ATE222774T1 - Antikörper gegen cd 18 zur verwendung gegen gehirnschlag - Google Patents
Antikörper gegen cd 18 zur verwendung gegen gehirnschlagInfo
- Publication number
- ATE222774T1 ATE222774T1 AT97903790T AT97903790T ATE222774T1 AT E222774 T1 ATE222774 T1 AT E222774T1 AT 97903790 T AT97903790 T AT 97903790T AT 97903790 T AT97903790 T AT 97903790T AT E222774 T1 ATE222774 T1 AT E222774T1
- Authority
- AT
- Austria
- Prior art keywords
- antibodies
- use against
- against brain
- brain stroke
- stroke
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58998296A | 1996-01-23 | 1996-01-23 | |
PCT/US1997/000492 WO1997026912A2 (en) | 1996-01-23 | 1997-01-11 | Anti-cd18 antibodies for use against stroke |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE222774T1 true ATE222774T1 (de) | 2002-09-15 |
Family
ID=24360401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97903790T ATE222774T1 (de) | 1996-01-23 | 1997-01-11 | Antikörper gegen cd 18 zur verwendung gegen gehirnschlag |
Country Status (13)
Country | Link |
---|---|
EP (2) | EP0877626B1 (de) |
JP (1) | JP4864175B2 (de) |
AR (1) | AR005535A1 (de) |
AT (1) | ATE222774T1 (de) |
AU (1) | AU724449B2 (de) |
CA (1) | CA2242414C (de) |
DE (1) | DE69714966T2 (de) |
DK (1) | DK0877626T3 (de) |
ES (1) | ES2183131T3 (de) |
IL (1) | IL125255A (de) |
PT (1) | PT877626E (de) |
WO (1) | WO1997026912A2 (de) |
ZA (1) | ZA97257B (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020081294A1 (en) | 1996-01-23 | 2002-06-27 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-CD18 antibody in stroke |
US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
JP3521382B2 (ja) | 1997-02-27 | 2004-04-19 | 日本たばこ産業株式会社 | 細胞間接着及びシグナル伝達を媒介する細胞表面分子 |
US7112655B1 (en) | 1997-02-27 | 2006-09-26 | Japan Tobacco, Inc. | JTT-1 protein and methods of inhibiting lymphocyte activation |
WO2000048681A2 (en) * | 1999-02-17 | 2000-08-24 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-cd18 antibody |
JP4210454B2 (ja) | 2001-03-27 | 2009-01-21 | 日本たばこ産業株式会社 | 炎症性腸疾患治療剤 |
JP3871503B2 (ja) | 1999-08-30 | 2007-01-24 | 日本たばこ産業株式会社 | 免疫性疾患治療剤 |
AU4574501A (en) | 2000-03-17 | 2001-10-03 | Millennium Pharm Inc | Method of inhibiting stenosis and restenosis |
WO2001070260A1 (en) * | 2000-03-17 | 2001-09-27 | Millennium Pharmaceuticals, Inc. | Cd18-binding antibodies inhibit stenosis-related disorders |
JP3597140B2 (ja) | 2000-05-18 | 2004-12-02 | 日本たばこ産業株式会社 | 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途 |
JP4212278B2 (ja) | 2001-03-01 | 2009-01-21 | 日本たばこ産業株式会社 | 移植片拒絶反応抑制剤 |
JP4460302B2 (ja) | 2002-02-05 | 2010-05-12 | ジェネンテック インコーポレイテッド | タンパク質精製法 |
DK1501369T3 (en) | 2002-04-26 | 2015-09-28 | Genentech Inc | Non-affinity purification of proteins |
WO2005016968A2 (en) | 2003-07-28 | 2005-02-24 | Genentech, Inc. | Reducing protein a leaching during protein a affinity chromatography |
US8354507B2 (en) | 2003-12-15 | 2013-01-15 | Dendreon Corporation | HLA-DR specific antibodies, compositions and methods |
US20060099203A1 (en) | 2004-11-05 | 2006-05-11 | Pease Larry R | B7-DC binding antibody |
US7501119B2 (en) | 2004-06-30 | 2009-03-10 | Mayo Foundation For Medical Education And Research | Methods and molecules for modulating an immune response |
ES2427147T3 (es) * | 2004-06-30 | 2013-10-29 | Mayo Foundation For Medical Education And Research | Anticuerpo sHlgM12 útil para tratar esclerosis múltiple |
US7655229B2 (en) | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
US7662926B2 (en) | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
WO2008079302A2 (en) | 2006-12-21 | 2008-07-03 | Millipore Corporation | Purification of proteins |
EP2120915B1 (de) | 2007-01-22 | 2011-09-28 | Genentech, Inc. | Abscheidung von polyelektrolyten und reinigung von antikörpern |
LT3327026T (lt) | 2007-07-09 | 2019-11-11 | Genentech Inc | Disulfidinio ryšio redukcijos prevencija rekombinantinių polipeptidų gaminimo metu |
ES2666170T3 (es) | 2007-10-30 | 2018-05-03 | Genentech, Inc. | Purificación de anticuerpos mediante cromatografía de intercambio catiónico |
WO2009151514A1 (en) | 2008-06-11 | 2009-12-17 | Millipore Corporation | Stirred tank bioreactor |
LT2848625T (lt) | 2008-08-14 | 2019-10-10 | Genentech, Inc. | Priemaišų pašalinimo būdai, panaudojant reziduojančio baltymo pakeitimą jonų mainų membraninės chromatografijos pagalba |
CN102209554A (zh) | 2008-09-10 | 2011-10-05 | 弗·哈夫曼-拉罗切有限公司 | 用于防止蛋白质氧化降解的组合物和方法 |
US20100190963A1 (en) | 2008-12-16 | 2010-07-29 | Millipore Corporation | Stirred Tank Reactor And Method |
CN102256993A (zh) | 2008-12-16 | 2011-11-23 | 米利波尔公司 | 蛋白的纯化 |
CN102333548B (zh) | 2009-02-27 | 2013-01-30 | 健泰科生物技术公司 | 用于蛋白质标记的方法和组合物 |
EP3431588A1 (de) | 2009-08-11 | 2019-01-23 | F. Hoffmann-La Roche AG | Herstellung von proteinen in glutamin-freien zellkulturmedien |
WO2011028753A1 (en) | 2009-09-01 | 2011-03-10 | Genentech, Inc. | Enhanced protein purification through a modified protein a elution |
KR101878369B1 (ko) | 2010-03-22 | 2018-07-16 | 제넨테크, 인크. | 단백질-함유 제제의 안정화에 유용한 조성물 및 방법 |
JP2013525484A (ja) | 2010-05-03 | 2013-06-20 | ジェネンテック, インコーポレイテッド | タンパク質含有製剤の粘度を低減させるために有用な組成物及び方法 |
WO2011146394A1 (en) | 2010-05-17 | 2011-11-24 | Millipore Corporation | Stimulus responsive polymers for the purification of biomolecules |
WO2011150241A2 (en) | 2010-05-28 | 2011-12-01 | Genentech, Inc. | Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase |
MY161390A (en) | 2010-06-24 | 2017-04-14 | Genentech Inc | Compositions and methods containing alkylglycosides for stabilizing protein-containing formulations |
EP2603525A1 (de) | 2010-08-13 | 2013-06-19 | F.Hoffmann-La Roche Ag | Antikörper gegen il-1beta und il-18 zur behandlung von krankheiten |
WO2012030512A1 (en) | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
SG194763A1 (en) | 2011-07-08 | 2013-12-30 | Emd Millipore Corp | Improved depth filters for disposable biotechnological processes |
EP2794635B8 (de) | 2011-12-22 | 2018-11-14 | H. Hoffnabb-La Roche Ag | Chromatographie mit ionenaustauschmembran |
CN104350156B (zh) | 2012-03-27 | 2019-04-02 | 弗·哈夫曼-拉罗切有限公司 | 用于重组蛋白质的改进的收获操作 |
US20130309226A1 (en) | 2012-05-18 | 2013-11-21 | Genentech, Inc. | High-concentration monoclonal antibody formulations |
US9393327B2 (en) | 2012-12-19 | 2016-07-19 | Genentech, Inc. | Methods and compositions for radiohalogen protein labeling |
EP3777535A1 (de) | 2014-07-09 | 2021-02-17 | F. Hoffmann-La Roche AG | Ph-anpassung zur verbesserung der auftauerholung von zellbanken |
CA3019373A1 (en) | 2016-03-29 | 2017-10-05 | Geltor, Inc. | Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1 |
CN110049778A (zh) | 2016-12-22 | 2019-07-23 | 豪夫迈·罗氏有限公司 | 减少冻干多肽重构时间的方法和制剂 |
US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
US20210253996A1 (en) | 2018-07-03 | 2021-08-19 | Bristol-Myers Squibb Company | Methods of producing recombinant proteins |
CN113166695A (zh) | 2018-10-10 | 2021-07-23 | 勃林格殷格翰国际公司 | 用于高密度生物反应器培养中的膜气体转移的方法 |
TW202102266A (zh) | 2019-04-01 | 2021-01-16 | 美商建南德克公司 | 用於穩定含有蛋白質之配方之組合物及方法 |
CN113993885A (zh) | 2019-04-12 | 2022-01-28 | 格尔托公司 | 重组弹性蛋白及其生产 |
JP2022543781A (ja) | 2019-08-01 | 2022-10-14 | ブリストル-マイヤーズ スクイブ カンパニー | フェッドバッチ細胞培養におけるタンパク質産生性の改良方法 |
KR20230073270A (ko) | 2020-09-22 | 2023-05-25 | 브리스톨-마이어스 스큅 컴퍼니 | 치료 단백질의 생산 방법 |
WO2023015234A1 (en) | 2021-08-05 | 2023-02-09 | Bristol-Myers Squibb Company | Cell culture methods for producing therapeutic proteins |
WO2023049687A1 (en) | 2021-09-21 | 2023-03-30 | Bristol-Myers Squibb Company | Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
WO1994002175A1 (en) * | 1992-07-16 | 1994-02-03 | Icos Corporation | Alleviation of symptoms associated with inflammatory disease states |
WO1994012214A1 (en) * | 1992-12-01 | 1994-06-09 | Protein Design Labs, Inc. | Humanized antibodies reactive with cd18 |
-
1997
- 1997-01-11 AT AT97903790T patent/ATE222774T1/de active
- 1997-01-11 DK DK97903790T patent/DK0877626T3/da active
- 1997-01-11 ES ES97903790T patent/ES2183131T3/es not_active Expired - Lifetime
- 1997-01-11 CA CA2242414A patent/CA2242414C/en not_active Expired - Lifetime
- 1997-01-11 JP JP52689497A patent/JP4864175B2/ja not_active Expired - Lifetime
- 1997-01-11 WO PCT/US1997/000492 patent/WO1997026912A2/en active IP Right Grant
- 1997-01-11 EP EP97903790A patent/EP0877626B1/de not_active Expired - Lifetime
- 1997-01-11 AU AU18273/97A patent/AU724449B2/en not_active Expired
- 1997-01-11 PT PT97903790T patent/PT877626E/pt unknown
- 1997-01-11 EP EP02078486A patent/EP1297847A3/de not_active Withdrawn
- 1997-01-11 DE DE69714966T patent/DE69714966T2/de not_active Expired - Lifetime
- 1997-01-11 IL IL12525597A patent/IL125255A/en not_active IP Right Cessation
- 1997-01-13 ZA ZA97257A patent/ZA97257B/xx unknown
- 1997-01-23 AR ARP970100281A patent/AR005535A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
ZA97257B (en) | 1998-07-14 |
PT877626E (pt) | 2003-01-31 |
DE69714966D1 (de) | 2002-10-02 |
JP2000517289A (ja) | 2000-12-26 |
JP4864175B2 (ja) | 2012-02-01 |
CA2242414C (en) | 2012-01-03 |
EP0877626B1 (de) | 2002-08-28 |
IL125255A0 (en) | 1999-03-12 |
ES2183131T3 (es) | 2003-03-16 |
CA2242414A1 (en) | 1997-07-31 |
EP1297847A3 (de) | 2003-05-07 |
EP1297847A2 (de) | 2003-04-02 |
DE69714966T2 (de) | 2003-04-24 |
EP0877626A2 (de) | 1998-11-18 |
AU724449B2 (en) | 2000-09-21 |
AR005535A1 (es) | 1999-06-23 |
DK0877626T3 (da) | 2002-12-30 |
IL125255A (en) | 2002-02-10 |
AU1827397A (en) | 1997-08-20 |
WO1997026912A2 (en) | 1997-07-31 |
WO1997026912A3 (en) | 1997-10-09 |
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