PT839134E - Benzoilpiperidinas/pirrolidinas para melhoramento da resposta sinaptica - Google Patents
Benzoilpiperidinas/pirrolidinas para melhoramento da resposta sinapticaInfo
- Publication number
- PT839134E PT839134E PT96916599T PT96916599T PT839134E PT 839134 E PT839134 E PT 839134E PT 96916599 T PT96916599 T PT 96916599T PT 96916599 T PT96916599 T PT 96916599T PT 839134 E PT839134 E PT 839134E
- Authority
- PT
- Portugal
- Prior art keywords
- improving
- compounds
- pyrrolidines
- subjects
- ampa receptors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/458,967 US5650409A (en) | 1995-06-02 | 1995-06-02 | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
Publications (1)
Publication Number | Publication Date |
---|---|
PT839134E true PT839134E (pt) | 2004-07-30 |
Family
ID=23822840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT96916599T PT839134E (pt) | 1995-06-02 | 1996-05-23 | Benzoilpiperidinas/pirrolidinas para melhoramento da resposta sinaptica |
Country Status (13)
Country | Link |
---|---|
US (2) | US5650409A (pt) |
EP (1) | EP0839134B1 (pt) |
JP (1) | JP3464800B2 (pt) |
KR (2) | KR100621499B1 (pt) |
AT (1) | ATE259788T1 (pt) |
AU (1) | AU708715B2 (pt) |
CA (1) | CA2222976C (pt) |
DE (1) | DE69631588T2 (pt) |
DK (1) | DK0839134T3 (pt) |
ES (1) | ES2216048T3 (pt) |
PL (1) | PL187895B1 (pt) |
PT (1) | PT839134E (pt) |
WO (1) | WO1996038414A1 (pt) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU721936B2 (en) * | 1996-04-03 | 2000-07-20 | Regents Of The University Of California, The | Benzoxazines for enhancing synaptic response |
US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
EP0918518A4 (en) * | 1996-04-19 | 2002-05-02 | Univ California | TREATMENT OF MIND AND MOOD DISEASES WITH GLUTAMATERGIC MODULATORS. |
AU4416197A (en) * | 1996-09-17 | 1998-04-14 | Regents Of The University Of California, The | Positive ampa receptor modulation to enhance brain neurotrophic factor expression |
US6110935A (en) * | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
US6329368B1 (en) | 1997-05-09 | 2001-12-11 | The Regents Of The University Of California | Endocrine modulation with positive modulators of AMPA type glutamate receptors |
DE69833451T2 (de) * | 1997-10-27 | 2006-09-28 | The Regents Of The University Of California, Oakland | Behandlung der schizophrenie mit ampakinen und neuroleptika |
US5985871A (en) * | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
US6943159B1 (en) | 1998-02-18 | 2005-09-13 | Neurosearch A/S | Compounds and their use as positive AMPA receptor modulators |
US6124278A (en) * | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
TWI232863B (en) * | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
CN1255413C (zh) * | 2001-06-14 | 2006-05-10 | 阿克佐诺贝尔公司 | 作为ampa受体正性调节剂的(吡啶并/噻吩并)-[f]-氧杂吖庚因-5-酮衍生物 |
US7799913B2 (en) * | 2001-11-26 | 2010-09-21 | Cortex Pharmaceuticals, Inc. | Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses |
AU2004204814B2 (en) | 2003-01-13 | 2009-10-08 | Cortex Pharmaceuticals, Inc. | Method of treating cognitive decline due to sleep deprivation and stress |
US20060063707A1 (en) * | 2004-09-17 | 2006-03-23 | Lifelike Biomatic, Inc. | Compositions for enhancing memory and methods therefor |
TW200800959A (en) | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
NZ578293A (en) * | 2007-01-03 | 2012-01-12 | Cortex Pharma Inc | 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses |
JP2010514837A (ja) * | 2007-01-03 | 2010-05-06 | コーテックス ファーマシューティカルズ, インコーポレイテッド | グルタミン酸作動性シナプス反応を強化するための3−置換−[1,2,3]ベンゾトリアジノン化合物 |
TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
WO2008116141A1 (en) * | 2007-03-21 | 2008-09-25 | Emisphere Technologies, Inc. | Allylqxy and alkyloxy benzoic acid delivery agents |
ES2657054T3 (es) * | 2007-05-17 | 2018-03-01 | Respirerx Pharmaceuticals Inc. | Amidas disustituidas para mejorar las respuestas sinápticas glutamatérgicas |
US8168632B2 (en) | 2007-08-10 | 2012-05-01 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for the treatment of respiratory disorders |
KR20100045507A (ko) | 2007-08-10 | 2010-05-03 | 코텍스 파마슈티칼스, 인크. | 글루타메이트성 시냅스 반응을 향상시키기 위한 비시클릭 아미드 |
WO2010054336A2 (en) * | 2008-11-10 | 2010-05-14 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
EP2544688B1 (en) | 2010-03-02 | 2016-09-07 | President and Fellows of Harvard College | Methods and compositions for treatment of angelman syndrome |
US9700596B2 (en) | 2011-03-04 | 2017-07-11 | The Regents Of The University Of California | Locally released growth factors to mediate motor recovery after stroke |
EP2948135B1 (en) | 2013-01-25 | 2019-01-02 | Case Western Reserve University | Compositions and methods for the treatment of pervasive development disorders |
AU2014277952A1 (en) | 2013-06-13 | 2016-01-28 | Veroscience Llc | Compositions and methods for treating metabolic disorders |
GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
US20180339985A1 (en) | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
GB201514928D0 (en) | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3406177A (en) * | 1965-05-12 | 1968-10-15 | Johnson & Son Inc S C | N-(meta-toluyl)-methylpiperidines |
US3463855A (en) * | 1965-05-12 | 1969-08-26 | Johnson & Son Inc S C | Insect repellent compositions of n-(meta-toluyl)-methyl piperidines |
JPH01207284A (ja) * | 1987-10-06 | 1989-08-21 | Takeda Chem Ind Ltd | アミド化合物 |
EP1156043B1 (en) * | 1992-07-24 | 2003-11-12 | The Regents Of The University Of California | Drugs that enhance synaptic responses mediated by ampa receptors |
-
1995
- 1995-06-02 US US08/458,967 patent/US5650409A/en not_active Expired - Fee Related
-
1996
- 1996-05-23 JP JP53656896A patent/JP3464800B2/ja not_active Expired - Fee Related
- 1996-05-23 KR KR1020037016547A patent/KR100621499B1/ko not_active IP Right Cessation
- 1996-05-23 DE DE69631588T patent/DE69631588T2/de not_active Expired - Lifetime
- 1996-05-23 ES ES96916599T patent/ES2216048T3/es not_active Expired - Lifetime
- 1996-05-23 AU AU59293/96A patent/AU708715B2/en not_active Ceased
- 1996-05-23 PT PT96916599T patent/PT839134E/pt unknown
- 1996-05-23 AT AT96916599T patent/ATE259788T1/de active
- 1996-05-23 EP EP96916599A patent/EP0839134B1/en not_active Expired - Lifetime
- 1996-05-23 PL PL96323667A patent/PL187895B1/pl not_active IP Right Cessation
- 1996-05-23 DK DK96916599T patent/DK0839134T3/da active
- 1996-05-23 WO PCT/US1996/007607 patent/WO1996038414A1/en active IP Right Grant
- 1996-05-23 CA CA002222976A patent/CA2222976C/en not_active Expired - Fee Related
- 1996-05-23 KR KR1019970708728A patent/KR100444539B1/ko not_active IP Right Cessation
-
1997
- 1997-03-21 US US08/822,027 patent/US5783587A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR100444539B1 (ko) | 2004-10-14 |
KR20040004716A (ko) | 2004-01-13 |
CA2222976A1 (en) | 1996-12-05 |
US5783587A (en) | 1998-07-21 |
AU5929396A (en) | 1996-12-18 |
WO1996038414A1 (en) | 1996-12-05 |
US5650409A (en) | 1997-07-22 |
DK0839134T3 (da) | 2004-08-16 |
KR19990022249A (ko) | 1999-03-25 |
JP2001503012A (ja) | 2001-03-06 |
PL323667A1 (en) | 1998-04-14 |
ATE259788T1 (de) | 2004-03-15 |
KR100621499B1 (ko) | 2006-09-14 |
AU708715B2 (en) | 1999-08-12 |
CA2222976C (en) | 2001-04-24 |
PL187895B1 (pl) | 2004-10-29 |
DE69631588T2 (de) | 2004-12-16 |
DE69631588D1 (de) | 2004-03-25 |
EP0839134A1 (en) | 1998-05-06 |
ES2216048T3 (es) | 2004-10-16 |
JP3464800B2 (ja) | 2003-11-10 |
EP0839134B1 (en) | 2004-02-18 |
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