ATE124267T1 - Blutplättchenspezifische immunokonjugate. - Google Patents

Blutplättchenspezifische immunokonjugate.

Info

Publication number
ATE124267T1
ATE124267T1 AT90905802T AT90905802T ATE124267T1 AT E124267 T1 ATE124267 T1 AT E124267T1 AT 90905802 T AT90905802 T AT 90905802T AT 90905802 T AT90905802 T AT 90905802T AT E124267 T1 ATE124267 T1 AT E124267T1
Authority
AT
Austria
Prior art keywords
immunoconjugates
antibody
specific
platele
thrombolytic agent
Prior art date
Application number
AT90905802T
Other languages
English (en)
Inventor
Christoph Bode
Edgar Haber
Gabriel Meinhardt
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Application granted granted Critical
Publication of ATE124267T1 publication Critical patent/ATE124267T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6815Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90905802T 1989-04-03 1990-04-03 Blutplättchenspezifische immunokonjugate. ATE124267T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33287489A 1989-04-03 1989-04-03

Publications (1)

Publication Number Publication Date
ATE124267T1 true ATE124267T1 (de) 1995-07-15

Family

ID=23300229

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90905802T ATE124267T1 (de) 1989-04-03 1990-04-03 Blutplättchenspezifische immunokonjugate.

Country Status (6)

Country Link
EP (1) EP0465556B1 (de)
JP (1) JP3436270B2 (de)
AT (1) ATE124267T1 (de)
CA (1) CA2051436A1 (de)
DE (1) DE69020548T2 (de)
WO (1) WO1990011783A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US5196403A (en) * 1989-01-27 1993-03-23 Biogen, Inc. Method of inhibiting platelet activation
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
WO1992018139A1 (en) * 1991-04-09 1992-10-29 Brigham And Women's Hospital Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
JP2776634B2 (ja) * 1991-09-17 1998-07-16 帝人株式会社 グリコプロテイン ▲II▼b/▲III▼aに対するヒト型モノクローナル抗体
WO1994009034A1 (en) * 1992-10-12 1994-04-28 Agen Limited Clot directed anticoagulant, process for making same and methods of use
EP0602290B1 (de) * 1992-12-04 1999-08-25 ConjuChem, Inc. Antikörper-konjugiertes-Hepatitis B-Oberflächenantigen und dessen Verwendung
EP1334730A3 (de) * 1993-11-05 2003-12-03 Centocor, Inc. Plättchen-spezifisches, chimäres Immunglobulin und Verfahren zu derer Verwendung
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US5951981A (en) * 1996-12-02 1999-09-14 Diatide, Inc. Thrombolytic agents with antithrombotic activity
EP1144452B1 (de) * 1998-11-03 2006-01-11 Centocor, Inc. Modifizierte antikörper und antikörper-fragmente mit verlängerter aktivitätsdauer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU595173B2 (en) * 1985-01-08 1990-03-29 General Hospital Corporation, The Method and use for site-specific activation of substances

Also Published As

Publication number Publication date
WO1990011783A1 (en) 1990-10-18
JPH07503450A (ja) 1995-04-13
CA2051436A1 (en) 1990-10-04
EP0465556A1 (de) 1992-01-15
EP0465556B1 (de) 1995-06-28
JP3436270B2 (ja) 2003-08-11
DE69020548T2 (de) 1996-03-07
DE69020548D1 (de) 1995-08-03

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties