DE69528784D1 - Pankreatische ribonuclease Mutante und ihre Verwendung - Google Patents

Pankreatische ribonuclease Mutante und ihre Verwendung

Info

Publication number
DE69528784D1
DE69528784D1 DE69528784T DE69528784T DE69528784D1 DE 69528784 D1 DE69528784 D1 DE 69528784D1 DE 69528784 T DE69528784 T DE 69528784T DE 69528784 T DE69528784 T DE 69528784T DE 69528784 D1 DE69528784 D1 DE 69528784D1
Authority
DE
Germany
Prior art keywords
mutant
pancreatic ribonuclease
ribonuclease
pancreatic
muteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69528784T
Other languages
English (en)
Other versions
DE69528784T2 (de
Inventor
Alessio Guiseppe D
Donato Alberto Di
Renata Piccoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNI DEGLI STUDI DI NAPOLI NEAP
Original Assignee
UNI DEGLI STUDI DI NAPOLI NEAP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNI DEGLI STUDI DI NAPOLI NEAP filed Critical UNI DEGLI STUDI DI NAPOLI NEAP
Application granted granted Critical
Publication of DE69528784D1 publication Critical patent/DE69528784D1/de
Publication of DE69528784T2 publication Critical patent/DE69528784T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6815—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69528784T 1994-02-16 1995-02-15 Pankreatische ribonuclease Mutante und ihre Verwendung Expired - Fee Related DE69528784T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM940073A IT1271864B (it) 1994-02-16 1994-02-16 Muteine della ribonucleasi pancreatica e loro usi.

Publications (2)

Publication Number Publication Date
DE69528784D1 true DE69528784D1 (de) 2002-12-19
DE69528784T2 DE69528784T2 (de) 2003-07-17

Family

ID=11402242

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528784T Expired - Fee Related DE69528784T2 (de) 1994-02-16 1995-02-15 Pankreatische ribonuclease Mutante und ihre Verwendung

Country Status (5)

Country Link
EP (1) EP0668349B1 (de)
AT (1) ATE227771T1 (de)
DE (1) DE69528784T2 (de)
ES (1) ES2186709T3 (de)
IT (1) IT1271864B (de)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389537A (en) * 1994-01-21 1995-02-14 Wisconsin Alumni Research Foundation Nuclease having altered specificity

Also Published As

Publication number Publication date
ITRM940073A0 (it) 1994-02-16
DE69528784T2 (de) 2003-07-17
EP0668349B1 (de) 2002-11-13
EP0668349A2 (de) 1995-08-23
ITRM940073A1 (it) 1995-08-16
EP0668349A3 (de) 1996-08-28
ES2186709T3 (es) 2003-05-16
ATE227771T1 (de) 2002-11-15
IT1271864B (it) 1997-06-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee