ATE438708T1 - Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon - Google Patents

Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon

Info

Publication number
ATE438708T1
ATE438708T1 AT02799882T AT02799882T ATE438708T1 AT E438708 T1 ATE438708 T1 AT E438708T1 AT 02799882 T AT02799882 T AT 02799882T AT 02799882 T AT02799882 T AT 02799882T AT E438708 T1 ATE438708 T1 AT E438708T1
Authority
AT
Austria
Prior art keywords
stem cells
placenta
fetal stem
chorionic
amnition
Prior art date
Application number
AT02799882T
Other languages
English (en)
Inventor
Anthony Atala
Coppi Paolo De
Original Assignee
Childrens Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application granted granted Critical
Publication of ATE438708T1 publication Critical patent/ATE438708T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
AT02799882T 2001-11-15 2002-11-15 Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon ATE438708T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33587801P 2001-11-15 2001-11-15
US35629502P 2002-02-13 2002-02-13
PCT/US2002/036966 WO2003042405A2 (en) 2001-11-15 2002-11-15 Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
ATE438708T1 true ATE438708T1 (de) 2009-08-15

Family

ID=26989930

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02799882T ATE438708T1 (de) 2001-11-15 2002-11-15 Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon

Country Status (8)

Country Link
US (4) US8021876B2 (de)
EP (1) EP1442115B9 (de)
JP (1) JP4330995B2 (de)
AT (1) ATE438708T1 (de)
AU (2) AU2002363659B2 (de)
CA (1) CA2468171C (de)
DE (1) DE60233248D1 (de)
WO (1) WO2003042405A2 (de)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4294316B2 (ja) * 2000-12-06 2009-07-08 ハリリ，ロバート，ジェイ． 胎盤幹細胞の回収方法
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
EP2336300B1 (de) * 2001-02-14 2015-07-08 Anthrogenesis Corporation Post-partum Säugetier-Plazenta, deren Verwendung und daraus gewonnene Stammzellen
ES2629155T3 (es) 2001-02-14 2017-08-07 Anthrogenesis Corporation Matrices de tejido que comprenden células madre placentarias, y métodos para su preparación
WO2003089619A2 (en) * 2002-04-19 2003-10-30 University Of Pittsburgh Of The Commonwealth System Of Higher Education Placental derived stem cells and uses thereof
US20040161419A1 (en) * 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
BR0316695A (pt) 2002-11-26 2005-10-18 Anthrogenesis Corp Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US8491883B2 (en) * 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
JP4950659B2 (ja) 2003-06-27 2012-06-13 エチコン、インコーポレイテッド 胎盤組織から由来最多分娩後細胞、及びそれらを作成し使用する方法。
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
WO2005017117A2 (en) * 2003-08-14 2005-02-24 Martin Haas Multipotent amniotic fetal stem cells (mafsc) and banking of same
TWI338714B (en) * 2003-12-02 2011-03-11 Cathay General Hospital Method of isolation and enrichment of mesenchymal stem cells from amniotic fluid
US20070269412A1 (en) 2003-12-02 2007-11-22 Celavie Biosciences, Llc Pluripotent cells
US7534606B2 (en) 2004-01-12 2009-05-19 National Health Research Institutes Placental stem cell and methods thereof
EP1711598A4 (de) * 2004-01-30 2009-04-08 Lifecord Inc Verfahren zur isolierung und kultivierung multipotenter vorläufer-/stammzellen aus nabelschnurblut sowie verfahren zur induktion ihrer differenzierung
CA2563518C (en) * 2004-04-23 2014-09-02 Bioe, Inc. Multi-lineage progenitor cells
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
NZ553695A (en) 2004-08-16 2009-10-30 Cellres Corp Pte Ltd Isolation of stem/progenitor cells from amniotic membrane of umbilical cord
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
JP5425399B2 (ja) * 2004-12-23 2014-02-26 エシコン・インコーポレイテッド 産褥由来細胞を用いたパーキンソン病および関連の障害の治療
WO2006074308A2 (en) 2005-01-07 2006-07-13 Wake Forest University Health Sciences Regeneration of pancreatic islets by amniotic fluid stem cell therapy
US7759120B2 (en) 2005-03-02 2010-07-20 Kps Bay Medical, Inc. Seeding implantable medical devices with cells
US20060199265A1 (en) 2005-03-02 2006-09-07 Wolf Michael F Seeding implantable medical devices with cells
US20060222634A1 (en) * 2005-03-31 2006-10-05 Clarke Diana L Amnion-derived cell compositions, methods of making and uses thereof
CN103361303B (zh) 2005-03-31 2015-09-30 斯丹姆涅恩有限公司 制备一种高度纯化来自羊膜的细胞群的方法
US8153430B2 (en) * 2005-03-31 2012-04-10 Stemnion, Inc. Methods related to surgery
US7883847B2 (en) 2005-04-01 2011-02-08 Wake Forest University Health Sciences Transcriptional profiling of stem cells and their multilineage differentiation
AU2006202209B2 (en) 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
US9074189B2 (en) 2005-06-08 2015-07-07 Janssen Biotech, Inc. Cellular therapy for ocular degeneration
WO2007005595A1 (en) * 2005-07-05 2007-01-11 The New England Medical Center Hospitals, Inc. Pregnancy-associated progenitor cells
MX343814B (es) 2005-10-13 2016-11-24 Anthrogenesis Corp Inmunomodulación usando celulas madre de la placenta.
EP2267114B1 (de) * 2005-10-28 2014-03-12 Universität Zürich Herstellung künstlicher gewebe aus homogenen populationen isolierter nicht-embryoblastischer foetaler zellen
US20090203543A1 (en) * 2005-11-10 2009-08-13 Pieter Jacob Boender Method for Assaying Enzyme Activity in Histological Sample
AU2006325710B2 (en) 2005-12-16 2012-05-17 Ethicon, Inc. Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
JP2009521930A (ja) 2005-12-29 2009-06-11 アントフロゲネシス コーポレーション 胎盤幹細胞及び第２供給源由来幹細胞の共存培養
NZ569562A (en) 2005-12-29 2012-04-27 Anthrogenesis Corp Placental stem cell populations, CD200
US8871198B2 (en) * 2006-03-29 2014-10-28 Stemnion, Inc. Methods related to wound healing
AU2007257594B2 (en) 2006-03-07 2012-11-01 Geeta Shroff Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
AU2007230902B2 (en) 2006-03-24 2013-03-14 Children's Medical Center Corporation Method to modulate hematopoietic stem cell growth
US7727763B2 (en) * 2006-04-17 2010-06-01 Bioe, Llc Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
US7829108B2 (en) 2006-04-21 2010-11-09 Wake Forest University Health Sciences Structurally modified acellular tissue engineering scaffolds and methods of production
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US8435786B2 (en) * 2006-05-31 2013-05-07 Cellect Biotechnology Ltd. Methods of selecting stem cells and uses thereof
WO2007146106A2 (en) * 2006-06-05 2007-12-21 Cryo- Cell International, Inc. Procurement, isolation and cryopreservation of maternal placental cells
US20080050814A1 (en) * 2006-06-05 2008-02-28 Cryo-Cell International, Inc. Procurement, isolation and cryopreservation of fetal placental cells
EP2035552A2 (de) * 2006-06-09 2009-03-18 Anthrogenesis Corporation Plazentare nische und ihre verwendung zur züchtung von stammzellen
WO2007145889A1 (en) 2006-06-14 2007-12-21 Stemnion, Inc. Methods of treating spinal cord injury and minimizing scarring
US7993918B2 (en) * 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
US8372437B2 (en) 2006-08-17 2013-02-12 Mimedx Group, Inc. Placental tissue grafts
US20080159999A1 (en) * 2006-10-23 2008-07-03 Konstantinos Stefanidis Compositions and methods for identifying, isolating and enriching germline-like stem cells from amniotic fluid
CN101631852A (zh) 2006-10-23 2010-01-20 人类起源公司 用胎盘细胞群治疗骨缺损的方法和组合物
KR100795708B1 (ko) * 2006-12-26 2008-01-17 주식회사 알앤엘바이오 인간 양막 상피세포 유래 성체 줄기세포의 분리 및 배양방법
US8221741B2 (en) 2007-01-17 2012-07-17 Marshall Vivienne S Methods for modulating inflammatory and/or immune responses
NZ612888A (en) 2007-02-12 2015-02-27 Anthrogenesis Corp Treatment of inflammatory diseases using placental stem cells
JP2010518812A (ja) 2007-02-12 2010-06-03 アンスロジェネシス コーポレーション 接着性胎盤幹細胞由来の肝細胞および軟骨細胞、ならびにｃｄ３４＋、ｃｄ４５−胎盤幹細胞の濃縮細胞集団
