	TR199701042T1 (de)
TW (1)	TW394765B (de)
UY (2)	UY24192A1 (de)
WO (2)	WO1996030355A1 (de)
ZA (1)	ZA962399B (de)

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US6500858B2 (en)	1994-10-28	2002-12-31	The Research Foundation Of The State University Of New York	Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6495579B1 (en)	1996-12-02	2002-12-17	Angiotech Pharmaceuticals, Inc.	Method for treating multiple sclerosis
US5811452A (en) *	1997-01-08	1998-09-22	The Research Foundation Of State University Of New York	Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US7288665B1 (en) *	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
FR2771092B1 (fr) *	1997-11-18	1999-12-17	Rhone Poulenc Rorer Sa	Procede de preparation de derives de la classe des taxoides
US6346543B1 (en) *	1998-08-17	2002-02-12	Aventis Pharma S.A.	Use of a taxoid to treat abnormal cell proliferation in the brain
EP0982027A1 (de) *	1998-08-17	2000-03-01	Aventis Pharma S.A.	Taxoid-Derivaten zur Behandlung von abnormaler Zellvermehrung des Gehirns
HUP0104000A3 (en) *	1998-08-20	2003-01-28	Aventis Pharma Sa	New use of taxoid derivatives
EP0982028A1 (de) *	1998-08-20	2000-03-01	Aventis Pharma S.A.	Neue Verwendung von Taxoidverbindungen
EP1020188A1 (de) *	1999-01-13	2000-07-19	Aventis Pharma S.A.	Neue Verwendung von Taxoid-Derivaten
EP1165068B1 (de) *	2000-02-02	2007-12-19	Florida State University Research Foundation, Inc.	Heterosubstituierte taxan-c10-acetate als antitumormittel
US6649632B2 (en)	2000-02-02	2003-11-18	Fsu Research Foundation, Inc.	C10 ester substituted taxanes
US8147816B2 (en) *	2000-08-16	2012-04-03	Encore Health, Llc	Presbyopia treatment by lens alteration
HUP0302599A3 (en)	2000-09-22	2005-05-30	Bristol Myers Squibb Co	Method for reducing toxicity of combined chemotherapic compositions
AU2001290636A1 (en) *	2000-09-22	2002-04-02	Bristol-Myers Squibb Company	Method for reducing toxicity of combined chemotherapies
US6593334B1 (en)	2002-05-02	2003-07-15	The University Of North Carolina At Chapel Hill	Camptothecin-taxoid conjugates as antimitotic and antitumor agents
KR101857900B1 (ko)	2002-09-06	2018-05-14	인설트 테라페틱스, 인코퍼레이티드	공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체
EP1558241A2 (de) *	2002-11-08	2005-08-03	Bristol-Myers Squibb Company	Pharmazeutische zusammensetzungen und verfahren zur verwendung von taxan-derivaten
EP1663153A4 (de) *	2003-05-20	2011-01-05	Aronex Pharmaceuticals Inc	Kombinationschemotherapie mit einem liposomalen platinkomplex
US7064980B2 (en) *	2003-09-17	2006-06-20	Sandisk Corporation	Non-volatile memory and method with bit line coupled compensation
FR2859996B1 (fr) *	2003-09-19	2006-02-03	Aventis Pharma Sa	Solvat acetonique du dimethoxy docetaxel et son procede de preparation
PE20050693A1 (es)	2004-02-13	2005-09-27	Univ Florida State Res Found	Taxanos sustituidos con esteres de ciclopentilo en c10
GT200500025A (es) *	2004-02-13	2005-09-30		Taxanos sustituidos con esteres de ciclopentilo en c10
CA2597682A1 (en) *	2005-02-14	2006-08-24	Florida State University Research Foundation, Inc.	C10 cyclopropyl ester substituted taxane compositions
WO2006102758A1 (en) *	2005-03-31	2006-10-05	Bioxel Pharma Inc.	Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii
CA2627943C (en) *	2005-11-04	2013-12-31	Bioxel Pharma Inc.	New methods for the preparation of taxanes using chiral auxiliaries
US7847111B2 (en) *	2006-06-19	2010-12-07	Canada Inc.	Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
US20080176958A1 (en)	2007-01-24	2008-07-24	Insert Therapeutics, Inc.	Cyclodextrin-based polymers for therapeutics delivery
WO2009006590A2 (en) *	2007-07-04	2009-01-08	Dr. Reddy's Laboratories Ltd.	Docetaxel process and polymorphs
FR2926551A1 (fr) *	2008-01-17	2009-07-24	Aventis Pharma Sa	Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
WO2009145981A1 (en) *	2008-03-31	2009-12-03	Florida State University Research Foundation, Inc.	C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes
WO2010019233A1 (en)	2008-08-11	2010-02-18	Nektar Therapeutics	Multi-arm polymeric alkanoate conjugates
FR2945211A1 (fr)	2009-05-06	2010-11-12	Sanofi Aventis	Combinaison antitumorale comprenant la cabazitaxel et la capecitabine
CA2779009A1 (en)	2009-10-29	2011-05-05	Aventis Pharma S.A.	Novel antitumoral use of cabazitaxel
BR112012012210B8 (pt) *	2009-11-23	2021-05-25	Cerulean Pharma Inc	conjugado de (cdp)-taxano de polímero contendo ciclodextrina, composição, composição farmacêutica, forma de dosagem, kit e uso de um conjugado de cdp-taxano
US8791279B2 (en) *	2010-12-13	2014-07-29	Yung Shin Pharm. Ind. Co., Ltd.	Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
WO2012088445A1 (en)	2010-12-22	2012-06-28	Nektar Therapeutics	Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130331443A1 (en)	2010-12-22	2013-12-12	Nektar Therapeutics	Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012088433A1 (en)	2010-12-22	2012-06-28	Nektar Therapeutics	Deuterated and/or fluorinated taxane derivatives
CN102060815B (zh) *	2010-12-24	2012-09-26	重庆泰濠制药有限公司	一种紫杉烷类化合物的制备方法
EP2620148A1 (de)	2012-01-27	2013-07-31	Aventis Pharma S.A.	Antitumorkombination mit Cabazitaxel und Cisplatin
SI2678011T1 (sl)	2011-02-25	2019-09-30	Aventis Pharma S.A.	Protitumorska kombinacija, ki vsebuje kabazitaksel in cisplatin
EP2491925A1 (de)	2011-02-25	2012-08-29	Aventis Pharma S.A.	Antitumorigene Kombinaton, die Cabazitaxel und Cisplatin umfasst
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CN102336726B (zh) *	2011-09-30	2014-11-26	重庆泰濠制药有限公司	一种卡巴他赛的制备方法
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CN102408397B (zh)	2011-10-19	2014-08-20	上海贝美医药科技有限公司	紫杉烷类衍生物及其制备方法
CN102516281B (zh) *	2011-10-20	2015-02-04	江苏红豆杉生物科技股份有限公司	一种10-脱乙酰基巴卡丁iii及其衍生物甲氧基化的方法
CN102603724B (zh) *	2011-10-20	2014-02-26	江苏红豆杉生物科技股份有限公司	二甲氧基紫杉烷类化合物纯化精制的方法
CN102424672A (zh) *	2011-10-20	2012-04-25	江苏红豆杉生物科技有限公司	脱保护基制备二甲氧基紫杉烷类化合物的方法
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CN102417491B (zh) *	2011-10-31	2013-11-06	江苏红豆杉生物科技有限公司	以10-去乙酰基-巴卡丁iii为原料制备卡巴他赛的方法
DE112012004569T5 (de) *	2011-11-01	2014-08-14	Fresenius Kabi Oncology Ltd.	Amorphe Form von Cabazitaxel und Verfahren zum Herstellen davon
CN103159705B (zh) *	2011-12-12	2015-05-27	福建南方制药股份有限公司	卡巴他赛中间体的制备方法
WO2013088335A1 (en)	2011-12-13	2013-06-20	Aventis Pharma S.A.	Crystalline form of cabazitaxel and process for preparing the same
CN102532064B (zh) *	2011-12-13	2015-06-17	重庆泰濠制药有限公司	二甲氧基多西他赛的合成方法
US9012665B2 (en) *	2012-07-31	2015-04-21	Yung Shin Pharm. Ind. Co., Ltd.	Amorphous cabazitaxel
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CN103804323A (zh) *	2012-11-14	2014-05-21	上海希迈医药科技有限公司	一种卡巴他赛溶剂化物及其制备方法和应用
KR101407353B1 (ko) *	2012-12-04	2014-06-17	주식회사 삼양바이오팜	10-디아세틸바카틴 iii으로부터 카바지탁셀을 고수율로 제조하는 새로운 방법 및 이를 위한 신규 중간체
EP2743264A1 (de)	2012-12-13	2014-06-18	INDENA S.p.A.	Neue kristalline Form von Cabazitaxel, Verfahren zur Herstellung und pharmazeutische Zusammensetzungen davon
EP2815749A1 (de)	2013-06-20	2014-12-24	IP Gesellschaft für Management mbH	Feste Form von 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindolin-1,3-dion mit spezifischem Röntgenbeugungsspektrum
EP2865675A1 (de)	2013-10-23	2015-04-29	INDENA S.p.A.	Kristalline wasserfreie Form von Cabazitaxel, Herstellungsverfahren dafür und pharmazeutische Zusammensetzungen damit
EP2865674A1 (de)	2013-10-23	2015-04-29	INDENA S.p.A.	Kristalline Solvatformen von Cabazitaxel
CN104650012A (zh)	2013-11-22	2015-05-27	天士力控股集团有限公司	一种紫杉烷类化合物
CN104086514A (zh) *	2014-06-19	2014-10-08	上海应用技术学院	紫杉醇衍生物及其制备方法
JP6841772B2 (ja)	2015-02-17	2021-03-10	エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム	前立腺癌の処置におけるカバジタキセルの使用
EP3093014A1 (de)	2015-05-13	2016-11-16	Aventis Pharma S.A.	Cabazitaxel und dessen verwendung zur behandlung von krebs
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CN114080225A (zh)	2019-08-08	2022-02-22	来凯有限公司	治疗癌症的方法
EP3808345A1 (de)	2019-10-15	2021-04-21	Sanofi Mature IP	Cabazitaxel bei mcrc-patienten, die zuvor mit docetaxel behandelt wurden und bei denen ein vorheriger, auf androgensignalisierung abzielender inhibitor versagt hat
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1996
- 1996-03-08 MA MA24180A patent/MA23823A1/fr unknown
- 1996-03-19 PE PE1996000181A patent/PE51097A1/es not_active IP Right Cessation
- 1996-03-24 IL IL11763696A patent/IL117636A/en active Protection Beyond IP Right Term
- 1996-03-25 KR KR1019970706762A patent/KR100485309B1/ko not_active IP Right Cessation
- 1996-03-25 US US08/913,972 patent/US5889043A/en not_active Expired - Lifetime
- 1996-03-25 DE DE69606028T patent/DE69606028T2/de not_active Expired - Lifetime
- 1996-03-25 PL PL96322465A patent/PL188284B1/pl not_active IP Right Cessation
- 1996-03-25 SK SK1301-97A patent/SK281927B6/sk not_active IP Right Cessation
- 1996-03-25 WO PCT/FR1996/000440 patent/WO1996030355A1/fr active IP Right Grant
- 1996-03-25 EP EP96909193A patent/EP0817780B1/de not_active Expired - Lifetime
- 1996-03-25 TR TR97/01042T patent/TR199701042T1/xx unknown
- 1996-03-25 DK DK96909192T patent/DK0817779T3/da active
- 1996-03-25 AP APAP/P/1997/001090A patent/AP785A/en active
- 1996-03-25 ES ES96909192T patent/ES2143187T3/es not_active Expired - Lifetime
- 1996-03-25 HU HU9801204A patent/HU223732B1/hu active IP Right Grant
- 1996-03-25 DE DE69604653T patent/DE69604653T2/de not_active Expired - Lifetime
- 1996-03-25 AT AT96909193T patent/ATE185562T1/de active
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- 1996-03-25 CA CA002214319A patent/CA2214319C/fr not_active Expired - Lifetime
- 1996-03-25 AT AT96909192T patent/ATE188471T1/de active
- 1996-03-25 JP JP52899696A patent/JP3790826B2/ja not_active Expired - Fee Related
- 1996-03-25 EP EP96909192A patent/EP0817779B1/de not_active Expired - Lifetime
- 1996-03-25 EA EA199700269A patent/EA000567B1/ru not_active IP Right Cessation
- 1996-03-25 WO PCT/FR1996/000441 patent/WO1996030356A1/fr not_active Application Discontinuation
- 1996-03-25 CN CNB961928867A patent/CN1213042C/zh not_active Expired - Lifetime
- 1996-03-25 RO RO97-01794A patent/RO115878B1/ro unknown
- 1996-03-25 BR BR9607929A patent/BR9607929A/pt not_active IP Right Cessation
- 1996-03-25 CZ CZ19973030A patent/CZ287326B6/cs not_active IP Right Cessation
- 1996-03-25 KR KR1019970706691A patent/KR100297196B1/ko active Protection Beyond IP Right Term
- 1996-03-25 AP APAP/P/1997/001093A patent/AP753A/en active
- 1996-03-25 EE EE9700323A patent/EE03609B1/xx not_active IP Right Cessation
- 1996-03-25 TR TR97/01040T patent/TR199701040T1/xx unknown
- 1996-03-25 RO RO97-01793A patent/RO115877B1/ro unknown
- 1996-03-25 GE GEAP19963956A patent/GEP20002188B/en unknown
- 1996-03-25 AU AU52780/96A patent/AU711227B2/en not_active Expired
- 1996-03-25 JP JP8528995A patent/JP2941951B2/ja not_active Expired - Lifetime
- 1996-03-25 EA EA199700270A patent/EA000709B1/ru not_active IP Right Cessation
- 1996-03-25 PT PT96909192T patent/PT817779E/pt unknown
- 1996-03-25 CN CNB961928840A patent/CN1152870C/zh not_active Expired - Fee Related
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- 1996-03-25 CZ CZ19973032A patent/CZ287468B6/cs not_active IP Right Cessation
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- 1996-03-25 SK SK1302-97A patent/SK281928B6/sk not_active IP Right Cessation
- 1996-03-25 AU AU52781/96A patent/AU703278B2/en not_active Ceased
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- 1996-03-25 CA CA002214321A patent/CA2214321C/fr not_active Expired - Fee Related
- 1996-03-25 DK DK96909193T patent/DK0817780T3/da active
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- 1996-03-26 TN TNTNSN96043A patent/TNSN96043A1/fr unknown
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- 1996-03-26 TW TW085103611A patent/TW394765B/zh not_active IP Right Cessation
- 1996-03-26 ZA ZA962399A patent/ZA962399B/xx unknown
- 1996-03-26 DZ DZ960050A patent/DZ2009A1/fr active
- 1996-03-27 UY UY24192A patent/UY24192A1/es not_active IP Right Cessation
- 1996-03-27 AR AR33592996A patent/AR001440A1/es active IP Right Grant
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1997
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- 1997-09-26 OA OA70086A patent/OA10513A/fr unknown
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1998
- 1998-04-28 US US09/066,929 patent/US6331635B1/en not_active Expired - Lifetime
1999
- 1999-10-14 GR GR990402228T patent/GR3031526T3/el unknown
2000
- 2000-01-07 GR GR990402501T patent/GR3032316T3/el unknown
2001
- 2001-09-25 US US09/985,956 patent/US6387946B1/en not_active Expired - Lifetime
2007
- 2007-09-11 PL PL96322499A patent/PL188987B1/pl unknown

Also Published As

Publication number	Publication date
CA2214319C (fr)	2004-02-17
SK281927B6 (sk)	2001-09-11
NO316607B1 (no)	2004-03-08
PL322499A1 (en)	1998-02-02
NO973922D0 (no)	1997-08-26
EP0817779A1 (de)	1998-01-14
PL322465A1 (en)	1998-02-02
TNSN96043A1 (fr)	2005-03-15
KR19980703357A (ko)	1998-10-15
JPH11500141A (ja)	1999-01-06
CZ303097A3 (cs)	1998-01-14
BG101917A (en)	1998-10-30
RO115877B1 (ro)	2000-07-28
KR100297196B1 (ko)	2001-11-22
GEP20002211B (en)	2000-08-25
MX9706568A (es)	1997-11-29
KR100485309B1 (ko)	2005-10-12
ATE185562T1 (de)	1999-10-15
US20020038038A1 (en)	2002-03-28
WO1996030355A1 (fr)	1996-10-03
DE69604653D1 (de)	1999-11-18
NZ304900A (en)	1998-09-24
IS2058B (is)	2005-10-14
SK281928B6 (sk)	2001-09-11
DE69606028T2 (de)	2000-08-10
PL188284B1 (pl)	2005-01-31
ES2143187T3 (es)	2000-05-01
JPH11502531A (ja)	1999-03-02
DZ2009A1 (fr)	2002-10-23
BR9607930A (pt)	1998-06-02
NZ304901A (en)	1998-12-23
NO973922L (no)	1997-08-26
BG63009B1 (bg)	2001-01-31
MA23823A1 (fr)	1996-10-01
EE03608B1 (et)	2002-02-15
HUP9801204A1 (hu)	2000-05-28
HU223732B1 (hu)	2004-12-28
EP0817779B1 (de)	2000-01-05
WO1996030356A1 (fr)	1996-10-03
MY121225A (en)	2006-01-28
CZ303297A3 (cs)	1998-01-14
NO973923L (no)	1997-08-26
DK0817780T3 (da)	2000-03-27
DK0817779T3 (da)	2000-06-19
GR3031526T3 (en)	2000-01-31
IS4536A (is)	1997-07-31
CN1179775A (zh)	1998-04-22
IL117636A (en)	2004-08-31
CA2214319A1 (fr)	1996-10-03
CA2214321C (fr)	2008-01-22
OA10513A (fr)	2002-04-22
CN1213042C (zh)	2005-08-03
IS4567A (is)	1997-09-23
RO115878B1 (ro)	2000-07-28
EP0817780A1 (de)	1998-01-14
JP3790826B2 (ja)	2006-06-28
IL117636A0 (en)	1996-07-23
CN1152870C (zh)	2004-06-09
AU711227B2 (en)	1999-10-07
HUP9801204A3 (en)	2000-12-28
CN1179776A (zh)	1998-04-22
MX9706278A (es)	1997-10-31
CO4700576A1 (es)	1998-12-29
AP9701093A0 (en)	1997-10-31
AR001440A1 (es)	1997-10-22
SK130197A3 (en)	1998-04-08
HU223666B1 (hu)	2004-11-29
PT817779E (pt)	2000-04-28
EE03609B1 (et)	2002-02-15
CA2214321A1 (fr)	1996-10-03
TR199701040T1 (xx)	1998-01-21
US6331635B1 (en)	2001-12-18
ZA962399B (en)	1996-10-01
SK130297A3 (en)	1998-03-04
BG101918A (en)	1998-10-30
GR3032316T3 (en)	2000-04-27
GEP20002188B (en)	2000-07-25
KR19980703287A (ko)	1998-10-15
AP9701090A0 (en)	1997-10-31
HUP9801201A2 (hu)	2000-05-28
OA10514A (fr)	2002-04-22
BR9607929A (pt)	1998-06-02
AU5278096A (en)	1996-10-16
CZ287326B6 (en)	2000-10-11
EP0817780B1 (de)	1999-10-13
DE69606028D1 (de)	2000-02-10
AU5278196A (en)	1996-10-16
IS2056B (is)	2005-10-14
EA199700270A1 (ru)	1998-02-26
PL188987B1 (pl)	2005-05-31
UY24192A1 (es)	1996-06-14
HUP9801201A3 (en)	2000-12-28
BG63121B1 (bg)	2001-04-30
EA199700269A1 (ru)	1998-04-30
JP2941951B2 (ja)	1999-08-30
AU703278B2 (en)	1999-03-25
ATE188471T1 (de)	2000-01-15
NO316379B1 (no)	2004-01-19
NO973923D0 (no)	1997-08-26
TR199701042T1 (xx)	1998-01-21
EA000709B1 (ru)	2000-02-28
CZ287468B6 (en)	2000-12-13
EE9700323A (et)	1998-06-15
UY24370A1 (es)	2001-10-25
EA000567B1 (ru)	1999-12-29
TW394765B (en)	2000-06-21
AP753A (en)	1999-07-21
AP785A (en)	1999-11-26
US5889043A (en)	1999-03-30
US6387946B1 (en)	2002-05-14
PE51097A1 (es)	1997-12-22
EE9700315A (et)	1998-06-15
ES2140075T3 (es)	2000-02-16

Legal Events

Date	Code	Title	Description
2000-11-02	8364	No opposition during term of opposition
2002-05-29	8327	Change in the person/name/address of the patent owner	Owner name: AVENTIS PHARMA S.A., ANTONY, FR
2006-10-26	8328	Change in the person/name/address of the agent	Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN
2009-07-30	8328	Change in the person/name/address of the agent	Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

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