IL125255A - Anti-cd18 antibodies for treating stroke - Google Patents

Anti-cd18 antibodies for treating stroke

Info

Publication number
IL125255A
IL125255A IL12525597A IL12525597A IL125255A IL 125255 A IL125255 A IL 125255A IL 12525597 A IL12525597 A IL 12525597A IL 12525597 A IL12525597 A IL 12525597A IL 125255 A IL125255 A IL 125255A
Authority
IL
Israel
Prior art keywords
antibody
ser
val
thr
leu
Prior art date
Application number
IL12525597A
Other languages
English (en)
Other versions
IL125255A0 (en
Original Assignee
Genentech Inc
Univ Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Univ Vermont filed Critical Genentech Inc
Publication of IL125255A0 publication Critical patent/IL125255A0/xx
Publication of IL125255A publication Critical patent/IL125255A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL12525597A 1996-01-23 1997-01-11 Anti-cd18 antibodies for treating stroke IL125255A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58998296A 1996-01-23 1996-01-23
PCT/US1997/000492 WO1997026912A2 (en) 1996-01-23 1997-01-11 Anti-cd18 antibodies for use against stroke

Publications (2)

Publication Number Publication Date
IL125255A0 IL125255A0 (en) 1999-03-12
IL125255A true IL125255A (en) 2002-02-10

Family

ID=24360401

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12525597A IL125255A (en) 1996-01-23 1997-01-11 Anti-cd18 antibodies for treating stroke

Country Status (13)

