ATE261306T1 - Benzoxazin-derivate zur erhöhung der synaptischen reaktion - Google Patents

Benzoxazin-derivate zur erhöhung der synaptischen reaktion

Info

Publication number
ATE261306T1
ATE261306T1 AT98964112T AT98964112T ATE261306T1 AT E261306 T1 ATE261306 T1 AT E261306T1 AT 98964112 T AT98964112 T AT 98964112T AT 98964112 T AT98964112 T AT 98964112T AT E261306 T1 ATE261306 T1 AT E261306T1
Authority
AT
Austria
Prior art keywords
compounds
ampa receptors
disclosed
methods
benzoxazine derivatives
Prior art date
Application number
AT98964112T
Other languages
English (en)
Inventor
Gary A Rogers
Christopher Marrs
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE261306T1 publication Critical patent/ATE261306T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT98964112T 1997-12-24 1998-12-16 Benzoxazin-derivate zur erhöhung der synaptischen reaktion ATE261306T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/998,300 US5985871A (en) 1997-12-24 1997-12-24 Benzoxazine compounds for enhancing synaptic response
PCT/US1998/027027 WO1999033469A1 (en) 1997-12-24 1998-12-16 Benzoxazine compounds for enhancing synaptic response

Publications (1)

Publication Number Publication Date
ATE261306T1 true ATE261306T1 (de) 2004-03-15

Family

ID=25545024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98964112T ATE261306T1 (de) 1997-12-24 1998-12-16 Benzoxazin-derivate zur erhöhung der synaptischen reaktion

Country Status (22)

Country Link
US (1) US5985871A (de)
EP (1) EP1054673B1 (de)
JP (1) JP4620244B2 (de)
KR (1) KR100561049B1 (de)
CN (1) CN1160360C (de)
AT (1) ATE261306T1 (de)
AU (1) AU746971B2 (de)
BR (1) BR9814478A (de)
CA (1) CA2316356C (de)
DE (1) DE69822344T2 (de)
DK (1) DK1054673T3 (de)
ES (1) ES2217615T3 (de)
HU (1) HUP0102056A3 (de)
IL (1) IL136783A (de)
MX (1) MXPA00006155A (de)
NO (1) NO325764B1 (de)
NZ (1) NZ505212A (de)
PL (1) PL194905B1 (de)
PT (1) PT1054673E (de)
RU (1) RU2246497C2 (de)
TR (1) TR200001971T2 (de)
WO (1) WO1999033469A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110935A (en) 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
US6124278A (en) * 1998-04-03 2000-09-26 The Regents Of The University Of California Acylbenzoxazines for enhancing synaptic response
DE10004572A1 (de) * 2000-02-02 2001-08-09 Boehringer Ingelheim Pharma Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
TWI232863B (en) * 2001-06-11 2005-05-21 Akzo Nobel Nv Benzoxazepine derivatives
CN1255413C (zh) 2001-06-14 2006-05-10 阿克佐诺贝尔公司 作为ampa受体正性调节剂的(吡啶并/噻吩并)－[f]－氧杂吖庚因－5－酮衍生物
AU2004204814B2 (en) 2003-01-13 2009-10-08 Cortex Pharmaceuticals, Inc. Method of treating cognitive decline due to sleep deprivation and stress
US20060063707A1 (en) * 2004-09-17 2006-03-23 Lifelike Biomatic, Inc. Compositions for enhancing memory and methods therefor
JP2010514837A (ja) * 2007-01-03 2010-05-06 コーテックス ファーマシューティカルズ， インコーポレイテッド グルタミン酸作動性シナプス反応を強化するための３−置換−［１，２，３］ベンゾトリアジノン化合物
NZ578293A (en) * 2007-01-03 2012-01-12 Cortex Pharma Inc 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
ES2657054T3 (es) 2007-05-17 2018-03-01 Respirerx Pharmaceuticals Inc. Amidas disustituidas para mejorar las respuestas sinápticas glutamatérgicas
KR20100045507A (ko) 2007-08-10 2010-05-03 코텍스 파마슈티칼스, 인크. 글루타메이트성 시냅스 반응을 향상시키기 위한 비시클릭 아미드
US8168632B2 (en) 2007-08-10 2012-05-01 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for the treatment of respiratory disorders
WO2010054336A2 (en) * 2008-11-10 2010-05-14 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
EP2544688B1 (de) 2010-03-02 2016-09-07 President and Fellows of Harvard College Verfahren und zusammensetzungen zur behandlung des angelman-syndroms
US9700596B2 (en) 2011-03-04 2017-07-11 The Regents Of The University Of California Locally released growth factors to mediate motor recovery after stroke
HUE027509T2 (en) * 2011-04-06 2016-10-28 Taiho Pharmaceutical Co Ltd New imidazo-oxazine compounds or salts thereof
AU2014277952A1 (en) 2013-06-13 2016-01-28 Veroscience Llc Compositions and methods for treating metabolic disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1156043B1 (de) * 1992-07-24 2003-11-12 The Regents Of The University Of California Arzneimittel die den durch AMPA Rezeptoren vermittelten synaptischen Response erhöhen
JPH0943929A (ja) * 1995-05-19 1997-02-14 Matsushita Electric Ind Co Ltd 電子写真複写装置
US5650409A (en) * 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response

Also Published As

Publication number Publication date
PT1054673E (pt) 2004-08-31
IL136783A0 (en) 2001-06-14
NO20003166D0 (no) 2000-06-19
AU746971B2 (en) 2002-05-09
NO20003166L (no) 2000-08-07
US5985871A (en) 1999-11-16
PL194905B1 (pl) 2007-07-31
JP4620244B2 (ja) 2011-01-26
AU1930599A (en) 1999-07-19
PL341427A1 (en) 2001-04-09
MXPA00006155A (es) 2002-04-24
DE69822344D1 (de) 2004-04-15
CN1160360C (zh) 2004-08-04
HUP0102056A3 (en) 2003-03-28
BR9814478A (pt) 2000-10-10
DE69822344T2 (de) 2005-02-17
EP1054673A1 (de) 2000-11-29
KR20010033615A (ko) 2001-04-25
WO1999033469A1 (en) 1999-07-08
CA2316356A1 (en) 1999-07-08
NO325764B1 (no) 2008-07-14
EP1054673A4 (de) 2001-07-18
JP2001527045A (ja) 2001-12-25
TR200001971T2 (tr) 2001-01-22
DK1054673T3 (da) 2004-07-05
HUP0102056A2 (hu) 2001-11-28
NZ505212A (en) 2003-02-28
IL136783A (en) 2005-11-20
EP1054673B1 (de) 2004-03-10
KR100561049B1 (ko) 2006-03-16
ES2217615T3 (es) 2004-11-01
CA2316356C (en) 2009-11-03
CN1283114A (zh) 2001-02-07
RU2246497C2 (ru) 2005-02-20

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