ATE1237T1 - Hypotensiv wirksamer 2,6dimethyl-4-(2,3-dichlorop henyl)-1,4-dihydropyridin - Google Patents

Hypotensiv wirksamer 2,6dimethyl-4-(2,3-dichlorop henyl)-1,4-dihydropyridin

Info

Publication number
ATE1237T1
ATE1237T1 AT79850057T AT79850057T ATE1237T1 AT E1237 T1 ATE1237 T1 AT E1237T1 AT 79850057 T AT79850057 T AT 79850057T AT 79850057 T AT79850057 T AT 79850057T AT E1237 T1 ATE1237 T1 AT E1237T1
Authority
AT
Austria
Prior art keywords
sub
sup
och
group
6dimethyl
Prior art date
Application number
AT79850057T
Other languages
English (en)
Inventor
Peter Bernhard Berntsson
Stig Ake Ingemar Carlsson
Jan Oernulf Gaarder
Bengt Richard Ljung
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20335348&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE1237(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Haessle Ab filed Critical Haessle Ab
Application granted granted Critical
Publication of ATE1237T1 publication Critical patent/ATE1237T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT79850057T 1978-06-30 1979-06-12 Hypotensiv wirksamer 2,6dimethyl-4-(2,3-dichlorop henyl)-1,4-dihydropyridin ATE1237T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE7807404A SE429652B (sv) 1978-06-30 1978-06-30 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
EP79850057A EP0007293B1 (de) 1978-06-30 1979-06-12 Hypotensiv wirksamer 2,6-Dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridin-3,5-dicarbonsäure-3-methylester-5-ethylester, Verfahren zu seiner Herstellung und diesen enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
ATE1237T1 true ATE1237T1 (de) 1982-07-15

Family

ID=20335348

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79850057T ATE1237T1 (de) 1978-06-30 1979-06-12 Hypotensiv wirksamer 2,6dimethyl-4-(2,3-dichlorop henyl)-1,4-dihydropyridin

Country Status (24)

