ATE221050T1 - Verfahren zur herstellung von lercanidipin hydrochlorid - Google Patents

Verfahren zur herstellung von lercanidipin hydrochlorid

Info

Publication number: ATE221050T1
Authority: AT; Austria
Prior art keywords: lercanidipine hydrochloride; producing lercanidipine; producing; hydrochloride; lercanidipine
Prior art date: 1995-05-12

Application number

AT96916111T

Other languages

English (en)

Inventor

Amedeo Leonardi

Gianni Motta

Original Assignee

Recordati Chem Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-12

Filing date

1996-05-09

Publication date

2002-08-15

1996-05-09 Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm

2002-08-15 Application granted granted Critical

2002-08-15 Publication of ATE221050T1 publication Critical patent/ATE221050T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Urology & Nephrology (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT96916111T 1995-05-12 1996-05-09 Verfahren zur herstellung von lercanidipin hydrochlorid ATE221050T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI950957A IT1274480B (it)	1995-05-12	1995-05-12	Procedimento migliorato per la preparazione della lercanidipina cloridrato
PCT/EP1996/002122 WO1996035668A1 (en)	1995-05-12	1996-05-09	A process for the preparation of lercanidipine hydrochloride

Publications (1)

Publication Number	Publication Date
ATE221050T1 true ATE221050T1 (de)	2002-08-15

Family

ID=11371581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96916111T ATE221050T1 (de)	1995-05-12	1996-05-09	Verfahren zur herstellung von lercanidipin hydrochlorid

Country Status (37)

Country	Link
EP (1)	EP0824517B1 (de)
JP (1)	JP4038622B2 (de)
KR (1)	KR100395441B1 (de)
CN (1)	CN1101810C (de)
AR (1)	AR002739A1 (de)
AT (1)	ATE221050T1 (de)
AU (1)	AU694046B2 (de)
BG (1)	BG62400B1 (de)
BR (1)	BR9608374A (de)
CA (1)	CA2217849C (de)
CZ (1)	CZ288634B6 (de)
DE (1)	DE69622552T2 (de)
DK (1)	DK0824517T3 (de)
DZ (1)	DZ2032A1 (de)
EA (1)	EA000346B1 (de)
EE (1)	EE03351B1 (de)
EG (1)	EG21755A (de)
ES (1)	ES2179942T3 (de)
HU (1)	HU226709B1 (de)
IL (1)	IL118143A (de)
IN (1)	IN188486B (de)
IT (1)	IT1274480B (de)
MA (1)	MA23858A1 (de)
MX (1)	MX9708662A (de)
MY (1)	MY113802A (de)
NO (1)	NO309423B1 (de)
NZ (1)	NZ309059A (de)
PL (1)	PL185260B1 (de)
PT (1)	PT824517E (de)
RO (1)	RO119616B1 (de)
SA (1)	SA96170216B1 (de)
SK (1)	SK283321B6 (de)
TN (1)	TNSN96069A1 (de)
TW (1)	TW404940B (de)
UA (1)	UA46769C2 (de)
WO (1)	WO1996035668A1 (de)
ZA (1)	ZA963716B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6852737B2 (en)	2001-08-06	2005-02-08	Recordati Ireland Limited	Crude and crystalline forms of lercanidipine hydrochloride
ITMI20011726A1 (it) *	2001-08-06	2003-02-06	Recordati Ind Chimica E Farma	Forme polimorfe della lercanidipina cloridrato
EP1553941A1 (de) *	2002-10-16	2005-07-20	Recordati Ireland Limited	Lisinopril/lercanidipine kombinations therapie
AR052918A1 (es)	2005-02-25	2007-04-11	Recordati Ireland Ltd	Clorhidrato de lercanidipina amorfo
KR100713136B1 (ko) *	2005-05-04	2007-05-02	주식회사 대희화학	무수 레르카니디핀 염화수소 결정다형의 개선된 신규결정화 방법
ES2335026T3 (es)	2005-06-15	2010-03-18	Hetero Drugs Limited	Nuevo procedimiento de preparacion de lercanipidina.
WO2007031865A2 (en)	2005-09-16	2007-03-22	Glenmark Pharmaceuticals Limited	Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof
KR100811497B1 (ko) *	2005-10-19	2008-03-07	신풍제약주식회사	무수 염산 1,4-디하이드로피리딘 유도체의 제조 방법
EP1860102B1 (de) *	2006-05-24	2008-11-26	CF Pharma Ltd.	Verfahren zur Herstellung von Lercanipidin
KR100808281B1 (ko) *	2006-06-30	2008-03-03	주식회사 하원정밀화학	레르카니디핀 및 그 산부가염의 제조방법
CN102020602B (zh) *	2009-09-18	2013-12-25	深圳信立泰药业股份有限公司	盐酸乐卡地平晶型及其制备方法和含有该晶型的药物组合物
WO2011161223A2 (en)	2010-06-23	2011-12-29	Krka, Tovarna Zdravil, D.D., Novo Mesto	Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts
EP2654729B1 (de)	2010-12-24	2016-05-04	KRKA, d.d., Novo mesto	Orale homogene pharmazeutische zubereitung enthaltend lercanidipine und enalapril oder ihre pharmazeutische salze zusammen mit einer organischen säure
CN102558032B (zh) *	2011-12-16	2014-02-26	华润赛科药业有限责任公司	一种无定形盐酸乐卡地平及其制备方法
CN102516160B (zh) *	2011-12-16	2014-04-02	华润赛科药业有限责任公司	一种高纯盐酸乐卡地平的合成工艺
CN102584682A (zh) *	2011-12-31	2012-07-18	苏州二叶制药有限公司	盐酸乐卡地平的制备方法
CN109956943B (zh) *	2019-04-18	2021-07-20	合肥合源药业有限公司	一种二氢吡啶类药物中脱羧缩合杂质及其制备、控制方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8403866D0 (en) *	1984-02-14	1984-03-21	Recordati Chem Pharm	Diphenylalkylaminoalkyl esters

