ATE256670T1 - Isoxazolcarboxamid-derivate als antagonisten des alpha1-adrenergischen rezeptors - Google Patents

Isoxazolcarboxamid-derivate als antagonisten des alpha1-adrenergischen rezeptors

Info

Publication number
ATE256670T1
ATE256670T1 AT00992436T AT00992436T ATE256670T1 AT E256670 T1 ATE256670 T1 AT E256670T1 AT 00992436 T AT00992436 T AT 00992436T AT 00992436 T AT00992436 T AT 00992436T AT E256670 T1 ATE256670 T1 AT E256670T1
Authority
AT
Austria
Prior art keywords
antagonists
adrenergic receptor
carboxamide derivatives
isoxazole carboxamide
alpha1 adrenergic
Prior art date
Application number
AT00992436T
Other languages
English (en)
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Elena Poggesi
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Application granted granted Critical
Publication of ATE256670T1 publication Critical patent/ATE256670T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT00992436T 1999-10-18 2000-10-16 Isoxazolcarboxamid-derivate als antagonisten des alpha1-adrenergischen rezeptors ATE256670T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI002173A IT1314191B1 (it) 1999-10-18 1999-10-18 Derivati isossazolcarbossamidici
PCT/EP2000/010144 WO2001029015A2 (en) 1999-10-18 2000-10-16 Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists

Publications (1)

Publication Number Publication Date
ATE256670T1 true ATE256670T1 (de) 2004-01-15

Family

ID=11383797

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00992436T ATE256670T1 (de) 1999-10-18 2000-10-16 Isoxazolcarboxamid-derivate als antagonisten des alpha1-adrenergischen rezeptors

Country Status (25)

Country Link
EP (1) EP1226131B1 (de)
JP (1) JP2003512362A (de)
KR (1) KR20020038944A (de)
CN (1) CN1139579C (de)
AR (1) AR029400A1 (de)
AT (1) ATE256670T1 (de)
AU (1) AU757614B2 (de)
BR (1) BR0014851A (de)
CA (1) CA2385472A1 (de)
DE (1) DE60007347T2 (de)
DK (1) DK1226131T3 (de)
ES (1) ES2210033T3 (de)
HK (1) HK1044940A1 (de)
HU (1) HUP0203184A3 (de)
IL (1) IL148837A0 (de)
IT (1) IT1314191B1 (de)
MX (1) MXPA02003432A (de)
MY (1) MY120400A (de)
NO (1) NO20021803L (de)
NZ (1) NZ517884A (de)
PL (1) PL356990A1 (de)
PT (1) PT1226131E (de)
RU (1) RU2002113096A (de)
WO (1) WO2001029015A2 (de)
ZA (1) ZA200203942B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0617306A2 (pt) 2005-10-11 2011-07-19 Hoffmann La Roche derivados de isoxazol
CN101304994B (zh) 2005-11-09 2011-06-29 弗·哈夫曼-拉罗切有限公司 3-芳基-异噁唑-4-羰基-苯并呋喃衍生物
AU2006328602B2 (en) 2005-12-23 2012-05-31 F. Hoffmann-La Roche Ag Aryl-isoxazolo-4-yl-oxadiazole derivatives
RU2425045C2 (ru) 2005-12-27 2011-07-27 Ф. Хоффманн-Ля Рош Аг Производные арил-изоксазол-4-ил-имидазола
CN101370807B (zh) 2006-01-17 2011-08-31 弗·哈夫曼-拉罗切有限公司 可用于经由gaba受体治疗阿尔茨海默病的芳基-异唑-4-基-咪唑并[1,2-a]吡啶
MX2008014796A (es) 2006-05-31 2008-12-02 Hoffmann La Roche Derivados de aril-4-etinil-isoxazol.
MX2009014001A (es) 2007-06-22 2010-01-28 Hoffmann La Roche Derivados de isoxazol-imidazol.
US7902201B2 (en) 2007-12-04 2011-03-08 Hoffmann-La Roche Inc. Isoxazolo-pyrazine derivatives
US7943619B2 (en) 2007-12-04 2011-05-17 Hoffmann-La Roche Inc. Isoxazolo-pyridazine derivatives
JP5301556B2 (ja) 2007-12-04 2013-09-25 エフ．ホフマン−ラ ロシュ アーゲー イソオキサゾロ−ピラジン誘導体
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
TW201033201A (en) 2009-02-19 2010-09-16 Hoffmann La Roche Isoxazole-isoxazole and isoxazole-isothiazole derivatives
US8389550B2 (en) 2009-02-25 2013-03-05 Hoffmann-La Roche Inc. Isoxazoles / O-pyridines with ethyl and ethenyl linker
US8222246B2 (en) 2009-04-02 2012-07-17 Hoffmann-La Roche Inc. Substituted isoxazoles
US8227461B2 (en) 2009-04-30 2012-07-24 Hoffmann-La Roche Inc. Isoxazoles
MX2011011477A (es) 2009-05-05 2011-11-18 Hoffmann La Roche Derivados de isoxazol-piridazina.
SG175869A1 (en) 2009-05-05 2011-12-29 Hoffmann La Roche Isoxazole-thiazole derivatives as gaba a receptor inverse agonists for use in the treatment of cognitive disorders
MX2011011489A (es) 2009-05-05 2011-11-18 Hoffmann La Roche Derivados de isoxazol-piridina.
MX2011011273A (es) 2009-05-05 2011-11-04 Hoffmann La Roche Derivados de isoxazol-pirazol.
SG175318A1 (en) 2009-05-07 2011-11-28 Hoffmann La Roche Isoxazole-pyridine derivatives as gaba modulators
US8785435B2 (en) 2011-10-20 2014-07-22 Hoffmann-La Roche Inc. Solid forms
CN113121540B (zh) * 2020-01-15 2024-01-26 鲁南制药集团股份有限公司 一种西格列汀游离碱的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
IT1266582B1 (it) * 1993-07-30 1997-01-09 Recordati Chem Pharm Derivati (di)azacicloesanici e diazacicloeptanici
DE4425146A1 (de) * 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen

Also Published As

Publication number Publication date
BR0014851A (pt) 2002-06-11
WO2001029015A2 (en) 2001-04-26
NO20021803L (no) 2002-06-17
CN1139579C (zh) 2004-02-25
CN1379767A (zh) 2002-11-13
HUP0203184A3 (en) 2004-12-28
PL356990A1 (en) 2004-07-12
EP1226131B1 (de) 2003-12-17
ZA200203942B (en) 2003-01-02
DK1226131T3 (da) 2004-04-19
EP1226131A2 (de) 2002-07-31
AU2834701A (en) 2001-04-30
HUP0203184A2 (hu) 2003-01-28
MY120400A (en) 2005-10-31
IT1314191B1 (it) 2002-12-06
DE60007347T2 (de) 2004-09-02
NO20021803D0 (no) 2002-04-17
NZ517884A (en) 2003-08-29
DE60007347D1 (de) 2004-01-29
KR20020038944A (ko) 2002-05-24
AR029400A1 (es) 2003-06-25
MXPA02003432A (es) 2002-08-20
ITMI992173A0 (it) 1999-10-18
HK1044940A1 (zh) 2002-11-08
IL148837A0 (en) 2002-09-12
PT1226131E (pt) 2004-05-31
RU2002113096A (ru) 2003-11-10
ES2210033T3 (es) 2004-07-01
WO2001029015A3 (en) 2001-11-01
AU757614B2 (en) 2003-02-27
CA2385472A1 (en) 2001-04-26
ITMI992173A1 (it) 2001-04-18
JP2003512362A (ja) 2003-04-02

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