PT1054673E - Compostos de benzoxazina para melhorar a resposta sinaptica - Google Patents

Compostos de benzoxazina para melhorar a resposta sinaptica

Info

Publication number
PT1054673E
PT1054673E PT98964112T PT98964112T PT1054673E PT 1054673 E PT1054673 E PT 1054673E PT 98964112 T PT98964112 T PT 98964112T PT 98964112 T PT98964112 T PT 98964112T PT 1054673 E PT1054673 E PT 1054673E
Authority
PT
Portugal
Prior art keywords
compounds
ampa receptors
improve
disclosed
methods
Prior art date
Application number
PT98964112T
Other languages
English (en)
Inventor
Gary A Rogers
Christopher Marrs
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of PT1054673E publication Critical patent/PT1054673E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT98964112T 1997-12-24 1998-12-16 Compostos de benzoxazina para melhorar a resposta sinaptica PT1054673E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/998,300 US5985871A (en) 1997-12-24 1997-12-24 Benzoxazine compounds for enhancing synaptic response

Publications (1)

Publication Number Publication Date
PT1054673E true PT1054673E (pt) 2004-08-31

Family

ID=25545024

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98964112T PT1054673E (pt) 1997-12-24 1998-12-16 Compostos de benzoxazina para melhorar a resposta sinaptica

Country Status (22)

Country Link
US (1) US5985871A (pt)
EP (1) EP1054673B1 (pt)
JP (1) JP4620244B2 (pt)
KR (1) KR100561049B1 (pt)
CN (1) CN1160360C (pt)
AT (1) ATE261306T1 (pt)
AU (1) AU746971B2 (pt)
BR (1) BR9814478A (pt)
CA (1) CA2316356C (pt)
DE (1) DE69822344T2 (pt)
DK (1) DK1054673T3 (pt)
ES (1) ES2217615T3 (pt)
HU (1) HUP0102056A3 (pt)
IL (1) IL136783A (pt)
MX (1) MXPA00006155A (pt)
NO (1) NO325764B1 (pt)
NZ (1) NZ505212A (pt)
PL (1) PL194905B1 (pt)
PT (1) PT1054673E (pt)
RU (1) RU2246497C2 (pt)
TR (1) TR200001971T2 (pt)
WO (1) WO1999033469A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110935A (en) 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
US6124278A (en) * 1998-04-03 2000-09-26 The Regents Of The University Of California Acylbenzoxazines for enhancing synaptic response
DE10004572A1 (de) * 2000-02-02 2001-08-09 Boehringer Ingelheim Pharma Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
TWI232863B (en) * 2001-06-11 2005-05-21 Akzo Nobel Nv Benzoxazepine derivatives
NZ529671A (en) 2001-06-14 2005-10-28 Akzo Nobel Nv (Pyrido/thieno)-[f]-oxazepin-5-one derivatives
EA200501117A1 (ru) 2003-01-13 2006-02-24 Кортекс Фармасеутикалс, Инк. Способ лечения снижения когнитивной способности вследствие лишения сна и стресса
WO2006034196A1 (en) * 2004-09-17 2006-03-30 Lifelike Biomatic Inc. Compositions for enhancing memory and methods therefor
PL2144506T3 (pl) * 2007-01-03 2012-04-30 Servier Lab 3-podstawiony-[1,2,3]-benzotriazynon jako związek do wzmacniania odpowiedzi glutaminianergicznych
EA200900937A1 (ru) * 2007-01-03 2009-12-30 Кортекс Фармасеутикалс, Инк. Соединения 3-замещенного-[1,2,3]бензотриазинона для усиления глутаматергических синаптических ответов
KR101599661B1 (ko) 2007-05-17 2016-03-03 코텍스 파마슈티칼스, 인크. 글루타메이트에 의한 시냅스 반응을 향상시키기 위한 이치환된 아미드 화합물
US8119632B2 (en) 2007-08-10 2012-02-21 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
BRPI0823262A2 (pt) 2007-08-10 2013-09-24 Cortex Pharma Inc mÉtodo de tratamento de depressço respiratària e uso de um composto na fabricaÇço de um medicamento para o tratamento de depressço respiratària
US20110218190A1 (en) * 2008-11-10 2011-09-08 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
WO2011109398A2 (en) 2010-03-02 2011-09-09 President And Fellows Of Harvard College Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
AU2012225784B2 (en) 2011-03-04 2016-03-17 The Regents Of The University Of California Locally released growth factors to mediate motor recovery after stroke
SG193327A1 (en) * 2011-04-06 2013-10-30 Taiho Pharmaceutical Co Ltd Novel imidazo-oxazine compound or salt thereof
AU2014277952A1 (en) 2013-06-13 2016-01-28 Veroscience Llc Compositions and methods for treating metabolic disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ255097A (en) * 1992-07-24 2001-04-27 Univ California Heterocyclic derivatives (such as 1-(1,4-bgenzodioxan-5-ylcarbonyl)-1,2,3,6-tetrahydropyridine) and medicaments that enhance synaptic responses
JPH0943929A (ja) * 1995-05-19 1997-02-14 Matsushita Electric Ind Co Ltd 電子写真複写装置
US5650409A (en) * 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response

Also Published As

Publication number Publication date
KR20010033615A (ko) 2001-04-25
BR9814478A (pt) 2000-10-10
TR200001971T2 (tr) 2001-01-22
WO1999033469A1 (en) 1999-07-08
MXPA00006155A (es) 2002-04-24
CA2316356A1 (en) 1999-07-08
RU2246497C2 (ru) 2005-02-20
CN1283114A (zh) 2001-02-07
JP4620244B2 (ja) 2011-01-26
ES2217615T3 (es) 2004-11-01
NZ505212A (en) 2003-02-28
CN1160360C (zh) 2004-08-04
DE69822344T2 (de) 2005-02-17
NO20003166D0 (no) 2000-06-19
ATE261306T1 (de) 2004-03-15
EP1054673A1 (en) 2000-11-29
CA2316356C (en) 2009-11-03
PL341427A1 (en) 2001-04-09
HUP0102056A3 (en) 2003-03-28
DK1054673T3 (da) 2004-07-05
IL136783A (en) 2005-11-20
NO325764B1 (no) 2008-07-14
EP1054673A4 (en) 2001-07-18
PL194905B1 (pl) 2007-07-31
EP1054673B1 (en) 2004-03-10
NO20003166L (no) 2000-08-07
US5985871A (en) 1999-11-16
KR100561049B1 (ko) 2006-03-16
IL136783A0 (en) 2001-06-14
AU746971B2 (en) 2002-05-09
DE69822344D1 (de) 2004-04-15
JP2001527045A (ja) 2001-12-25
AU1930599A (en) 1999-07-19
HUP0102056A2 (hu) 2001-11-28

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