Country Link
EP (2) EP1297847A3 (de)
JP (1) JP4864175B2 (de)
AR (1) AR005535A1 (de)
AT (1) ATE222774T1 (de)
AU (1) AU724449B2 (de)
CA (1) CA2242414C (de)
DE (1) DE69714966T2 (de)
DK (1) DK0877626T3 (de)
ES (1) ES2183131T3 (de)
IL (1) IL125255A (de)
PT (1) PT877626E (de)
WO (1) WO1997026912A2 (de)
ZA (1) ZA97257B (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
US7122636B1 (en) 1997-02-21 2006-10-17 Genentech, Inc. Antibody fragment-polymer conjugates and uses of same
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
US7112655B1 (en) 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
AU4000500A (en) * 1999-02-17 2000-09-04 Genentech Inc. Co-administration of a thrombolytic and an anti-cd18 antibody
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
JP2003527439A (ja) 2000-03-17 2003-09-16 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 抗ｃｄ１８抗体と抗ｃｃｒ２抗体の混合物を用いる狭窄および再狭窄を抑制する方法
WO2001070260A1 (en) * 2000-03-17 2001-09-27 Millennium Pharmaceuticals, Inc. Cd18-binding antibodies inhibit stenosis-related disorders
JP3597140B2 (ja) 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤
EP2048154B2 (de) 2002-02-05 2015-06-03 Genentech, Inc. Proteinreinigung
AU2003265235A1 (en) 2002-04-26 2003-12-19 Genetech, Inc. Non-affinity purification of proteins
DK3095793T3 (da) 2003-07-28 2020-05-25 Genentech Inc Reducering af udvaskning af protein A under en protein A-affinitetskromatografi
JP2007513976A (ja) * 2003-12-15 2007-05-31 デンドレオン コーポレイション Ｈｌａ−ｄｒ特異的抗体、組成物、および方法
CA2572098C (en) * 2004-06-30 2015-01-27 Mayo Foundation For Medical Education And Research B7-dc binding antibody
US7501119B2 (en) 2004-06-30 2009-03-10 Mayo Foundation For Medical Education And Research Methods and molecules for modulating an immune response
US20060099203A1 (en) 2004-11-05 2006-05-11 Pease Larry R B7-DC binding antibody
US7655229B2 (en) 2004-09-02 2010-02-02 Chan Andrew C Anti-FC-gamma RIIB receptor antibody and uses therefor
US7662926B2 (en) 2004-09-02 2010-02-16 Genentech, Inc. Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
FR2902799B1 (fr) 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
WO2008079302A2 (en) 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
NZ577933A (en) 2007-01-22 2011-12-22 Genentech Inc Polyelectrolyte precipitation and purification of antibodies
KR20190140090A (ko) 2007-07-09 2019-12-18 제넨테크, 인크. 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지
RU2498991C2 (ru) 2007-10-30 2013-11-20 Дженентек, Инк. Очистка антител с помощью катионообменной хроматографии
WO2009151514A1 (en) 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
EP3604324B1 (de) 2008-08-14 2024-02-28 Genentech, Inc. Verfahren zur entfernung einer verunreinigung unter verwendung von ionenaustauschmembranchromatografie mit verschiebung ansässiger proteine
EP2684570A1 (de) 2008-09-10 2014-01-15 F. Hoffmann-La Roche AG Zusammensetzungen und Verfahren zur Prävention des oxidativen Abbaus von Proteinen
SG171446A1 (en) 2008-12-16 2011-07-28 Millipore Corp Stirred tank reactor and method
WO2010074702A1 (en) 2008-12-16 2010-07-01 Millipore Corporation Purification of proteins
EP2400992B1 (de) 2009-02-27 2015-07-22 Genentech, Inc. Verfahren und zusammensetzungen zur kennzeichnung von proteinen
SG10201901417UA (en) 2009-08-11 2019-03-28 Genentech Inc Production of proteins in glutamine-free cell culture media
KR101764449B1 (ko) 2009-09-01 2017-08-02 제넨테크, 인크. 변형된 단백질 ａ 용리를 통한 증진된 단백질 정제
CA2792125C (en) 2010-03-22 2019-02-12 Genentech, Inc. Compositions and methods useful for stabilizing protein-containing formulations
MX2012012743A (es) 2010-05-03 2012-11-23 Genentech Inc Composiciones y metodos utiles para reducir la viscosidad de formulaciones que contienen proteina.
CN102892791B (zh) 2010-05-17 2017-05-17 Emd密理博公司 用于纯化生物分子的刺激响应性聚合物
RU2614125C2 (ru) 2010-05-28 2017-03-22 Дженентек, Инк. Снижение уровня лактата и увеличение продукции полипептида путем ингибирования экспрессии лактатдегидрогеназы и киназы пируватдегидрогеназы
SG186783A1 (en) 2010-06-24 2013-02-28 Genentech Inc Compositions and methods containing alkylgycosides for stabilizing protein- containing formulations
CA2808185A1 (en) 2010-08-13 2012-02-16 Genentech, Inc. Antibodies to il-1.beta. and il-18, for treatment of disease
WO2012030512A1 (en) 2010-09-03 2012-03-08 Percivia Llc. Flow-through protein purification process
KR101949187B1 (ko) 2011-07-08 2019-04-22 이엠디 밀리포어 코포레이션 일회용 생명공학적 공정용의 개선된 심층 필터
TR201815709T4 (tr) 2011-12-22 2018-11-21 Hoffmann La Roche İyon değişim membranı kromatografisi.
EP2831261B1 (de) 2012-03-27 2017-10-18 F. Hoffmann-La Roche AG Verfahren zur Herstellung von rekombinanter Proteinen mit niedrigem Gehalt an DHNA (1,4-Dihydroxy-2-Naphthoate)
SG10201709555SA (en) 2012-05-18 2017-12-28 Genentech Inc High-concentration monoclonal antibody formulations
CN104994885B (zh) 2012-12-19 2017-09-29 基因泰克公司 用于放射性卤素蛋白质标记的方法和组合物
BR112017000142B1 (pt) 2014-07-09 2021-08-17 Genentech, Inc Métodos para melhorar a recuperação por descongelamento de bancos de células e para congelamento de células cho para armazenamento, grupo de células cho para o congelamento de células de mamíferos, e banco de células
MX2018011834A (es) 2016-03-29 2019-03-06 Geltor Inc Expresión de proteínas en bacterias gram negativas en la que la relación del volumen periplasmático con respecto al volumen citoplasmático está entre 0.5:1 y 10:1.
JP2020503316A (ja) 2016-12-22 2020-01-30 ジェネンテック， インコーポレイテッド 凍結乾燥ポリペプチドの再構成時間を低減するための方法及び製剤
US11180541B2 (en) 2017-09-28 2021-11-23 Geltor, Inc. Recombinant collagen and elastin molecules and uses thereof
CA3104684A1 (en) 2018-07-03 2020-01-09 Bristol-Myers Squibb Company Methods of producing recombinant proteins
KR20210074341A (ko) 2018-10-10 2021-06-21 베링거 인겔하임 인터내셔날 게엠베하 고밀도 생물 반응기 배양에서 막 기체 전달을 위한 방법
CA3133652A1 (en) 2019-04-01 2020-10-08 Genentech, Inc. Compositions and methods for stabilizing protein-containing formulations
CN113993885A (zh) 2019-04-12 2022-01-28 格尔托公司 重组弹性蛋白及其生产
KR20220039777A (ko) 2019-08-01 2022-03-29 브리스톨-마이어스 스큅 컴퍼니 유가식 세포 배양에서 단백질 생산성을 개선시키는 방법
JP2023542924A (ja) 2020-09-22 2023-10-12 ブリストル－マイヤーズ スクイブ カンパニー 治療タンパク質を生産するための方法
WO2023015234A1 (en) 2021-08-05 2023-02-09 Bristol-Myers Squibb Company Cell culture methods for producing therapeutic proteins
WO2023049687A1 (en) 2021-09-21 2023-03-30 Bristol-Myers Squibb Company Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
EP0604647A4 (en) * 1992-07-16 1996-09-25 Icos Corp Alleviation of symptoms associated with inflammatory disease states.
WO1994012214A1 (en) * 1992-12-01 1994-06-09 Protein Design Labs, Inc. Humanized antibodies reactive with cd18

Also Published As

Publication number Publication date
DK0877626T3 (da) 2002-12-30
EP0877626A2 (de) 1998-11-18
CA2242414C (en) 2012-01-03
IL125255A0 (en) 1999-03-12
CA2242414A1 (en) 1997-07-31
AU1827397A (en) 1997-08-20
ATE222774T1 (de) 2002-09-15
WO1997026912A3 (en) 1997-10-09
DE69714966T2 (de) 2003-04-24
ES2183131T3 (es) 2003-03-16
AU724449B2 (en) 2000-09-21
EP0877626B1 (de) 2002-08-28
ZA97257B (en) 1998-07-14
EP1297847A3 (de) 2003-05-07
DE69714966D1 (de) 2002-10-02
EP1297847A2 (de) 2003-04-02
PT877626E (pt) 2003-01-31
JP2000517289A (ja) 2000-12-26
AR005535A1 (es) 1999-06-23
WO1997026912A2 (en) 1997-07-31
JP4864175B2 (ja) 2012-02-01

Similar Documents

Publication Publication Date Title
EP0877626B1 (de) Antikörper gegen cd 18 zur verwendung gegen gehirnschlag
US5914112A (en) Anti-CD18 antibodies in stroke
WO1997026912A9 (en) Anti-cd18 antibodies for use against stroke
US7655230B2 (en) Co-administration of a tissue plasminogen activator, anti-CD11b antibody and anti-CD18 antibody in stroke
US5840299A (en) Humanized antibodies against leukocyte adhesion molecule VLA-4
DK175491B1 (da) Anvendelse af ICAM-1 og dets funktionelle derivater til behandling af ikke-specifik inflammation
US20090041785A1 (en) Use of anti-integrin antibodies for reducing scar tissue formation
US6297049B1 (en) Methods and compositions for ameliorating the symptoms of sepsis
US20150056205A1 (en) Steroid sparing agents and methods of using same
BG66149B1 (bg) Използване на антитяло хомолог като антагонист на интегрин алфа-4 субединица за получаване на фармацевтичен състав за лечение на фиброзни състояния
AU3605993A (en) Treatment for inflammatory bowel disease
JP2007524605A5 (de)
US6168790B1 (en) Use of antibodies to block the effects of gram-positive bacteria and mycobacteria
US5512442A (en) Detection of vascular adhesion protein-1 (VAP-1)
US10087252B2 (en) Methods and compositions for treating and preventing disease associated with αvβ5 integrin
AU7245800A (en) Anti-CD18 antibodies for use against stroke
WO2000048681A2 (en) Co-administration of a thrombolytic and an anti-cd18 antibody
US20210060161A1 (en) Treatment of ovarian cancer in patients with ascites using a specific binding agent of human angiopoietin-2 in combination with a taxane
AU2011213878B2 (en) Steroid sparing agents and methods of using same
AU719499B2 (en) Use of antibodies to block the effects of Gram-positive bacteria and mycobacteria
MXPA99011741A (en) Cd154 blockade therapy for therapeutic protein inhibitor syndrome

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired