KR100915482B1 - 태반 줄기 세포의 회수 방법 - Google Patents
태반 줄기 세포의 회수 방법Info
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- KR100915482B1 KR100915482B1 KR1020037007561A KR20037007561A KR100915482B1 KR 100915482 B1 KR100915482 B1 KR 100915482B1 KR 1020037007561 A KR1020037007561 A KR 1020037007561A KR 20037007561 A KR20037007561 A KR 20037007561A KR 100915482 B1 KR100915482 B1 KR 100915482B1
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- perfusion
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Abstract
Description
WBC(1000/㎖) | Lym(%) | MID(%) | GRA(%) | 총 부피 | 세포수 | |
CB(제대혈) | 10.5 | 43.2 | 8 | 48.8 | 60㎖ | 6.3x108 |
PP(태반 관류액, 실온) | 12.0 | 62.9 | 18.2 | 18.9 | 15㎖ | 1.8x108 |
PP2 (태반 관류액, 37℃) | 11.7 | 56.0 | 19.2 | 24.8 | 30㎖ | 3.5x108 |
PP 샘플은 피콜(Ficoll) 분리후에 얻은 것임.피콜 분리후 PP의 총 세포수는 5.3x108이고, 처리전 CB의 수는 6.3x108이다.Lym(%)는 림프구의 백분율이고; MID(%)는 중간범위 백혈구의 백분율이며; GRA(%)는 과립구의 백분율이다. |
Claims (43)
- 분리되고 방혈된 포유류 태반으로부터 태반 줄기 세포를 수집하는 방법으로서,상기 태반으로부터 검출가능한 양의 줄기 세포를 수집하기에 충분한 양과 시간 동안 관류 용액으로 상기 태반을 관류시키고 상기 태반으로부터 상기 줄기 세포 및 관류 용액을 수집하는 것을 포함하고,상기 태반은 상기 관류 전에 제대혈이 배출되고 잔류 혈액을 제거하기 위하여 분출된 것이며, 상기 관류는 상기 태반의 제대 정맥 및 제대 동맥중 하나 또는 둘 모두에 상기 관류 용액을 통과시켜 수행되는 것인 방법.
- 제 1 항에 있어서,상기 관류 용액으로부터 상기 줄기 세포를 분리하는 것을 추가로 포함하는 방법.
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- 제 1 항에 있어서,상기 태반 줄기 세포가 CD34+ 태반 줄기 세포인 방법.
- 제 1 항에 있어서,상기 태반 줄기 세포가 CD34- 태반 줄기 세포인 방법.
- 제 1 항에 있어서,상기 태반을 상기 잔류 혈액의 제거 후 및 상기 관류 전에 4시간 동안 배양하는 방법.
- 제 1 항에 있어서,상기 태반을 상기 잔류 혈액의 제거 후 및 상기 관류 전에 12시간 동안 배양하는 방법.
- 제 1 항에 있어서,상기 태반을 상기 잔류 혈액의 제거 후 및 상기 관류 전에 24시간 동안 배양하는 방법.
- 제 1 항에 있어서,상기 관류가 상기 관류 용액을 30ml 내지 150ml의 제 1 부피로 사용하여 수행되는 방법.
- 제 30 항에 있어서,상기 관류 용액을 30ml 내지 150ml의 제 2 부피로 사용하여 상기 관류를 계속하는 것을 추가로 포함하고 상기 제 2 부피가 상기 제 1 부피와 별도로 수집되는 방법.
- 제 1 항에 있어서,상기 관류가 여러번 수행되는 방법.
- 제 32 항에 있어서,매번 상기 관류가 30ml 내지 150ml 부피의 상기 관류 용액을 사용하여 수행되는 방법.
- 제 1 항에 있어서,상기 관류 용액이 항응고제를 포함하는 방법.
- 제 1 항에 있어서,상기 관류 용액이 헤파린, 에틸렌 다이아민 4차 아세트산(EDTA) 또는 크레아틴 포스페이트 덱스트로스(CPDA)를 포함하는 방법.
- 제 1 항에 있어서,상기 관류 용액이 증식 인자 또는 사이토카인을 포함하는 방법.
- 제 36 항에 있어서,상기 증식 인자 또는 사이토카인이 콜로니-자극 인자, 인터페론, 에리트로포이에틴, 줄기 세포 인자, 트롬보포이에틴, 인터루킨, 과립구 콜로니-자극 인자 및 이들의 조합으로 구성된 군으로부터 선택되는 방법.
- 제 1 항에 있어서,상기 분리된 포유류 태반이 성공적인 분만 후에 남은 산후 태반인 방법.
- 제 1 항에 있어서,상기 줄기 세포가 다능성인 방법.
- 제 1 항에 있어서,상기 줄기 세포가, 태반이 2 내지 24 시간 동안 실온에서 유지된 후 4, 8, 12 또는 24 시간에 수집되는 방법.
- 제 1 항에 있어서,상기 관류가 상기 잔류 혈액의 제거 후 4 시간에 수행되는 방법.
- 제 1 항에 있어서,상기 관류가 상기 잔류 혈액의 제거 후 12 시간에 수행되는 방법.
- 제 1 항에 있어서,상기 관류가 상기 잔류 혈액의 제거 후 24 시간에 수행되는 방법.
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