US8465976B2 (en) * 2007-02-12 2013-06-18 Cedars-Sinai Medical Center Methods for isolating and using hematopoietic and embryonic stem cells of the peritoneal cavity
US8338113B2 (en) * 2007-05-01 2012-12-25 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods for detecting fetal cells in the maternal blood
EP2164505B1 (de) * 2007-05-28 2014-09-17 Monash University Behandlung von chronischer lungenkrankheit
KR100900309B1 (ko) 2007-05-29 2009-06-02 차의과학대학교 산학협력단 태반 융모막판막-유래 중간엽 줄기 세포의 고순도 분리방법
WO2008153568A1 (en) * 2007-06-13 2008-12-18 Lifescan, Inc. Chorionic villus derived cells
CA2688504A1 (en) 2007-06-18 2008-12-24 Children's Hospital & Research Center At Oakland Method of isolating stem and progenitor cells from placenta
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
EP2192908A4 (de) * 2007-07-25 2010-09-01 Bioe Inc Differenzierung von vorläuferzellen mehrerer abstammung gegenüber chondrozyten
EP2610336A1 (de) 2007-07-31 2013-07-03 Lifescan, Inc. Differenzierung von menschlichen embryonalen Stammzellen
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
US20100196923A1 (en) * 2007-08-14 2010-08-05 Anthony Atala Pluripotent adult stem cells
KR20210022148A (ko) 2007-09-28 2021-03-02 안트로제네시스 코포레이션 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법
WO2009052132A1 (en) * 2007-10-15 2009-04-23 Children's Medical Center Corporation Human amniotic fluid derived mesenchymal stem cells
US9062290B2 (en) 2007-11-27 2015-06-23 Lifescan, Inc. Differentiation of human embryonic stem cells
WO2009075001A1 (en) * 2007-12-13 2009-06-18 Biocell Center S.P.A. Method of collection and preservation of fluids and/or materials, in particular of organic fluids and/or materials containing stem cells, and device employable in such method
KR20190057164A (ko) 2008-02-21 2019-05-27 얀센 바이오테크 인코포레이티드 세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
US20090275011A1 (en) * 2008-04-30 2009-11-05 Johann Eibl Sessile stem cells
US9200256B2 (en) * 2008-05-12 2015-12-01 Saint Peter's College Multipotent stem cell cultures
EP2294187A2 (de) * 2008-05-21 2011-03-16 BioE LLC Differenzierung von mehrlinien-vorläuferzellen zu pankreaszellen
CA2729121C (en) 2008-06-30 2019-04-09 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
KR20230031991A (ko) 2008-08-20 2023-03-07 셀룰래리티 인코포레이티드 단리된 태반 세포를 사용한 뇌졸중 치료
PE20110400A1 (es) 2008-08-20 2011-06-22 Anthrogenesis Corp Composiciones mejoradas de celulas y metodos para preparar las mismas
CN102176919A (zh) 2008-08-22 2011-09-07 人类起源公司 用胎盘细胞群治疗骨缺损的方法和组合物
CA2742268C (en) 2008-10-31 2020-02-18 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
MX2011004563A (es) 2008-10-31 2011-06-01 Centocor Ortho Biotech Inc Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico.
EP2367932B1 (de) 2008-11-19 2019-06-12 Celularity, Inc. Aus fruchtwasser stammende adhärente zellen
CA2744227C (en) 2008-11-20 2018-10-02 Centocor Ortho Biotech Inc. Methods and compositions for cell attachment and cultivation on planar substrates
KR101837080B1 (ko) 2008-11-20 2018-03-09 얀센 바이오테크 인코포레이티드 마이크로-캐리어 상의 만능 줄기 세포 배양
CN107028983A (zh) * 2008-12-19 2017-08-11 德普伊新特斯产品有限责任公司 肺部疾病和病症的治疗
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
US8771677B2 (en) 2008-12-29 2014-07-08 Vladimir B Serikov Colony-forming unit cell of human chorion and method to obtain and use thereof
US20100209399A1 (en) * 2009-02-13 2010-08-19 Celavie Biosciences, Llc Brain-derived stem cells for repair of musculoskeletal system in vertebrate subjects
CA2756600C (en) 2009-03-26 2019-08-20 Advanced Technologies And Regenerative Medicine, Llc Human umbilical cord tissue cells as therapy for alzheimer's disease
US20100273167A1 (en) * 2009-04-20 2010-10-28 Jennifer Hipp Methods for determining prenatal alcohol exposure
MX2012000110A (es) 2009-07-02 2012-04-02 Anthrogenesis Corp Metodo para producir eritrocitos sin celulas alimetadoras.
BR112012001107A2 (pt) * 2009-07-09 2015-09-01 Janssen Biotech Inc Células derivadas de tecido cardíaco
US8647617B2 (en) 2009-07-13 2014-02-11 Stemnion, Inc. Methods for modulating inflammatory and/or immune responses
WO2011011349A2 (en) 2009-07-20 2011-01-27 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells
GB2485112B (en) 2009-07-20 2014-02-26 Janssen Biotech Inc Differentiation of human embryonic stem cells
KR102058901B1 (ko) 2009-07-20 2019-12-24 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
WO2011079017A2 (en) 2009-12-23 2011-06-30 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells
SG181822A1 (en) 2009-12-23 2012-08-30 Centocor Ortho Biotech Inc Differentiation of human embryonic stem cells
US20120301443A1 (en) * 2009-12-29 2012-11-29 Cornell University Methods for developing endothelial cells from pluripotent cells and endothelial cells derived
EP2521587B1 (de) * 2010-01-08 2020-04-08 Wake Forest University Health Sciences Freisetzungssystem
DK3284818T3 (da) 2010-01-26 2022-06-20 Celularity Inc Behandling af knoglerelateret kræft ved hjælp af placenta stamceller
AR080219A1 (es) 2010-02-18 2012-03-21 Osiris Therapeutics Inc Productos de membranas corionicas inmunocompatibles
EP2542667A4 (de) 2010-03-01 2013-07-31 Janssen Biotech Inc Verfahren zur reinigung von aus pluripotenten stammzellen gewonnenen zellen
US9254302B2 (en) 2010-04-07 2016-02-09 Anthrogenesis Corporation Angiogenesis using placental stem cells
JP2013523823A (ja) 2010-04-08 2013-06-17 アントフロゲネシス コーポレーション 胎盤幹細胞を用いるサルコイドーシスの治療
US8481317B2 (en) 2010-04-13 2013-07-09 Cellular Dynamics International, Inc. Hepatocyte production by forward programming
KR101903562B1 (ko) 2010-05-12 2018-10-02 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
US20110312001A1 (en) 2010-06-15 2011-12-22 Emile Nuwaysir Compendium of ready-built stem cell models for interrogation of biological response
US8785192B2 (en) 2010-07-07 2014-07-22 Cellular Dynamics International, Inc. Endothelial cell production by programming
KR20220053695A (ko) 2010-07-13 2022-04-29 셀룰래리티 인코포레이티드 천연 킬러 세포의 생성 방법
IT1405069B1 (it) 2010-07-27 2013-12-16 Uni Degli Studi Perugia Isolamento di cellule staminali pluripotenti da liquido amniotico e loro uso nel trattamento o nella prevenzione di malattie autoimmuni .
