ATE288278T1 - Verfahren und zusammensetzungen zur peptidsynthese - Google Patents

Verfahren und zusammensetzungen zur peptidsynthese

Info

Publication number
ATE288278T1
ATE288278T1 AT00992116T AT00992116T ATE288278T1 AT E288278 T1 ATE288278 T1 AT E288278T1 AT 00992116 T AT00992116 T AT 00992116T AT 00992116 T AT00992116 T AT 00992116T AT E288278 T1 ATE288278 T1 AT E288278T1
Authority
AT
Austria
Prior art keywords
compositions
peptide synthesis
peptide
synthesis
Prior art date
Application number
AT00992116T
Other languages
English (en)
Inventor
Brian Bray
Marc Andersen
Paul E Friedrich
Myung-Chol Kang
Original Assignee
Trimeris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trimeris Inc filed Critical Trimeris Inc
Application granted granted Critical
Publication of ATE288278T1 publication Critical patent/ATE288278T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00992116T 1999-07-07 2000-07-05 Verfahren und zusammensetzungen zur peptidsynthese ATE288278T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/349,205 US6469136B1 (en) 1999-07-07 1999-07-07 Methods and composition for peptide synthesis
PCT/US2000/035725 WO2001034635A2 (en) 1999-07-07 2000-07-05 Methods and compositions for peptide synthesis

Publications (1)

Publication Number Publication Date
ATE288278T1 true ATE288278T1 (de) 2005-02-15

Family

ID=23371340

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00992116T ATE288278T1 (de) 1999-07-07 2000-07-05 Verfahren und zusammensetzungen zur peptidsynthese

Country Status (17)

Country Link
US (2) US6469136B1 (de)
EP (1) EP1372686B1 (de)
JP (1) JP2003530311A (de)
KR (1) KR100631874B1 (de)
CN (1) CN1267449C (de)
AR (1) AR024686A1 (de)
AT (1) ATE288278T1 (de)
AU (1) AU4133701A (de)
BR (1) BR0012249A (de)
CA (1) CA2378086A1 (de)
DE (1) DE60017955T2 (de)
DK (1) DK1372686T3 (de)
ES (1) ES2236043T3 (de)
MX (1) MXPA02000021A (de)
PT (1) PT1372686E (de)
TW (1) TWI237640B (de)
WO (1) WO2001034635A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6656906B1 (en) * 1998-05-20 2003-12-02 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
SK782002A3 (en) * 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
BR0312841A (pt) * 2002-07-24 2005-12-06 Hoffmann La Roche Polipeptìdeo t1249 peguilado
US20040158037A1 (en) * 2003-02-12 2004-08-12 Bohling James Charles Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith
AU2004200485A1 (en) * 2003-02-25 2004-09-09 Rohm And Haas Company Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
EP3552627A1 (de) * 2003-05-06 2019-10-16 Bioverativ Therapeutics Inc. Chimäre proteine mit gerinnungsfaktor fc zur behandlung von hämophilie
US7348004B2 (en) 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
ATE410437T1 (de) * 2003-12-31 2008-10-15 Hoffmann La Roche Verfahren und systeme zur rückgewinnung von peptiden
WO2005063800A2 (en) * 2003-12-31 2005-07-14 F. Hoffmann-La Roche Ag Peptide synthesis using decanting filter
WO2005063792A2 (en) * 2003-12-31 2005-07-14 F. Hoffmann-La Roche Ag Methods for recovering cleaved peptide from a support
ES2295961T3 (es) * 2003-12-31 2008-04-16 F. Hoffmann-La Roche Ag Proceso para la sintesis peptidica utilizacndo una cantidad reducida de agente de desproteccion.
WO2005063799A2 (en) * 2003-12-31 2005-07-14 F.Hoffmann-La Roche Ag Peptide synthesis and deprotection with co-solvent
CN101132812A (zh) * 2004-03-15 2008-02-27 阿拉巴马耐科塔医药公司 Hiv进入抑制剂的聚合物基组合物和结合物
WO2006069697A1 (en) * 2004-12-30 2006-07-06 F. Hoffmann-La Roche Ag Colorimetrically assessing peptide characteristics
EP1856142B1 (de) * 2004-12-30 2009-08-12 F. Hoffmann-Roche AG Synthese von peptid t-1249 mit peptidzwischenproduktfragmenten
WO2006069779A1 (en) * 2004-12-30 2006-07-06 F. Hoffmann-La Roche Ag Preparing of peptides with excellent solubility
EP1833843B1 (de) * 2004-12-30 2009-10-14 F. Hoffmann-La Roche Ag Synthese des peptides t-20 aus peptidfragmenten als zwischenprodukte
WO2006105199A2 (en) * 2005-03-30 2006-10-05 Trimeris, Inc. Compositions and methods for synthesis of peptide and related conjugate
TW200745163A (en) 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
AU2007248855A1 (en) 2006-05-03 2007-11-15 Mallinckrodt Inc. Composition and method for the release of protected peptides from a resin
CN101195653B (zh) * 2006-12-08 2010-05-12 吉尔生化（上海）有限公司 亮丙瑞林的固液合成法
EA201070231A1 (ru) * 2007-08-09 2010-10-29 Синтоникс Фармасьютикалз, Инк. Иммуномодулирующие пептиды
CA2700354A1 (en) * 2007-09-25 2009-04-02 Trimeris, Inc. Novel methods of synthesis for therapeutic antiviral peptides
JP5473925B2 (ja) * 2007-10-27 2014-04-16 コーデン ファーマ コロラド インコーポレイテッド 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成
EP2222695A2 (de) * 2007-12-11 2010-09-01 F. Hoffmann-La Roche AG Synthese eines insulinotropen peptids mithilfe von feststoff- und flüssigphasenkombinationsverfahren
US20100048488A1 (en) * 2008-08-01 2010-02-25 Syntonix Pharmaceuticals, Inc. Immunomodulatory peptides
EA201291482A1 (ru) 2010-07-09 2013-10-30 Байоджен Айдек Хемофилия Инк. Химерные факторы коагуляции
CN102268065A (zh) * 2011-06-23 2011-12-07 成都圣诺科技发展有限公司 氨基保护丝氨酸寡肽及其制备方法和用途
CN102603869B (zh) * 2012-03-27 2013-03-27 西安华澳丽康生物工程有限公司 六胜肽的合成方法
TWI788044B (zh) 2013-03-15 2022-12-21 美商百歐維拉提夫治療公司 因子ｉｘ多肽調配物
HUE034308T2 (en) 2013-03-21 2018-02-28 Sanofi Aventis Deutschland Preparation of hydantoin-containing peptide products
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
CN108572171A (zh) * 2017-03-10 2018-09-25 江苏金斯瑞生物科技有限公司 一种检测哌啶残留的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4010560B2 (ja) * 1992-07-20 2007-11-21 ドューク ユニバーシティー Ｈｉｖ複製を阻害する化合物
EP0945504A3 (de) 1992-12-11 1999-12-08 The University Of Florida Stoffe und verfahren zur Schädlingskontrolle
US6479055B1 (en) 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US5864027A (en) 1993-06-07 1999-01-26 Genentech, Inc. HIV envelope polypeptides
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
DE69926061T2 (de) * 1998-03-23 2006-06-01 Trimeris Inc. Verfahren und zusammensetzungen zur peptidsynthese (t-20)
US6258782B1 (en) * 1998-05-20 2001-07-10 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
US6217666B1 (en) 1998-08-31 2001-04-17 Danieli Technology, Inc. Countercurrent reduction of oxides on moving metal

Also Published As

Publication number Publication date
DK1372686T3 (da) 2005-05-30
ES2236043T3 (es) 2005-07-16
WO2001034635A9 (en) 2002-08-01
PT1372686E (pt) 2005-05-31
US6767993B2 (en) 2004-07-27
JP2003530311A (ja) 2003-10-14
CN1450906A (zh) 2003-10-22
KR20020038676A (ko) 2002-05-23
TWI237640B (en) 2005-08-11
WO2001034635A3 (en) 2003-10-16
WO2001034635A2 (en) 2001-05-17
MXPA02000021A (es) 2002-07-02
US6469136B1 (en) 2002-10-22
EP1372686A4 (de) 2004-01-02
BR0012249A (pt) 2003-11-11
DE60017955T2 (de) 2006-01-12
US20030125516A1 (en) 2003-07-03
EP1372686A2 (de) 2004-01-02
CN1267449C (zh) 2006-08-02
EP1372686B1 (de) 2005-02-02
AR024686A1 (es) 2002-10-23
KR100631874B1 (ko) 2006-10-09
CA2378086A1 (en) 2001-05-17
DE60017955D1 (de) 2005-03-10
AU4133701A (en) 2001-06-06

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