ATE221118T1 - Verwendung von stammzellenfaktor und löslichen interleukin-6-rezeptor zur vermehrung der hämatopoietischen vorläuferzellen - Google Patents

Verwendung von stammzellenfaktor und löslichen interleukin-6-rezeptor zur vermehrung der hämatopoietischen vorläuferzellen

Info

Publication number
ATE221118T1
ATE221118T1 AT95942865T AT95942865T ATE221118T1 AT E221118 T1 ATE221118 T1 AT E221118T1 AT 95942865 T AT95942865 T AT 95942865T AT 95942865 T AT95942865 T AT 95942865T AT E221118 T1 ATE221118 T1 AT E221118T1
Authority
AT
Austria
Prior art keywords
receptor
stem cell
cell factor
propify
precursor cells
Prior art date
Application number
AT95942865T
Other languages
English (en)
Inventor
Tatsutoshi Nakahata
Original Assignee
Amgen Inc
Tosoh Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/340,559 external-priority patent/US5610056A/en
Application filed by Amgen Inc, Tosoh Corp filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE221118T1 publication Critical patent/ATE221118T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT95942865T 1994-11-16 1995-11-16 Verwendung von stammzellenfaktor und löslichen interleukin-6-rezeptor zur vermehrung der hämatopoietischen vorläuferzellen ATE221118T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/340,559 US5610056A (en) 1994-11-16 1994-11-16 Use of stem cell factor interleukin-6 and soluble interleukin-6 receptor to induce the development of hematopoietic stem cells
US39314695A 1995-02-21 1995-02-21
PCT/US1995/014999 WO1996015230A2 (en) 1994-11-16 1995-11-16 Use of stem cell factor and soluble interleukin-6 receptor for the ex vivo expansion of hematopoietic multipotential cells

Publications (1)

Publication Number Publication Date
ATE221118T1 true ATE221118T1 (de) 2002-08-15

Family

ID=26992162

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95942865T ATE221118T1 (de) 1994-11-16 1995-11-16 Verwendung von stammzellenfaktor und löslichen interleukin-6-rezeptor zur vermehrung der hämatopoietischen vorläuferzellen

Country Status (13)

