ATE258444T1 - Therapeutische chemokine rezeptor antagonisten - Google Patents
Therapeutische chemokine rezeptor antagonistenInfo
- Publication number
- ATE258444T1 ATE258444T1 AT99908703T AT99908703T ATE258444T1 AT E258444 T1 ATE258444 T1 AT E258444T1 AT 99908703 T AT99908703 T AT 99908703T AT 99908703 T AT99908703 T AT 99908703T AT E258444 T1 ATE258444 T1 AT E258444T1
- Authority
- AT
- Austria
- Prior art keywords
- therapeutic
- treatment
- pharmacologically acceptable
- cxcr4
- provides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002226391A CA2226391A1 (en) | 1998-03-13 | 1998-03-13 | N-terminal peptides of sdf-1 have functional activities mediated by cxcr4 |
CA002245224A CA2245224A1 (en) | 1998-08-14 | 1998-08-14 | Chemokine receptor antagonists and chemotherapeutics |
PCT/CA1999/000221 WO1999047158A2 (en) | 1998-03-13 | 1999-03-12 | Therapeutic chemokine receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE258444T1 true ATE258444T1 (de) | 2004-02-15 |
Family
ID=25679974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99908703T ATE258444T1 (de) | 1998-03-13 | 1999-03-12 | Therapeutische chemokine rezeptor antagonisten |
Country Status (7)
Country | Link |
---|---|
US (2) | US6946445B1 (de) |
EP (1) | EP1061944B1 (de) |
JP (2) | JP2002506830A (de) |
AT (1) | ATE258444T1 (de) |
AU (1) | AU762472B2 (de) |
DE (1) | DE69914463T2 (de) |
WO (1) | WO1999047158A2 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6506770B1 (en) | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
CA2245224A1 (en) * | 1998-08-14 | 2000-02-14 | Jiang-Hong Giong | Chemokine receptor antagonists and chemotherapeutics |
JP2002506830A (ja) * | 1998-03-13 | 2002-03-05 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | 治療的ケモカイン受容体アンタゴニスト |
CA2305787A1 (en) | 2000-05-09 | 2001-11-09 | The University Of British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
US20080318855A1 (en) * | 1998-03-13 | 2008-12-25 | Chemokine Corporation | Dna encoding for recombinant polypeptide emutants of human stromal cell-derived factor 1 |
US6863887B1 (en) | 1998-03-30 | 2005-03-08 | Northwest Biotherapeutics, Inc. | Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis |
DE1068357T1 (de) | 1998-03-30 | 2001-07-19 | Northwest Biotherapeutics Inc | Therapeutische und diagnostische anwendungen welche auf der rolle von cxcr-4 in der tumorgenese basieren |
US20030215421A1 (en) * | 1999-07-21 | 2003-11-20 | Mcdonald John R. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
US6949243B1 (en) * | 1999-11-24 | 2005-09-27 | Schering Corporation | Methods of inhibiting metastasis |
US20050059584A1 (en) | 2002-08-16 | 2005-03-17 | Ahmed Merzouk | Novel chemokine mimetics synthesis and their use |
US7368425B2 (en) | 2006-03-24 | 2008-05-06 | Chemokine Therapeutics Corp. | Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis |
US7378098B2 (en) | 2000-04-12 | 2008-05-27 | The University Of British Columbia | CXC chemokine receptor 4 agonist peptides |
CA2335109A1 (en) * | 2000-04-12 | 2001-10-12 | Chemokine Therapeutics Corporation | Cxcr4 agonist treatment of hematopoietic cells |
US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
WO2002020561A1 (fr) | 2000-09-05 | 2002-03-14 | Seikagaku Corporation | Nouveaux polypeptides et medicaments anti-vih contenant lesdits polypeptides |
WO2002022657A2 (en) * | 2000-09-12 | 2002-03-21 | University Of British Columbia | Peptide antagonist of multiple chemokine receptors and uses thereof |
US7871619B2 (en) * | 2001-11-30 | 2011-01-18 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
US7253007B2 (en) | 2001-11-30 | 2007-08-07 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
WO2003094950A2 (en) | 2002-05-10 | 2003-11-20 | Ipf Pharmaceuticals Gmbh | A method of inhibiting the emigration of cells from the intravascular compartment into tissues |
JP4781621B2 (ja) * | 2002-08-27 | 2011-09-28 | バイオカイン セラピューティックス リミテッド | Cxcr4拮抗薬およびその用途 |
EP2426139B1 (de) | 2002-08-27 | 2014-10-01 | Biokine Therapeutics Ltd. | CXCR4-Antagonisten und Verwendung davon |
DE10240064A1 (de) * | 2002-08-30 | 2004-03-11 | Universitätsklinikum Freiburg | CXCR4-Rezeptor-Antagonisten |
CA2522703A1 (en) * | 2003-04-16 | 2004-11-04 | Genebact Biotechnologies, Inc. | Prophylactic and therapeutic benefits of new class of immune stimulating peptides |
WO2004094465A2 (en) * | 2003-04-23 | 2004-11-04 | The Board Of Trustees Of The University Of Illinois Office Of Technology Management University Of Illinois At Urbana-Champaign | Synthetic molecules that mimic chemokines |
US20050214287A1 (en) * | 2004-02-03 | 2005-09-29 | Chemocentryx, Inc. | Methods and compositions for modulating angiogenesis |
CA2593612A1 (en) | 2005-01-07 | 2006-07-13 | Emory University | Cxcr4 antagonists for the treatment of hiv infection |
CA2649253A1 (en) | 2005-05-25 | 2006-11-30 | Hadasit Medical Research Services & Development Ltd. | Cxcr4 antagonists for wound healing and re-epithelialization |
JP2009513689A (ja) * | 2005-10-31 | 2009-04-02 | ラボラトワール セローノ ソシエテ アノニム | 神経学的疾患の治療、及び/又は予防のためのsdf−1の使用 |
EP2397148A3 (de) | 2006-02-02 | 2012-04-25 | Allergan, Inc. | Zusammensetzungen und Verfahren zur Behandlung von Augenerkrankungen |
JP2009526861A (ja) * | 2006-02-14 | 2009-07-23 | ゲイシンガー クリニック | 血管新生標的としてのgpcr |
WO2008008854A2 (en) | 2006-07-11 | 2008-01-17 | Emory University | Cxcr4 antagonists including diazine and triazine structures for the treatment of medical disorders |
US7696309B2 (en) * | 2006-10-23 | 2010-04-13 | The Brigham And Women's Hospital, Inc. | Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
WO2008075370A2 (en) * | 2006-12-21 | 2008-06-26 | Biokine Therapeutics Ltd. | T-140 peptide analogs having cxcr4 super-agonist activity for cancer therapy |
WO2008096359A2 (en) * | 2007-02-08 | 2008-08-14 | Rappaport Family Institute For Research In The Medical Sciences | Agents for the treatment of multiple sclerosis and methods of using same |
WO2008109076A1 (en) * | 2007-03-02 | 2008-09-12 | Oxigene, Inc. | Methods for enhancing the efficacy of vascular disrupting agents |
GB0716897D0 (en) * | 2007-08-30 | 2007-10-10 | Univ Muenchen Tech | Cancer imaging and treatment |
EP2237798A2 (de) | 2007-12-12 | 2010-10-13 | Imperial Innovations Limited | Verfahren |
US8338448B2 (en) | 2008-03-28 | 2012-12-25 | Altiris Therapeutics, Inc. | Chemokine receptor modulators |
US9427456B2 (en) | 2009-06-14 | 2016-08-30 | Biokine Therapeutics Ltd. | Peptide therapy for increasing platelet levels |
WO2011083141A2 (en) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Method for generation of immunoglobulin sequences by using lipoprotein particles |
WO2011106234A1 (en) | 2010-02-25 | 2011-09-01 | Provasculon, Inc. | Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
JP5522072B2 (ja) | 2010-03-04 | 2014-06-18 | 株式会社デンソー | 車両用通信装置および車両用通信システム |
WO2012095849A1 (en) | 2011-01-10 | 2012-07-19 | Biokine Therapeutics Ltd. | Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma |
JP2014513727A (ja) | 2011-05-16 | 2014-06-05 | ジェンザイム・コーポレーション | Cxcr4拮抗薬の使用 |
US10662234B2 (en) | 2011-06-07 | 2020-05-26 | Mesoblast International Sàrl | Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1 |
EP2841084B1 (de) | 2012-04-24 | 2018-05-30 | Biokine Therapeutics Ltd. | Cxcr4 antagonist peptid zur verwendung in der behandlung von lungenkrebs |
PL224854B1 (pl) * | 2013-08-23 | 2017-02-28 | Univ Warszawski | Nowy peptydomimetyk o aktywności antyangiogennej i zawierająca go kompozycja farmaceutyczna |
