FI821504L - Aminocyklopentanolsyror och -estrar och deras framstaellning och farmaceutiska komposition - Google Patents

Aminocyklopentanolsyror och -estrar och deras framstaellning och farmaceutiska komposition

Info

Publication number
FI821504L
FI821504L FI821504A FI821504A FI821504L FI 821504 L FI821504 L FI 821504L FI 821504 A FI821504 A FI 821504A FI 821504 A FI821504 A FI 821504A FI 821504 L FI821504 L FI 821504L
Authority
FI
Finland
Prior art keywords
och
sub
aminocyclopentanolsyror
estrar
pharmaceutical composition
Prior art date
Application number
FI821504A
Other languages
English (en)
Other versions
FI821504A0 (fi
FI78478C (fi
FI78478B (fi
Inventor
Eric William Collington
Peter Hallett
Christopher John Wallis
Alan Wadsworth
Norman Frank Hayes
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FI821504A0 publication Critical patent/FI821504A0/fi
Publication of FI821504L publication Critical patent/FI821504L/fi
Application granted granted Critical
Publication of FI78478B publication Critical patent/FI78478B/fi
Publication of FI78478C publication Critical patent/FI78478C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
FI821504A 1981-04-29 1982-04-29 Foerfarande foer framstaellning av terapeutiskt anvaendbara aminocyklopentanolsyraderivat och fysiologiskt godtagbara salter och solvat daerav. FI78478C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8113238 1981-04-29
GB8113238 1981-04-29
GB8120459 1981-07-02
GB8120459 1981-07-02

Publications (4)

Publication Number Publication Date
FI821504A0 FI821504A0 (fi) 1982-04-29
FI821504L true FI821504L (fi) 1982-10-30
FI78478B FI78478B (fi) 1989-04-28
FI78478C FI78478C (fi) 1989-08-10

Family

ID=26279290

Family Applications (1)

Application Number Title Priority Date Filing Date
FI821504A FI78478C (fi) 1981-04-29 1982-04-29 Foerfarande foer framstaellning av terapeutiskt anvaendbara aminocyklopentanolsyraderivat och fysiologiskt godtagbara salter och solvat daerav.

Country Status (14)

Country Link
US (1) US4977163A (fi)
EP (1) EP0069447B1 (fi)
AT (1) ATE23155T1 (fi)
AU (1) AU564950B2 (fi)
CA (1) CA1191134A (fi)
DE (1) DE3273978D1 (fi)
DK (1) DK162441C (fi)
ES (4) ES511813A0 (fi)
FI (1) FI78478C (fi)
HK (1) HK45689A (fi)
IE (1) IE53169B1 (fi)
IL (1) IL65656A (fi)
MY (1) MY8500957A (fi)
NZ (1) NZ200461A (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU576476B2 (en) * 1982-09-16 1988-09-01 Glaxo Group Limited Piperidinylcyclopentanol heptenoic acid salt
GB8601985D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Chemical process
US5221695A (en) * 1987-12-22 1993-06-22 Glaxo Group Limited Aqueous formulation containing a piperidinylcyclopentylheptenoic acid derivative and beta-cyclodextrin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1553293A (en) * 1976-02-23 1979-09-26 Lepetit Spa Azaprostaglandins
US4189606A (en) * 1976-02-23 1980-02-19 Gruppo Lepetit S.P.A. 13-Azaprostaglandins
AU530907B2 (en) * 1978-07-11 1983-08-04 Glaxo Group Limited Prostanoid compounds
GB2028805B (en) * 1978-07-11 1982-11-03 Glaxo Group Ltd Prostanoid compounds
US4239778A (en) * 1978-09-12 1980-12-16 The University Of Illinois Foundation Azaprostanoic acid analogs and their use as inhibitors of platelet aggregation
ZA81114B (en) * 1980-01-09 1982-01-27 Glaxo Group Ltd Prostanoid compounds and their preparation and pharmaceutical formalation
AU542949B2 (en) * 1980-01-09 1985-03-28 Glaxo Group Limited Prostanoid compounds
US4438111A (en) * 1980-01-09 1984-03-20 Glaxo Group Limited Prostanoid compounds and pharmaceutical formulations
JPS5718671A (en) * 1980-04-30 1982-01-30 Glaxo Group Ltd Aminocyclopentane alkenoic acid and esters thereof,manufacture and drug composition
US4371530A (en) * 1980-07-04 1983-02-01 Glaxo Group Limited Aminocyclopentanone amides and pharmaceutical formulation
EP0044711B1 (en) * 1980-07-22 1984-03-14 Ono Pharmaceutical Co., Ltd. 9,11-methano-13-aza-11a-carbathrombanoic acid analogues and pharmaceutical use thereof
US4410521A (en) * 1981-09-16 1983-10-18 Glaxo Group Limited Aminocyclopentane esters and pharmaceutical formulations

Also Published As

Publication number Publication date
DK191882A (da) 1982-10-30
DK162441C (da) 1992-03-23
HK45689A (en) 1989-06-16
ES8306732A1 (es) 1983-06-01
NZ200461A (en) 1985-09-13
IL65656A (en) 1985-10-31
DK162441B (da) 1991-10-28
FI821504A0 (fi) 1982-04-29
ES532049A0 (es) 1986-06-16
US4977163A (en) 1990-12-11
ES525669A0 (es) 1985-08-16
ATE23155T1 (de) 1986-11-15
ES8507126A1 (es) 1985-08-16
AU8310782A (en) 1982-11-04
FI78478C (fi) 1989-08-10
ES8608501A1 (es) 1986-06-16
CA1191134A (en) 1985-07-30
FI78478B (fi) 1989-04-28
ES511813A0 (es) 1983-06-01
EP0069447B1 (en) 1986-10-29
DE3273978D1 (en) 1986-12-04
AU564950B2 (en) 1987-09-03
EP0069447A2 (en) 1983-01-12
MY8500957A (en) 1985-12-31
IE53169B1 (en) 1988-08-03
IL65656A0 (en) 1982-07-30
IE821015L (en) 1982-10-29
ES8403468A1 (es) 1984-03-16
ES519454A0 (es) 1984-03-16
EP0069447A3 (en) 1983-03-16

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Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: GLAXO GROUP LIMITED