ATE243693T1 - Substituierte bisindolylmaleimide zur inhibierung der zellproliferation - Google Patents

Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Info

Publication number: ATE243693T1
Authority: AT; Austria
Prior art keywords: bisindolylmaleimide; substituted; cell proliferation; inhibit cell; inhibit
Prior art date: 1998-03-17

Application number

AT99915558T

Other languages

English (en)

Inventor

Urvashi Hooda Dhingra

Donna Mary Huryn

June Ke

Giuseppe Federico Weber

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-17

Filing date

1999-03-10

Publication date

2003-07-15

1999-03-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-07-15 Application granted granted Critical

2003-07-15 Publication of ATE243693T1 publication Critical patent/ATE243693T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

AT99915558T 1998-03-17 1999-03-10 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation ATE243693T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7833198P	1998-03-17	1998-03-17
PCT/EP1999/001534 WO1999047518A1 (en)	1998-03-17	1999-03-10	Substituted bisindolymaleimides for the inhibition of cell proliferation

Publications (1)

Publication Number	Publication Date
ATE243693T1 true ATE243693T1 (de)	2003-07-15

Family

ID=22143350

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99915558T ATE243693T1 (de)	1998-03-17	1999-03-10	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Country Status (34)

Country	Link
US (1)	US6048887A (de)
EP (1)	EP1064279B1 (de)
JP (2)	JP5026633B2 (de)
KR (1)	KR100659411B1 (de)
CN (1)	CN1127500C (de)
AR (1)	AR018162A1 (de)
AT (1)	ATE243693T1 (de)
AU (1)	AU755673B2 (de)
BR (1)	BR9908882A (de)
CA (1)	CA2322689C (de)
CO (1)	CO5070675A1 (de)
CZ (1)	CZ299068B6 (de)
DE (1)	DE69909068T2 (de)
DK (1)	DK1064279T3 (de)
ES (1)	ES2203111T3 (de)
HK (1)	HK1036452A1 (de)
HR (1)	HRP20000585B1 (de)
HU (1)	HU228831B1 (de)
ID (1)	ID26353A (de)
IL (1)	IL138247A (de)
MA (1)	MA26613A1 (de)
MY (1)	MY121046A (de)
NO (1)	NO320306B1 (de)
NZ (1)	NZ506476A (de)
PE (1)	PE20000340A1 (de)
PL (1)	PL195323B1 (de)
PT (1)	PT1064279E (de)
RS (1)	RS49965B (de)
RU (1)	RU2208612C2 (de)
SA (1)	SA99191295B1 (de)
TR (1)	TR200002580T2 (de)
TW (1)	TW539676B (de)
WO (1)	WO1999047518A1 (de)
ZA (1)	ZA992072B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RS49965B (sr) *	1998-03-17	2008-09-29	F.Hoffmann-La Roche Ag.,	Supstituisani bisindolmaleimidi za inhibiciju ćelijske proliferacije
US6350786B1 (en) *	1998-09-22	2002-02-26	Hoffmann-La Roche Inc.	Stable complexes of poorly soluble compounds in ionic polymers
DE60006990T2 (de) *	1999-10-12	2004-10-28	F. Hoffmann-La Roche Ag	Pyrrolderivate mit antiproliferativer wirkung geeignet für die behandlung von krebs
US6559164B1 (en)	1999-10-12	2003-05-06	Hoffmann-La Roche Inc.	Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) *	1999-12-16	2001-11-06	Hoffmann-La Roche Inc.	Substituted pyrroles
US6281356B1 (en) *	1999-12-22	2001-08-28	Hoffmann-La Roche Inc.	Substituted pyrroles
US6326501B1 (en) *	2000-04-19	2001-12-04	Hoffmann-La Roche Inc.	Methylation of indole compounds using dimethyl carbonate
US7129250B2 (en) *	2000-05-19	2006-10-31	Aegera Therapeutics Inc.	Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) *	2000-05-19	2001-11-19	Aegera Therapeutics Inc.	Neuroprotective compounds
US6482847B2 (en)	2000-10-03	2002-11-19	Hoffmann-La Roche Inc.	Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6469179B1 (en)	2000-10-03	2002-10-22	Hoffmann-La Roche Inc.	Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6548531B2 (en)	2001-02-09	2003-04-15	Hoffmann-La Roche Inc.	Method for cancer therapy
WO2002102373A1 (en) *	2001-06-15	2002-12-27	F. Hoffmann-La Roche Ag	Method for administration of cancer therapeutic
US20030139373A1 (en) *	2001-11-20	2003-07-24	Breimer Lars Holger	Method for cancer therapy
WO2008117935A1 (en) *	2007-03-28	2008-10-02	Industry-Academic Cooperation Foundation, Yonsei University	Nk cell activating molecules, nk cells and pharmaceutical compositons comprising the same
CN102924437B (zh) *	2012-11-19	2014-07-02	东华大学	3-哌嗪基-4-吲哚马来酰亚胺化合物及其制备和应用
WO2019000224A1 (zh) *	2017-06-27	2019-01-03	中国海洋大学	双吲哚马来酰亚胺衍生物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK75289A3 (en) *	1988-02-10	1998-05-06	Hoffmann La Roche	Substituted pyrroles, their use for producing a drug, and the drug on their base
US5380746A (en) *	1989-05-05	1995-01-10	Goedecke Aktiengesellschaft	Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
AU1339895A (en) *	1993-12-23	1995-07-10	Eli Lilly And Company	Protein kinase c inhibitors
PE91598A1 (es) *	1996-07-29	1998-12-24	Hoffmann La Roche	Pirroles sustituidos
PE91698A1 (es) *	1996-07-29	1998-12-24	Hoffmann La Roche	Pirroles sustituidos
PE91498A1 (es) *	1996-07-29	1998-12-22	Hoffmann La Roche	Pirroles sustituidos
RS49965B (sr) *	1998-03-17	2008-09-29	F.Hoffmann-La Roche Ag.,	Supstituisani bisindolmaleimidi za inhibiciju ćelijske proliferacije

1999
- 1999-03-10 RS YUP-552/00A patent/RS49965B/sr unknown
- 1999-03-10 RU RU2000125889/04A patent/RU2208612C2/ru active
- 1999-03-10 PT PT99915558T patent/PT1064279E/pt unknown
- 1999-03-10 ID IDW20001730A patent/ID26353A/id unknown
- 1999-03-10 HU HU0101258A patent/HU228831B1/hu unknown
- 1999-03-10 AU AU34099/99A patent/AU755673B2/en not_active Expired
- 1999-03-10 TR TR2000/02580T patent/TR200002580T2/xx unknown
- 1999-03-10 AT AT99915558T patent/ATE243693T1/de active
- 1999-03-10 CZ CZ20003384A patent/CZ299068B6/cs not_active IP Right Cessation
- 1999-03-10 CA CA002322689A patent/CA2322689C/en not_active Expired - Lifetime
- 1999-03-10 CN CN99804045A patent/CN1127500C/zh not_active Expired - Lifetime
- 1999-03-10 NZ NZ506476A patent/NZ506476A/en not_active IP Right Cessation
- 1999-03-10 ES ES99915558T patent/ES2203111T3/es not_active Expired - Lifetime
- 1999-03-10 PL PL342964A patent/PL195323B1/pl unknown
- 1999-03-10 WO PCT/EP1999/001534 patent/WO1999047518A1/en active IP Right Grant
- 1999-03-10 IL IL13824799A patent/IL138247A/xx not_active IP Right Cessation
- 1999-03-10 EP EP99915558A patent/EP1064279B1/de not_active Expired - Lifetime
- 1999-03-10 DK DK99915558T patent/DK1064279T3/da active
- 1999-03-10 KR KR1020007010323A patent/KR100659411B1/ko not_active IP Right Cessation
- 1999-03-10 JP JP2000536713A patent/JP5026633B2/ja not_active Expired - Lifetime
- 1999-03-10 DE DE69909068T patent/DE69909068T2/de not_active Expired - Lifetime
- 1999-03-10 BR BR9908882-7A patent/BR9908882A/pt not_active Application Discontinuation
- 1999-03-12 PE PE1999000199A patent/PE20000340A1/es not_active IP Right Cessation
- 1999-03-12 MA MA25492A patent/MA26613A1/fr unknown
- 1999-03-15 ZA ZA9902072A patent/ZA992072B/xx unknown
- 1999-03-15 AR ARP990101117A patent/AR018162A1/es active IP Right Grant
- 1999-03-15 CO CO99015752A patent/CO5070675A1/es unknown
- 1999-03-15 TW TW088103914A patent/TW539676B/zh not_active IP Right Cessation
- 1999-03-15 MY MYPI99000952A patent/MY121046A/en unknown
- 1999-03-16 US US09/268,887 patent/US6048887A/en not_active Expired - Lifetime
- 1999-04-13 SA SA99191295A patent/SA99191295B1/ar unknown
2000
- 2000-09-06 HR HR20000585A patent/HRP20000585B1/xx not_active IP Right Cessation
- 2000-09-14 NO NO20004579A patent/NO320306B1/no not_active IP Right Cessation
2001
- 2001-10-15 HK HK01107189A patent/HK1036452A1/xx not_active IP Right Cessation
2010
- 2010-06-02 JP JP2010126632A patent/JP2010222366A/ja active Pending

Also Published As

Publication number	Publication date
PL195323B1 (pl)	2007-09-28
NO20004579D0 (no)	2000-09-14
AU3409999A (en)	1999-10-11
JP5026633B2 (ja)	2012-09-12
IL138247A0 (en)	2001-10-31
RS49965B (sr)	2008-09-29
CA2322689C (en)	2008-11-25
IL138247A (en)	2005-08-31
PL342964A1 (en)	2001-07-16
SA99191295B1 (ar)	2006-04-26
DE69909068T2 (de)	2004-05-06
NZ506476A (en)	2003-12-19
HU228831B1 (en)	2013-05-28
DE69909068D1 (de)	2003-07-31
HUP0101258A2 (hu)	2001-10-28
BR9908882A (pt)	2000-11-21
HRP20000585A2 (en)	2001-08-31
AR018162A1 (es)	2001-10-31
JP2002506864A (ja)	2002-03-05
AU755673B2 (en)	2002-12-19
MA26613A1 (fr)	2004-12-20
MY121046A (en)	2005-12-30
HK1036452A1 (en)	2002-01-04
ZA992072B (en)	1999-09-22
CN1293671A (zh)	2001-05-02
CZ299068B6 (cs)	2008-04-16
CZ20003384A3 (cs)	2000-12-13
CO5070675A1 (es)	2001-08-28
ES2203111T3 (es)	2004-04-01
CN1127500C (zh)	2003-11-12
US6048887A (en)	2000-04-11
HUP0101258A3 (en)	2002-08-28
ID26353A (id)	2000-12-14
DK1064279T3 (da)	2003-10-06
TW539676B (en)	2003-07-01
NO320306B1 (no)	2005-11-21
HRP20000585B1 (en)	2009-02-28
EP1064279A1 (de)	2001-01-03
EP1064279B1 (de)	2003-06-25
NO20004579L (no)	2000-09-14
PE20000340A1 (es)	2000-05-13
WO1999047518A1 (en)	1999-09-23
PT1064279E (pt)	2003-10-31
TR200002580T2 (tr)	2000-11-21
YU55200A (sh)	2002-11-15
KR20010041995A (ko)	2001-05-25
CA2322689A1 (en)	1999-09-23
KR100659411B1 (ko)	2006-12-18
RU2208612C2 (ru)	2003-07-20
JP2010222366A (ja)	2010-10-07

Legal Events

Date

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Title

Description

2004-03-15

UEP

Publication of translation of european patent specification

Ref document number: 1064279

Country of ref document: EP

Publication	Publication Date	Title
ATE240318T1 (de)	2003-05-15	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
ATE224889T1 (de)	2002-10-15	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
ATE243693T1 (de)	2003-07-15	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
DE69932032D1 (de)	2006-08-03	Inhibitoren der alpha4 vermittelten zelladhäsion
NO990113D0 (no)	1999-01-12	Flerskrog-fart°y
ATE260248T1 (de)	2004-03-15	Zellproliferation inhibitoren
DE69903248D1 (de)	2002-11-07	Leitfähige zusammensetzung
ID30114A (id)	2001-11-08	Zat-zat herbisida dengan fenoksisulfonilurea tersubstitusi
DE69835502D1 (de)	2006-09-21	Elektrochemisches Bauelement
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ID27346A (id)	2001-04-05	Peralatan pengenal suara
ATE238547T1 (de)	2003-05-15	Energieverbrauchsmessen
ATE347551T1 (de)	2006-12-15	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
ID25957A (id)	2000-11-16	Peralatan untuk memisahkan cairan padatan
ID27522A (id)	2001-04-12	Fasilitas untuk bermain
DE69918180D1 (de)	2004-07-22	Kathodische elektrotauchlackzusammensetzung
ATE306484T1 (de)	2005-10-15	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
ID25939A (id)	2000-11-16	Peralatan untuk memproduksi makanan kecil
DE69834626D1 (de)	2006-06-29	Elektrochemisches Bauelement
ID29969A (id)	2001-10-25	Peralatan untuk mendistribusikan adonan dalam pengekstrusi
PT1121349E (pt)	2004-08-31	Tiadiazolsulfonamidas substituidas como inibidores de interleucina-1-beta
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DE29901324U1 (de)	1999-07-08	Schaltung zur Vermeidung von Netzrückwirkungen
DE29805436U1 (de)	1998-05-28	Skateboard