AR246528A1 - Procedimiento para la preparacion de isoxazolidinas 2,3-disustituidos y procedimiento para preparar composiciones farmaceuticas. - Google Patents

Procedimiento para la preparacion de isoxazolidinas 2,3-disustituidos y procedimiento para preparar composiciones farmaceuticas.

Info

Publication number
AR246528A1
AR246528A1 AR87309602A AR30960287A AR246528A1 AR 246528 A1 AR246528 A1 AR 246528A1 AR 87309602 A AR87309602 A AR 87309602A AR 30960287 A AR30960287 A AR 30960287A AR 246528 A1 AR246528 A1 AR 246528A1
Authority
AR
Argentina
Prior art keywords
alkyl
sulfamoil
coo
halogen
aryl
Prior art date
Application number
AR87309602A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of AR246528A1 publication Critical patent/AR246528A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PREPARACION DE COMPUESTO DE FORM.(I),DONDE A ES A1)ALQUILO,ALCANOILO,ALCOXICARBONILO,O ALQUILSULFONILO,QUE ESTAN SUST.O NO X-COO-,N,MONO O DIALQUILAMINO,OH,RO,HALOGENO,-NCOO-,SULFAMOILO,ARILO,SUST.O NO X CICLOALQUILO,(ALQUIL O ARILALQUIL)-SULFINILO,(ALQUIL O ARIL ALQUIL)SULFONILO,HETEROARILO Y HETEROARILOXI SUST.O NO X-COO-,AMINO,MONO O DIALQUILAMINO,OH,RO-,HALOGENO,-HNCOO- ,SULFAMOILO,ARILO;A2)CICLOALQUILO,ARILO,AR ILSULFONILO O HETEROARILO,SIENDO LOS RADICALES DEFINIDOS BAJO A1) Y A2)C/VEZ ARILO C6-C12 O BIEN HETEROARILO C3-C9 SUST.O NO X RADICALES -COO-,-NH2,-NO2,MONO O DIALQUILAMINO C1- C4,OH,RO,HALOGENO,-CN,-NH-COO- SULFAMOILO Y ROCO-;A3)RADICAL DE FORM.(IIA) O (IIB);R1 ES B1)H O B2)SE DEFINE X A BAJO A1)O A2);C1)R2 Y R2'SON H O - CH3,R3 Y R3'SON H O ALQUILO,MONOSUST.O NO ENTRE OTROS X NH2,OH,-COO- ,CARBAMOILO,GUANIDINO,UREIDO,FENILO SUT.X HALO NITRO,OH,OH2,FTALIMIDO,4- IMIDAZOLILO,3-INDOLILO,TIENILO,PIRIDILO,O CICLOHEXILO;C2)R2YR3 Y/O R2'Y R3'JUNTOS FORMAN PROPILENO,DONDE CH2 PUE DE SER O NO C3)R2YR3 Y/O R2'OR3'SON C/VEZ CONJUNT.(B),B ES ENTRE OTROS RCO- ,TIOCARBONILO,-S-C:O-,N-ALQUILCARBIMIDOILO,SULFINILO,CR5R6 O ENLACE;D1)R5YR6 SON H,ALQUILO,CICLOALQUILO O D2)R5YR6 JUNTOS SON -/CH2/MCON M=4 O 5,Y 1 O 2 GRUPOS CH2,PUEDEN SER O NO O,S Y/O NR7,D ES -N=C- ,OXI,METILEN O ENLACE;E ES R-C:O-,C=NR7,C=N-OR7 O SULFINILO Y CDO.F SEA ENLACE,PUEDE SER HIDROXIMETILENO,R7 ES R5 X D1),F OXI,-C=N-,CH3-N=C- O ENLACE R4 ALQUILO,CICLOALQUILO,ARILO,ARILOXI,HETEROARIL,DONDE ALQUILO SUST.O NO X -COOR,RNH-CON R=H,ALQUILO,OH,RO- ,HALOGENO,ALQUILAMINO,CARBAMOILO,SULFAMOILO,ALCOXICARBONILO,A RILO Y ARIL- ALQUILO,Y DONDE ARILO O BIEN HETEROARILO SUST.O NO X -OOC-,CN,-NOH2,- NO2,MONO DIALQUILAMINO,OH,RO-,HALOGENO,-NH-C:OO,SULFAMOILO Y RO-C:O,R8 ES R3 X C1).
AR87309602A 1986-12-17 1987-12-15 Procedimiento para la preparacion de isoxazolidinas 2,3-disustituidos y procedimiento para preparar composiciones farmaceuticas. AR246528A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863643012 DE3643012A1 (de) 1986-12-17 1986-12-17 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung

Publications (1)

Publication Number Publication Date
AR246528A1 true AR246528A1 (es) 1994-08-31

Family

ID=6316346

Family Applications (1)

Application Number Title Priority Date Filing Date
AR87309602A AR246528A1 (es) 1986-12-17 1987-12-15 Procedimiento para la preparacion de isoxazolidinas 2,3-disustituidos y procedimiento para preparar composiciones farmaceuticas.

Country Status (21)

Country Link
US (2) US5422342A (es)
EP (1) EP0271865B1 (es)
JP (1) JP2703912B2 (es)
KR (1) KR960010349B1 (es)
AR (1) AR246528A1 (es)
AT (1) ATE81344T1 (es)
AU (1) AU599177B2 (es)
CA (1) CA1338484C (es)
DE (2) DE3643012A1 (es)
DK (1) DK171894B1 (es)
ES (1) ES2052539T3 (es)
FI (1) FI88303C (es)
GR (1) GR3006699T3 (es)
HU (1) HU201961B (es)
IE (1) IE61034B1 (es)
IL (1) IL84841A (es)
NO (1) NO175058B (es)
NZ (1) NZ222921A (es)
PH (1) PH24746A (es)
PT (1) PT86380B (es)
ZA (1) ZA879400B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3818850A1 (de) * 1988-06-03 1989-12-07 Hoechst Ag Oligopeptide mit zyklischen prolin-analogen aminosaeuren
DD284030A5 (de) 1988-11-24 1990-10-31 Hoechst Ag,De Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
DE3842197A1 (de) * 1988-12-15 1990-06-21 Hoechst Ag Rasch spaltbares substrat fuer die hiv-protease
DE4016596A1 (de) * 1990-05-23 1991-11-28 Hoechst Ag Ein neues kupplungsreagenz fuer die peptidsynthese
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
DE4443892A1 (de) * 1994-12-09 1996-06-13 Bayer Ag 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
ATE212990T1 (de) 1996-03-20 2002-02-15 Hoechst Ag Inhibitoren der knochenresorption und vitronectinrezeptor-antagonisten
US5801187A (en) * 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US7141589B2 (en) * 2001-08-23 2006-11-28 The United States Of America As Represented By The Department Of Health And Human Services Methods of inhibiting formation of vascular channels and methods of inhibiting proliferation
CN101006065B (zh) 2004-06-17 2012-07-11 英菲尼蒂发现公司 抑制bcl蛋白与结合伴侣的相互作用的化合物和方法
US7842815B2 (en) 2004-06-17 2010-11-30 Infinity Pharmaceuticals, Inc. Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
TWI389895B (zh) 2006-08-21 2013-03-21 Infinity Discovery Inc 抑制ｂｃｌ蛋白質與結合夥伴間之交互作用的化合物及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944562A (en) * 1974-04-17 1976-03-16 The Upjohn Company αS, 4S, 5R α-Amino-3-chloro-4-hydroxy-2-isoxazoline-5-acetic acid
US4269772A (en) * 1980-01-14 1981-05-26 Merck & Co., Inc. Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline
DE3002989A1 (de) * 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
US4562187A (en) * 1985-01-22 1985-12-31 Hoechst-Roussel Pharmaceuticals Inc. (Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical use
DE3643957A1 (de) * 1986-12-22 1988-06-30 Bayer Ag Substituierte n-methylisoxazolidine

Also Published As

Publication number Publication date
HUT47956A (en) 1989-04-28
PT86380B (pt) 1990-11-20
ZA879400B (en) 1988-07-27
EP0271865B1 (de) 1992-10-07
ATE81344T1 (de) 1992-10-15
JPS63165374A (ja) 1988-07-08
KR880007497A (ko) 1988-08-27
DK662087D0 (da) 1987-12-16
IE61034B1 (en) 1994-09-07
HU201961B (en) 1991-01-28
EP0271865A3 (en) 1990-02-07
US5610146A (en) 1997-03-11
IE873418L (en) 1988-06-17
EP0271865A2 (de) 1988-06-22
PH24746A (en) 1990-10-01
DK662087A (da) 1988-06-18
CA1338484C (en) 1996-07-23
US5422342A (en) 1995-06-06
NO875263L (no) 1988-06-20
NO175058B (no) 1994-05-16
DE3643012A1 (de) 1988-06-30
ES2052539T3 (es) 1994-07-16
FI875503A (fi) 1988-06-18
IL84841A0 (en) 1988-06-30
NO175058C (es) 1994-08-24
FI88303C (fi) 1993-04-26
FI875503A0 (fi) 1987-12-15
PT86380A (de) 1988-01-01
KR960010349B1 (ko) 1996-07-30
AU599177B2 (en) 1990-07-12
DE3782149D1 (es) 1992-11-12
IL84841A (en) 1992-07-15
GR3006699T3 (es) 1993-06-30
DK171894B1 (da) 1997-08-04
JP2703912B2 (ja) 1998-01-26
FI88303B (fi) 1993-01-15
NZ222921A (en) 1989-08-29
AU8258987A (en) 1988-06-23
NO875263D0 (no) 1987-12-16

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