HRP20000585B1 - Substituted bisindolymaleimides for the inhibition of cell proliferation - Google Patents

Substituted bisindolymaleimides for the inhibition of cell proliferation

Info

Publication number: HRP20000585B1
Authority: HR; Croatia
Prior art keywords: bisindolymaleimides; inhibition; substituted; cell proliferation; methyl
Prior art date: 1998-03-17

Application number

HR20000585A

Other languages

English (en)

Croatian (hr)

Inventor

Hooda Dhingra Urvashi

Mary Huryn Donna

Ke June

Federico Weber Giuseppe

Original Assignee

F. Hoffmann - La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-17

Filing date

2000-09-06

Publication date

2009-02-28

2000-09-06 Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag

2001-08-31 Publication of HRP20000585A2 publication Critical patent/HRP20000585A2/hr

2009-02-28 Publication of HRP20000585B1 publication Critical patent/HRP20000585B1/xx

Links

230000035407 negative regulation of cell proliferation Effects 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

HR20000585A 1998-03-17 2000-09-06 Substituted bisindolymaleimides for the inhibition of cell proliferation HRP20000585B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7833198P	1998-03-17	1998-03-17
PCT/EP1999/001534 WO1999047518A1 (en)	1998-03-17	1999-03-10	Substituted bisindolymaleimides for the inhibition of cell proliferation

Publications (2)

Publication Number	Publication Date
HRP20000585A2 HRP20000585A2 (en)	2001-08-31
HRP20000585B1 true HRP20000585B1 (en)	2009-02-28

Family

ID=22143350

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20000585A HRP20000585B1 (en)	1998-03-17	2000-09-06	Substituted bisindolymaleimides for the inhibition of cell proliferation

Country Status (34)

Country	Link
US (1)	US6048887A (de)
EP (1)	EP1064279B1 (de)
JP (2)	JP5026633B2 (de)
KR (1)	KR100659411B1 (de)
CN (1)	CN1127500C (de)
AR (1)	AR018162A1 (de)
AT (1)	ATE243693T1 (de)
AU (1)	AU755673B2 (de)
BR (1)	BR9908882A (de)
CA (1)	CA2322689C (de)
CO (1)	CO5070675A1 (de)
CZ (1)	CZ299068B6 (de)
DE (1)	DE69909068T2 (de)
DK (1)	DK1064279T3 (de)
ES (1)	ES2203111T3 (de)
HK (1)	HK1036452A1 (de)
HR (1)	HRP20000585B1 (de)
HU (1)	HU228831B1 (de)
ID (1)	ID26353A (de)
IL (1)	IL138247A (de)
MA (1)	MA26613A1 (de)
MY (1)	MY121046A (de)
NO (1)	NO320306B1 (de)
NZ (1)	NZ506476A (de)
PE (1)	PE20000340A1 (de)
PL (1)	PL195323B1 (de)
PT (1)	PT1064279E (de)
RS (1)	RS49965B (de)
RU (1)	RU2208612C2 (de)
SA (1)	SA99191295B1 (de)
TR (1)	TR200002580T2 (de)
TW (1)	TW539676B (de)
WO (1)	WO1999047518A1 (de)
ZA (1)	ZA992072B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1064279B1 (de) *	1998-03-17	2003-06-25	F.Hoffmann-La Roche Ag	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
US6350786B1 (en) *	1998-09-22	2002-02-26	Hoffmann-La Roche Inc.	Stable complexes of poorly soluble compounds in ionic polymers
WO2001027106A1 (en) *	1999-10-12	2001-04-19	F. Hoffmann-La Roche Ag	Substituted pyrroles as antiproliferative agents for the treatment of cancer
US6559164B1 (en)	1999-10-12	2003-05-06	Hoffmann-La Roche Inc.	Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) *	1999-12-16	2001-11-06	Hoffmann-La Roche Inc.	Substituted pyrroles
US6281356B1 (en) *	1999-12-22	2001-08-28	Hoffmann-La Roche Inc.	Substituted pyrroles
US6326501B1 (en) *	2000-04-19	2001-12-04	Hoffmann-La Roche Inc.	Methylation of indole compounds using dimethyl carbonate
US7129250B2 (en) *	2000-05-19	2006-10-31	Aegera Therapeutics Inc.	Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) *	2000-05-19	2001-11-19	Aegera Therapeutics Inc.	Neuroprotective compounds
US6469179B1 (en)	2000-10-03	2002-10-22	Hoffmann-La Roche Inc.	Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6482847B2 (en)	2000-10-03	2002-11-19	Hoffmann-La Roche Inc.	Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6548531B2 (en)	2001-02-09	2003-04-15	Hoffmann-La Roche Inc.	Method for cancer therapy
WO2002102373A1 (en) *	2001-06-15	2002-12-27	F. Hoffmann-La Roche Ag	Method for administration of cancer therapeutic
US20030139373A1 (en) *	2001-11-20	2003-07-24	Breimer Lars Holger	Method for cancer therapy
WO2008117935A1 (en) *	2007-03-28	2008-10-02	Industry-Academic Cooperation Foundation, Yonsei University	Nk cell activating molecules, nk cells and pharmaceutical compositons comprising the same
CN102924437B (zh) *	2012-11-19	2014-07-02	东华大学	3-哌嗪基-4-吲哚马来酰亚胺化合物及其制备和应用
WO2019000224A1 (zh) *	2017-06-27	2019-01-03	中国海洋大学	双吲哚马来酰亚胺衍生物及其制备方法和用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0328026A1 (de) *	1988-02-10	1989-08-16	F. Hoffmann-La Roche Ag	Substituierte Pyrrole
WO1998004551A1 (en) *	1996-07-29	1998-02-05	F. Hoffmann-La Roche Ag	Substituted bisindolylmaleimides for the inhibition of cell proliferation
WO1998004552A1 (en) *	1996-07-29	1998-02-05	F. Hoffmann-La Roche Ag	Substituted bisindolylmaleimides for the inhibition of cell proliferation
WO1998004553A1 (en) *	1996-07-29	1998-02-05	F.Hoffmann-La Roche Ag	Substituted bisindolylmaleimides for the inhibition of cell proliferation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5380746A (en) *	1989-05-05	1995-01-10	Goedecke Aktiengesellschaft	Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DK0817627T3 (da) *	1993-12-23	2005-06-06	Lilly Co Eli	Inhibitorer af proteinkinase C
EP1064279B1 (de) *	1998-03-17	2003-06-25	F.Hoffmann-La Roche Ag	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

1999
- 1999-03-10 EP EP99915558A patent/EP1064279B1/de not_active Expired - Lifetime
- 1999-03-10 CN CN99804045A patent/CN1127500C/zh not_active Expired - Lifetime
- 1999-03-10 BR BR9908882-7A patent/BR9908882A/pt not_active Application Discontinuation
- 1999-03-10 RS YUP-552/00A patent/RS49965B/sr unknown
- 1999-03-10 JP JP2000536713A patent/JP5026633B2/ja not_active Expired - Lifetime
- 1999-03-10 CA CA002322689A patent/CA2322689C/en not_active Expired - Lifetime
- 1999-03-10 AU AU34099/99A patent/AU755673B2/en not_active Expired
- 1999-03-10 IL IL13824799A patent/IL138247A/xx not_active IP Right Cessation
- 1999-03-10 TR TR2000/02580T patent/TR200002580T2/xx unknown
- 1999-03-10 NZ NZ506476A patent/NZ506476A/en not_active IP Right Cessation
- 1999-03-10 RU RU2000125889/04A patent/RU2208612C2/ru active
- 1999-03-10 DE DE69909068T patent/DE69909068T2/de not_active Expired - Lifetime
- 1999-03-10 HU HU0101258A patent/HU228831B1/hu unknown
- 1999-03-10 DK DK99915558T patent/DK1064279T3/da active
- 1999-03-10 PT PT99915558T patent/PT1064279E/pt unknown
- 1999-03-10 KR KR1020007010323A patent/KR100659411B1/ko not_active IP Right Cessation
- 1999-03-10 CZ CZ20003384A patent/CZ299068B6/cs not_active IP Right Cessation
- 1999-03-10 PL PL342964A patent/PL195323B1/pl unknown
- 1999-03-10 WO PCT/EP1999/001534 patent/WO1999047518A1/en active IP Right Grant
- 1999-03-10 ES ES99915558T patent/ES2203111T3/es not_active Expired - Lifetime
- 1999-03-10 ID IDW20001730A patent/ID26353A/id unknown
- 1999-03-10 AT AT99915558T patent/ATE243693T1/de active
- 1999-03-12 MA MA25492A patent/MA26613A1/fr unknown
- 1999-03-12 PE PE1999000199A patent/PE20000340A1/es not_active IP Right Cessation
- 1999-03-15 AR ARP990101117A patent/AR018162A1/es active IP Right Grant
- 1999-03-15 CO CO99015752A patent/CO5070675A1/es unknown
- 1999-03-15 ZA ZA9902072A patent/ZA992072B/xx unknown
- 1999-03-15 TW TW088103914A patent/TW539676B/zh not_active IP Right Cessation
- 1999-03-15 MY MYPI99000952A patent/MY121046A/en unknown
- 1999-03-16 US US09/268,887 patent/US6048887A/en not_active Expired - Lifetime
- 1999-04-13 SA SA99191295A patent/SA99191295B1/ar unknown
2000
- 2000-09-06 HR HR20000585A patent/HRP20000585B1/xx not_active IP Right Cessation
- 2000-09-14 NO NO20004579A patent/NO320306B1/no not_active IP Right Cessation
2001
- 2001-10-15 HK HK01107189A patent/HK1036452A1/xx not_active IP Right Cessation
2010
- 2010-06-02 JP JP2010126632A patent/JP2010222366A/ja active Pending

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0328026A1 (de) *	1988-02-10	1989-08-16	F. Hoffmann-La Roche Ag	Substituierte Pyrrole
WO1998004551A1 (en) *	1996-07-29	1998-02-05	F. Hoffmann-La Roche Ag	Substituted bisindolylmaleimides for the inhibition of cell proliferation
WO1998004552A1 (en) *	1996-07-29	1998-02-05	F. Hoffmann-La Roche Ag	Substituted bisindolylmaleimides for the inhibition of cell proliferation
WO1998004553A1 (en) *	1996-07-29	1998-02-05	F.Hoffmann-La Roche Ag	Substituted bisindolylmaleimides for the inhibition of cell proliferation

Also Published As

Publication number	Publication date
PE20000340A1 (es)	2000-05-13
ATE243693T1 (de)	2003-07-15
MY121046A (en)	2005-12-30
ID26353A (id)	2000-12-14
DE69909068D1 (de)	2003-07-31
AU755673B2 (en)	2002-12-19
DK1064279T3 (da)	2003-10-06
NO20004579D0 (no)	2000-09-14
JP5026633B2 (ja)	2012-09-12
HUP0101258A2 (hu)	2001-10-28
TR200002580T2 (tr)	2000-11-21
NO320306B1 (no)	2005-11-21
CN1127500C (zh)	2003-11-12
AU3409999A (en)	1999-10-11
EP1064279B1 (de)	2003-06-25
AR018162A1 (es)	2001-10-31
BR9908882A (pt)	2000-11-21
MA26613A1 (fr)	2004-12-20
IL138247A (en)	2005-08-31
PT1064279E (pt)	2003-10-31
CA2322689A1 (en)	1999-09-23
JP2002506864A (ja)	2002-03-05
SA99191295B1 (ar)	2006-04-26
US6048887A (en)	2000-04-11
NZ506476A (en)	2003-12-19
ZA992072B (en)	1999-09-22
HU228831B1 (en)	2013-05-28
RS49965B (sr)	2008-09-29
TW539676B (en)	2003-07-01
IL138247A0 (en)	2001-10-31
YU55200A (sh)	2002-11-15
CN1293671A (zh)	2001-05-02
NO20004579L (no)	2000-09-14
EP1064279A1 (de)	2001-01-03
ES2203111T3 (es)	2004-04-01
WO1999047518A1 (en)	1999-09-23
HK1036452A1 (en)	2002-01-04
PL342964A1 (en)	2001-07-16
CZ20003384A3 (cs)	2000-12-13
KR100659411B1 (ko)	2006-12-18
CZ299068B6 (cs)	2008-04-16
CO5070675A1 (es)	2001-08-28
JP2010222366A (ja)	2010-10-07
RU2208612C2 (ru)	2003-07-20
KR20010041995A (ko)	2001-05-25
HUP0101258A3 (en)	2002-08-28
HRP20000585A2 (en)	2001-08-31
CA2322689C (en)	2008-11-25
PL195323B1 (pl)	2007-09-28
DE69909068T2 (de)	2004-05-06

Legal Events

Date	Code	Title	Description
2001-08-31	A1OB	Publication of a patent application
2002-02-20	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2009-02-28	B1PR	Patent granted
2018-03-06	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20180306 Year of fee payment: 20
2019-03-22	PB20	Patent expired after termination of 20 years	Effective date: 20190310

Publication	Publication Date	Title
HRP20000585B1 (en)	2009-02-28	Substituted bisindolymaleimides for the inhibition of cell proliferation
YU35697A (en)	1999-11-22	Substituted 6,6-hetero-bicyclic derivatives
RS49688B (sr)	2007-12-31	Novi derivat 3-aril-2- hidroksipropionske kiseline (i)
CA2293247A1 (en)	1998-12-17	4-phenylpiperidine compounds
TR199700419A2 (xx)	1997-12-21	Yeni piridazinon t�revleri.
DK1485359T3 (da)	2008-04-14	Natriumkanalblokkere
RS50145B (sr)	2009-03-25	Tetrahidropiridoetri
HRP20000292B1 (en)	2008-09-30	2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
DK1052984T3 (da)	2004-09-20	Antibakterielle midler
RS49531B (sr)	2006-12-15	Estrogen agonisti/antagonisti
ATE297203T1 (de)	2005-06-15	Antithrombotische mitteln
EP0513387A4 (en)	1993-04-21	Active oxygen inhibitor
ATE306261T1 (de)	2005-10-15	Antithrombosemittel
AP2002002637A0 (en)	2002-09-30	Novel piperazine
ATE194336T1 (de)	2000-07-15	Morpholin tachykinin rezeptor antagonisten
RS51200B (sr)	2010-12-31	(imidazol-1-il-metil)-piridazin kao blokator nmda receptora
RS53428B (en)	2014-12-31	COMPOSITIONS AND ANTI-VIRUS ACTIVITY OF SUBSTITUTED AZAINDOLOXOSCETER PIPERAZINE DERIVATIVES
RS49792B (sr)	2008-06-05	Piperidinilaminometil trifluorometil ciklična etarska jedinjenja kao antagonisti supstance
RS50229B (sr)	2009-07-15	Analozi vitamina d3
MY117092A (en)	2004-05-31	Chemotherapeutic pyrrolocarbazole derivatives
DE69709933D1 (en)	2002-02-28	Aromatische amidinderivate als selektive thrombininhibitoren
TR200201128T2 (tr)	2002-08-21	PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
YU7191A (sh)	1994-06-24	Oralno aktivni inhibitori renina
NO981393D0 (no)	1998-03-27	Guanidinoproteasehemmere
ES2152379T3 (es)	2001-02-01	Dihidropiridinas condensadas y su utilizacion para la produccion de preparados farmaceuticos.