Country Link
US (1) US5861315A (de)
EP (1) EP0793714B1 (de)
JP (1) JP3600244B2 (de)
CN (1) CN1170926C (de)
AT (1) ATE221118T1 (de)
AU (1) AU699479B2 (de)
CA (1) CA2198603C (de)
DE (1) DE69527540T2 (de)
DK (1) DK0793714T3 (de)
ES (1) ES2180665T3 (de)
MX (1) MX9701512A (de)
PT (1) PT793714E (de)
WO (1) WO1996015230A2 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078224B1 (en) * 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US6582960B1 (en) * 1998-09-18 2003-06-24 Massachusetts Institute Of Technology Use of fibroblast growth factor 2 for expansion of chondrocytes and tissue engineering
KR100915482B1 (ko) * 2000-12-06 2009-09-03 하리리 로버트 제이 태반 줄기 세포의 회수 방법
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
MX348185B (es) * 2001-02-14 2017-06-02 Anthrogenesis Corp Placenta de mamíferos postparto, su uso y células madres placentales extraídas de ella.
EP2316919B1 (de) 2001-02-14 2015-10-07 Anthrogenesis Corporation Post-partum Säugetier-Plazenta, deren Verwendung und daraus gewonnene Stammzellen
US7202080B2 (en) 2001-03-29 2007-04-10 Ixion Biotechnology, Inc. Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
CN1564864A (zh) * 2001-08-07 2005-01-12 麒麟麦酒株式会社 造血干细胞的制备方法
ATE438708T1 (de) * 2001-11-15 2009-08-15 Childrens Medical Center Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon
KR101176146B1 (ko) * 2002-02-13 2012-08-22 안트로제네시스 코포레이션 산후 포유류 태반으로부터 유래한 배아-유사 줄기 세포와그 세포를 사용한 용도 및 치료방법
EP1490478A4 (de) * 2002-03-18 2006-03-22 Nat Jewish Med & Res Center Verfahren zur produktion von neutrophilen und verwendungen dafür
CA2483010A1 (en) * 2002-04-19 2003-10-30 University Of Pittsburgh Of The Commonwealth System Of Higher Education Placental derived stem cells and uses thereof
US20040161419A1 (en) * 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
US20040076620A1 (en) * 2002-09-03 2004-04-22 Donnie Rudd Method of repairing primate mammalian tissue
US20040076605A1 (en) * 2002-09-03 2004-04-22 Donnie Rudd Method of regenerating human tissue
US20040042997A1 (en) * 2002-09-03 2004-03-04 Donnie Rudd Method of regenerating human tissue
US20040044300A1 (en) * 2002-09-03 2004-03-04 Donnie Rudd Method of replenishing cells damaged by treatment for cancer
US20040077985A1 (en) * 2002-09-03 2004-04-22 Donnie Rudd Method of replenishing cells damaged by treatment for cancer
US20040043009A1 (en) * 2002-09-03 2004-03-04 Donnie Rudd Method of repairing primate mammalian tissue
EP1400587A1 (de) * 2002-09-19 2004-03-24 MainGen Biotechnologie GmbH Verwendung von Fusionspolypeptiden zur Herstellung von pluripotenten nicht embryonalen Stammzellen
WO2004046312A2 (en) * 2002-11-15 2004-06-03 The Board Of Trustees Of The University Of Illinois Methods for in vitro expansion of hematopoietic stem cells
JP2006509770A (ja) * 2002-11-26 2006-03-23 アンソロジェネシス コーポレーション 細胞治療学、細胞治療単位、およびそれらを利用した治療法
WO2004071283A2 (en) * 2003-02-13 2004-08-26 Anthrogenesis Corporation Use of umbilical cord blood to treat individuals having a disease, disorder or condition
GB0321337D0 (en) * 2003-09-11 2003-10-15 Massone Mobile Advertising Sys Method and system for distributing advertisements
US7829336B2 (en) * 2003-11-24 2010-11-09 The Rockefeller University Method for isolating a self-renewing, multipotent, slow-cycling cell
MXPA06006061A (es) * 2003-12-02 2006-08-11 Celgene Corp Metodos y composiciones para el tratamiento y manejo de la hemoglinopatia y la anemia.
PL1789534T3 (pl) 2004-08-16 2015-03-31 Cellresearch Corp Pte Ltd Wyodrębnienie komórek macierzystych/progenitorowych z błony owodniowej pępowiny
EA200701600A1 (ru) * 2005-02-28 2008-02-28 Редженетек, Инк. Способ получения лёгкодоступного клеточного материала из периферической крови и композиция на его основе
EP1907585A4 (de) * 2005-07-01 2010-04-07 Promega Corp Netzwerk aus auftriebspartikeln für die biomolekülreinigung und verwendung von auftriebspartikeln oder dem netzwerk aus auftriebspartikeln zur biomolekülreinigung
NZ597304A (en) * 2005-10-13 2013-06-28 Anthrogenesis Corp Immunomodulation using placental stem cells
WO2007070381A2 (en) 2005-12-09 2007-06-21 Promega Corporation Nucleic acid purification with a binding matrix
ZA200804718B (en) 2005-12-29 2010-04-28 Anthrogenesis Corp Co-culture of placental stem cells and stem cells from a second source
WO2007102814A2 (en) * 2006-03-07 2007-09-13 Regenetech, Inc. Recombinant mammalian molecules and method for production thereof
CN101688177A (zh) * 2007-02-12 2010-03-31 人类起源公司 来自贴壁胎盘干细胞的肝细胞和软骨细胞；以及cd34+、cd45-胎盘干细胞富集的细胞群
CN101657206B (zh) * 2007-02-12 2013-07-03 人类起源公司 利用胎盘干细胞治疗炎性疾病
US20100172830A1 (en) * 2007-03-29 2010-07-08 Cellx Inc. Extraembryonic Tissue cells and method of use thereof
EP2155860B1 (de) 2007-05-03 2014-08-27 The Brigham and Women's Hospital, Inc. Multipotente stammzellen und ihre verwendung
US8574567B2 (en) * 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
CN101878034B (zh) 2007-09-28 2013-11-20 细胞基因细胞疗法公司 使用人胎盘灌洗液和人来自胎盘的中间体自然杀伤细胞的肿瘤抑制
DK2217329T3 (en) * 2007-11-07 2018-04-23 Anthrogenesis Corp APPLICATION OF NAVLINE BLOOD IN THE TREATMENT OF COMPLIANCES IN CONNECTION WITH PREGNANCY BIRTH
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
US8222397B2 (en) * 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
ES2336637B1 (es) * 2009-11-02 2011-01-21 Banc De Sang I Teixits Procedimiento parala expansion indiferenciada u orientada a linaje mieloide de celulas madre hematopoyeticas procedentes de sangre de cordonumbilical, sangre periferica movilizada o medula osea.
WO2012009422A1 (en) 2010-07-13 2012-01-19 Anthrogenesis Corporation Methods of generating natural killer cells
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
CN113559126A (zh) 2011-06-01 2021-10-29 人类起源公司 利用胎盘干细胞治疗疼痛
WO2013055476A1 (en) 2011-09-09 2013-04-18 Anthrogenesis Corporation Treatment of amyotrophic lateral sclerosis using placental stem cells
EP3622960A1 (de) 2013-02-05 2020-03-18 Celularity, Inc. Natürliche killerzellen aus plazenta
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
EP3613841B1 (de) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passives ersetzen von medien
EP3198006B1 (de) 2014-09-26 2021-03-24 Terumo BCT, Inc. Geplante fütterung
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
EP3656842A1 (de) 2017-03-31 2020-05-27 Terumo BCT, Inc. Zellexpansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE206309T1 (de) * 1992-04-23 2001-10-15 Sloan Kettering Inst Cancer Ligand für den c-kit-rezepten und verfahren zu seiner nutzung
US5599703A (en) * 1993-10-28 1997-02-04 The United States Of America As Represented By The Secretary Of The Navy In vitro amplification/expansion of CD34+ stem and progenitor cells

Also Published As

Publication number Publication date
AU4407396A (en) 1996-06-06
JPH10509040A (ja) 1998-09-08
DK0793714T3 (da) 2002-09-02
JP3600244B2 (ja) 2004-12-15
MX9701512A (es) 1997-05-31
WO1996015230A3 (en) 1996-07-11
EP0793714B1 (de) 2002-07-24
CN1224461A (zh) 1999-07-28
PT793714E (pt) 2002-12-31
DE69527540D1 (de) 2002-08-29
ES2180665T3 (es) 2003-02-16
CA2198603A1 (en) 1996-05-23
DE69527540T2 (de) 2003-01-30
CN1170926C (zh) 2004-10-13
US5861315A (en) 1999-01-19
EP0793714A2 (de) 1997-09-10
CA2198603C (en) 2000-06-27
WO1996015230A2 (en) 1996-05-23
AU699479B2 (en) 1998-12-03

Similar Documents

Publication Publication Date Title
ATE221118T1 (de) Verwendung von stammzellenfaktor und löslichen interleukin-6-rezeptor zur vermehrung der hämatopoietischen vorläuferzellen
ATE252113T1 (de) Verwendung von wnt polypeptiden
ES2114786A1 (es) Tromboyetina. trombopoyetina recombinante y procedimiento de obtencion.
IL135068A0 (en) Stimulation of hematopoietic cells in vitro
DE69535328D1 (de) In-vitro wachstum von langerhans'schen inseln und ihre verwendungen
ATE265219T1 (de) Verwendung von cxcr4 antagonisten zur behandlung von krebs und autoimmunkrankheiten
DE69433921D1 (de) Rekombinante zellen der monozyten-makrophagen zelllinie zur gen-therapie
IL107897A0 (en) Pyrrolopyrimidines
ES2196082T3 (es) Analagos del factor de crecimiento de queratinocitos.
NO971341D0 (no) Promoter for reseptor tyrosinkinase TIE
PT809437E (pt) Tiois para promover crescimento de celulas progenitoras hematopoieticas
NZ541480A (en) Use of Bv8 and/or EG-VEGF to promote hematopoiesis
PT786002E (pt) Isoforma intracelular do antagonista do receptor da interleuquina-1
ES2192199T3 (es) Ligandos de la familia eph biologicamente activos.
ES2107414T3 (es) Utilizacion de interferon-beta humano para la estimulacion de la eritropoyesis.
DE60115222D1 (de) Kombination von defibrotid und g-csf und ihre verwendung zur aktivierung hämatopoietischer vorläuferzellen
ES2061566T3 (es) Anticuerpos monoclonales contra la proteina e7 del papilomavirus humano tipo 16, procedimiento para su preparacion, asi como su empleo.
ATE225183T1 (de) Verwendung von hepatozyten-wachstumsfaktor zur induzierung der proliferation und differenzierung von hämatopoietischen zellen
ES2080954T3 (es) Uso de beta-aletina en cultivos de celulas y en terapia.
Carella et al. Eradication of the Philadelphia chromosome-positive clone and persistent restoration of normal polyclonal haemopoiesis in a chronic myelogenous leukemia patient after autologous transplant with peripheral blood Philadelphia-negative haemopoietic cells
DE3852022D1 (de) Rekonstituierte Tumoren, Herstellungsverfahren und Zusammensetzung für ihre Anwendung.
TR199800705T2 (de)
ES2075810A1 (es) Uso farmacologico del factor de creciemiento de fibroblastos y sus derivados en enfermedades neurodegenerativas.
DE69528784D1 (de) Pankreatische ribonuclease Mutante und ihre Verwendung
ATE43595T1 (de) Derivate des 2-furylbutyrolactons, ihre herstellung, diese enthaltende zusammensetzungen und ihre verwendung zur veraenderung des immunsystems bei saeugetieren.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0793714

Country of ref document: EP

REN Ceased due to non-payment of the annual fee