US9181528B2 (en) 2010-08-31 2015-11-10 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
EP2611909B1 (de) 2010-08-31 2018-01-17 Janssen Biotech, Inc. Differenzierung menschlicher embryonischer stammzellen
CN103154239B (zh) 2010-08-31 2018-05-15 詹森生物科技公司 人胚胎干细胞的分化
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US8574899B2 (en) 2010-12-22 2013-11-05 Vladimir B Serikov Methods for augmentation collection of placental hematopoietic stem cells and uses thereof
AU2011352036A1 (en) 2010-12-31 2013-07-18 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
US9574179B2 (en) 2011-02-08 2017-02-21 Cellular Dynamics International, Inc. Hematopoietic precursor cell production by programming
US20140050705A1 (en) * 2011-02-25 2014-02-20 Kyungpook National University Hospital Agent for treating urinary incontinence including stem cells derived from amniotic fluid
CA2828705A1 (en) 2011-03-07 2012-09-13 Wake Forest University Health Sciences Delivery system
WO2012140681A1 (en) * 2011-04-13 2012-10-18 Biocell Center S.P.A. Method of collection, classification and preservation of samples containing stem cells
WO2012166844A2 (en) 2011-06-01 2012-12-06 Anthrogenesis Corporation Treatment of pain using placental stem cells
JP2014526887A (ja) 2011-08-01 2014-10-09 アルナイラム ファーマシューティカルズ， インコーポレイテッド 造血幹細胞移植の成功率を改善する方法
US9925221B2 (en) 2011-09-09 2018-03-27 Celularity, Inc. Treatment of amyotrophic lateral sclerosis using placental stem cells
EP3449929A1 (de) * 2011-11-30 2019-03-06 Astellas Institute for Regenerative Medicine Mesenchymale stromazellen und verwendungen im zusammenhang damit
EP2785839A2 (de) 2011-11-30 2014-10-08 University of Bremen Expression von mirnas in plazentagewebe
CN105143446B (zh) 2011-12-22 2020-11-03 詹森生物科技公司 人胚胎干细胞分化成单一激素胰岛素阳性细胞
ES2676556T3 (es) 2011-12-23 2018-07-20 Depuy Synthes Products Llc Detección de células derivadas de tejido del cordón umbilical humano
CN104160018A (zh) 2012-03-07 2014-11-19 詹森生物科技公司 用于扩增和维持多能干细胞的成分确定的培养基
RU2018108850A (ru) 2012-06-08 2019-02-26 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки
US10058306B2 (en) 2012-06-22 2018-08-28 Preprogen, LLC Method for obtaining fetal cells and fetal cellular components
DK2938724T3 (da) 2012-12-31 2020-12-14 Janssen Biotech Inc Dyrkning af humane embryonale stamceller ved luft-væskegrænsefladen til differentiering til endokrine pankreasceller
WO2014106141A1 (en) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
US10138465B2 (en) 2012-12-31 2018-11-27 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
AU2014215458A1 (en) 2013-02-05 2015-08-13 Anthrogenesis Corporation Natural killer cells from placenta
AU2014218807A1 (en) 2013-02-22 2015-09-03 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
US9220817B2 (en) 2013-03-13 2015-12-29 Stemnion, Inc. Medical device
SG11201507515YA (en) 2013-03-15 2015-10-29 Marcus Kare Torleif Larsson Cells, methods and apparatuses for umbilical cord blood collection and isolation of cells
EP3649961B1 (de) 2013-03-15 2021-02-24 Amniotics AB Vorrichtungen zur fruchtwasserentnahme
JP6602288B2 (ja) 2013-04-03 2019-11-06 フジフィルム セルラー ダイナミクス，インコーポレイテッド 浮遊液中で内胚葉前駆細胞を培養するための方法および組成物
WO2014191978A2 (en) * 2013-05-30 2014-12-04 Cells For Cells Chorion-derived mscs cells and conditioned media as inducer for angiogenesis application for the treatment of cardiac degeneration.
CN113648323A (zh) 2013-06-05 2021-11-16 再生疗法有限公司 用于哺乳动物物种中诱导性组织再生的组合物和方法
WO2015023901A1 (en) 2013-08-15 2015-02-19 The Regents Of The University Of California Placenta-derived multipotent stem cells
JP6512759B2 (ja) 2013-08-19 2019-05-15 国立研究開発法人国立循環器病研究センター 羊膜間葉系細胞組成物の製造方法及び凍結保存方法、並びに治療剤
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
KR101669038B1 (ko) * 2014-01-08 2016-10-26 사회복지법인 삼성생명공익재단 영양막 기저층으로부터 유래된 줄기세포 및 이를 포함하는 세포치료제
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US10369254B2 (en) 2014-02-26 2019-08-06 The Regents Of The University Of California Method and apparatus for in vitro kidney organogenesis
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2015164228A1 (en) 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
WO2015170347A2 (en) 2014-05-09 2015-11-12 Reelabs Private Limited Foetal polymix of mesenchymal stem cells under hypoxic conditions for the treatment of clinical disorders
JP6588969B2 (ja) 2014-05-16 2019-10-09 ヤンセン バイオテツク，インコーポレーテツド 膵内分泌細胞内のｍａｆａ発現を強化するための小分子の使用
US10363278B2 (en) 2014-06-15 2019-07-30 Amnio Technology Llc Frozen therapeutic dose and package
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
CA2956723C (en) 2014-08-12 2023-04-11 Nextgen Jane, Inc. System and method for monitoring health based on collected bodily fluid
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
US11464838B2 (en) * 2015-04-01 2022-10-11 Colorado State University Research Foundation Optimized cancer stem cell vaccines
MA45272A (fr) 2015-06-27 2018-05-02 Stimlabs Llc Produits issus de liquide amniotique et procédés d'utilisation
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11077147B2 (en) * 2015-07-20 2021-08-03 Vivex Biologics Group, Inc. Acellular biologic composition and method of manufacture
EP3190176A1 (de) 2016-01-11 2017-07-12 IMBA-Institut für Molekulare Biotechnologie GmbH Verfahren zur gewebekulturentwicklung auf einem gerüst und differenzierte gewebekultur
EP3442706A4 (de) 2016-04-13 2020-02-19 NextGen Jane, Inc. Probensammel- und konservierungsvorrichtungen, systeme und verfahren
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
EP3464565A4 (de) 2016-05-25 2020-01-01 Terumo BCT, Inc. Zellexpansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
WO2018073615A1 (en) 2016-10-21 2018-04-26 Longboat Explorers Ab Methods and compositions for generating hematopoietic cells
EP3656842A1 (de) 2017-03-31 2020-05-27 Terumo BCT, Inc. Zellexpansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3395942A1 (de) 2017-04-25 2018-10-31 IMBA-Institut für Molekulare Biotechnologie GmbH Bi- oder multi-differenziertes organoid
EP3673046A1 (de) 2017-08-23 2020-07-01 Wake Forest University Health Sciences Postnatale transplantation von faktor viii-exprimierenden zellen zur behandlung von hämophilie
US20200368286A1 (en) 2017-08-23 2020-11-26 Wake Forest University Health Sciences In utero transplantation of factor viii-expressing cells for treatment of hemophilia
EP3681998A1 (de) 2017-09-11 2020-07-22 IMBA-Institut für Molekulare Biotechnologie GmbH Tumororganoidmodell
KR102492885B1 (ko) * 2019-09-19 2023-01-27 하유진 융모막판 인접 융모 유래 줄기세포 및 이를 포함하는 조직재생용 세포 치료제
CN114765957A (zh) 2019-10-18 2022-07-19 Amniotics公司 从羊水中获得羊膜间充质干细胞的方法和设备及其来源的细胞
CN115551994A (zh) 2020-03-11 2022-12-30 倍特博有限公司 产生肝细胞的方法
EP3909593A1 (de) 2020-05-15 2021-11-17 Rigshospitalet Stammzellen zur behandlung von hautläsionen
CN111647551B (zh) * 2020-06-12 2022-12-23 银丰生物工程集团有限公司 同一胎盘绒毛小叶组织来源细胞的提取及保存方法
JP2024511064A (ja) 2021-03-23 2024-03-12 テルモ ビーシーティー、インコーポレーテッド 細胞捕獲及び増殖

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744347A (en) * 1987-01-16 1998-04-28 Ohio University Edison Biotechnology Institute Yolk sac stem cells and their uses
US5192553A (en) 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
CA1335181C (en) 1988-10-11 1995-04-11 R. Alan Hardwick System for selective cell separation from cell concentrate
WO1990007380A2 (en) 1988-12-28 1990-07-12 Stefan Miltenyi Methods and materials for high gradient magnetic separation of biological materials
AU4543193A (en) 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5672346A (en) 1992-07-27 1997-09-30 Indiana University Foundation Human stem cell compositions and methods
US6555324B1 (en) 1993-11-04 2003-04-29 Becton Dickinson & Company Method to distinguish hematopoietic progenitor cells
US5580724A (en) 1994-03-25 1996-12-03 Board Of Regents, The University Of Texas System Differential expansion of fetal stem cells in maternal circulation for use in prenatal genetic analysis
US5646004A (en) 1994-08-31 1997-07-08 Activated Cell Therapy, Inc. Methods for enriching fetal cells from maternal body fluids
US5840502A (en) * 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US5827742A (en) 1994-09-01 1998-10-27 Beth Israel Deaconess Medical Center, Inc. Method of selecting pluripotent hematopioetic progenitor cells
US5665557A (en) * 1994-11-14 1997-09-09 Systemix, Inc. Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof
US5677136A (en) 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
ES2180665T3 (es) * 1994-11-16 2003-02-16 Amgen Inc Uso de factor de celulas madre y de receptor soluble de interleuquina-6 para la expansion ex-vivo de celulas hematopoyeticas multipotenciales.
US5874301A (en) 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5750339A (en) 1994-11-30 1998-05-12 Thomas Jefferson University Methods for identifying fetal cells
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6455678B1 (en) * 1996-04-26 2002-09-24 Amcell Corporation Human hematopoietic stem and progenitor cell antigen
WO1998021334A2 (en) 1996-11-13 1998-05-22 Morphogenesis, Inc. Antibody mg1 recognizing a small subset of human hematopoietic cells
AU5436998A (en) 1996-11-15 1998-06-03 Osiris Therapeutics, Inc. MSC-megakaryocyte precursor composition and method of isolating MSCs asso ciated with isolated megakaryocytes by isolating megakaryocytes
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
WO2000073421A2 (en) 1999-06-02 2000-12-07 Lifebank Services, L.L.C. Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells
WO2001030980A2 (en) 1999-10-27 2001-05-03 Mount Sinai Hospital Methods and compositions for enhancing developmental potential of oocytes and zygotes
EP1257282A4 (de) 1999-12-06 2003-05-02 Gen Hospital Corp Pankreatische stammzellen und deren verwendung in transplantation
US20020164307A1 (en) 1999-12-06 2002-11-07 Habener Joel F. Stem cells of the islets of langerhans and their use in treating diabetes mellitus
US20020142457A1 (en) 1999-12-28 2002-10-03 Akihiro Umezawa Cell having the potentiality of differentiation into cardiomyocytes
JP2004500824A (ja) 2000-03-09 2004-01-15 クリオ−セル　インターナショナル　インコーポレーティッド 脳および脊髄の修復のための神経組織源としてのヒト臍帯血
US20010049139A1 (en) 2000-03-23 2001-12-06 Eric Lagasse Hepatic regeneration from hematopoietic stem cells
WO2001096532A2 (en) 2000-06-15 2001-12-20 Tanja Dominko Method of generating pluripotent mammalian cells by fusion of a cytoplast fragment with a karyoplast
CN100422315C (zh) 2000-11-30 2008-10-01 斯坦姆荣公司 分离的纯合干细胞,由其衍生的分化细胞,以及制备和使用上述细胞的材料和方法
JP4294316B2 (ja) 2000-12-06 2009-07-08 ハリリ，ロバート，ジェイ． 胎盤幹細胞の回収方法
US6673904B2 (en) 2000-12-23 2004-01-06 Kirin Beer Kabushiki Kaisha Stem cell growth factor-like polypeptides
ES2629155T3 (es) 2001-02-14 2017-08-07 Anthrogenesis Corporation Matrices de tejido que comprenden células madre placentarias, y métodos para su preparación
US20030017587A1 (en) 2001-07-18 2003-01-23 Rader William C. Embryonic stem cells, clinical applications and methods for expanding in vitro
WO2003089619A2 (en) * 2002-04-19 2003-10-30 University Of Pittsburgh Of The Commonwealth System Of Higher Education Placental derived stem cells and uses thereof
DE60327199D1 (de) * 2002-04-26 2009-05-28 Chugai Pharmaceutical Co Ltd Verfahren zum screening auf agonistische antikörper
GB2506936A (en) 2012-10-15 2014-04-16 Innovia Films Ltd Birefringence authentication apparatus and method

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