US20160206592A1 (en) | 2013-08-30 | 2016-07-21 | Ramot At Tel-Aviv University Ltd. | Method for treating amyotrophic lateral sclerosis by inhibition of cxcr4/cxcl12 signaling |
JP2017506259A (ja) | 2014-02-03 | 2017-03-02 | イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム・リミテッドYissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | 幹細胞を枯渇させるためのカゼインキナーゼi阻害剤の使用 |
KR20160132031A (ko) * | 2014-02-19 | 2016-11-16 | 마이크로콘스탄스 차이나 아이엔씨 | 케모카인 수용체 대항물질 및 그것의 병용 요법 |
CA2986705A1 (en) | 2015-07-16 | 2017-01-19 | Biokine Therapeutics Ltd. | A cxcr4 inhibitor and a pdi antagonist for use in treating cancer |
JP6676182B2 (ja) | 2016-02-23 | 2020-04-08 | バイオラインアールエックス・リミテッドBioLineRx Ltd. | 急性骨髄性白血病の治療方法 |
US20190175557A1 (en) * | 2016-06-16 | 2019-06-13 | Centre National De La Recherche Scientifique | Compounds useful for decreasing interferon level |
TWI734027B (zh) | 2017-09-18 | 2021-07-21 | 泰宗生物科技股份有限公司 | 用於治療癌症之組合物 |
CN108009443A (zh) * | 2017-11-30 | 2018-05-08 | 广州天鹏计算机科技有限公司 | 数据的访问方法和*** |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2760992A (en) | 1956-08-28 | Naphthalene | ||
US2530369A (en) | 1948-01-29 | 1950-11-21 | Phillips Petroleum Co | Oxidation of aromatic compounds |
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
DE3681787D1 (de) | 1985-07-05 | 1991-11-07 | Whitehead Biomedical Inst | Expression von fremdem genetischem material in epithelzellen. |
US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
EP0378576B1 (de) | 1987-09-11 | 1995-01-18 | Whitehead Institute For Biomedical Research | Transduktionsveränderte fibroblasten und ihre anwendung |
US4890286A (en) * | 1987-12-11 | 1989-12-26 | Sanyo Electric Co., Ltd. | Method and apparatus for decoding error correcting code |
ATE110108T1 (de) | 1987-12-11 | 1994-09-15 | Whitehead Biomedical Inst | Genetische modifizierung von endothelialen zellen. |
JP2917998B2 (ja) | 1988-02-05 | 1999-07-12 | ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ | 修飾された肝細胞およびその用途 |
US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
DK0494268T4 (da) | 1989-09-25 | 1999-11-08 | Genetics Inst | Fremgangsmåde til inhibering af stamcellers vækst |
US5350836A (en) | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
JP3249516B2 (ja) | 1990-10-31 | 2002-01-21 | ソマティクス セラピー コーポレイション | 遺伝子治療のためのレトロウイルスのベクター |
US5401651A (en) | 1991-10-16 | 1995-03-28 | Walz; Alfred | DNA encoding ENA-78, a neutrophil activating factor |
DE69228127T2 (de) | 1991-11-15 | 1999-09-02 | Univ California | Therapie des zentralnervensystems mit genetisch modifizierten zellen |
EP0627003A1 (de) | 1991-12-23 | 1994-12-07 | British Bio-Technology Limited | Stammzellen hemmende proteine |
AU694111B2 (en) | 1993-03-31 | 1998-07-16 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
EP0802800B1 (de) | 1993-08-12 | 2002-06-12 | Neurotech S.A. | Biokompatible immunoisolatorische Kapseln, die genetisch veränderte Zellen enthalten |
JPH09505465A (ja) | 1993-09-28 | 1997-06-03 | ザ ジェネラル ホスピタル コーポレイション | 神経増殖を調整し、β/A4アミロイド誘発形態を逆転させる為のアンチセンスオリゴヌクレオチドの使用 |
CA2117953C (en) | 1993-10-14 | 2001-12-11 | Tasuku Honjo | Human stromal derived factor 1 alpha and 1 beta and dnas encoding the same |
ATE347594T1 (de) | 1994-01-13 | 2006-12-15 | Univ California | Monocyten protein rezeptoren aus säugern, mit chemoattraktion auslösender wirkung |
ATE216425T1 (de) | 1994-08-13 | 2002-05-15 | Roche Diagnostics Gmbh | Verwendung von interferon-gamma zur vermeidung der proliferation und differenzierung der primitiven hämapoietischen vorläuferzellen |
US5990163A (en) | 1995-01-13 | 1999-11-23 | The Salk Institute For Biological Studies | Selective modulation of processes mediated by retinoid X receptors, and compounds useful therefor |
US6221361B1 (en) | 1995-01-19 | 2001-04-24 | Syntro Corporation | Recombinant swinepox virus |
US5871723A (en) | 1995-06-06 | 1999-02-16 | The Regent Of The University Of Michigan | CXC chemokines as regulators of angiogenesis |
US5767078A (en) * | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
JPH09206071A (ja) | 1996-01-29 | 1997-08-12 | Novo Nordisk As | バクテリア由来の酸化酵素 |
EP0854918A1 (de) * | 1996-01-30 | 1998-07-29 | The National Institutes of Health | Zellen, die sowohl menschliches cd4 als auch cxcr4 exprimieren |
EP0912505A4 (de) | 1996-06-27 | 2001-10-24 | Smithkline Beecham Corp | Il-8 rezeptor-antagonisten |
US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
FR2751658B1 (fr) | 1996-07-26 | 1998-10-02 | Pasteur Institut | Utilisation d'une chemokine (sdf-1) ligand pour le recepteur de lestr/fusin/cxcr4 pour prevenir ou traiter l'infection par des virus de type vih |
AR008290A1 (es) | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios. |
AU4251197A (en) * | 1996-09-06 | 1998-03-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Therapeutic chemokine antagonists |
US5962462A (en) | 1996-12-13 | 1999-10-05 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
US5919776A (en) | 1996-12-20 | 1999-07-06 | Merck & Co., Inc. | Substituted aminoquinolines as modulators of chemokine receptor activity |
US6124319A (en) | 1997-01-21 | 2000-09-26 | Merck & Co., Inc. | 3,3-disubstituted piperidines as modulators of chemokine receptor activity |
IT1291353B1 (it) * | 1997-05-12 | 1999-01-07 | San Raffaele Centro Fond | Peptidi con attivita' antivirale |
US6136827A (en) | 1997-07-25 | 2000-10-24 | Merck & Co., Inc. | Cyclic amine modulations of chemokine receptor activity |
US6166037A (en) | 1997-08-28 | 2000-12-26 | Merck & Co., Inc. | Pyrrolidine and piperidine modulators of chemokine receptor activity |
US6013644A (en) | 1997-12-12 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
US6140349A (en) | 1998-02-02 | 2000-10-31 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
WO2000009152A1 (en) | 1998-08-14 | 2000-02-24 | The University Of British Columbia | Therapeutic chemokine receptor antagonists |
JP2002506830A (ja) | 1998-03-13 | 2002-03-05 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | 治療的ケモカイン受容体アンタゴニスト |
CA2245224A1 (en) | 1998-08-14 | 2000-02-14 | Jiang-Hong Giong | Chemokine receptor antagonists and chemotherapeutics |
CA2305787A1 (en) * | 2000-05-09 | 2001-11-09 | The University Of British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
WO2000059928A1 (en) * | 1999-04-07 | 2000-10-12 | Thomas Jefferson University | Chemokine-derived synthetic peptides |
WO2000066112A1 (en) | 1999-05-03 | 2000-11-09 | Smithkline Beecham Corporation | Cxcr-4 receptor antagonists - thrombopoietin mimetics |
US6356887B1 (en) | 1999-06-28 | 2002-03-12 | Microsoft Corporation | Auto-parameterization of database queries |
US20050059584A1 (en) | 2002-08-16 | 2005-03-17 | Ahmed Merzouk | Novel chemokine mimetics synthesis and their use |
US7378098B2 (en) | 2000-04-12 | 2008-05-27 | The University Of British Columbia | CXC chemokine receptor 4 agonist peptides |
CA2335109A1 (en) | 2000-04-12 | 2001-10-12 | Chemokine Therapeutics Corporation | Cxcr4 agonist treatment of hematopoietic cells |
US7091310B2 (en) | 2002-09-13 | 2006-08-15 | Chemokine Therapeutics Corporation | Chemokine analogs for the treatment of human disease |
JP2003532683A (ja) | 2000-05-09 | 2003-11-05 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | 造血細胞のcxcr4アンタゴニスト治療 |
US6639134B2 (en) * | 2000-10-03 | 2003-10-28 | Eric T. Schmidt | High flow stringed instrument sound hole |
US20030202963A1 (en) * | 2000-10-12 | 2003-10-30 | Cornell Research Foundation, Inc. | Method of treating cancer |
US6515001B2 (en) | 2001-03-05 | 2003-02-04 | Chemokine Therapeutic Corporation | IL-8 receptor ligands-drugs for inflammatory and autoimmune diseases |
US20030004136A1 (en) | 2001-03-05 | 2003-01-02 | Geeta Saxena | IL-8 receptor ligands-drugs for inflammatory and autoimmune diseases |
US6693134B2 (en) | 2001-05-29 | 2004-02-17 | Chemokine Therapeutics Corporation | Bicyclic aromatic chemokine receptor ligands |
US20030092674A1 (en) | 2001-06-14 | 2003-05-15 | Geeta Saxena | Tricyclic rantes receptor ligands |
US6831101B2 (en) | 2001-06-14 | 2004-12-14 | Chemokine Therapeutics Corporation | Tricyclic rantes receptor ligands |
-
1999
- 1999-03-12 JP JP2000536397A patent/JP2002506830A/ja active Pending
- 1999-03-12 US US09/646,192 patent/US6946445B1/en not_active Expired - Fee Related
- 1999-03-12 AT AT99908703T patent/ATE258444T1/de not_active IP Right Cessation
- 1999-03-12 DE DE69914463T patent/DE69914463T2/de not_active Expired - Lifetime
- 1999-03-12 WO PCT/CA1999/000221 patent/WO1999047158A2/en active IP Right Grant
- 1999-03-12 AU AU28216/99A patent/AU762472B2/en not_active Ceased
- 1999-03-12 EP EP99908703A patent/EP1061944B1/de not_active Expired - Lifetime
-
2005
- 2005-05-23 US US11/136,097 patent/US7423011B2/en not_active Expired - Fee Related
-
2009
- 2009-10-21 JP JP2009242544A patent/JP2010047598A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE69914463D1 (en) | 2004-03-04 |
US7423011B2 (en) | 2008-09-09 |
AU762472B2 (en) | 2003-06-26 |
WO1999047158A3 (en) | 1999-11-25 |
AU2821699A (en) | 1999-10-11 |
JP2010047598A (ja) | 2010-03-04 |
EP1061944B1 (de) | 2004-01-28 |
WO1999047158A2 (en) | 1999-09-23 |
EP1061944A2 (de) | 2000-12-27 |
JP2002506830A (ja) | 2002-03-05 |
DE69914463T2 (de) | 2004-11-11 |
US20050265969A1 (en) | 2005-12-01 |
US6946445B1 (en) | 2005-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE258444T1 (de) | Therapeutische chemokine rezeptor antagonisten | |
CY1118849T1 (el) | Θεραπεια συνδυασμου για τη θεραπευτικη αγωγη διαταραχων ανεπαρκειας πρωτεϊνης | |
RU2008116931A (ru) | Применение n-десметилклозапина для лечения нейропсихиатрических заболеваний у людей | |
RU2010101892A (ru) | Гиалуронидаза и способ ее применения | |
CO4950524A1 (es) | Inhibidores de acido nitrico sintasa | |
NO975334D0 (no) | Anvendelse av flavanolignaner for fremstilling av medikamenter med antiproliferativ aktivitet i uterus, ovarium og bryst | |
HUP0300027A2 (en) | Nucleoside analogs with carboxamidine modified monocyclic base and process for their use | |
SE0100568D0 (sv) | Compounds | |
WO1997049373A3 (en) | Treatment and prevention of hiv infection by administration of derivatives of human chorionic gonadotropin | |
IL147852A0 (en) | Chemokine receptor antagonists and pharmaceutical compositions containing the same | |
JP2002523370A5 (de) | ||
CA2444821A1 (en) | Combination therapy using anti-angiogenic agents and tnfa | |
KR920004418A (ko) | 브래디키닌 길항제 | |
MY139203A (en) | Pharmaceutical composition | |
JPH06505483A (ja) | サイトカイン阻害剤 | |
JP2007119497A (ja) | インターフェロン−ガンマスティミュレーター含有医薬組成物 | |
SE0100566D0 (sv) | Compounds | |
WO1992003145A1 (en) | Method of treating viral infection | |
CA2501738A1 (en) | Method of treating chronic pelvic pain syndrome by administration of chrorionic gonadotropin | |
EP0999840B1 (de) | Verwendung von einem draflazin analog zur schmerzbehandlung | |
MY106603A (en) | Treatment of genital warts with a combination of liquid nitrogen and recombinant dna human alpha interferon | |
EA200200801A1 (ru) | Применение фолликулостимулирующего гормона (fsh) для лечения бесплодия | |
MY143571A (en) | Eplerenone crystalline form | |
JP2004536834A5 (de) | ||
RU2003100517A (ru) | Новый интерферон для лечения рассеянного склероза |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |