TR200001971T2 - Nevronların birleşmesinde karşılığı geliştirmek için benzoksazin bileşikler. - Google Patents
Nevronların birleşmesinde karşılığı geliştirmek için benzoksazin bileşikler.Info
- Publication number
- TR200001971T2 TR200001971T2 TR2000/01971T TR200001971T TR200001971T2 TR 200001971 T2 TR200001971 T2 TR 200001971T2 TR 2000/01971 T TR2000/01971 T TR 2000/01971T TR 200001971 T TR200001971 T TR 200001971T TR 200001971 T2 TR200001971 T2 TR 200001971T2
- Authority
- TR
- Turkey
- Prior art keywords
- neurons
- compounds
- association
- improve
- improve response
- Prior art date
Links
- 210000002569 neuron Anatomy 0.000 title abstract 3
- 150000005130 benzoxazines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000003678 AMPA Receptors Human genes 0.000 abstract 2
- 108090000078 AMPA Receptors Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 abstract 1
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical group C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000036992 cognitive tasks Effects 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000003340 mental effect Effects 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
AMPA alicilari tarafindan yayilan nevronlarin birlesmesitik karsililari gelistirmek için kullanisli, belirli bir benzoksazin halka sistemine sahip bilesikler ve bunlarin habercileri açiklanmaktadir. Ayrica bu tür bilesikleri hazirlamak için yöntemler ve bunlarin harekete geçirici nevronlarin birlesmelerinin sayisindaki veya AMPA alicilarinin sayisindaki eksiklikler yüzünden zarar verici sinirsel veya zihinsel islemeden sikinti çeken öznelerin tedavisinde kullanimi için yöntemler açiklanmaktadir. Bulusun bilesikleri, AMPA alicilarini kullanan betin sebekelerine bagli duyumsal-motor ve bilissel islerdeki performansini gelistirmek için zarar görmemis öznelerin tedavisi ve hafiza kodlamasini gelistirmek için de kullanilabilmektedir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/998,300 US5985871A (en) | 1997-12-24 | 1997-12-24 | Benzoxazine compounds for enhancing synaptic response |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200001971T2 true TR200001971T2 (tr) | 2001-01-22 |
Family
ID=25545024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/01971T TR200001971T2 (tr) | 1997-12-24 | 1998-12-16 | Nevronların birleşmesinde karşılığı geliştirmek için benzoksazin bileşikler. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5985871A (tr) |
EP (1) | EP1054673B1 (tr) |
JP (1) | JP4620244B2 (tr) |
KR (1) | KR100561049B1 (tr) |
CN (1) | CN1160360C (tr) |
AT (1) | ATE261306T1 (tr) |
AU (1) | AU746971B2 (tr) |
BR (1) | BR9814478A (tr) |
CA (1) | CA2316356C (tr) |
DE (1) | DE69822344T2 (tr) |
DK (1) | DK1054673T3 (tr) |
ES (1) | ES2217615T3 (tr) |
HU (1) | HUP0102056A3 (tr) |
IL (1) | IL136783A (tr) |
MX (1) | MXPA00006155A (tr) |
NO (1) | NO325764B1 (tr) |
NZ (1) | NZ505212A (tr) |
PL (1) | PL194905B1 (tr) |
PT (1) | PT1054673E (tr) |
RU (1) | RU2246497C2 (tr) |
TR (1) | TR200001971T2 (tr) |
WO (1) | WO1999033469A1 (tr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6110935A (en) | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
US6124278A (en) * | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
DE10004572A1 (de) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
TWI232863B (en) * | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
NZ529671A (en) | 2001-06-14 | 2005-10-28 | Akzo Nobel Nv | (Pyrido/thieno)-[f]-oxazepin-5-one derivatives |
EA200501117A1 (ru) | 2003-01-13 | 2006-02-24 | Кортекс Фармасеутикалс, Инк. | Способ лечения снижения когнитивной способности вследствие лишения сна и стресса |
WO2006034196A1 (en) * | 2004-09-17 | 2006-03-30 | Lifelike Biomatic Inc. | Compositions for enhancing memory and methods therefor |
PL2144506T3 (pl) * | 2007-01-03 | 2012-04-30 | Servier Lab | 3-podstawiony-[1,2,3]-benzotriazynon jako związek do wzmacniania odpowiedzi glutaminianergicznych |
EA200900937A1 (ru) * | 2007-01-03 | 2009-12-30 | Кортекс Фармасеутикалс, Инк. | Соединения 3-замещенного-[1,2,3]бензотриазинона для усиления глутаматергических синаптических ответов |
KR101599661B1 (ko) | 2007-05-17 | 2016-03-03 | 코텍스 파마슈티칼스, 인크. | 글루타메이트에 의한 시냅스 반응을 향상시키기 위한 이치환된 아미드 화합물 |
US8119632B2 (en) | 2007-08-10 | 2012-02-21 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
BRPI0823262A2 (pt) | 2007-08-10 | 2013-09-24 | Cortex Pharma Inc | mÉtodo de tratamento de depressço respiratària e uso de um composto na fabricaÇço de um medicamento para o tratamento de depressço respiratària |
US20110218190A1 (en) * | 2008-11-10 | 2011-09-08 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
WO2011109398A2 (en) | 2010-03-02 | 2011-09-09 | President And Fellows Of Harvard College | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
AU2012225784B2 (en) | 2011-03-04 | 2016-03-17 | The Regents Of The University Of California | Locally released growth factors to mediate motor recovery after stroke |
SG193327A1 (en) * | 2011-04-06 | 2013-10-30 | Taiho Pharmaceutical Co Ltd | Novel imidazo-oxazine compound or salt thereof |
AU2014277952A1 (en) | 2013-06-13 | 2016-01-28 | Veroscience Llc | Compositions and methods for treating metabolic disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ255097A (en) * | 1992-07-24 | 2001-04-27 | Univ California | Heterocyclic derivatives (such as 1-(1,4-bgenzodioxan-5-ylcarbonyl)-1,2,3,6-tetrahydropyridine) and medicaments that enhance synaptic responses |
JPH0943929A (ja) * | 1995-05-19 | 1997-02-14 | Matsushita Electric Ind Co Ltd | 電子写真複写装置 |
US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
-
1997
- 1997-12-24 US US08/998,300 patent/US5985871A/en not_active Expired - Fee Related
-
1998
- 1998-12-16 HU HU0102056A patent/HUP0102056A3/hu unknown
- 1998-12-16 KR KR1020007007128A patent/KR100561049B1/ko not_active IP Right Cessation
- 1998-12-16 PL PL341427A patent/PL194905B1/pl not_active IP Right Cessation
- 1998-12-16 PT PT98964112T patent/PT1054673E/pt unknown
- 1998-12-16 EP EP98964112A patent/EP1054673B1/en not_active Expired - Lifetime
- 1998-12-16 IL IL13678398A patent/IL136783A/xx not_active IP Right Cessation
- 1998-12-16 BR BR9814478-2A patent/BR9814478A/pt not_active Application Discontinuation
- 1998-12-16 AU AU19305/99A patent/AU746971B2/en not_active Ceased
- 1998-12-16 RU RU2000119735/04A patent/RU2246497C2/ru not_active IP Right Cessation
- 1998-12-16 CN CNB988125390A patent/CN1160360C/zh not_active Expired - Fee Related
- 1998-12-16 AT AT98964112T patent/ATE261306T1/de active
- 1998-12-16 WO PCT/US1998/027027 patent/WO1999033469A1/en not_active Application Discontinuation
- 1998-12-16 JP JP2000526226A patent/JP4620244B2/ja not_active Expired - Fee Related
- 1998-12-16 DK DK98964112T patent/DK1054673T3/da active
- 1998-12-16 ES ES98964112T patent/ES2217615T3/es not_active Expired - Lifetime
- 1998-12-16 TR TR2000/01971T patent/TR200001971T2/tr unknown
- 1998-12-16 CA CA002316356A patent/CA2316356C/en not_active Expired - Fee Related
- 1998-12-16 MX MXPA00006155A patent/MXPA00006155A/es not_active IP Right Cessation
- 1998-12-16 DE DE69822344T patent/DE69822344T2/de not_active Expired - Lifetime
-
2000
- 2000-06-16 NZ NZ505212A patent/NZ505212A/xx unknown
- 2000-06-19 NO NO20003166A patent/NO325764B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20010033615A (ko) | 2001-04-25 |
BR9814478A (pt) | 2000-10-10 |
WO1999033469A1 (en) | 1999-07-08 |
MXPA00006155A (es) | 2002-04-24 |
CA2316356A1 (en) | 1999-07-08 |
RU2246497C2 (ru) | 2005-02-20 |
CN1283114A (zh) | 2001-02-07 |
JP4620244B2 (ja) | 2011-01-26 |
ES2217615T3 (es) | 2004-11-01 |
NZ505212A (en) | 2003-02-28 |
CN1160360C (zh) | 2004-08-04 |
DE69822344T2 (de) | 2005-02-17 |
NO20003166D0 (no) | 2000-06-19 |
ATE261306T1 (de) | 2004-03-15 |
EP1054673A1 (en) | 2000-11-29 |
CA2316356C (en) | 2009-11-03 |
PL341427A1 (en) | 2001-04-09 |
HUP0102056A3 (en) | 2003-03-28 |
DK1054673T3 (da) | 2004-07-05 |
IL136783A (en) | 2005-11-20 |
NO325764B1 (no) | 2008-07-14 |
EP1054673A4 (en) | 2001-07-18 |
PL194905B1 (pl) | 2007-07-31 |
EP1054673B1 (en) | 2004-03-10 |
NO20003166L (no) | 2000-08-07 |
US5985871A (en) | 1999-11-16 |
PT1054673E (pt) | 2004-08-31 |
KR100561049B1 (ko) | 2006-03-16 |
IL136783A0 (en) | 2001-06-14 |
AU746971B2 (en) | 2002-05-09 |
DE69822344D1 (de) | 2004-04-15 |
JP2001527045A (ja) | 2001-12-25 |
AU1930599A (en) | 1999-07-19 |
HUP0102056A2 (hu) | 2001-11-28 |
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