TR200002580T2 - Hücre çoğalmasının engellenmesinde kullanılan ikameli bisindolimaleimitler - Google Patents
Hücre çoğalmasının engellenmesinde kullanılan ikameli bisindolimaleimitlerInfo
- Publication number
- TR200002580T2 TR200002580T2 TR2000/02580T TR200002580T TR200002580T2 TR 200002580 T2 TR200002580 T2 TR 200002580T2 TR 2000/02580 T TR2000/02580 T TR 2000/02580T TR 200002580 T TR200002580 T TR 200002580T TR 200002580 T2 TR200002580 T2 TR 200002580T2
- Authority
- TR
- Turkey
- Prior art keywords
- substituted
- bisindolimaleimides
- cell proliferation
- inhibit cell
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
R'1'in hidrojen, R2'nin ise metil veya R1'in metil, R'2'nin ise hidrojen veya R1'in hidroksimetil, R2'nin ise metil oldugu formül (I)'in ikameli pirolleri ve ayrica, bunlarin farmasötik açidan kabul görür ön ilaçlari veya farmasötik açidan kabul görür tuzlari, kanser tedavisinde yararli olan antiproliferatif maddelerdir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7833198P | 1998-03-17 | 1998-03-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200002580T2 true TR200002580T2 (tr) | 2000-11-21 |
Family
ID=22143350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/02580T TR200002580T2 (tr) | 1998-03-17 | 1999-03-10 | Hücre çoğalmasının engellenmesinde kullanılan ikameli bisindolimaleimitler |
Country Status (34)
Country | Link |
---|---|
US (1) | US6048887A (tr) |
EP (1) | EP1064279B1 (tr) |
JP (2) | JP5026633B2 (tr) |
KR (1) | KR100659411B1 (tr) |
CN (1) | CN1127500C (tr) |
AR (1) | AR018162A1 (tr) |
AT (1) | ATE243693T1 (tr) |
AU (1) | AU755673B2 (tr) |
BR (1) | BR9908882A (tr) |
CA (1) | CA2322689C (tr) |
CO (1) | CO5070675A1 (tr) |
CZ (1) | CZ299068B6 (tr) |
DE (1) | DE69909068T2 (tr) |
DK (1) | DK1064279T3 (tr) |
ES (1) | ES2203111T3 (tr) |
HK (1) | HK1036452A1 (tr) |
HR (1) | HRP20000585B1 (tr) |
HU (1) | HU228831B1 (tr) |
ID (1) | ID26353A (tr) |
IL (1) | IL138247A (tr) |
MA (1) | MA26613A1 (tr) |
MY (1) | MY121046A (tr) |
NO (1) | NO320306B1 (tr) |
NZ (1) | NZ506476A (tr) |
PE (1) | PE20000340A1 (tr) |
PL (1) | PL195323B1 (tr) |
PT (1) | PT1064279E (tr) |
RS (1) | RS49965B (tr) |
RU (1) | RU2208612C2 (tr) |
SA (1) | SA99191295B1 (tr) |
TR (1) | TR200002580T2 (tr) |
TW (1) | TW539676B (tr) |
WO (1) | WO1999047518A1 (tr) |
ZA (1) | ZA992072B (tr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1064279B1 (en) * | 1998-03-17 | 2003-06-25 | F.Hoffmann-La Roche Ag | Substituted bisindolylmaleimides for the inhibition of cell proliferation |
US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
WO2001027106A1 (en) * | 1999-10-12 | 2001-04-19 | F. Hoffmann-La Roche Ag | Substituted pyrroles as antiproliferative agents for the treatment of cancer |
US6559164B1 (en) | 1999-10-12 | 2003-05-06 | Hoffmann-La Roche Inc. | Substituted pyrroles suitable for continuous infusion |
US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
US7129250B2 (en) * | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
US6469179B1 (en) | 2000-10-03 | 2002-10-22 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
US6482847B2 (en) | 2000-10-03 | 2002-11-19 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
US6548531B2 (en) | 2001-02-09 | 2003-04-15 | Hoffmann-La Roche Inc. | Method for cancer therapy |
WO2002102373A1 (en) * | 2001-06-15 | 2002-12-27 | F. Hoffmann-La Roche Ag | Method for administration of cancer therapeutic |
US20030139373A1 (en) * | 2001-11-20 | 2003-07-24 | Breimer Lars Holger | Method for cancer therapy |
WO2008117935A1 (en) * | 2007-03-28 | 2008-10-02 | Industry-Academic Cooperation Foundation, Yonsei University | Nk cell activating molecules, nk cells and pharmaceutical compositons comprising the same |
CN102924437B (zh) * | 2012-11-19 | 2014-07-02 | 东华大学 | 3-哌嗪基-4-吲哚马来酰亚胺化合物及其制备和应用 |
WO2019000224A1 (zh) * | 2017-06-27 | 2019-01-03 | 中国海洋大学 | 双吲哚马来酰亚胺衍生物及其制备方法和用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK278989B6 (sk) * | 1988-02-10 | 1998-05-06 | F. Hoffmann-La Roche Ag | Substituované pyroly, ich použitie na výrobu lieči |
US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
DK0817627T3 (da) * | 1993-12-23 | 2005-06-06 | Lilly Co Eli | Inhibitorer af proteinkinase C |
PE91698A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
PE91498A1 (es) * | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | Pirroles sustituidos |
PE91598A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
EP1064279B1 (en) * | 1998-03-17 | 2003-06-25 | F.Hoffmann-La Roche Ag | Substituted bisindolylmaleimides for the inhibition of cell proliferation |
-
1999
- 1999-03-10 EP EP99915558A patent/EP1064279B1/en not_active Expired - Lifetime
- 1999-03-10 CN CN99804045A patent/CN1127500C/zh not_active Expired - Lifetime
- 1999-03-10 BR BR9908882-7A patent/BR9908882A/pt not_active Application Discontinuation
- 1999-03-10 RS YUP-552/00A patent/RS49965B/sr unknown
- 1999-03-10 JP JP2000536713A patent/JP5026633B2/ja not_active Expired - Lifetime
- 1999-03-10 CA CA002322689A patent/CA2322689C/en not_active Expired - Lifetime
- 1999-03-10 AU AU34099/99A patent/AU755673B2/en not_active Expired
- 1999-03-10 IL IL13824799A patent/IL138247A/xx not_active IP Right Cessation
- 1999-03-10 TR TR2000/02580T patent/TR200002580T2/tr unknown
- 1999-03-10 NZ NZ506476A patent/NZ506476A/en not_active IP Right Cessation
- 1999-03-10 RU RU2000125889/04A patent/RU2208612C2/ru active
- 1999-03-10 DE DE69909068T patent/DE69909068T2/de not_active Expired - Lifetime
- 1999-03-10 HU HU0101258A patent/HU228831B1/hu unknown
- 1999-03-10 DK DK99915558T patent/DK1064279T3/da active
- 1999-03-10 PT PT99915558T patent/PT1064279E/pt unknown
- 1999-03-10 KR KR1020007010323A patent/KR100659411B1/ko not_active IP Right Cessation
- 1999-03-10 CZ CZ20003384A patent/CZ299068B6/cs not_active IP Right Cessation
- 1999-03-10 PL PL342964A patent/PL195323B1/pl unknown
- 1999-03-10 WO PCT/EP1999/001534 patent/WO1999047518A1/en active IP Right Grant
- 1999-03-10 ES ES99915558T patent/ES2203111T3/es not_active Expired - Lifetime
- 1999-03-10 ID IDW20001730A patent/ID26353A/id unknown
- 1999-03-10 AT AT99915558T patent/ATE243693T1/de active
- 1999-03-12 MA MA25492A patent/MA26613A1/fr unknown
- 1999-03-12 PE PE1999000199A patent/PE20000340A1/es not_active IP Right Cessation
- 1999-03-15 AR ARP990101117A patent/AR018162A1/es active IP Right Grant
- 1999-03-15 CO CO99015752A patent/CO5070675A1/es unknown
- 1999-03-15 ZA ZA9902072A patent/ZA992072B/xx unknown
- 1999-03-15 TW TW088103914A patent/TW539676B/zh not_active IP Right Cessation
- 1999-03-15 MY MYPI99000952A patent/MY121046A/en unknown
- 1999-03-16 US US09/268,887 patent/US6048887A/en not_active Expired - Lifetime
- 1999-04-13 SA SA99191295A patent/SA99191295B1/ar unknown
-
2000
- 2000-09-06 HR HR20000585A patent/HRP20000585B1/xx not_active IP Right Cessation
- 2000-09-14 NO NO20004579A patent/NO320306B1/no not_active IP Right Cessation
-
2001
- 2001-10-15 HK HK01107189A patent/HK1036452A1/xx not_active IP Right Cessation
-
2010
- 2010-06-02 JP JP2010126632A patent/JP2010222366A/ja active Pending
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