1995
- 1995-05-12 IT ITMI950957A patent/IT1274480B/it active IP Right Grant
1996
- 1996-05-03 IL IL11814396A patent/IL118143A/en not_active IP Right Cessation
- 1996-05-06 IN IN822CA1996 patent/IN188486B/en unknown
- 1996-05-07 MA MA24223A patent/MA23858A1/fr unknown
- 1996-05-08 DZ DZ960075A patent/DZ2032A1/fr active
- 1996-05-09 HU HU9801913A patent/HU226709B1/hu unknown
- 1996-05-09 JP JP53379796A patent/JP4038622B2/ja not_active Expired - Lifetime
- 1996-05-09 DK DK96916111T patent/DK0824517T3/da active
- 1996-05-09 RO RO97-02101A patent/RO119616B1/ro unknown
- 1996-05-09 EE EE9700303A patent/EE03351B1/xx unknown
- 1996-05-09 SK SK1514-97A patent/SK283321B6/sk not_active IP Right Cessation
- 1996-05-09 CZ CZ19973567A patent/CZ288634B6/cs not_active IP Right Cessation
- 1996-05-09 AT AT96916111T patent/ATE221050T1/de active
- 1996-05-09 NZ NZ309059A patent/NZ309059A/xx not_active IP Right Cessation
- 1996-05-09 EP EP96916111A patent/EP0824517B1/de not_active Expired - Lifetime
- 1996-05-09 WO PCT/EP1996/002122 patent/WO1996035668A1/en active IP Right Grant
- 1996-05-09 BR BR9608374A patent/BR9608374A/pt not_active Application Discontinuation
- 1996-05-09 MY MYPI96001751A patent/MY113802A/en unknown
- 1996-05-09 ES ES96916111T patent/ES2179942T3/es not_active Expired - Lifetime
- 1996-05-09 CN CN96193842A patent/CN1101810C/zh not_active Expired - Lifetime
- 1996-05-09 PL PL96323236A patent/PL185260B1/pl unknown
- 1996-05-09 CA CA002217849A patent/CA2217849C/en not_active Expired - Lifetime
- 1996-05-09 EG EG40296A patent/EG21755A/xx active
- 1996-05-09 AU AU58985/96A patent/AU694046B2/en not_active Expired
- 1996-05-09 KR KR1019970707905A patent/KR100395441B1/ko not_active IP Right Cessation
- 1996-05-09 PT PT96916111T patent/PT824517E/pt unknown
- 1996-05-09 EA EA199700374A patent/EA000346B1/ru not_active IP Right Cessation
- 1996-05-09 DE DE69622552T patent/DE69622552T2/de not_active Expired - Lifetime
- 1996-05-09 UA UA97125981A patent/UA46769C2/uk unknown
- 1996-05-10 TW TW085105567A patent/TW404940B/zh not_active IP Right Cessation
- 1996-05-10 TN TNTNSN96069A patent/TNSN96069A1/fr unknown
- 1996-05-10 ZA ZA963716A patent/ZA963716B/xx unknown
- 1996-05-10 AR ARP960102528A patent/AR002739A1/es unknown
- 1996-08-07 SA SA96170216A patent/SA96170216B1/ar unknown
1997
- 1997-11-07 BG BG102034A patent/BG62400B1/bg unknown
- 1997-11-11 MX MX9708662A patent/MX9708662A/es unknown
- 1997-11-11 NO NO975176A patent/NO309423B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ309059A (en)	1998-10-28
SA96170216B1 (ar)	2005-12-21
EE03351B1 (et)	2001-02-15
ES2179942T3 (es)	2003-02-01
EG21755A (en)	2002-02-27
WO1996035668A1 (en)	1996-11-14
IT1274480B (it)	1997-07-17
DZ2032A1 (fr)	2002-07-21
NO975176D0 (no)	1997-11-11
NO975176L (no)	1997-11-11
DE69622552T2 (de)	2003-01-23
CZ356797A3 (cs)	1998-04-15
EP0824517A1 (de)	1998-02-25
MY113802A (en)	2002-05-31
ITMI950957A0 (it)	1995-05-12
RO119616B1 (ro)	2005-01-28
ZA963716B (en)	1996-11-20
JP4038622B2 (ja)	2008-01-30
IL118143A0 (en)	1996-09-12
CZ288634B6 (cs)	2001-08-15
KR100395441B1 (ko)	2004-02-05
UA46769C2 (uk)	2002-06-17
EA199700374A1 (ru)	1998-10-29
EP0824517B1 (de)	2002-07-24
HU226709B1 (en)	2009-07-28
BR9608374A (pt)	1999-08-24
SK283321B6 (sk)	2003-06-03
TNSN96069A1 (fr)	2005-03-15
IL118143A (en)	2001-06-14
NO309423B1 (no)	2001-01-29
SK151497A3 (en)	1998-05-06
IN188486B (de)	2002-10-05
KR19990008378A (ko)	1999-01-25
MA23858A1 (fr)	1996-12-31
TW404940B (en)	2000-09-11
PL323236A1 (en)	1998-03-16
CN1101810C (zh)	2003-02-19
EA000346B1 (ru)	1999-04-29
DE69622552D1 (de)	2002-08-29
AU5898596A (en)	1996-11-29
HUP9801913A3 (en)	1999-01-28
BG102034A (en)	1998-04-30
ITMI950957A1 (it)	1996-11-12
CA2217849A1 (en)	1996-11-14
PL185260B1 (pl)	2003-04-30
AR002739A1 (es)	1998-04-29
AU694046B2 (en)	1998-07-09
BG62400B1 (bg)	1999-10-29
MX9708662A (es)	1998-08-30
JPH11504932A (ja)	1999-05-11
PT824517E (pt)	2002-12-31
CN1184468A (zh)	1998-06-10
HUP9801913A2 (hu)	1998-12-28
CA2217849C (en)	2007-09-11
DK0824517T3 (da)	2002-11-18

Legal Events

Date

Code

Title

Description

2003-03-15

UEP

Publication of translation of european patent specification

Ref document number: 0824517

Country of ref document: EP

Publication	Publication Date	Title
DE59504072D1 (de)	1998-12-03	Verfahren zur herstellung von esterquats
ATE243211T1 (de)	2003-07-15	Verfahren zur herstellung von dihalogenazolopyrimidinen
DE69620461D1 (de)	2002-05-08	Verfahren zur herstellung von 1,1,1,3,3,-pentafluoropropanen
DE69631298D1 (de)	2004-02-12	Verfahren zur Herstellung von Paroxetinhydrochloridanhydrat
DE59604922D1 (de)	2000-05-11	Verfahren zur herstellung von polyalkoholen
DE69618476D1 (de)	2002-02-14	Verfahren zur herstellung von 1,1,1,3,3-pentafluorpropan
DE69519379D1 (de)	2000-12-14	Verfahren zur herstellung von trifluorethylene
DE69604277D1 (de)	1999-10-21	Verfahren zur herstellung von nootkaton
DE69816440D1 (de)	2003-08-21	Verfahren zur herstellung von flurbiprofen-lutschtabletten
DE69622552D1 (de)	2002-08-29	Verfahren zur herstellung von lercanidipin hydrochlorid
ATE249417T1 (de)	2003-09-15	Verfahren zur herstellung von l- phenylephrinhydrochlorid
DE59611017D1 (de)	2004-07-01	Verfahren zur herstellung von n-substituierten 3-hydroxypyrazolen
ATE187727T1 (de)	2000-01-15	Verfahren zur herstellung von imidazo- benzodiazepin-derivaten
DE59601604D1 (de)	1999-05-12	Verfahren zur herstellung von n-aryl- und n-hetarylhydroxylaminen
ATE229021T1 (de)	2002-12-15	Verfahren zur herstellung von imidazochinazolinon-derivaten
ATE240300T1 (de)	2003-05-15	Verfahren zur herstellung von phenylimidazolin- derivaten
ATE309230T1 (de)	2005-11-15	Verfahren zur herstellung von 2- chlorthiazolderivaten
ATE181554T1 (de)	1999-07-15	Verfahren zur herstellung von n- phosphonomethylglyzin
DE59601895D1 (de)	1999-06-17	Verfahren zur herstellung von butyrolactonen
DE69616543D1 (de)	2001-12-06	Verfahren zur herstellung von ropivacainehydrochlorid-monohydrat
DE59709989D1 (de)	2003-06-05	Verfahren zur herstellung von n-substituierten 3-hydroxypyrazolen
DE69616322D1 (de)	2001-11-29	Verfahren zur herstellung von 3-isochromanonen
DE69615836D1 (de)	2001-11-15	Verfahren zur herstellung von boroxyd
ATE182143T1 (de)	1999-07-15	Verfahren zur herstellung von 1,2- benzisothiazolonen
ATE214372T1 (de)	2002-03-15	Verfahren zur herstellung von anti-malaria arzneimittel