Country Link
US (1) US4264611A (de)
EP (1) EP0007293B1 (de)
JP (1) JPS559083A (de)
AT (1) ATE1237T1 (de)
AU (1) AU529116B2 (de)
BG (1) BG61420B2 (de)
CA (1) CA1117530A (de)
CS (1) CS241021B2 (de)
CY (1) CY1299A (de)
DD (1) DD144667A5 (de)
DE (1) DE2963150D1 (de)
DK (1) DK148978C (de)
FI (1) FI70573C (de)
HK (1) HK60585A (de)
HU (1) HU178568B (de)
IE (1) IE48650B1 (de)
LU (2) LU88666I2 (de)
NL (2) NL930054I2 (de)
NO (3) NO151965C (de)
NZ (1) NZ190809A (de)
SE (1) SE429652B (de)
SG (1) SG26085G (de)
SU (2) SU856380A3 (de)
ZA (1) ZA792804B (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
SE7910521L (sv) * 1979-12-20 1981-06-21 Haessle Ab Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma
IL68604A0 (en) * 1982-05-21 1983-09-30 Haessle Ab Processes for preparing therapeutically active dihydropyridines and intermediates for the processes
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen
AU561213B2 (en) * 1983-06-02 1987-04-30 Teijin Limited 1, 4-dihydropyridine derivative
DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
DE4342196A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Neue 4-Phenyl-substituierte 1,4-Dihydropyridine
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
FI852359L (fi) * 1984-06-27 1985-12-28 Hoffmann La Roche Dihydropyridinderivat.
US4757071A (en) * 1984-12-14 1988-07-12 Nisshin Flour Milling Co., Ltd. 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases
DE3447169A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE3447170A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
NZ220022A (en) * 1986-04-22 1990-04-26 Byk Gulden Lomberg Chem Fab 1,4-dihydropyridine derivatives and pharmaceutical compositions
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
JPS63255071A (ja) * 1987-04-14 1988-10-21 株式会社　岡田吾作郎商店 磁石内蔵健康棒
AT391269B (de) * 1988-12-30 1990-09-10 Burghart Kurt Pharmazeutische zubereitung
US5310917A (en) * 1991-09-13 1994-05-10 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropydrines
US5834496A (en) * 1991-12-02 1998-11-10 Sepracor, Inc. Methods for treating hypertension using optically pure S(-) felodipine
AU3245493A (en) * 1991-12-02 1993-06-28 Sepracor, Inc. Methods and compositions for treating hypertension, angina, and other disorders using optically pure s(-) felodipine
DK0657432T3 (da) 1993-12-10 2003-07-07 Bayer Ag Phenylsubstituerede 1,4-dihydropyridiner med cerebral aktivitet
DE4430639A1 (de) * 1994-08-29 1996-03-07 Bayer Ag Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
SE9600086D0 (sv) * 1996-01-10 1996-01-10 Astra Ab New manufacturing process
IT1283793B1 (it) * 1996-08-23 1998-04-30 Lusochimica Spa Processo per la preparazione di diidropiridine
EP1108710A4 (de) * 1998-07-23 2001-11-21 Chen Ing Jun Guaiacoxypropanolamine mit alpha/beta-adrenerger hemmaktivität
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6569456B2 (en) 2000-01-13 2003-05-27 Osmotica Corp. Osmotic device containing diltiazem and an ACE inhibitor or diuretic
CZ301790B6 (cs) * 2000-04-11 2010-06-23 Sankyo Company Limited Farmaceutický prípravek obsahující blokátor vápníku
US6653481B2 (en) * 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
EP2316468A1 (de) 2002-02-22 2011-05-04 Shire LLC Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
RS20050106A (en) 2002-08-19 2007-11-15 Pfizer Products Inc., Combination therapy for hyperproliferative diseases
SG141430A1 (en) * 2003-05-30 2008-04-28 Ranbaxy Lab Ltd Substituted pyrrole derivatives and their use as hmg-co inhibitors
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
US20060147520A1 (en) * 2004-07-26 2006-07-06 Curtis Ruegg Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (de) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Kombinationstherapie mit Fasudil zur Behandlung von pulmonaler Hypertonie
EP1951253A2 (de) * 2005-10-26 2008-08-06 Cotherix, Inc. Fasudil in kombinationstherapien zur behandlung von pulmonaler arterieller hypertonie
BRPI0618379A2 (pt) * 2005-11-08 2011-08-30 Ranbaxy Lab Ltd processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
TW200744583A (en) * 2006-03-14 2007-12-16 Ranbaxy Lab Ltd Statin stabilizing dosage formulations
US20080153896A1 (en) * 2006-07-14 2008-06-26 Gyan Chand Yadav Polymorphic Forms of an HMG-CoA Reductase Inhibitor and Uses Thereof
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
WO2009032286A2 (en) 2007-09-06 2009-03-12 Nektar Therapeutics Al, Corporation Oligomer-calcium channel blocker conjugates
US20090118258A1 (en) * 2007-11-07 2009-05-07 Bruce Damiano Combination therapy comprising angiotensin converting enzyme inhibitors and vasopressin receptor antagonists
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
WO2012123966A1 (en) 2011-03-04 2012-09-20 Arch Pharmalabs Limited Process for the preparation of 4 -substituted -1, 4-dihydropyridines
CN102827068A (zh) * 2011-06-17 2012-12-19 张锐豪 一种4-(2, 3-二氯苯基)-2, 6-二甲基-1, 4-二氢-5-甲氧基羰基-3-吡啶羧酸的制备方法
WO2013030725A1 (en) 2011-08-26 2013-03-07 Wockhardt Limited Methods for treating cardiovascular disorders
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
CN104177286A (zh) * 2014-08-11 2014-12-03 广东东阳光药业有限公司 一种地平类药物的制备方法
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
KR101824982B1 (ko) 2015-10-07 2018-02-02 엘지전자 주식회사 차량 및 그 제어방법
CN107952483B (zh) * 2017-12-18 2020-07-28 万华化学集团股份有限公司 一种催化剂，使用该催化剂的反应器，以及一种制备β-苯乙醇的方法
CN108840819B (zh) * 2018-04-02 2021-07-30 常州瑞明药业有限公司 一种非洛地平的制备方法
CA3103616A1 (en) 2018-06-14 2019-12-19 Astrazeneca Uk Limited Methods for lowering blood pressure with a dihydropyridine-type calcium channel blocker pharmaceutical composition
JOP20210193A1 (ar) 2019-01-18 2023-01-30 Astrazeneca Ab مثبطات pcsk9 وطرق استخدامها

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE2117573C3 (de) * 1971-04-10 1978-07-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
DE2117572C3 (de) * 1971-04-10 1980-03-20 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2210672C3 (de) * 1972-03-06 1980-03-20 Bayer Ag, 5090 Leverkusen N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof

Also Published As

Publication number Publication date
FI70573B (fi) 1986-06-06
IE48650B1 (en) 1985-04-03
ZA792804B (en) 1980-06-25
NL930054I1 (nl) 1993-09-01
DK148978C (da) 1986-08-18
NL940012I1 (nl) 1994-08-01
NO151965B (no) 1985-04-01
NO792112L (no) 1980-01-03
DD144667A5 (de) 1980-10-29
NZ190809A (en) 1982-03-09
US4264611A (en) 1981-04-28
DK275079A (da) 1979-12-31
NO1994026I1 (no) 1994-12-21
US4264611B1 (de) 1984-07-17
DK148978B (da) 1985-12-09
CA1117530A (en) 1982-02-02
SE429652B (sv) 1983-09-19
HU178568B (en) 1982-05-28
SU856380A3 (ru) 1981-08-15
SU915799A3 (en) 1982-03-23
SG26085G (en) 1986-01-24
FI70573C (fi) 1986-09-24
AU4831679A (en) 1980-02-07
EP0007293B1 (de) 1982-06-23
EP0007293A1 (de) 1980-01-23
HK60585A (en) 1985-08-23
DE2963150D1 (en) 1982-08-12
CY1299A (en) 1985-10-18
LU88306I2 (fr) 1994-05-04
CS241021B2 (en) 1986-03-13
JPS6121550B2 (de) 1986-05-27
NO151965C (no) 1985-07-10
JPS559083A (en) 1980-01-22
SE7807404L (sv) 1979-12-31
FI792058A (fi) 1979-12-31
BG61420B2 (bg) 1997-07-31
LU88666I2 (fr) 1996-02-01
IE791217L (en) 1979-12-30
AU529116B2 (en) 1983-05-26
NO1996006I1 (no) 1996-06-24
NL930054I2 (nl) 1994-02-16

Similar Documents

Publication Publication Date Title
ATE1237T1 (de) Hypotensiv wirksamer 2,6dimethyl-4-(2,3-dichlorop henyl)-1,4-dihydropyridin
DK159148C (da) Analogifremgangsmaade til fremstilling af tranexamsyrederivater
OA06889A (fr) Nouveaux dérivés du 4H-1,2,4-triazole, leur préparation, leur application comme médicament, les compositions les renfermant et les intermédiaires obtenus.
FI821583A0 (fi) Nya 1-pyrrolintiolaktimetrar och foerfarande foer deras framstaellning
FI821504L (fi) Aminocyklopentanolsyror och -estrar och deras framstaellning och farmaceutiska komposition
SE8701524D0 (sv) Nya sulfonamider och deras framstellningsforfarande
FI833025A0 (fi) Substituerade 1,3,4-benzotriazepiner, foerfarande foer deras framstaellning och deras anvaendning slaekemedel
JPS5233627A (en) Preparation of novel o,o-dialkyl-o-(n-alkoxy-halogeno-acycimidoyl) pho sphates or thionophosphates
FR2432505A1 (fr) Nouveaux sels de 5-iodo-3-nitro-4-hydroxybenzonitrile, leur preparation et compositions qui les contiennent
JPS5414987A (en) Novel s-triazine compounds and its preparation
TH6256EX (th) อนุพันธ์ แอริล สารต่อต้านการอักเสบ
JPS5271447A (en) Synthesis of 2,3-epoxycyclopentanone derivatives
JPS53124276A (en) Uracil derivatives
TH1362EX (th) สารประกอบเพื่อกำจัดวัชพีชชนิดใหม่ (newherbicidal compounds)
JPS5227780A (en) Preparation of 2;3'-lixoepithiouridine
JPS525743A (en) Process for preparation of 3-oxo-5-substituted -cyclohexene-1-ylmalona tes