DE69020548D1 - Blutplättchenspezifische immunokonjugate. - Google Patents

Blutplättchenspezifische immunokonjugate.

Info

Publication number
DE69020548D1
DE69020548D1 DE69020548T DE69020548T DE69020548D1 DE 69020548 D1 DE69020548 D1 DE 69020548D1 DE 69020548 T DE69020548 T DE 69020548T DE 69020548 T DE69020548 T DE 69020548T DE 69020548 D1 DE69020548 D1 DE 69020548D1
Authority
DE
Germany
Prior art keywords
immunoconjugates
specific
antibody
blood plate
thrombolytic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69020548T
Other languages
English (en)
Other versions
DE69020548T2 (de
Inventor
Christoph Bode
Edgar Haber
Gabriel Meinhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Application granted granted Critical
Publication of DE69020548D1 publication Critical patent/DE69020548D1/de
Publication of DE69020548T2 publication Critical patent/DE69020548T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6815—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE69020548T 1989-04-03 1990-04-03 Blutplättchenspezifische immunokonjugate. Expired - Fee Related DE69020548T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33287489A 1989-04-03 1989-04-03
PCT/US1990/001773 WO1990011783A1 (en) 1989-04-03 1990-04-03 Platelet specific immunoconjugates

Publications (2)

Publication Number Publication Date
DE69020548D1 true DE69020548D1 (de) 1995-08-03
DE69020548T2 DE69020548T2 (de) 1996-03-07

Family

ID=23300229

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69020548T Expired - Fee Related DE69020548T2 (de) 1989-04-03 1990-04-03 Blutplättchenspezifische immunokonjugate.

Country Status (6)

Country Link
EP (1) EP0465556B1 (de)
JP (1) JP3436270B2 (de)
AT (1) ATE124267T1 (de)
CA (1) CA2051436A1 (de)
DE (1) DE69020548T2 (de)
WO (1) WO1990011783A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US5196403A (en) * 1989-01-27 1993-03-23 Biogen, Inc. Method of inhibiting platelet activation
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
AU1873092A (en) * 1991-04-09 1992-11-17 Brigham And Women's Hospital Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
DE69223606T2 (de) * 1991-09-17 1998-07-16 Teijin Ltd Humaner monoklonaler antikörper gegen glycoprotein-iib/iiia
ZA937553B (en) * 1992-10-12 1994-05-03 Agen Ltd Clot directed anticoagulant process for making same and methods of use
EP0602290B1 (de) * 1992-12-04 1999-08-25 ConjuChem, Inc. Antikörper-konjugiertes-Hepatitis B-Oberflächenantigen und dessen Verwendung
AU1172495A (en) * 1993-11-05 1995-05-23 Centocor Inc. Platelet-specific chimeric immunoglobulin and methods of use therefor
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US5951981A (en) * 1996-12-02 1999-09-14 Diatide, Inc. Thrombolytic agents with antithrombotic activity
ES2257094T3 (es) * 1998-11-03 2006-07-16 Centocor, Inc. Anticuerpos modificados y fragmentos de anticuerpo con duracion de actividad aumentada.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU595173B2 (en) * 1985-01-08 1990-03-29 General Hospital Corporation, The Method and use for site-specific activation of substances

Also Published As

Publication number Publication date
EP0465556A1 (de) 1992-01-15
CA2051436A1 (en) 1990-10-04
JP3436270B2 (ja) 2003-08-11
EP0465556B1 (de) 1995-06-28
DE69020548T2 (de) 1996-03-07
WO1990011783A1 (en) 1990-10-18
ATE124267T1 (de) 1995-07-15
JPH07503450A (ja) 1995-04-13

Similar Documents

Publication Publication Date Title
DE69020548D1 (de) Blutplättchenspezifische immunokonjugate.
DE3486030D1 (de) Monoklonale antikoerper, spezifisch von in vivo von fibrinogen abgeleiteten derivatstuecken.
KR910018039A (ko) 양특이성 단일클론 항체, 이들의 생산 및 이용
DK0478328T3 (da) Hidtil ukendte fibrinogenreceptorantagonister
ES2115596T3 (es) Recombinados inmunoconjugados para terapias que comprenden interleucina-2.
DE69937899D1 (de) Antikörper-serumprotein hybride
ATE267610T1 (de) Glykosylierte igg antikörper
DK0673255T3 (da) Monoklonale antistoffer, som specifikt binder til vaskulært tumorendotel, og anvendelser deraf
ES2183805T3 (es) Procedimiento de preparacion de un medicamento trombolitico.
ES2182833T3 (es) Agentes antitromboticos multimeros polivalentes.
ATE214739T1 (de) Plättchen-spezifisches chimärisches immunglobulin
ES2070921T3 (es) Procedimiento de preparacion de una fraccion concentrada de factor viia y su aplicacion a titulo de medicamento.
DK382381A (da) Fremgangsmaade og anlaeg til udvinding af en peptidholdig forbindelse
MX9207459A (es) Anticuerpos humanizados reactivos con gpiib/iiia.
ATE151882T1 (de) Karzinomverwandtes haptoglobin (hpr)
DK213589A (da) Antistoffer mod fibrin og immunogen til brug ved fremstilling deraf
ATE188248T1 (de) Monoklonale antikörper gegen rezeptor-induzierte bindungsstellen auf liganden, die an proteine der cytoadhesin-superfamilie binden
ES2060927T3 (es) Anticuerpos contra la fibrina; peptidos inmunogenos adecuados para preparar los anticuerpos, metodo para determinar fibrina y preparacion farmaceutica basada en los anticuerpos.
HK1054682A1 (en) Platelet-specific chimeric immunoglobulin and methods of use therefor
ATE83930T1 (de) Antikoerper enthaltende stabilisierte waesserige zusammensetzung.
ATE86261T1 (de) Tumorassoziiertes antigen.
RO95315B1 (ro) Procedeu de preparare a unui reactiv pentru determinarea autoanticorpilor tiroidieni microsomali
Gogstad et al. Complex-formation between the fibrin-derived plasmic fragments DD and E demonstrated by crossed immunoelectrophoresis
GR1001087B (el) Μεθοδος και συστηματα για τον προσδιορισμο της παρουσιας ενος αντιγονου του pneumocystis carinii στο αιμα
IE891354L (en) Monoclonal antibodies to tissue plasminogen activator

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee