ATE188874T1 - Monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor, zellen und verfahren zur ihrer herstellung und sie erhaltende zusammensetzungen - Google Patents
Monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor, zellen und verfahren zur ihrer herstellung und sie erhaltende zusammensetzungenInfo
- Publication number
- ATE188874T1 ATE188874T1 AT93202428T AT93202428T ATE188874T1 AT E188874 T1 ATE188874 T1 AT E188874T1 AT 93202428 T AT93202428 T AT 93202428T AT 93202428 T AT93202428 T AT 93202428T AT E188874 T1 ATE188874 T1 AT E188874T1
- Authority
- AT
- Austria
- Prior art keywords
- monoclonal antibody
- egf
- tumor cells
- growth factor
- inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU1992100A CU22387A1 (es) | 1992-08-18 | 1992-08-18 | Anticuerpos monoclonados que reconocen el receptor del factor de crecimiento epidermico. procedimiento de obtencion |
CU1993017 | 1993-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE188874T1 true ATE188874T1 (de) | 2000-02-15 |
Family
ID=25746823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93202428T ATE188874T1 (de) | 1992-08-18 | 1993-08-18 | Monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor, zellen und verfahren zur ihrer herstellung und sie erhaltende zusammensetzungen |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0586002B1 (de) |
AT (1) | ATE188874T1 (de) |
DE (1) | DE69327620T2 (de) |
DK (1) | DK0586002T3 (de) |
ES (1) | ES2144440T3 (de) |
GR (1) | GR3033290T3 (de) |
PT (1) | PT586002E (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
ATE207366T1 (de) * | 1993-12-24 | 2001-11-15 | Merck Patent Gmbh | Immunokonjugate |
US6149921A (en) * | 1993-12-29 | 2000-11-21 | Centro De Inmunologia Molecular | Vaccine compositions for eliciting an immune response against N-acetylated gangliosides and their use for cancer treatment |
CU22420A1 (es) * | 1993-12-29 | 1996-01-31 | Centro Inmunologia Molecular | Composicion vacunal para el desarrollo de una respuesta contra gangliosidos n glicolilados y su uso para el tratamiento del cancer |
GB9405046D0 (en) * | 1994-03-15 | 1994-04-27 | Unilever Plc | Skin treatment composition |
CU22615A1 (es) * | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
ES2167391T3 (es) * | 1994-09-16 | 2002-05-16 | Merck Patent Gmbh | Inmunoconjugados ii. |
IT1277827B1 (it) * | 1995-03-01 | 1997-11-12 | Ministero Uni Ricerca Scient E | Anticorpo monoclonale chimerico murino/umano o un suo frammento specifico per il recettore egf (egf-r) |
EP0745612B1 (de) * | 1995-05-26 | 2001-11-07 | MERCK PATENT GmbH | Antiidiotypische Antikörper die eine Immunantwort gegen den Rezeptor für epidermalen Wachstumsfaktor induzieren |
DE69616651D1 (de) * | 1995-05-26 | 2001-12-13 | Merck Patent Gmbh | Antiidiotypische Antikörper die eine Immunantwort gegen den Rezeptor für epidermalen Wachstumsfaktor induzieren |
US5942602A (en) * | 1997-02-13 | 1999-08-24 | Schering Aktiengessellschaft | Growth factor receptor antibodies |
US20020173629A1 (en) | 1997-05-05 | 2002-11-21 | Aya Jakobovits | Human monoclonal antibodies to epidermal growth factor receptor |
US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
CN1239701C (zh) * | 2000-05-19 | 2006-02-01 | 梨树化学株式会社 | 抗表皮生长因子受体的人源化抗体 |
CU22979A1 (es) * | 2000-12-08 | 2004-09-09 | Centro Inmunologia Molecular | Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina |
US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
AU2002241922B2 (en) * | 2001-01-17 | 2007-10-25 | Aptevo Research And Development Llc | Binding domain-immunoglobulin fusion proteins |
CU23007A1 (es) * | 2001-04-06 | 2004-12-17 | Ct De Inmunologia Molecular Ct De Inmunologia Mole | Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
ES2552281T3 (es) | 2001-05-11 | 2015-11-26 | Ludwig Institute For Cancer Research Ltd. | Proteínas de unión específica y usos de las mismas |
CN100497389C (zh) | 2001-06-13 | 2009-06-10 | 根马布股份公司 | 表皮生长因子受体(egfr)的人单克隆抗体 |
US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
US7754209B2 (en) | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
DE10355904A1 (de) | 2003-11-29 | 2005-06-30 | Merck Patent Gmbh | Feste Formen von anti-EGFR-Antikörpern |
DK1912675T3 (en) | 2005-07-25 | 2014-03-24 | Emergent Product Dev Seattle | B-cell reduction using specific and cd37-cd20-specific binding molecules |
JP2009539413A (ja) | 2006-06-12 | 2009-11-19 | トゥルビオン・ファーマシューティカルズ・インコーポレーテッド | エフェクター機能を有する単鎖多価結合タンパク質 |
US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
MX2009009782A (es) | 2007-03-15 | 2010-09-10 | Ludwig Inst Cancer Res | Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas. |
WO2009023265A1 (en) | 2007-08-14 | 2009-02-19 | Ludwig Institute For Cancer Research | Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof |
ES2368700T3 (es) | 2008-04-11 | 2011-11-21 | Emergent Product Development Seattle, Llc | Agente inmunoterapéutico para cd37 y combinación con un agente quimioterapéutico bifuncional del mismo. |
RU2636046C2 (ru) | 2009-01-12 | 2017-11-17 | Сайтомкс Терапьютикс, Инк | Композиции модифицированных антител, способы их получения и применения |
CU24070B1 (es) * | 2011-12-27 | 2015-01-29 | Ct De Inmunología Molecular | Composiciones farmacéuticas para el tratamiento de tumores que expresan regf y gangliósidos n-glicolilados gm3 (neugcgm3) |
SG11201604758PA (en) | 2013-12-23 | 2016-07-28 | Bayer Pharma AG | Antibody drug conjugates (adcs) with kinesin spindel protein (ksp) |
SG10202006685XA (en) | 2014-10-23 | 2020-08-28 | Innate Pharma | Treatment of Cancers Using Anti-NKG2A Agents |
MX2017017172A (es) | 2015-06-22 | 2018-02-23 | Bayer Pharma AG | Conjugados de ligador-principio activo (adcs) y conjugados de ligador-profarmaco (apdcs) con grupos enzimaticamente escindibles. |
KR20180020225A (ko) | 2015-06-23 | 2018-02-27 | 바이엘 파마 악티엔게젤샤프트 | Ksp 억제제의 표적화된 접합체 |
WO2017017133A1 (en) | 2015-07-27 | 2017-02-02 | Innocimab Pte Ltd | Treatment of patients diagnosed with pancreatic ductal adenocarcinoma using using monoclonal antibodies against the epidermal growth factor receptor (egfr) |
EP3352760A4 (de) | 2015-09-21 | 2019-03-06 | Aptevo Research and Development LLC | Cd3-bindende polypeptide |
WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
JP7022707B2 (ja) | 2016-06-15 | 2022-02-18 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ksp阻害剤および抗cd123抗体を含む特異的抗体-薬物-コンジュゲート(adc) |
CA3047522A1 (en) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Specific antibody drug conjugates (adcs) having ksp inhibitors |
WO2018114578A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Binder-wirkstoff-konjugate (adcs) mit enzymatisch spaltbaren gruppen |
WO2020136147A1 (en) | 2018-12-26 | 2020-07-02 | Innate Pharma | Compounds and methods for treatment of head and neck cancer |
-
1993
- 1993-08-18 DK DK93202428T patent/DK0586002T3/da not_active Application Discontinuation
- 1993-08-18 ES ES93202428T patent/ES2144440T3/es not_active Expired - Lifetime
- 1993-08-18 PT PT93202428T patent/PT586002E/pt unknown
- 1993-08-18 DE DE69327620T patent/DE69327620T2/de not_active Expired - Lifetime
- 1993-08-18 EP EP93202428A patent/EP0586002B1/de not_active Expired - Lifetime
- 1993-08-18 AT AT93202428T patent/ATE188874T1/de active
-
2000
- 2000-04-20 GR GR20000400972T patent/GR3033290T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69327620D1 (de) | 2000-02-24 |
DE69327620T2 (de) | 2000-08-03 |
PT586002E (pt) | 2000-07-31 |
ES2144440T3 (es) | 2000-06-16 |
EP0586002B1 (de) | 2000-01-19 |
EP0586002A2 (de) | 1994-03-09 |
GR3033290T3 (en) | 2000-09-29 |
DK0586002T3 (da) | 2000-06-19 |
EP0586002A3 (en) | 1994-05-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE188874T1 (de) | Monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor, zellen und verfahren zur ihrer herstellung und sie erhaltende zusammensetzungen | |
JP6181089B2 (ja) | 条件依存活性抗上皮細胞増殖因子受容体抗体およびその使用方法 | |
KR101301011B1 (ko) | 마이탄시노이드 항체 접합체 제조 방법 | |
JP6282745B2 (ja) | 修飾抗上皮成長因子受容体抗体およびその使用法 | |
HUP0101160A2 (hu) | Humán szöveti faktor (TF) elleni humanizált antitest és eljárás előállítására | |
AU2308595A (en) | Monoclonal antibodies against hiv-1 and vaccines made thereo f | |
WO2006086733A2 (en) | Process for preparing maytansinoid antibody conjugates | |
UA41929C2 (uk) | Анти-ефрр одноланцюжковий fv,молекула днк,яка його кодує, анти-ефрр антитіло,спосіб одержання анти-ефрр одноланцюжкового fv,спосіб одержання повного анти-ефрр антитіла та фармацевтична композиція (варіанти) | |
KR20060073540A (ko) | 상피 성장 인자 수용체의 결실 돌연변이체 지향 항체 및 그용도 | |
NZ210867A (en) | Tumour-specific monoclonal antibodies, production thereof and use | |
MY137078A (en) | Recombinant antibodies associated to gangliosides. their use indiagnosis and treatment of tumors. | |
KR20190129056A (ko) | 항-ly75 항체를 포함하는 약학적 조합물 | |
CN1930187B (zh) | 针对表皮生长因子受体的缺失突变体的抗体及其使用 | |
KR20210021489A (ko) | 약학적 배합물 | |
AU2020200746A1 (en) | Process for preparing purified drug conjugates | |
EA042216B1 (ru) | Фармацевтические комбинации, содержащие антитело к ly75 | |
MX9705445A (es) | Anticuerpos monoclonales anti-cd6 y su usos. |